spacer gif spacer gif spacer gif spacer gif ARCHIVE ANNOUNCEMENT! spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Copenhaver, P. F.
Right arrow Articles by Taghert, P. H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Copenhaver, P. F.
Right arrow Articles by Taghert, P. H.

Development, Vol 109, Issue 1 17-28, Copyright © 1990 by Company of Biologists

JOURNAL ARTICLES

Neurogenesis in the insect enteric nervous system: generation of premigratory neurons from an epithelial placode

PF Copenhaver and PH Taghert
Department of Anatomy and Neurobiology, Washington University School of Medicine, Saint Louis, MO 63110.

The enteric plexus (EP) is a major division of the enteric nervous system (ENS) in the moth Manduca sexta and contains a dispersed population of about 360 bipolar neurons, the EP cells. Previously we showed that embryonic EP cells achieve their mature distributions by extensive migration along the gut surface and then display position-specific phenotypes. We now demonstrate that the entire EP cell population is generated from an ectodermal placode that invaginates from the embryonic foregut. Individual EP cells become postmitotic just as they leave the epithelium, but their terminal differentiation is subsequently delayed until after their migratory dispersal. Clonal analysis by injection of lineage-tracing dyes has shown that the EP cell population is derived from a large number of placodal cells, each of which contributes a limited number of neurons to the ENS. Placodally derived clones produce neurons exclusively, while clones arising from cells adjacent to the placode are incorporated into the gut epithelium. These results indicate that neurogenesis in the insect ENS involves a developmental strategy that is distinct from that seen in the insect CNS and which resembles the generation of certain cell classes in the vertebrate nervous system.


This article has been cited by other articles:


Home page
 J. Neurosci.Home page
T. M. Coate, J. A. Wirz, and P. F. Copenhaver
Reverse Signaling via a Glycosyl-Phosphatidylinositol-Linked Ephrin Prevents Midline Crossing by Migratory Neurons during Embryonic Development in Manduca
J. Neurosci., April 9, 2008; 28(15): 3846 - 3860.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
A. M. Horgan and P. F. Copenhaver
G Protein-Mediated Inhibition of Neuronal Migration Requires Calcium Influx
J. Neurosci., June 1, 1998; 18(11): 4189 - 4200.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
A. Horgan, M. Lagrange, and P. Copenhaver
Developmental expression of G proteins in a migratory population of embryonic neurons
Development, January 4, 1994; 120(4): 729 - 742.
[Abstract] [PDF]


© The Company of Biologists Ltd 1990