|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 109, Issue 2 435-447, Copyright © 1990 by Company of Biologists
JOURNAL ARTICLES |
P Bovolenta and J Dodd
Department of Physiology & Cellular Biophysics, Columbia University, New York, NY 10032.
The floor plate of the embryonic rat spinal cord has been proposed to act as an intermediate target that plays a role in the pattern of extension of commissural axons. To begin to examine the role of the floor plate in axon guidance at the midline, we have studied the precision of the commissural axon projection to and across the floor plate during development. To delineate the pathway, the fluorescent carbocyanine dye, Di-I, has been used as a probe. We show that commissural axons traverse the floor plate and turn rostrally at its contralateral border with remarkable precision. Axons were not observed to turn ipsilaterally and turned only upon reaching the contralateral edge of the floor plate. Virtually all commissural axons follow this route. The morphology of commissural growth cones was also examined. As they encountered the floor plate, commissural growth cones became larger and increased in complexity. The reorientation of axons in register with the floor plate boundary and the change in the morphological properties of commissural growth cones as they traverse the midline suggest that the floor plate may act as a guidepost with functions similar to cells that have been implicated in axon guidance in invertebrates.
This article has been cited by other articles:
|
|
 |
|
  S. Zisman, K. Marom, O. Avraham, L. Rinsky-Halivni, U. Gai, G. Kligun, V. Tzarfaty-Majar, T. Suzuki, and A. Klar Proteolysis and membrane capture of F-spondin generates combinatorial guidance cues from a single molecule J. Cell Biol., September 24, 2007; 178(7): 1237 - 1249. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Matsumoto, F. Irie, M. Inatani, M. Tessier-Lavigne, and Y. Yamaguchi Netrin-1/DCC Signaling in Commissural Axon Guidance Requires Cell-Autonomous Expression of Heparan Sulfate J. Neurosci., April 18, 2007; 27(16): 4342 - 4350. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. P. Kulkarni, M. Bak-Maier, and S. E. Fraser Differences in protein mobility between pioneer versus follower growth cones PNAS, January 23, 2007; 104(4): 1207 - 1212. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. I. Lyuksyutova, C.-C. Lu, N. Milanesio, L. A. King, N. Guo, Y. Wang, J. Nathans, M. Tessier-Lavigne, and Y. Zou Anterior-Posterior Guidance of Commissural Axons by Wnt-Frizzled Signaling Science, December 12, 2003; 302(5652): 1984 - 1988. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Bak and S. E. Fraser Axon fasciculation and differences in midline kinetics between pioneer and follower axons within commissural fascicles Development, October 15, 2003; 130(20): 4999 - 5008. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. B. Samat and L. Flores-Samat Neuropathologic Research Strategies in Holoprosencephaly J Child Neurol, December 1, 2001; 16(12): 918 - 931. [Abstract] [PDF]
|
|
|
|
|
|
R. Imondi and Z. Kaprielian Commissural axon pathfinding on the contralateral side of the floor plate: a role for B-class ephrins in specifying the dorsoventral position of longitudinally projecting commissural axons Development, December 1, 2001; 128(23): 4859 - 4871. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Trousse, E. Marti, P. Gruss, M. Torres, and P. Bovolenta Control of retinal ganglion cell axon growth: a new role for Sonic hedgehog Development, October 15, 2001; 128(20): 3927 - 3936. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. J. Paquette, S. E. Perez, and D. J. Anderson Constitutive expression of the neuron-restrictive silencer factor (NRSF)/REST in differentiating neurons disrupts neuronal gene expression and causes axon pathfinding errors in vivo PNAS, October 24, 2000; 97(22): 12318 - 12323. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
U. Rutishauser Defining a Role and Mechanism for IgCAM Function in Vertebrate Axon Guidance J. Cell Biol., May 15, 2000; 149(4): 757 - 760. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Skaliora, R. Adams, and C. Blakemore Morphology and Growth Patterns of Developing Thalamocortical Axons J. Neurosci., May 15, 2000; 20(10): 3650 - 3662. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Beattie, E Melancon, and J. Eisen Mutations in the stumpy gene reveal intermediate targets for zebrafish motor axons Development, January 6, 2000; 127(12): 2653 - 2662. [Abstract] [PDF]
|
|
|
|
|
|
R Imondi, C Wideman, and Z Kaprielian Complementary expression of transmembrane ephrins and their receptors in the mouse spinal cord: a possible role in constraining the orientation of longitudinally projecting axons Development, January 4, 2000; 127(7): 1397 - 1410. [Abstract] [PDF]
|
|
|
|
|
|
M. Matise, M Lustig, T Sakurai, M Grumet, and A. Joyner Ventral midline cells are required for the local control of commissural axon guidance in the mouse spinal cord Development, January 8, 1999; 126(16): 3649 - 3659. [Abstract] [PDF]
|
|
|
|
|
|
K Sharma and E Frank Sensory axons are guided by local cues in the developing dorsal spinal cord Development, January 2, 1998; 125(4): 635 - 643. [Abstract] [PDF]
|
|
|
|
|
|
E. Melancon, D. W. C. Liu, M. Westerfield, and J. S. Eisen Pathfinding by Identified Zebrafish Motoneurons in the Absence of Muscle Pioneers J. Neurosci., October 15, 1997; 17(20): 7796 - 7804. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. J. MacLennan, D. L. McLaurin, L. Marks, E. N. Vinson, M. Pfeifer, S. V. Szulc, M. B. Heaton, and N. Lee Immunohistochemical Localization of Netrin-1 in the Embryonic Chick Nervous System J. Neurosci., July 15, 1997; 17(14): 5466 - 5479. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. J. Jacobs, G. P. Swain, J. A. Snedeker, D. S. Pijak, L. J. Gladstone, and M. E. Selzer Recovery of Neurofilament Expression Selectively in Regenerating Reticulospinal Neurons J. Neurosci., July 1, 1997; 17(13): 5206 - 5220. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. A. Mason and L.-C. Wang Growth Cone Form Is Behavior-Specific and, Consequently, Position-Specific along the Retinal Axon Pathway J. Neurosci., February 1, 1997; 17(3): 1086 - 1100. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C De Felipe, R. Pinnock, and S. Hunt Modulation of chemotropism in the developing spinal cord by substance P Science, February 10, 1995; 267(5199): 899 - 902. [Abstract] [PDF]
|
|
|
|
|
|
O Lefebvre, C Regnier, M. Chenard, C Wendling, P Chambon, P Basset, and M. Rio Developmental expression of mouse stromelysin-3 mRNA Development, January 4, 1995; 121(4): 947 - 955. [Abstract] [PDF]
|
|
|
|
|
|
A. Kurtz, A. Zimmer, F. Schnutgen, G. Bruning, F. Spener, and T. Muller The expression pattern of a novel gene encoding brain-fatty acid binding protein correlates with neuronal and glial cell development Development, September 1, 1994; 120(9): 2637 - 2649. [Abstract] [PDF]
|
|
|
|
|
|
R. M. Campbell and A. C. Peterson Expression of a lacZ transgene reveals floor plate cell morphology and macromolecular transfer to commissural axons Development, December 1, 1993; 119(4): 1217 - 1228. [Abstract] [PDF]
|
|
|
|
|
|
Y Sumi, M. Dent, D. Owen, P. Seeley, and R. Morris The expression of tissue and urokinase-type plasminogen activators in neural development suggests different modes of proteolytic involvement in neuronal growth Development, January 11, 1992; 116(3): 625 - 637. [Abstract] [PDF]
|
|
|
|
|
|
S Hirano, S Fuse, and G. Sohal The effect of the floor plate on pattern and polarity in the developing central nervous system Science, January 18, 1991; 251(4991): 310 - 313. [Abstract] [PDF]
|
|
|
|
|
|
M Placzek, M Tessier-Lavigne, T Yamada, T Jessell, and J Dodd Mesodermal control of neural cell identity: floor plate induction by the notochord Science, November 16, 1990; 250(4983): 985 - 988. [Abstract] [PDF]
|
|
