|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 109, Issue 3 553-566, Copyright © 1990 by Company of Biologists
JOURNAL ARTICLES |
JR Bermingham, A Martinez-Arias, MG Petitt and MP Scott
Howard Hughes Medical Institute, University of Colorado, Boulder 80309-0347.
The homeotic genes of Drosophila control the differentiation of segments during development. Mutations in these genes cause one or more segments to develop structures normally found elsewhere in the organism. Several studies have shown that the spatial patterns of homeotic gene transcription are highly complex, and that these precise patterns of transcription are critical to normal development. The homeotic gene Antennapedia (Antp), a member of the Antennapedia Complex, is required for the correct differentiation of thoracic segments in both embryos and adults. The patterns of total Antp transcript and protein accumulation have been described in detail, but the contribution of each promoter to the overall pattern in embryos has not been reported. We have examined in detail the spatial distribution of transcripts from each of the Antp promoters in both embryo sections and whole embryos by in situ hybridization using promoter-specific probes. We show that the transcripts from each of the two promoters accumulate in distinct, but overlapping patterns during embryogenesis. The results demonstrate that the two Antp promoters are differentially regulated in embryos and provide a basis for examining the regulation of the two promoters and characterizing more fully the function of Antp during embryogenesis. In addition, we have examined the regulation of each of the Antp promoters by genes of the bithorax complex (BX-C). We show that in BX-C- embryos both promoters are derepressed in the abdomen.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati 
Twitter What's this?
This article has been cited by other articles:
|
|
 |
|
  E. Tour, C. T. Hittinger, and W. McGinnis Evolutionarily conserved domains required for activation and repression functions of the Drosophila Hox protein Ultrabithorax Development, December 1, 2005; 132(23): 5271 - 5281. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D Perissinotto, P Iacopetti, I Bellina, R Doliana, A Colombatti, Z Pettway, M Bronner-Fraser, T Shinomura, K Kimata, M Morgelin, et al. Avian neural crest cell migration is diversely regulated by the two major hyaluronan-binding proteoglycans PG-M/versican and aggrecan Development, January 7, 2000; 127(13): 2823 - 2842. [Abstract] [PDF]
|
|
|
|
 |
|
 T. R. Breen Mutant Alleles of the Drosophila trithorax Gene Produce Common and Unusual Homeotic and Other Developmental Phenotypes Genetics, May 1, 1999; 152(1): 319 - 344. [Abstract] [Full Text]
|
|
|
|
 |
|
 M. J. Telford and R. H. Thomas Expression of homeobox genes shows chelicerate arthropods retain their deutocerebral segment PNAS, September 1, 1998; 95(18): 10671 - 10675. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A Gould, A Morrison, G Sproat, R A White, and R Krumlauf Positive cross-regulation and enhancer sharing: two mechanisms for specifying overlapping Hox expression patterns. Genes & Dev., April 1, 1997; 11(7): 900 - 913. [Abstract] [PDF]
|
|
|
|
|
|
A. Prokop and G. M. Technau Early tagma-specific commitment of Drosophila CNS progenitor NB1-1 Development, September 1, 1994; 120(9): 2567 - 2578. [Abstract] [PDF]
|
|
|
|
|
|
Y Sedkov, S Tillib, L Mizrokhi, and A Mazo The bithorax complex is regulated by trithorax earlier during Drosophila embryogenesis than is the Antennapedia complex, correlating with a bithorax-like expression pattern of distinct early trithorax transcripts Development, January 7, 1994; 120(7): 1907 - 1917. [Abstract] [PDF]
|
|
|
|
|
|
T. R. Breen and P. J. Harte Trithorax regulates multiple homeotic genes in the bithorax and Antennapedia complexes and exerts different tissue-specific, parasegment-specific and promoter-specific effects on each Development, January 1, 1993; 117(1): 119 - 134. [Abstract] [PDF]
|
|
|
|
|
|
L Roder, C Vola, and S Kerridge The role of the teashirt gene in trunk segmental identity in Drosophila Development, January 8, 1992; 115(4): 1017 - 1033. [Abstract] [PDF]
|
|
