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Development, Vol 109, Issue 3 647-653, Copyright © 1990 by Company of Biologists

JOURNAL ARTICLES

Normal structure and expression of Zfy genes in XY female mice mutant in Tdy

J Gubbay, P Koopman, J Collignon, P Burgoyne and R Lovell-Badge
Laboratory of Eukaryotic Molecular Genetics, National Institute for Medical Research, The Ridgeway, Mill Hill, London, UK.

Zfy-1 and Zfy-2 are candidate genes for Tdy, the testis-determining gene in mice. We have analysed these genes in a line of XY female mice that have been shown to be mutated in Tdy. We have used Southern blot analysis to show that the Zfy genes have not undergone any major structural alterations, and have also demonstrated that both genes are transcribed normally from the mutant Y chromosome (Y) in both adult XYY testis and XY female embryonic gonads. The fact that these genes show a normal structure and expression pattern in mice with a Y chromosome known to carry a mutation in Tdy and that mutant embryos develop into females despite Zfy-1 expression, strongly supports other recent evidence that Zfy genes are not directly involved in primary testis determination.


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© The Company of Biologists Ltd 1990