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Development, Vol 109, Issue 3 667-682, Copyright © 1990 by Company of Biologists
JOURNAL ARTICLES |
CD Stern
Department of Human Anatomy, UK.
The marginal zone of the chick embryo has been shown to play an important role in the formation of the hypoblast and of the primitive streak. In this study, time-lapse filming, fate mapping, ablation and transplantation experiments were combined to study its contribution to these structures. It was found that the deep (endodermal) portion of the posterior marginal zone contributes to the hypoblast and to the junctional endoblast, while the epiblast portion of the same region contributes to the epiblast of the primitive streak and to the definitive (gut) endoderm derived from it. Within the deep part of the posterior marginal zone, a subpopulation of HNK-1-positive cells contributes to the hypoblast. Removal of the deep part of the marginal zone prevents regeneration of the hypoblast but not the formation of a primitive streak. Removal of both layers of the marginal zone leads to a primitive streak of abnormal morphology but mesendodermal cells nevertheless differentiate. These results show that the two main properties of the posterior marginal zone (contributing to the hypoblast and controlling the site of primitive streak formation) are separable, and reside in different germ layers. This conclusion does not support the idea that the influence of the posterior marginal zone on the development of axial structures is due to it being the source of secondary hypoblast cells.
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R. Bachvarova, I Skromne, and C. Stern Induction of primitive streak and Hensen's node by the posterior marginal zone in the early chick embryo Development, January 9, 1998; 125(17): 3521 - 3534. [Abstract] [PDF]
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K. Storey, A Goriely, C. Sargent, J. Brown, H. Burns, H. Abud, and J. Heath Early posterior neural tissue is induced by FGF in the chick embryo Development, January 2, 1998; 125(3): 473 - 484. [Abstract] [PDF]
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A Streit, K. Lee, I Woo, C Roberts, T. Jessell, and C. Stern Chordin regulates primitive streak development and the stability of induced neural cells, but is not sufficient for neural induction in the chick embryo Development, January 2, 1998; 125(3): 507 - 519. [Abstract] [PDF]
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S. Shah, I Skromne, C. Hume, D. Kessler, K. Lee, C. Stern, and J Dodd Misexpression of chick Vg1 in the marginal zone induces primitive streak formation Development, January 12, 1997; 124(24): 5127 - 5138. [Abstract] [PDF]
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A. Foley, K. Storey, and C. Stern The prechordal region lacks neural inducing ability, but can confer anterior character to more posterior neuroepithelium Development, January 8, 1997; 124(15): 2983 - 2996. [Abstract] [PDF]
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A Streit, C. Stern, C Thery, G. Ireland, S Aparicio, M. Sharpe, and E Gherardi A role for HGF/SF in neural induction and its expression in Hensen's node during gastrulation Development, January 3, 1995; 121(3): 813 - 824. [Abstract] [PDF]
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K. Storey, M. Selleck, and C. Stern Neural induction and regionalisation by different subpopulations of cells in Hensen's node Development, January 2, 1995; 121(2): 417 - 428. [Abstract] [PDF]
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C Gordon-Thomson and B. Fabian Hypoblastic tissue and fibroblast growth factor induce blood tissue (haemoglobin) in the early chick embryo Development, January 12, 1994; 120(12): 3571 - 3579. [Abstract] [PDF]
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Y Hatada and C. Stern A fate map of the epiblast of the early chick embryo Development, January 10, 1994; 120(10): 2879 - 2889. [Abstract] [PDF]
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C. R. Hume and J. Dodd Cwnt-8C: a novel Wnt gene with a potential role in primitive streak formation and hindbrain organization Development, December 1, 1993; 119(4): 1147 - 1160. [Abstract] [PDF]
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A Frumkin, R Haffner, E Shapira, N Tarcic, Y Gruenbaum, and A Fainsod The chicken CdxA homeobox gene and axial positioning during gastrulation Development, January 6, 1993; 118(2): 553 - 562. [Abstract] [PDF]
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