|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 109, Issue 3 691-698, Copyright © 1990 by Company of Biologists
JOURNAL ARTICLES |
G Wolswijk, PN Riddle and M Noble
Ludwig Institute for Cancer Research, London, UK.
We have studied the developmental appearance of the O-2A(adult) progenitor cell, a specific type of oligodendrocyte-type-2 astrocyte (O-2A) progenitor cell that we have identified previously in cultures prepared from the optic nerves of adult rats. O-2A(adult) progenitors differ from their counterparts in perinatal animals (O-2A perinatal progenitor cells) in antigenic phenotype, morphology, cell cycle time, rate of migration, time course of differentiation into oligodendrocytes or type-2 astrocytes and sensitivity to the lytic effects of complement in vitro. In the present study, we have found that O-2A(adult) progenitor-like cells first appear in the developing optic nerve approximately 7 days after birth and that by 1 month after birth these cells appear to be the dominant progenitor population in the nerve. However, the perinatal-to-adult transition in progenitor populations is a gradual one and O-2A(adult) and O-2A perinatal progenitors coexist in the optic nerve for 3 weeks or more. In addition, cells derived from optic nerves of P21 rats express characteristic features of O-2adult and O-2A perinatal progenitors for extended periods of growth in the same tissue culture dish. Our results thus indicate that the properties that distinguish these two types of O-2A progenitors from each other are expressed in apparently identical environments. Thus, these cells must either respond to different signals present in the environment, or must respond with markedly different behaviours to the binding of identical signalling molecules.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati 
Twitter What's this?
This article has been cited by other articles:
|
|
 |
|
  J. Imitola, E. Y. Snyder, and S. J. Khoury Genetic programs and responses of neural stem/progenitor cells during demyelination: potential insights into repair mechanisms in multiple sclerosis Physiol Genomics, August 15, 2003; 14(3): 171 - 197. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Belachew, A. A. Aguirre, H. Wang, F. Vautier, X. Yuan, S. Anderson, M. Kirby, and V. Gallo Cyclin-Dependent Kinase-2 Controls Oligodendrocyte Progenitor Cell Cycle Progression and Is Downregulated in Adult Oligodendrocyte Progenitors J. Neurosci., October 1, 2002; 22(19): 8553 - 8562. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Noble Precursor Cell Transitions in Oligodendrocyte Development J. Cell Biol., March 6, 2000; 148(5): 839 - 842. [Full Text] [PDF]
|
|
|
|
 |
|
 S.-C. Zhang, B. Ge, and I. D. Duncan Adult brain retains the potential to generate oligodendroglial progenitors with extensive myelination capacity PNAS, March 30, 1999; 96(7): 4089 - 4094. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Shi, A. Marinovich, and B. A. Barres Purification and Characterization of Adult Oligodendrocyte Precursor Cells from the Rat Optic Nerve J. Neurosci., June 15, 1998; 18(12): 4627 - 4636. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J Zajicek and A Compston Mechanisms of damage and repair in multiple sclerosis -- a review Multiple Sclerosis, June 1, 1995; 1(2): 61 - 72. [Abstract] [PDF]
|
|
