|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Journal Articles |
A comparison of the patterns of expression of AS-C (T3) RNA and protein suggests that an important level of regulation occurs post- transcriptionally. First, when the RNA is abundant in the early embryo the protein is barely detectable. Later, the protein starts to accumulate in only a subset of the nuclei of those cells expressing the RNA. Only the cells in the subsets become the neuroblasts. This post- transcriptional regulation is suppressed in embryos mutant for the genes Notch and Delta; where all cells expressing RNA accumulate protein. These findings suggest that deployment of T3 protein expression is one of the causal factors that assigns specific fates to the neuroblasts and, in consequence, a basis for the mechanism of lateral inhibition is proposed.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati 
Twitter What's this?
This article has been cited by other articles:
|
|
 |
|
  B. Castro, S. Barolo, A. M. Bailey, and J. W. Posakony Lateral inhibition in proneural clusters: cis-regulatory logic and default repression by Suppressor of Hairless Development, August 1, 2005; 132(15): 3333 - 3344. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. S. Wesley and L.-P. Mok Regulation of Notch Signaling by a Novel Mechanism Involving Suppressor of Hairless Stability and Carboxyl Terminus-Truncated Notch Mol. Cell. Biol., August 15, 2003; 23(16): 5581 - 5593. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Sriuranpong, M. W. Borges, C. L. Strock, E. K. Nakakura, D. N. Watkins, C. M. Blaumueller, B. D. Nelkin, and D. W. Ball Notch Signaling Induces Rapid Degradation of Achaete-Scute Homolog 1 Mol. Cell. Biol., May 1, 2002; 22(9): 3129 - 3139. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. K. Kim and M. Hebrok Intercellular signals regulating pancreas development and function Genes & Dev., January 15, 2001; 15(2): 111 - 127. [Full Text]
|
|
|
|
 |
|
 C. S. Wesley and L. Saez Analysis of Notch Lacking the Carboxyl Terminus Identified in Drosophila Embryos J. Cell Biol., May 1, 2000; 149(3): 683 - 696. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. S. Wesley and L. Saez Notch Responds Differently to Delta and Wingless in Cultured Drosophila Cells J. Biol. Chem., March 24, 2000; 275(13): 9099 - 9101. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. S. Wesley Notch and Wingless Regulate Expression of Cuticle Patterning Genes Mol. Cell. Biol., August 1, 1999; 19(8): 5743 - 5758. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J Zhang and R. Carthew Interactions between Wingless and DFz2 during Drosophila wing development Development, January 8, 1998; 125(16): 3075 - 3085. [Abstract] [PDF]
|
|
|
|
|
|
J. Skeath and C. Doe Sanpodo and Notch act in opposition to Numb to distinguish sibling neuron fates in the Drosophila CNS Development, January 5, 1998; 125(10): 1857 - 1865. [Abstract] [PDF]
|
|
|
|
 |
|
 B. Giebel and J. A. Campos-Ortega Functional dissection of the Drosophila Enhancer of split protein, a suppressor of neurogenesis PNAS, June 10, 1997; 94(12): 6250 - 6254. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S Artavanis-Tsakonas, K Matsuno, and M. Fortini Notch signaling Science, April 14, 1995; 268(5208): 225 - 232. [Abstract] [PDF]
|
|
|
|
|
|
C. Austin, D. Feldman, J. Ida, and C. Cepko Vertebrate retinal ganglion cells are selected from competent progenitors by the action of Notch Development, January 11, 1995; 121(11): 3637 - 3650. [Abstract] [PDF]
|
|
|
|
|
|
R. Kopan, J. S. Nye, and H. Weintraub The intracellular domain of mouse Notch: a constitutively activated repressor of myogenesis directed at the basic helix-loop-helix region of MyoD Development, September 1, 1994; 120(9): 2385 - 2396. [Abstract] [PDF]
|
|
|
|
|
|
C. Cabrera, M. Alonso, and H Huikeshoven Regulation of scute function by extramacrochaete in vitro and in vivo Development, January 12, 1994; 120(12): 3595 - 3603. [Abstract] [PDF]
|
|
|
|
|
|
J. Skeath, G. Panganiban, and S. Carroll The ventral nervous system defective gene controls proneural gene expression at two distinct steps during neuroblast formation in Drosophila Development, January 6, 1994; 120(6): 1517 - 1524. [Abstract] [PDF]
|
|
|
|
|
|
B Kramatschek and J. Campos-Ortega Neuroectodermal transcription of the Drosophila neurogenic genes E(spl) and HLH-m5 is regulated by proneural genes Development, January 4, 1994; 120(4): 815 - 826. [Abstract] [PDF]
|
|
|
|
|
|
Y. Ip, M Levine, and E Bier Neurogenic expression of snail is controlled by separable CNS and PNS promoter elements Development, January 1, 1994; 120(1): 199 - 207. [Abstract] [PDF]
|
|
|
|
|
|
T Lieber, S Kidd, E Alcamo, V Corbin, and M W Young Antineurogenic phenotypes induced by truncated Notch proteins indicate a role in signal transduction and may point to a novel function for Notch in nuclei. Genes & Dev., October 1, 1993; 7(10): 1949 - 1965. [Abstract] [PDF]
|
|
|
|
|
|
A Ghysen, C Dambly-Chaudiere, L Y Jan, and Y N Jan Cell interactions and gene interactions in peripheral neurogenesis. Genes & Dev., May 1, 1993; 7(5): 723 - 733. [PDF]
|
|
|
|
|
|
M Brand, A. Jarman, L. Jan, and Y. Jan asense is a Drosophila neural precursor gene and is capable of initiating sense organ formation Development, January 9, 1993; 119(1): 1 - 17. [Abstract] [PDF]
|
|
|
|
|
|
S. Parkhurst, H. Lipshitz, and D Ish-Horowicz achaete-scute feminizing activities and Drosophila sex determination Development, January 2, 1993; 117(2): 737 - 749. [Abstract] [PDF]
|
|
|
|
|
|
C. Q. Doe Molecular markers for identified neuroblasts and ganglion mother cells in the Drosophila central nervous system Development, December 1, 1992; 116(4): 855 - 863. [Abstract] [PDF]
|
|
|
|
|
|
J B Skeath, G Panganiban, J Selegue, and S B Carroll Gene regulation in two dimensions: the proneural achaete and scute genes are controlled by combinations of axis-patterning genes through a common intergenic control region. Genes & Dev., December 1, 1992; 6(12b): 2606 - 2619. [Abstract] [PDF]
|
|
|
|
|
|
Y Rao, R Bodmer, L. Jan, and Y. Jan The big brain gene of Drosophila functions to control the number of neuronal precursors in the peripheral nervous system Development, January 9, 1992; 116(1): 31 - 40. [Abstract] [PDF]
|
|
|
|
|
|
C. Cabrera The generation of cell diversity during early neurogenesis in Drosophila Development, January 8, 1992; 115(4): 893 - 901. [PDF]
|
|
|
|
|
|
L C Lo, J E Johnson, C W Wuenschell, T Saito, and D J Anderson Mammalian achaete-scute homolog 1 is transiently expressed by spatially restricted subsets of early neuroepithelial and neural crest cells. Genes & Dev., September 1, 1991; 5(9): 1524 - 1537. [Abstract] [PDF]
|
|
|
|
|
|
K Blochlinger, L Y Jan, and Y N Jan Transformation of sensory organ identity by ectopic expression of Cut in Drosophila. Genes & Dev., July 1, 1991; 5(7): 1124 - 1135. [Abstract] [PDF]
|
|
|
|
|
|
J B Skeath and S B Carroll Regulation of achaete-scute gene expression and sensory organ pattern formation in the Drosophila wing. Genes & Dev., June 1, 1991; 5(6): 984 - 995. [Abstract] [PDF]
|
|
|
|
|
|
H Weintraub, R Davis, S Tapscott, M Thayer, M Krause, R Benezra, T. Blackwell, D Turner, R Rupp, S Hollenberg, et al. The myoD gene family: nodal point during specification of the muscle cell lineage Science, February 15, 1991; 251(4995): 761 - 766. [Abstract] [PDF]
|
|
