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Development, Vol 109, Issue 4 833-844, Copyright © 1990 by Company of Biologists
JOURNAL ARTICLES |
KM Lyons, RW Pelton and BL Hogan
Department of Cell Biology, Vanderbilt University Medical School, Nashville, Tennessee 37232-2175.
Bone morphogenetic protein-2A (BMP-2A) is a member of the transforming growth factor beta (TGF beta) gene family that has been implicated in cartilage and bone formation. Here we use in situ hybridization to show that BMP-2A RNA is expressed in a variety of embryonic epithelial and mesenchymal tissues outside of the developing skeletal system, including cell populations known to play important roles in morphogenesis. Thus, high levels of transcripts are found in developing limb buds (ventral ectoderm and apical ectodermal ridge), heart (myocardium of the atrioventricular canal), whisker follicles (ectodermal placodes, hair matrix and precortex cells), tooth buds (epithelial buds, dental papilla and odontoblasts), and craniofacial mesenchyme, as well as a number of other sites. The expression patterns of BMP-2A are different from those of TGF beta-1, -2 and -3, and this is illustrated in detail in the developing whisker follicles. These results suggest that BMP-2A plays multiple roles in morphogenesis and pattern formation in the vertebrate embryo.
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H. Zou, R. Wieser, J. Massague, and L. Niswander Distinct roles of type I bone morphogenetic protein receptors in the formation and differentiation of cartilage Genes & Dev., September 1, 1997; 11(17): 2191 - 2203. [Abstract] [Full Text] [PDF] |
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S. Varghese and E. Canalis Regulation of Collagenase-3 by Bone Morphogenetic Protein-2 in Bone Cell Cultures Endocrinology, March 1, 1997; 138(3): 1035 - 1040. [Abstract] [Full Text] [PDF] |
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J. Cygan, R. Johnson, and A. McMahon Novel regulatory interactions revealed by studies of murine limb pattern in Wnt-7a and En-1 mutants Development, January 12, 1997; 124(24): 5021 - 5032. [Abstract] [PDF] |
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Y Kishimoto, K. Lee, L Zon, M Hammerschmidt, and S Schulte-Merker The molecular nature of zebrafish swirl: BMP2 function is essential during early dorsoventral patterning Development, January 11, 1997; 124(22): 4457 - 4466. [Abstract] [PDF] |
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Y Yokouchi, S Nakazato, M Yamamoto, Y Goto, T Kameda, H Iba, and A Kuroiwa Misexpression of Hoxa-13 induces cartilage homeotic transformation and changes cell adhesiveness in chick limb buds. Genes & Dev., October 15, 1995; 9(20): 2509 - 2522. [Abstract] [PDF] |
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S. Iwasaki, N. Tsuruoka, A. Hattori, M. Sato, M. Tsujimoto, and M. Kohno Distribution and Characterization of Specific Cellular Binding Proteins for Bone Morphogenetic Protein-2 J. Biol. Chem., March 10, 1995; 270(10): 5476 - 5482. [Abstract] [Full Text] [PDF] |
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D M Kingsley The TGF-beta superfamily: new members, new receptors, and new genetic tests of function in different organisms. Genes & Dev., January 15, 1994; 8(2): 133 - 146. [PDF] |
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D Lohnes, M Mark, C Mendelsohn, P Dolle, A Dierich, P Gorry, A Gansmuller, and P Chambon Function of the retinoic acid receptors (RARs) during development (I). Craniofacial and skeletal abnormalities in RAR double mutants Development, January 10, 1994; 120(10): 2723 - 2748. [Abstract] [PDF] |
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F. Conlon, K. Lyons, N Takaesu, K. Barth, A Kispert, B Herrmann, and E. Robertson A primary requirement for nodal in the formation and maintenance of the primitive streak in the mouse Development, January 7, 1994; 120(7): 1919 - 1928. [Abstract] [PDF] |
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E N Olson and W H Klein bHLH factors in muscle development: dead lines and commitments, what to leave in and what to leave out. Genes & Dev., January 1, 1994; 8(1): 1 - 8. [PDF] |
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M Blessing, L B Nanney, L E King, C M Jones, and B L Hogan Transgenic mice as a model to study the role of TGF-beta-related molecules in hair follicles. Genes & Dev., February 1, 1993; 7(2): 204 - 215. [Abstract] [PDF] |
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S. Wheatley, C. Isacke, and P. Crossley Restricted expression of the hyaluronan receptor, CD44, during postimplantation mouse embryogenesis suggests key roles in tissue formation and patterning Development, January 10, 1993; 119(2): 295 - 306. [Abstract] [PDF] |
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V Garcia-Martinez, D Macias, Y Ganan, J. Garcia-Lobo, M. Francia, M. Fernandez-Teran, and J. Hurle Internucleosomal DNA fragmentation and programmed cell death (apoptosis) in the interdigital tissue of the embryonic chick leg bud J. Cell Sci., January 9, 1993; 106(1): 201 - 208. [Abstract] [PDF] |
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A Vogel and C Tickle FGF-4 maintains polarizing activity of posterior limb bud cells in vivo and in vitro Development, January 9, 1993; 119(1): 199 - 206. [Abstract] [PDF] |
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L Niswander and G. Martin FGF-4 regulates expression of Evx-1 in the developing mouse limb Development, January 9, 1993; 119(1): 287 - 294. [Abstract] [PDF] |
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U. Ripamonti and A. Hari Reddi Growth and Morphogenetic Factors in Bone Induction: Role of Osteogenin and Related Bone Morphogenetic Proteins in Craniofacial and Periodontal Bone Repair Critical Reviews in Oral Biology & Medicine, January 1, 1992; 3(1): 1 - 14. [Abstract] [Full Text] [PDF] |
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N. C. Milos Mesoderm and Jaw Development in Vertebrates: The Role of Growth Factors Critical Reviews in Oral Biology & Medicine, January 1, 1992; 4(1): 73 - 91. [Abstract] [Full Text] [PDF] |
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