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Development, Vol 109, Issue 4 833-844, Copyright © 1990 by Company of Biologists
JOURNAL ARTICLES |
KM Lyons, RW Pelton and BL Hogan
Department of Cell Biology, Vanderbilt University Medical School, Nashville, Tennessee 37232-2175.
Bone morphogenetic protein-2A (BMP-2A) is a member of the transforming growth factor beta (TGF beta) gene family that has been implicated in cartilage and bone formation. Here we use in situ hybridization to show that BMP-2A RNA is expressed in a variety of embryonic epithelial and mesenchymal tissues outside of the developing skeletal system, including cell populations known to play important roles in morphogenesis. Thus, high levels of transcripts are found in developing limb buds (ventral ectoderm and apical ectodermal ridge), heart (myocardium of the atrioventricular canal), whisker follicles (ectodermal placodes, hair matrix and precortex cells), tooth buds (epithelial buds, dental papilla and odontoblasts), and craniofacial mesenchyme, as well as a number of other sites. The expression patterns of BMP-2A are different from those of TGF beta-1, -2 and -3, and this is illustrated in detail in the developing whisker follicles. These results suggest that BMP-2A plays multiple roles in morphogenesis and pattern formation in the vertebrate embryo.
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S. Millar, M. Miller, M. Stevens, and G. Barsh Expression and transgenic studies of the mouse agouti gene provide insight into the mechanisms by which mammalian coat color patterns are generated Development, January 10, 1995; 121(10): 3223 - 3232. [Abstract] [PDF]
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M Weil, A Itin, and E Keshet A role for mesenchyme-derived tachykinins in tooth and mammary gland morphogenesis Development, January 8, 1995; 121(8): 2419 - 2428. [Abstract] [PDF]
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B. Rutherford and M. Fitzgerald A New Biological Approach To Vital Pulp Therapy Critical Reviews in Oral Biology & Medicine, January 1, 1995; 6(3): 218 - 229. [Abstract] [Full Text] [PDF]
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C van Genderen, R M Okamura, I Farinas, R G Quo, T G Parslow, L Bruhn, and R Grosschedl Development of several organs that require inductive epithelial-mesenchymal interactions is impaired in LEF-1-deficient mice. Genes & Dev., November 15, 1994; 8(22): 2691 - 2703. [Abstract] [PDF]
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K Arora, M S Levine, and M B O'Connor The screw gene encodes a ubiquitously expressed member of the TGF-beta family required for specification of dorsal cell fates in the Drosophila embryo. Genes & Dev., November 1, 1994; 8(21): 2588 - 2601. [Abstract] [PDF]
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M. Nagai and M. Ota Pulsating Electromagnetic Field Stimulates mRNA Expression of Bone Morphogenetic Protein-2 and -4 Journal of Dental Research, October 1, 1994; 73(10): 1601 - 1605. [Abstract] [PDF]
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M. Nakashima Induction of Dentin Formation on Canine Amputated Pulp by Recombinant Human Bone Morphogenetic Proteins (BMP)-2 and -4 Journal of Dental Research, September 1, 1994; 73(9): 1515 - 1522. [Abstract] [PDF]
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K. Heikinheimo Stage-specific Expression of Decapentaplegic-Vg-related Genes 2, 4, and 6 (Bone Morphogenetic Proteins 2, 4, and 6) During Human Tooth Morphogenesis Journal of Dental Research, March 1, 1994; 73(3): 590 - 597. [Abstract] [PDF]
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A C Karaplis, A Luz, J Glowacki, R T Bronson, V L Tybulewicz, H M Kronenberg, and R C Mulligan Lethal skeletal dysplasia from targeted disruption of the parathyroid hormone-related peptide gene. Genes & Dev., February 1, 1994; 8(3): 277 - 289. [Abstract] [PDF]
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D M Kingsley The TGF-beta superfamily: new members, new receptors, and new genetic tests of function in different organisms. Genes & Dev., January 15, 1994; 8(2): 133 - 146. [PDF]
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D Lohnes, M Mark, C Mendelsohn, P Dolle, A Dierich, P Gorry, A Gansmuller, and P Chambon Function of the retinoic acid receptors (RARs) during development (I). Craniofacial and skeletal abnormalities in RAR double mutants Development, January 10, 1994; 120(10): 2723 - 2748. [Abstract] [PDF]
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F. Conlon, K. Lyons, N Takaesu, K. Barth, A Kispert, B Herrmann, and E. Robertson A primary requirement for nodal in the formation and maintenance of the primitive streak in the mouse Development, January 7, 1994; 120(7): 1919 - 1928. [Abstract] [PDF]
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E N Olson and W H Klein bHLH factors in muscle development: dead lines and commitments, what to leave in and what to leave out. Genes & Dev., January 1, 1994; 8(1): 1 - 8. [PDF]
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M Blessing, L B Nanney, L E King, C M Jones, and B L Hogan Transgenic mice as a model to study the role of TGF-beta-related molecules in hair follicles. Genes & Dev., February 1, 1993; 7(2): 204 - 215. [Abstract] [PDF]
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S. Wheatley, C. Isacke, and P. Crossley Restricted expression of the hyaluronan receptor, CD44, during postimplantation mouse embryogenesis suggests key roles in tissue formation and patterning Development, January 10, 1993; 119(2): 295 - 306. [Abstract] [PDF]
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 V Garcia-Martinez, D Macias, Y Ganan, J. Garcia-Lobo, M. Francia, M. Fernandez-Teran, and J. Hurle Internucleosomal DNA fragmentation and programmed cell death (apoptosis) in the interdigital tissue of the embryonic chick leg bud J. Cell Sci., January 9, 1993; 106(1): 201 - 208. [Abstract] [PDF]
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A Vogel and C Tickle FGF-4 maintains polarizing activity of posterior limb bud cells in vivo and in vitro Development, January 9, 1993; 119(1): 199 - 206. [Abstract] [PDF]
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L Niswander and G. Martin FGF-4 regulates expression of Evx-1 in the developing mouse limb Development, January 9, 1993; 119(1): 287 - 294. [Abstract] [PDF]
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U. Ripamonti and A. Hari Reddi Growth and Morphogenetic Factors in Bone Induction: Role of Osteogenin and Related Bone Morphogenetic Proteins in Craniofacial and Periodontal Bone Repair Critical Reviews in Oral Biology & Medicine, January 1, 1992; 3(1): 1 - 14. [Abstract] [Full Text] [PDF]
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N. C. Milos Mesoderm and Jaw Development in Vertebrates: The Role of Growth Factors Critical Reviews in Oral Biology & Medicine, January 1, 1992; 4(1): 73 - 91. [Abstract] [Full Text] [PDF]
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