|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 109, Issue 4 865-874, Copyright © 1990 by Company of Biologists
JOURNAL ARTICLES |
NB Zak, RJ Wides, ED Schejter, E Raz and BZ Shilo
Department of Molecular Genetics and Virology, Weizmann Institute of Science, Rehovot, Israel.
Antibodies were raised against the Drosophila EGF receptor homolog (DER) and used for immunohistochemical analyses of Drosophila embryos. We found that DER is localized in a wide array of embryonic tissues, displaying a dynamic pattern of expression. DER appears to be expressed in all cells at the cellular blastoderm and gastrula stages. In extended-germ-band embryos, it is found predominantly in the mesoderm and the head. Finally, in retracted-germ-band embryos, DER immunoreactivity is most pronounced at sites of somatic muscle attachments and along the ventral midline of the CNS. We have thus observed that DER is expressed in the diverse tissues which are affected in the DER faint little ball (flb) embryonic lethal phenotype. The different pattern and extent of expression in each tissue suggests that the disparate aspects of the flb phenotype may result from different mechanisms of DER function. To understand the basis for the CNS phenotype of DER/flb mutants, we have closely followed the collapse of the CNS in mutant embryos. Our observations on the evolution of the final CNS phenotype, in combination with the temporo-spatial pattern of appearance of DER in the ventral neuroepithelium, suggest that this receptor participates in the second phase of neuron-glia interactions, namely in stabilization of the ladder-like CNS scaffolding formed by outgrowth of pioneer axonal processes along the glial pre-pattern.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati 
Twitter What's this?
This article has been cited by other articles:
|
|
 |
|
  R. Islam, L. V. Kristiansen, S. Romani, L. Garcia-Alonso, and M. Hortsch Activation of EGF Receptor Kinase by L1-mediated Homophilic Cell Interactions Mol. Biol. Cell, April 1, 2004; 15(4): 2003 - 2012. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Dumstrei, F. Wang, D. Shy, U. Tepass, and V. Hartenstein Interaction between EGFR signaling and DE-cadherin during nervous system morphogenesis Development, September 1, 2002; 129(17): 3983 - 3994. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Tsruya, A. Schlesinger, A. Reich, L. Gabay, A. Sapir, and B.-Z. Shilo Intracellular trafficking by Star regulates cleavage of the Drosophila EGF receptor ligand Spitz Genes & Dev., January 15, 2002; 16(2): 222 - 234. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Sedaghat, W. F. Miranda, and M. J. Sonnenfeld The jing Zn-finger transcription factor is a mediator of cellular differentiation in the Drosophila CNS midline and trachea Development, January 6, 2002; 129(11): 2591 - 2606. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Szüts, S. Eresh, and M. Bienz Functional intertwining of Dpp and EGFR signaling during Drosophila endoderm induction Genes & Dev., July 1, 1998; 12(13): 2022 - 2035. [Abstract] [Full Text]
|
|
|
|
|
|
G Udolph, J Urban, G Rusing, K Luer, and G. Technau Differential effects of EGF receptor signalling on neuroblast lineages along the dorsoventral axis of the Drosophila CNS Development, January 9, 1998; 125(17): 3291 - 3299. [Abstract] [PDF]
|
|
|
|
|
|
J. Skeath The Drosophila EGF receptor controls the formation and specification of neuroblasts along the dorsal-ventral axis of the Drosophila embryo Development, January 9, 1998; 125(17): 3301 - 3312. [Abstract] [PDF]
|
|
|
|
|
|
K Dumstrei, C Nassif, G Abboud, A Aryai, A Aryai, and V Hartenstein EGFR signaling is required for the differentiation and maintenance of neural progenitors along the dorsal midline of the Drosophila embryonic head Development, January 9, 1998; 125(17): 3417 - 3426. [Abstract] [PDF]
|
|
|
|
|
|
E Buff, A Carmena, S Gisselbrecht, F Jimenez, and A. Michelson Signalling by the Drosophila epidermal growth factor receptor is required for the specification and diversification of embryonic muscle progenitors Development, January 6, 1998; 125(11): 2075 - 2086. [Abstract] [PDF]
|
|
|
|
|
|
L Gabay, R Seger, and B. Shilo MAP kinase in situ activation atlas during Drosophila embryogenesis Development, January 9, 1997; 124(18): 3535 - 3541. [Abstract] [PDF]
|
|
|
|
|
|
D Szuts, M Freeman, and M Bienz Antagonism between EGFR and Wingless signalling in the larval cuticle of Drosophila Development, January 8, 1997; 124(16): 3209 - 3219. [Abstract] [PDF]
|
|
|
|
|
|
K Giesen, T Hummel, A Stollewerk, S Harrison, A Travers, and C Klambt Glial development in the Drosophila CNS requires concomitant activation of glial and repression of neuronal differentiation genes Development, January 6, 1997; 124(12): 2307 - 2316. [Abstract] [PDF]
|
|
|
|
|
|
B Schnepp, G Grumbling, T Donaldson, and A Simcox Vein is a novel component in the Drosophila epidermal growth factor receptor pathway with similarity to the neuregulins. Genes & Dev., September 15, 1996; 10(18): 2302 - 2313. [Abstract] [PDF]
|
|
|
|
|
|
L Gabay, H Scholz, M Golembo, A Klaes, B. Shilo, and C Klambt EGF receptor signaling induces pointed P1 transcription and inactivates Yan protein in the Drosophila embryonic ventral ectoderm Development, January 11, 1996; 122(11): 3355 - 3362. [Abstract] [PDF]
|
|
|
|
|
|
L. Frank and C Rushlow A group of genes required for maintenance of the amnioserosa tissue in Drosophila Development, January 5, 1996; 122(5): 1343 - 1352. [Abstract] [PDF]
|
|
|
|
|
|
M Roark, M A Sturtevant, J Emery, H Vaessin, E Grell, and E Bier scratch, a pan-neural gene encoding a zinc finger protein related to snail, promotes neuronal development. Genes & Dev., October 1, 1995; 9(19): 2384 - 2398. [Abstract] [PDF]
|
|
|
|
|
|
R Schweitzer, M Shaharabany, R Seger, and B Z Shilo Secreted Spitz triggers the DER signaling pathway and is a limiting component in embryonic ventral ectoderm determination. Genes & Dev., June 15, 1995; 9(12): 1518 - 1529. [Abstract] [PDF]
|
|
|
|
|
|
M. A. Sturtevant, J. W. O'Neill, and E. Bier Down-regulation of Drosophila Egf-r mRNA levels following hyperactivated receptor signaling Development, September 1, 1994; 120(9): 2593 - 2600. [Abstract] [PDF]
|
|
|
|
|
|
E Raz and B Z Shilo Establishment of ventral cell fates in the Drosophila embryonic ectoderm requires DER, the EGF receptor homolog. Genes & Dev., October 1, 1993; 7(10): 1937 - 1948. [Abstract] [PDF]
|
|
|
|
|
|
M A Sturtevant, M Roark, and E Bier The Drosophila rhomboid gene mediates the localized formation of wing veins and interacts genetically with components of the EGF-R signaling pathway. Genes & Dev., June 1, 1993; 7(6): 961 - 973. [Abstract] [PDF]
|
|
|
|
 |
|
 D Buttgereit Redundant enhancer elements guide beta 1 tubulin gene expression in apodemes during Drosophila embryogenesis J. Cell Sci., January 7, 1993; 105(3): 721 - 727. [Abstract] [PDF]
|
|
|
|
|
|
S. Kim and S. Crews Influence of Drosophila ventral epidermal development by the CNS midline cells and spitz class genes Development, January 7, 1993; 118(3): 893 - 901. [Abstract] [PDF]
|
|
|
|
|
|
C. Klambt The Drosophila gene pointed encodes two ETS-like proteins which are involved in the development of the midline glial cells Development, January 1, 1993; 117(1): 163 - 176. [Abstract] [PDF]
|
|
|
|
|
|
B J Rutledge, K Zhang, E Bier, Y N Jan, and N Perrimon The Drosophila spitz gene encodes a putative EGF-like growth factor involved in dorsal-ventral axis formation and neurogenesis. Genes & Dev., August 1, 1992; 6(8): 1503 - 1517. [Abstract] [PDF]
|
|
|
|
|
|
L Glazer and B Z Shilo The Drosophila FGF-R homolog is expressed in the embryonic tracheal system and appears to be required for directed tracheal cell extension. Genes & Dev., April 1, 1991; 5(4): 697 - 705. [Abstract] [PDF]
|
|
|
|
|
|
J M Rothberg, J R Jacobs, C S Goodman, and S Artavanis-Tsakonas slit: an extracellular protein necessary for development of midline glia and commissural axon pathways contains both EGF and LRR domains. Genes & Dev., December 1, 1990; 4(12a): 2169 - 2187. [Abstract] [PDF]
|
|
|
|
|
|
R J Fleming, T N Scottgale, R J Diederich, and S Artavanis-Tsakonas The gene Serrate encodes a putative EGF-like transmembrane protein essential for proper ectodermal development in Drosophila melanogaster. Genes & Dev., December 1, 1990; 4(12a): 2188 - 2201. [Abstract] [PDF]
|
|
