spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Charpentier, G.
Right arrow Articles by Magre, S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Charpentier, G.
Right arrow Articles by Magre, S.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Development, Vol 110, Issue 3 839-849, Copyright © 1990 by Company of Biologists

JOURNAL ARTICLES

Masculinizing effect of testes on developing rat ovaries in organ culture

G Charpentier and S Magre
Laboratoire de Physiologie du Developpement, College de France, Paris.

Masculinizing effect of testes on developing rat ovaries was shown in vitro by culturing testes from 17.5-day-old fetuses in contact with female genital tracts from 14.5-day-old rat fetuses. The testes induced the differentiation of epithelial cells staining for cytokeratin in the ovarian blastema. These cells formed seminiferous cord-like structures delineated by a basement membrane, in a way that resembles early stages of testicular organogenesis. In addition to the morphological masculinization, functional masculinization was obtained since the ovaries produced the anti-Mullerian hormone as shown by bioassay and immunohistochemical procedures. Across a distance, testes from 17.5-day-old fetuses failed to induce masculinization. These results suggest that testes from 17.5-day-old fetuses produce a locally diffusible factor interfering with the development and the differentiation of the fetal ovaries. The possibility that the anti-Mullerian hormone secreted by the testes may be the factor involved is discussed comparing these results with those obtained with testes from different stages and with bibliographic data.
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 Biol. Reprod.Home page
C. J. Guigon and S. Magre
Contribution of Germ Cells to the Differentiation and Maturation of the Ovary: Insights from Models of Germ Cell Depletion
Biol Reprod, March 1, 2006; 74(3): 450 - 458.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
C. J. Guigon, N. Coudouel, S. Mazaud-Guittot, M. G. Forest, and S. Magre
Follicular Cells Acquire Sertoli Cell Characteristics after Oocyte Loss
Endocrinology, July 1, 2005; 146(7): 2992 - 3004.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
J. M. Hutson, S. Hasthorpe, and C. F. Heyns
Anatomical and Functional Aspects of Testicular Descent and Cryptorchidism
Endocr. Rev., April 1, 1997; 18(2): 259 - 280.
[Abstract] [Full Text]

Home page
 DevelopmentHome page
D. Whitworth, G Shaw, and M. Renfree
Gonadal sex reversal of the developing marsupial ovary in vivo and in vitro
Development, January 12, 1996; 122(12): 4057 - 4063.
[Abstract] [PDF]


© The Company of Biologists Ltd 1990