Development, Vol 110, Issue 4 1057-1069, Copyright © 1990 by Company of Biologists

JOURNAL ARTICLES

Gonadal expression of c-kit encoded at the W locus of the mouse

K Manova, K Nocka, P Besmer and RF Bachvarova
Department of Cell Biology and Anatomy, Cornell University Medical College, New York, NY 10021.

Recently, it has been shown that the c-kit proto-oncogene is encoded at the white spotting (W) locus in mice. Mutations of this gene cause depletion of germ cells, some hematopoietic cells and melanocytes. In order to define further the role of c-kit in gametogenesis, we have examined its expression in late fetal and postnatal ovaries and in postnatal testis. By RNA blot analysis, c-kit transcripts were not detected in late fetal ovaries but appeared at birth. The relative amount reached a maximum in ovaries of juvenile mice, and decreased in adult ovaries. c-kit transcripts were present in increasing amounts in isolated primordial, growing and full-grown oocytes, as well as in ovulated eggs. Little was detected in early 2-cell embryos and none in blastocysts. In situ hybridization revealed c-kit transcripts in a few oocytes of late fetal ovaries and in all oocytes (from primordial to full-grown) in ovaries from juvenile and adult mice. Expression was also observed in ovarian interstitial tissue from 14 days of age onward. Using indirect immunofluorescence, the c-kit protein was detected on the surface of primordial, growing and full-grown oocytes, as well as on embryos at the 1- and 2-cell stages; little remained in blastocysts. In situ hybridization analysis of testes from mice of different ages demonstrated expression in spermatogonia from 6 days of age onward. Using information provided by determining the stage of the cycle of the seminiferous epithelium for a given tubule and by following the age dependence of labeling, it was concluded that the period of expression of c-kit extends from at least as early as type A2 spermatogonia through type B spermatogonia and into preleptotene spermatocytes. Leydig cells were labelled at all ages examined. The expression pattern in oocytes correlates most strongly with oocyte growth and in male germ cells with gonial proliferation.
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				D. Church, K. Guan, and E. Lambie Three genes of the MAP kinase cascade, mek-2, mpk-1/sur-1 and let-60 ras, are required for meiotic cell cycle progression in Caenorhabditis elegans Development, January 8, 1995; 121(8): 2525 - 2535. [Abstract] [PDF]

				O Epifano, L. Liang, M Familari, M. Moos, and J Dean Coordinate expression of the three zona pellucida genes during mouse oogenesis Development, January 7, 1995; 121(7): 1947 - 1956. [Abstract] [PDF]

				R Duttlinger, K Manova, T. Chu, C Gyssler, A. Zelenetz, R. Bachvarova, and P Besmer W-sash affects positive and negative elements controlling c-kit expression: ectopic c-kit expression at sites of kit-ligand expression affects melanogenesis Development, January 7, 1993; 118(3): 705 - 717. [Abstract] [PDF]

				P Ray, K M Higgins, J C Tan, T Y Chu, N S Yee, H Nguyen, E Lacy, and P Besmer Ectopic expression of a c-kitW42 minigene in transgenic mice: recapitulation of W phenotypes and evidence for c-kit function in melanoblast progenitors. Genes & Dev., December 1, 1991; 5(12a): 2265 - 2273. [Abstract] [PDF]

				J. J. Eppig, K. Wigglesworth, and F. L. Pendola The mammalian oocyte orchestrates the rate of ovarian follicular development PNAS, March 5, 2002; 99(5): 2890 - 2894. [Abstract] [Full Text] [PDF]