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Development, Vol 110, Issue 4 1133-1151, Copyright © 1990 by Company of Biologists

JOURNAL ARTICLES

Retinoic acid receptors and cellular retinoid binding proteins. I. A systematic study of their differential pattern of transcription during mouse organogenesis

P Dolle, E Ruberte, P Leroy, G Morriss-Kay and P Chambon
Laboratoire de Genetique Moleculaire des Eucaryotes du CNRS, Unite 184, Strasbourg, France.

We report here the gene expression patterns, as revealed by in situ hybridisation, of the retinoic acid receptors alpha, beta and gamma (RAR-alpha, -beta and -gamma), and the cellular binding proteins for retinol and retinoic acid (CRBP, CRABP) in non-neural tissues of mouse embryos during the period of organogenesis. At all stages, RAR-alpha transcripts were almost ubiquitous, whereas the distribution of transcripts of the other four genes was distinctive in all systems. At early stages in the formation of an organ, the expression patterns were different in the epithelium, the adjacent mesenchyme, and in mesenchyme more distant from the epithelium, suggesting a role for RA and RA receptors in epithelial-mesenchymal tissue interactions. In the developing face, limb bud and genital tubercle, where large expanses of mesenchyme are present, differential patterns of expression were established before the onset of overt tissue differentiation, suggesting some significance for pattern formation in these regions. The distribution of RAR-beta transcripts in tracheobronchial, intestinal and genital tract epithelial is consistent with the possibility that RAR-beta plays a role in mediating retinoid effects on the differentiated stage of these epithelia. Possible developmental roles of RARs in relation to the expression patterns of other genes are discussed. CRBP expression domains showed a high degree of overlap with RAR-beta and RAR-gamma, and a mutual exclusivity with CRABP expression domains. Correlation of these expression patterns with the morphogenetic effects of vitamin A deficiency and retinoid excess lead us to propose that the function of CRBP is to store and release retinol where high levels of RA are required for specific morphogenetic processes, while CRABP serves to sequester RA in regions where normal developmental functions require RA levels to be low. Where both binding protein genes are expressed in a non-overlapping pattern within a large area of mesenchyme, a gradient of free RA may be created between them by release of retinol-derived RA from CRBP-expressing cells, with binding to CRABP enhancing the steepness of the decline in concentration distant to the source.
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 CROBMHome page
M.C. Johnston and P.T. Bronsky
Prenatal Craniofacial Development: New Insights On Normal and Abnormal Mechanisms
Critical Reviews in Oral Biology & Medicine, January 1, 1995; 6(1): 25 - 79.
[Abstract] [Full Text] [PDF]

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 CROBMHome page
C. Fisher, M. Blumenberg, and M. Tomic-Canic
Retinoid Receptors and Keratinocytes
Critical Reviews in Oral Biology & Medicine, January 1, 1995; 6(4): 284 - 301.
[Abstract] [Full Text] [PDF]

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 CROBMHome page
M.C. Johnston and P.T. Bronsky
Prenatal Craniofacial Development: New Insights on Normal and Abnormal Mechanisms
Critical Reviews in Oral Biology & Medicine, January 1, 1995; 6(4): 368 - 422.
[Abstract] [Full Text] [PDF]

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 DevelopmentHome page
D Lohnes, M Mark, C Mendelsohn, P Dolle, A Dierich, P Gorry, A Gansmuller, and P Chambon
Function of the retinoic acid receptors (RARs) during development (I). Craniofacial and skeletal abnormalities in RAR double mutants
Development, January 10, 1994; 120(10): 2723 - 2748.
[Abstract] [PDF]

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 DevelopmentHome page
C Mendelsohn, D Lohnes, D Decimo, T Lufkin, M LeMeur, P Chambon, and M Mark
Function of the retinoic acid receptors (RARs) during development (II). Multiple abnormalities at various stages of organogenesis in RAR double mutants
Development, January 10, 1994; 120(10): 2749 - 2771.
[Abstract] [PDF]

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 J. Cell Sci.Home page
J. Frangioni, N Moghal, A Stuart-Tilley, B. Neel, and S. Alper
The DNA binding domain of retinoic acid receptor beta is required for ligand-dependent suppression of proliferation. Application of general purpose mammalian coexpression vectors
J. Cell Sci., January 4, 1994; 107(4): 827 - 838.
[Abstract] [PDF]

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 DevelopmentHome page
E Noll and R. Miller
Regulation of oligodendrocyte differentiation: a role for retinoic acid in the spinal cord
Development, January 3, 1994; 120(3): 649 - 660.
[Abstract] [PDF]

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 DevelopmentHome page
L. Pecorino, D. Lo, and J. Brockes
Isoform-specific induction of a retinoid-responsive antigen after biolistic transfection of chimaeric retinoic acid/thyroid hormone receptors into a regenerating limb
Development, January 2, 1994; 120(2): 325 - 333.
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 DevelopmentHome page
M. W. Kelley, X. M. Xu, M. A. Wagner, M. E. Warchol, and J. T. Corwin
The developing organ of Corti contains retinoic acid and forms supernumerary hair cells in response to exogenous retinoic acid in culture
Development, December 1, 1993; 119(4): 1041 - 1053.
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 ScienceHome page
P. Lefebvre, B Malgrange, H Staecker, G Moonen, and T. Van de Water
Retinoic acid stimulates regeneration of mammalian auditory hair cells
Science, April 30, 1993; 260(5108): 692 - 695.
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 Genes Dev.Home page
M Tini, G Otulakowski, M L Breitman, L C Tsui, and V Giguere
An everted repeat mediates retinoic acid induction of the gamma F-crystallin gene: evidence of a direct role for retinoids in lens development.
Genes & Dev., February 1, 1993; 7(2): 295 - 307.
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 DevelopmentHome page
A. Perez-Castro, V. Tran, and M. Nguyen-Huu
Defective lens fiber differentiation and pancreatic tumorigenesis caused by ectopic expression of the cellular retinoic acid-binding protein I
Development, January 10, 1993; 119(2): 363 - 375.
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 DevelopmentHome page
E Ruberte, V Friederich, P Chambon, and G Morriss-Kay
Retinoic acid receptors and cellular retinoid binding proteins. III. Their differential transcript distribution during mouse nervous system development
Development, January 5, 1993; 118(1): 267 - 282.
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 DevelopmentHome page
D. Hill, C. Ragsdale, and J. Brockes
Isoform-specific immunological detection of newt retinoic acid receptor delta 1 in normal and regenerating limbs
Development, January 3, 1993; 117(3): 937 - 945.
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 DevelopmentHome page
A. Gustafson, L Dencker, and U Eriksson
Non-overlapping expression of CRBP I and CRABP I during pattern formation of limbs and craniofacial structures in the early mouse embryo
Development, January 2, 1993; 117(2): 451 - 460.
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 DevelopmentHome page
M. Dickson, H. Slager, E Duffie, C. Mummery, and R. Akhurst
RNA and protein localisations of TGF beta 2 in the early mouse embryo suggest an involvement in cardiac development
Development, January 2, 1993; 117(2): 625 - 639.
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 DevelopmentHome page
K. Horne and C. Jahoda
Restoration of hair growth by surgical implantation of follicular dermal sheath
Development, January 11, 1992; 116(3): 563 - 571.
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 DevelopmentHome page
E Ruberte, V Friederich, G Morriss-Kay, and P Chambon
Differential distribution patterns of CRABP I and CRABP II transcripts during mouse embryogenesis
Development, January 8, 1992; 115(4): 973 - 987.
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 DevelopmentHome page
C. Chuong, S. Ting, R. Widelitz, and Y. Lee
Mechanism of skin morphogenesis. II. Retinoic acid modulates axis orientation and phenotypes of skin appendages
Development, January 7, 1992; 115(3): 839 - 852.
[Abstract] [PDF]

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 CROBMHome page
J. M. Richman
The Role of Retinoids in Normal and Abnormal Embryonic Craniofacial Morphogenesis
Critical Reviews in Oral Biology & Medicine, January 1, 1992; 4(1): 93 - 109.
[Abstract] [Full Text] [PDF]

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 Genes Dev.Home page
J Rossant, R Zirngibl, D Cado, M Shago, and V Giguere
Expression of a retinoic acid response element-hsplacZ transgene defines specific domains of transcriptional activity during mouse embryogenesis.
Genes & Dev., August 1, 1991; 5(8): 1333 - 1344.
[Abstract] [PDF]

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 J. Biol. Chem.Home page
S. Vogel, C. L. Mendelsohn, J. R. Mertz, R. Piantedosi, C. Waldburger, M. E. Gottesman, and W. S. Blaner
Characterization of a New Member of the Fatty Acid-binding Protein Family That Binds All-trans-retinol
J. Biol. Chem., January 5, 2001; 276(2): 1353 - 1360.
[Abstract] [Full Text] [PDF]

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 Proc. Natl. Acad. Sci. USAHome page
D. L. Misner, S. Jacobs, Y. Shimizu, A. M. de Urquiza, L. Solomin, T. Perlmann, L. M. De Luca, C. F. Stevens, and R. M. Evans
Vitamin A deprivation results in reversible loss of hippocampal long-term synaptic plasticity
PNAS, September 25, 2001; 98(20): 11714 - 11719.
[Abstract] [Full Text] [PDF]

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 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
M. Hind, J. Corcoran, and M. Maden
Pre- and Postnatal Lung Development, Maturation, and Plasticity: Temporal/spatial expression of retinoid binding proteins and RAR isoforms in the postnatal lung
Am J Physiol Lung Cell Mol Physiol, March 1, 2002; 282(3): L468 - L476.
[Abstract] [Full Text] [PDF]


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