|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 111, Issue 1 131-143, Copyright © 1991 by Company of Biologists
JOURNAL ARTICLES |
FA Millan, F Denhez, P Kondaiah and RJ Akhurst
Duncan Guthrie Institute of Medical Genetics, University of Glasgow, UK.
We have compared the expression of the genes encoding transforming growth factors beta 1, beta 2 and beta 3 during mouse embryogenesis from 9.5 to 16.5 days p.c. using in situ hybridisation to cellular RNAs. Each gene has a different expression pattern, which gives some indication of possible biological function in vivo. All three genes appear to be involved in chondroossification, though each is expressed in a different cell type. Transcripts of each gene are also present in embryonic epithelia. Epithelial expression of TGF beta 1, beta 2 and beta 3 RNA is associated with regions of active morphogenesis involving epithelial-mesenchymal interactions. In addition, widespread epithelial expression of TGF beta 2 RNA can be correlated with epithelial differentiation per se. The localisation of TGF beta 2 RNA in neuronal tissue might also be correlated with differentiation. Finally both TGF beta 1 and beta 2 transcripts are seen in regions actively undergoing cardiac septation and valve formation, suggesting some interaction of these growth factors in this developmental process.
This article has been cited by other articles:
|
|
 |
|
  F. Chen, T. J. Desai, J. Qian, K. Niederreither, J. Lu, and W. V. Cardoso Inhibition of Tgf{beta} signaling by endogenous retinoic acid is essential for primary lung bud induction Development, August 15, 2007; 134(16): 2969 - 2979. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Spagnoli, L. O'Rear, R. L. Chandler, F. Granero-Molto, D. P. Mortlock, A. E. Gorska, J. A. Weis, L. Longobardi, A. Chytil, K. Shimer, et al. TGF-{beta} signaling is essential for joint morphogenesis J. Cell Biol., July 30, 2007; 177(6): 1105 - 1117. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Van de Putte, A. Francis, L. Nelles, L. A. van Grunsven, and D. Huylebroeck Neural crest-specific removal of Zfhx1b in mouse leads to a wide range of neurocristopathies reminiscent of Mowat-Wilson syndrome Hum. Mol. Genet., June 15, 2007; 16(12): 1423 - 1436. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Dickinson, D. W. Walker, E. M. Wintour, and K. Moritz Maternal dexamethasone treatment at midgestation reduces nephron number and alters renal gene expression in the fetal spiny mouse Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2007; 292(1): R453 - R461. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Araya, S. Cambier, A. Morris, W. Finkbeiner, and S. L. Nishimura Integrin-Mediated Transforming Growth Factor-{beta} Activation Regulates Homeostasis of the Pulmonary Epithelial-Mesenchymal Trophic Unit Am. J. Pathol., August 1, 2006; 169(2): 405 - 415. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. N. WEITZMANN and R. PACIFICI Estrogen Regulation of Immune Cell Bone Interactions Ann. N.Y. Acad. Sci., April 1, 2006; 1068(1): 256 - 274. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Clotman, P. Jacquemin, N. Plumb-Rudewiez, C. E. Pierreux, P. Van der Smissen, H. C. Dietz, P. J. Courtoy, G. G. Rousseau, and F. P. Lemaigre Control of liver cell fate decision by a gradient of TGF{beta} signaling modulated by Onecut transcription factors Genes & Dev., August 15, 2005; 19(16): 1849 - 1854. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Wurdak, L. M. Ittner, K. S. Lang, P. Leveen, U. Suter, J. A. Fischer, S. Karlsson, W. Born, and L. Sommer Inactivation of TGF{beta} signaling in neural crest stem cells leads to multiple defects reminiscent of DiGeorge syndrome Genes & Dev., March 1, 2005; 19(5): 530 - 535. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. L. C. Carvalho, L. Jonker, M.-J. Goumans, J. Larsson, P. Bouwman, S. Karlsson, P. t. Dijke, H. M. Arthur, and C. L. Mummery Defective paracrine signalling by TGF{beta} in yolk sac vasculature of endoglin mutant mice: a paradigm for hereditary haemorrhagic telangiectasia Development, December 15, 2004; 131(24): 6237 - 6247. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. De Luca, M. De Falco, L. De Luca, R. Penta, V. Shridhar, F. Baldi, M. Campioni, M. G. Paggi, and A. Baldi Pattern of Expression of HtrA1 During Mouse Development J. Histochem. Cytochem., December 1, 2004; 52(12): 1609 - 1617. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. J. Skill, T. S. Johnson, I. G. C. Coutts, R. E. Saint, M. Fisher, L. Huang, A. M. El Nahas, R. J. Collighan, and M. Griffin Inhibition of Transglutaminase Activity Reduces Extracellular Matrix Accumulation Induced by High Glucose Levels in Proximal Tubular Epithelial Cells J. Biol. Chem., November 12, 2004; 279(46): 47754 - 47762. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. A. Bhowmick, A. Chytil, D. Plieth, A. E. Gorska, N. Dumont, S. Shappell, M. K. Washington, E. G. Neilson, and H. L. Moses TGF-{beta} Signaling in Fibroblasts Modulates the Oncogenic Potential of Adjacent Epithelia Science, February 6, 2004; 303(5659): 848 - 851. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. P. Annes, J. S. Munger, and D. B Rifkin Making sense of latent TGF{beta} activation J. Cell Sci., January 15, 2003; 116(2): 217 - 224. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Braybrook, S. Lisgo, K. Doudney, D. Henderson, A. C. B. Marcano, T. Strachan, M. A. Patton, L. Villard, G. E. Moore, P. Stanier, et al. Craniofacial expression of human and murine TBX22 correlates with the cleft palate and ankyloglossia phenotype observed in CPX patients Hum. Mol. Genet., October 15, 2002; 11(22): 2793 - 2804. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Leveen, J. Larsson, M. Ehinger, C. M. Cilio, M. Sundler, L. J. Sjostrand, R. Holmdahl, and S. Karlsson Induced disruption of the transforming growth factor beta type II receptor gene in mice causes a lethal inflammatory disorder that is transplantable Blood, June 28, 2002; 100(2): 560 - 568. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 U. Bartram, D. G. M. Molin, L. J. Wisse, A. Mohamad, L. P. Sanford, T. Doetschman, C. P. Speer, R. E. Poelmann, and A. C. Gittenberger-de Groot Double-Outlet Right Ventricle and Overriding Tricuspid Valve Reflect Disturbances of Looping, Myocardialization, Endocardial Cushion Differentiation, and Apoptosis in TGF-{beta}2-Knockout Mice Circulation, June 5, 2001; 103(22): 2745 - 2752. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Yang, L. Chen, X. Xu, C. Li, C. Huang, and C.-X. Deng TGF-{beta}/Smad3 Signals Repress Chondrocyte Hypertrophic Differentiation and Are Required for Maintaining Articular Cartilage J. Cell Biol., March 26, 2001; 153(1): 35 - 46. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. ITO, R. GOLDSCHMEDING, R. J. BENDE, N. CLAESSEN, M. A. CHAND, L. KLEIJ, T. J. RABELINK, J. J. WEENING, and J. ATEN Kinetics of Connective Tissue Growth Factor Expression during Experimental Proliferative Glomerulonephritis J. Am. Soc. Nephrol., March 1, 2001; 12(3): 472 - 484. [Abstract] [Full Text]
|
|
|
|
 |
|
 L. Konrad, M. Albrecht, H. Renneberg, and G. Aumuller Transforming Growth Factor-{beta}2 Mediates Mesenchymal-Epithelial Interactions of Testicular Somatic Cells Endocrinology, October 1, 2000; 141(10): 3679 - 3686. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. L. Kingsley-Kallesen, D. Kelly, and A. Rizzino Transcriptional Regulation of the Transforming Growth Factor-beta 2 Promoter by cAMP-responsive Element-binding Protein (CREB) and Activating Transcription Factor-1 (ATF-1) Is Modulated by Protein Kinases and the Coactivators p300 and CREB-binding Protein J. Biol. Chem., November 26, 1999; 274(48): 34020 - 34028. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L Hagedorn, U Suter, and L Sommer P0 and PMP22 mark a multipotent neural crest-derived cell type that displays community effects in response to TGF-beta family factors Development, January 9, 1999; 126(17): 3781 - 3794. [Abstract] [PDF]
|
|
|
|
 |
|
 A. Gupta,, N. H. Ing,, F. W. Bazer,, L. S. Bustamante,, and L. A. Jaeger Beta Transforming Growth Factors (TGFß) at the Porcine Conceptus-Maternal Interface. Part I: Expression of TGFß1, TGFß2, and TGFß3 Messenger Ribonucleic Acids Biol Reprod, October 1, 1998; 59(4): 905 - 910. [Abstract] [Full Text]
|
|
|
|
|
|
L. M. Montuenga, J. M. Mariano, M. A. Prentice, F. Cuttitta, and S. B. Jakowlew Coordinate Expression of Transforming Growth Factor-{beta}1 and Adrenomedullin in Rodent Embryogenesis Endocrinology, September 1, 1998; 139(9): 3946 - 3957. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D Sun, C. Vanderburg, G. Odierna, and E. Hay TGFbeta3 promotes transformation of chicken palate medial edge epithelium to mesenchyme in vitro Development, January 1, 1998; 125(1): 95 - 105. [Abstract] [PDF]
|
|
|
|
 |
|
 M. R. Ward, A. Agrotis, P. Kanellakis, R. Dilley, G. Jennings, and A. Bobik Inhibition of Protein Tyrosine Kinases Attenuates Increases in Expression of Transforming Growth Factor-ß Isoforms and Their Receptors Following Arterial Injury Arterioscler. Thromb. Vasc. Biol., November 1, 1997; 17(11): 2461 - 2470. [Abstract] [Full Text]
|
|
|
|
 |
|
 A. Dobbertin, P. Schmid, M. Gelman, J. Glowinski, and M. Mallat Neurons Promote Macrophage Proliferation by Producing Transforming Growth Factor-beta 2 J. Neurosci., July 15, 1997; 17(14): 5305 - 5315. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. E. McGowan, S. K. Jackson, P. J. Olson, T. Parekh, and L. I. Gold Exogenous and Endogenous Transforming Growth Factors-beta Influence Elastin Gene Expression in Cultured Lung Fibroblasts Am. J. Respir. Cell Mol. Biol., July 1, 1997; 17(1): 25 - 35. [Abstract] [Full Text]
|
|
|
|
 |
|
 A. M. Hales, C. G. Chamberlain, C. R. Murphy, and J. W. McAvoy Estrogen Protects Lenses against Cataract Induced by Transforming Growth Factor-beta (TGFbeta ) J. Exp. Med., January 20, 1997; 185(2): 273 - 280. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Sanford, I Ormsby, A. Gittenberger-de Groot, H Sariola, R Friedman, G. Boivin, E. Cardell, and T Doetschman TGFbeta2 knockout mice have multiple developmental defects that are non-overlapping with other TGFbeta knockout phenotypes Development, January 7, 1997; 124(13): 2659 - 2670. [Abstract] [PDF]
|
|
|
|
|
|
S. Frank, M. Madlener, and S. Werner Transforming Growth Factors beta1, beta2, and beta3 and Their Receptors Are Differentially Regulated during Normal and Impaired Wound Healing J. Biol. Chem., April 26, 1996; 271(17): 10188 - 10193. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Hoffman, M. Kibbey, J. Letterio, and H. Kleinman Role of laminin-1 and TGF-beta 3 in acinar differentiation of a human submandibular gland cell line (HSG) J. Cell Sci., January 8, 1996; 109(8): 2013 - 2021. [Abstract] [PDF]
|
|
|
|
|
|
Y Ganan, D Macias, M Duterque-Coquillaud, M. Ros, and J. Hurle Role of TGF beta s and BMPs as signals controlling the position of the digits and the areas of interdigital cell death in the developing chick limb autopod Development, January 8, 1996; 122(8): 2349 - 2357. [Abstract] [PDF]
|
|
|
|
|
|
Y Yokouchi, S Nakazato, M Yamamoto, Y Goto, T Kameda, H Iba, and A Kuroiwa Misexpression of Hoxa-13 induces cartilage homeotic transformation and changes cell adhesiveness in chick limb buds. Genes & Dev., October 15, 1995; 9(20): 2509 - 2522. [Abstract] [PDF]
|
|
|
|
|
|
W. Yin, E. Smiley, J. Germiller, R. P. Mecham, J. B. Florer, R. J. Wenstrup, and J. Bonadio Isolation of a Novel Latent Transforming Growth Factor-[IMAGE] Binding Protein Gene (LTBP-3) J. Biol. Chem., April 28, 1995; 270(17): 10147 - 10160. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C Soudais, M Bielinska, M Heikinheimo, C. MacArthur, N Narita, J. Saffitz, M. Simon, J. Leiden, and D. Wilson Targeted mutagenesis of the transcription factor GATA-4 gene in mouse embryonic stem cells disrupts visceral endoderm differentiation in vitro Development, January 11, 1995; 121(11): 3877 - 3888. [Abstract] [PDF]
|
|
|
|
|
|
M Shah, D. Foreman, and M. Ferguson Neutralisation of TGF-beta 1 and TGF-beta 2 or exogenous addition of TGF-beta 3 to cutaneous rat wounds reduces scarring J. Cell Sci., January 3, 1995; 108(3): 985 - 1002. [Abstract] [PDF]
|
|
|
|
|
|
J. Letterio, A. Geiser, A. Kulkarni, N. Roche, M. Sporn, and A. Roberts Maternal rescue of transforming growth factor-beta 1 null mice Science, June 24, 1994; 264(5167): 1936 - 1938. [Abstract] [PDF]
|
|
|
|
|
|
A Feijen, M. Goumans, and A. van den Eijnden-van Raaij Expression of activin subunits, activin receptors and follistatin in postimplantation mouse embryos suggests specific developmental functions for different activins Development, January 12, 1994; 120(12): 3621 - 3637. [Abstract] [PDF]
|
|
|
|
|
|
V. Buchman, M Sporn, and A. Davies Role of transforming growth factor-beta isoforms in regulating the expression of nerve growth factor and neurotrophin-3 mRNA levels in embryonic cutaneous cells at different stages of development Development, January 6, 1994; 120(6): 1621 - 1629. [Abstract] [PDF]
|
|
|
|
|
|
E. Filvaroff, R Ebner, and R Derynck Inhibition of myogenic differentiation in myoblasts expressing a truncated type II TGF-beta receptor Development, January 5, 1994; 120(5): 1085 - 1095. [Abstract] [PDF]
|
|
|
|
|
|
M. Cusella-De Angelis, S Molinari, A Le Donne, M Coletta, E Vivarelli, M Bouche, M Molinaro, S Ferrari, and G Cossu Differential response of embryonic and fetal myoblasts to TGF beta: a possible regulatory mechanism of skeletal muscle histogenesis Development, January 4, 1994; 120(4): 925 - 933. [Abstract] [PDF]
|
|
|
|
|
|
M. Nieto, M. Bennett, M. Sargent, and D. Wilkinson Cloning and developmental expression of Sna, a murine homologue of the Drosophila snail gene Development, January 9, 1992; 116(1): 227 - 237. [Abstract] [PDF]
|
|
|
|
|
|
M Delannet and J. Duband Transforming growth factor-beta control of cell-substratum adhesion during avian neural crest cell emigration in vitro Development, January 9, 1992; 116(1): 275 - 287. [Abstract] [PDF]
|
|
|
|
|
|
M Blauer, J Kohonen, I Leivonen, P Vilja, and P Tuohimaa Inhibin alpha- and beta A-subunit immunoreactivity in the chicken embryo during morphogenesis Development, January 8, 1992; 115(4): 1079 - 1086. [Abstract] [PDF]
|
|
