|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 111, Issue 1 35-43, Copyright © 1991 by Company of Biologists
JOURNAL ARTICLES |
M Maden, P Hunt, U Eriksson, A Kuroiwa, R Krumlauf and D Summerbell
Anatomy & Human Biology Group, King's College London, Strand, UK.
We have investigated by immunocytochemistry the spatial and temporal distribution of cellular retinoic acid-binding protein (CRABP) in the developing nervous system of the chick embryo in order to answer two specific questions: do neural crest cells contain CRABP and where and when do CRABP-positive neuroblasts first arise in the neural tube? With regard to the neural crest, we have compared CRABP staining with HNK-1 staining (a marker of migrating neural crest) and found that they do indeed co-localise, but cephalic and trunk crest behave slightly differently. In the cephalic region in tissues such as the frontonasal mass and branchial arches, HNK-1 immunoreactivity is intense at early stages, but it disappears as CRABP immunoreactivity appears. Thus the two staining patterns do not overlap, but are complementary. In the trunk, HNK-1 and CRABP stain the same cell populations at the same time, such as those migrating through the anterior halves of the somites. In the neural tube, CRABP-positive neuroblasts first appear in the rhombencephalon just after the neural folds close and then a particular pattern of immunoreactivity appears within the rhombomeres of the hindbrain. Labelled cells are present in the future spinal cord, the posterior rhombencephalon up to rhombomere 6 and in rhombomere 4 thus producing a single stripe pattern. This pattern is dynamic and gradually changes as anterior rhombomeres begin to label. The similarity of this initial pattern to the arrangement of certain homeobox genes in the mouse stimulated us to examine the expression of the chicken Hox-2.9 gene. We show that at stage 15 the pattern of expression of this gene is closely related to that of CRABP. The relationship between retinoic acid, CRABP and homeobox genes is discussed.
This article has been cited by other articles:
|
|
 |
|
  S. Bel-Vialar, N. Itasaki, and R. Krumlauf Initiating Hox gene expression: in the early chick neural tube differential sensitivity to FGF and RA signaling subdivides the HoxB genes in two distinct groups Development, March 13, 2003; 129(22): 5103 - 5115. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. P. Golding, M. Dixon, and M. Gassmann Cues from neuroepithelium and surface ectoderm maintain neural crest-free regions within cranial mesenchyme of the developing chick Development, January 3, 2002; 129(5): 1095 - 1105. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Neuville, M.-L. Bochaton-Piallat, and G. Gabbiani Retinoids and Arterial Smooth Muscle Cells Arterioscler. Thromb. Vasc. Biol., August 1, 2000; 20(8): 1882 - 1888. [Full Text] [PDF]
|
|
|
|
 |
|
 C. J. Forehand, E. B. Ezerman, J. P. Goldblatt, D. L. Skidmore, and J. C. Glover Segment-specific pattern of sympathetic preganglionic projections in the chicken embryo spinal cord is altered by retinoids PNAS, September 1, 1998; 95(18): 10878 - 10883. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S Yuan and G. Schoenwolf De novo induction of the organizer and formation of the primitive streak in an experimental model of notochord reconstitution in avian embryos Development, January 1, 1998; 125(2): 201 - 213. [Abstract] [PDF]
|
|
|
|
|
|
A Grapin-Botton, M. Bonnin, L. McNaughton, R Krumlauf, and N. Le Douarin Plasticity of transposed rhombomeres: Hox gene induction is correlated with phenotypic modifications Development, January 9, 1995; 121(9): 2707 - 2721. [Abstract] [PDF]
|
|
|
|
|
|
Y. Lee, N Osumi-Yamashita, Y Ninomiya, C. Moon, U Eriksson, and K Eto Retinoic acid stage-dependently alters the migration pattern and identity of hindbrain neural crest cells Development, January 3, 1995; 121(3): 825 - 837. [Abstract] [PDF]
|
|
|
|
 |
|
 M Studer, H Popperl, H Marshall, A Kuroiwa, and R Krumlauf Role of a conserved retinoic acid response element in rhombomere restriction of Hoxb-1 Science, September 16, 1994; 265(5179): 1728 - 1732. [Abstract] [PDF]
|
|
|
|
|
|
E Noll and R. Miller Regulation of oligodendrocyte differentiation: a role for retinoic acid in the spinal cord Development, January 3, 1994; 120(3): 649 - 660. [Abstract] [PDF]
|
|
|
|
|
|
L Shum, Y Sakakura, P Bringas, W Luo, M. Snead, M Mayo, C Crohin, S Millar, Z Werb, S Buckley, et al. EGF abrogation-induced fusilli-form dysmorphogenesis of Meckel's cartilage during embryonic mouse mandibular morphogenesis in vitro Development, January 7, 1993; 118(3): 903 - 917. [Abstract] [PDF]
|
|
|
|
|
|
A. Gustafson, L Dencker, and U Eriksson Non-overlapping expression of CRBP I and CRABP I during pattern formation of limbs and craniofacial structures in the early mouse embryo Development, January 2, 1993; 117(2): 451 - 460. [Abstract] [PDF]
|
|
|
|
|
|
M. A. Nieto, P. Gilardi-Hebenstreit, P. Charnay, and D. G. Wilkinson A receptor protein tyrosine kinase implicated in the segmental patterning of the hindbrain and mesoderm Development, December 1, 1992; 116(4): 1137 - 1150. [Abstract] [PDF]
|
|
|
|
 |
|
 J Rossant, R Zirngibl, D Cado, M Shago, and V Giguere Expression of a retinoic acid response element-hsplacZ transgene defines specific domains of transcriptional activity during mouse embryogenesis. Genes & Dev., August 1, 1991; 5(8): 1333 - 1344. [Abstract] [PDF]
|
|
