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Development, Vol 111, Issue 2 451-454, Copyright © 1991 by Company of Biologists

JOURNAL ARTICLES

alpha-Actin proteins and gene transcripts are colocalized in embryonic mouse muscle

GE Lyons, ME Buckingham and HG Mannherz
Department of Molecular Biology, URA CNRS 1148, Pasteur Institute, Paris, France.

The alpha-actins are among the earliest muscle-specific mRNAs to appear in developing cardiac and skeletal muscle. To determine if there is coexpression of the alpha-actin proteins at early stages of myogenesis, we have used an alpha-actin-specific polyclonal antibody and in situ hybridization with specific cRNA probes to cardiac and skeletal alpha-actin transcripts on serial slides of mouse embryo sections. As soon as we can detect alpha-actin mRNAs in embryonic striated muscle, we also detect the protein suggesting that alpha-actin transcripts are translated very rapidly after transcription during myogenesis. In skeletal muscle, this colocalization of alpha-actin mRNA and protein was observed both in the myotomes of somites and in developing muscles in the limbs. In cardiac muscle, alpha-actin transcripts and proteins are abundantly expressed as soon as a cardiac tube forms.


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© The Company of Biologists Ltd 1991