Development, Vol 111, Issue 2 531-542, Copyright © 1991 by Company of Biologists

JOURNAL ARTICLES

Involvement of Bone Morphogenetic Protein-4 (BMP-4) and Vgr-1 in morphogenesis and neurogenesis in the mouse

CM Jones, KM Lyons and BL Hogan
Department of Cell Biology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-2175.

Bone Morphogenetic Protein-4 (BMP-4) and Vgr-1 are members of the TGF-beta gene family most closely related to the Drosophila Decapentaplegic and Xenopus Vg-1 genes. Members of this gene family have been implicated in diverse processes during embryogenesis including epithelial-mesenchymal interactions. Here, we use in situ hybridization to localize BMP-4 and Vgr-1 transcripts during murine development. BMP-4 mRNA is found in a variety of tissues. In the 8.5 days p.c. embryo, transcripts are localized to the mesoderm posterior to the last somite. Later gestation embryos show expression in developing limbs, the embryonic heart, the facial processes and condensed mesenchymal cells associated with early whisker follicle formation. In the developing central nervous system (CNS), BMP-4 expression is restricted to the floor of the diencephalon associated with pituitary development. In contrast, Vgr-1 transcripts are found along the anteroposterior axis of the CNS, in cells immediately adjacent to the floor plate and in the roof plate extending to the forebrain. Together, the data support the hypothesis that polypeptide growth factors of the TGF-beta superfamily play key roles in the initial stages of neurogenesis and organogenesis during murine development.
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				Z Gu, E. Reynolds, J Song, H Lei, A Feijen, L Yu, W He, D. MacLaughlin, J van den Eijnden-van Raaij, P. Donahoe, et al. The type I serine/threonine kinase receptor ActRIA (ALK2) is required for gastrulation of the mouse embryo Development, January 6, 1999; 126(11): 2551 - 2561. [Abstract] [PDF]

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				D Houzelstein, G Auda-Boucher, Y Cheraud, T Rouaud, I Blanc, S Tajbakhsh, M. Buckingham, J Fontaine-Perus, and B Robert The homeobox gene Msx1 is expressed in a subset of somites, and in muscle progenitor cells migrating into the forelimb Development, January 6, 1999; 126(12): 2689 - 2701. [Abstract] [PDF]

				T. Yamaguchi, A Bradley, A. McMahon, and S Jones A Wnt5a pathway underlies outgrowth of multiple structures in the vertebrate embryo Development, January 3, 1999; 126(6): 1211 - 1223. [Abstract] [PDF]

				E Coucouvanis and G. Martin BMP signaling plays a role in visceral endoderm differentiation and cavitation in the early mouse embryo Development, January 2, 1999; 126(3): 535 - 546. [Abstract] [PDF]

				S. Cheifetz BMP Receptors in Limb and Tooth Formation Critical Reviews in Oral Biology & Medicine, January 1, 1999; 10(2): 182 - 198. [Abstract] [Full Text] [PDF]

				A. Tucker, A Al Khamis, C. Ferguson, I Bach, M. Rosenfeld, and P. Sharpe Conserved regulation of mesenchymal gene expression by Fgf-8 in face and limb development Development, January 1, 1999; 126(2): 221 - 228. [Abstract] [PDF]

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				K. J. Lee, M. Mendelsohn, and T. M. Jessell Neuronal patterning by BMPs: a requirement for GDF7 in the generation of a discrete class of commissural interneurons in the mouse spinal cord Genes & Dev., November 1, 1998; 12(21): 3394 - 3407. [Abstract] [Full Text]

				D. J. Van Den Berg, A. K. Sharma, E. Bruno, and R. Hoffman Role of Members of the Wnt Gene Family in Human Hematopoiesis Blood, November 1, 1998; 92(9): 3189 - 3202. [Abstract] [Full Text] [PDF]

				M. Treier, A. S. Gleiberman, S. M. O'Connell, D. P. Szeto, J. A. McMahon, A. P. McMahon, and M. G. Rosenfeld Multistep signaling requirements for pituitary organogenesis in vivo Genes & Dev., June 1, 1998; 12(11): 1691 - 1704. [Abstract] [Full Text]

				S. J. Ritter and P. J. A. Davies Identification of a Transforming Growth Factor-beta 1/Bone Morphogenetic Protein 4 (TGF-beta 1/BMP4) Response Element within the Mouse Tissue Transglutaminase Gene Promoter J. Biol. Chem., May 22, 1998; 273(21): 12798 - 12806. [Abstract] [Full Text] [PDF]

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				N Takuma, H. Sheng, Y Furuta, J. Ward, K Sharma, B. Hogan, S. Pfaff, H Westphal, S Kimura, and K. Mahon Formation of Rathke's pouch requires dual induction from the diencephalon Development, January 12, 1998; 125(23): 4835 - 4840. [Abstract] [PDF]

				A. Roebroek, L Umans, I. Pauli, E. Robertson, F van Leuven, W. Van de Ven, and D. Constam Failure of ventral closure and axial rotation in embryos lacking the proprotein convertase Furin Development, January 12, 1998; 125(24): 4863 - 4876. [Abstract] [PDF]

				R. Godin, N. Takaesu, E. Robertson, and A. Dudley Regulation of BMP7 expression during kidney development Development, January 9, 1998; 125(17): 3473 - 3482. [Abstract] [PDF]

				J Ericson, S Norlin, T. Jessell, and T Edlund Integrated FGF and BMP signaling controls the progression of progenitor cell differentiation and the emergence of pattern in the embryonic anterior pituitary Development, January 3, 1998; 125(6): 1005 - 1015. [Abstract] [PDF]

				An Extensive 3' Regulatory Region Controls Expression of Bmp5 in Specific Anatomical Structures of the Mouse Embryo Genetics, January 1, 1998; 148(1): 401 - 408.

				H. Zou, R. Wieser, J. Massague, and L. Niswander Distinct roles of type I bone morphogenetic protein receptors in the formation and differentiation of cartilage Genes & Dev., September 1, 1997; 11(17): 2191 - 2203. [Abstract] [Full Text] [PDF]

				S. D. Boden, G. Hair, L. Titus, M. Racine, K. McCuaig, J. M. Wozney, and M. S. Nanes Glucocorticoid-Induced Differentiation of Fetal Rat Calvarial Osteoblasts Is Mediated by Bone Morphogenetic Protein-6 Endocrinology, July 1, 1997; 138(7): 2820 - 2828. [Abstract] [Full Text] [PDF]

				P. C. Mabie, M. F. Mehler, R. Marmur, A. Papavasiliou, Q. Song, and J. A. Kessler Bone Morphogenetic Proteins Induce Astroglial Differentiation of Oligodendroglial-Astroglial Progenitor Cells J. Neurosci., June 1, 1997; 17(11): 4112 - 4120. [Abstract] [Full Text] [PDF]

				T Miya, K Morita, A Suzuki, N Ueno, and N Satoh Functional analysis of an ascidian homologue of vertebrate Bmp-2/Bmp-4 suggests its role in the inhibition of neural fate specification Development, January 12, 1997; 124(24): 5149 - 5159. [Abstract] [PDF]

				M. Fishman and K. Chien Fashioning the vertebrate heart: earliest embryonic decisions Development, January 6, 1997; 124(11): 2099 - 2117. [Abstract] [PDF]

				Y Furuta, D. Piston, and B. Hogan Bone morphogenetic proteins (BMPs) as regulators of dorsal forebrain development Development, January 6, 1997; 124(11): 2203 - 2212. [Abstract] [PDF]

				D Macias, Y Ganan, T. Sampath, M. Piedra, M. Ros, and J. Hurle Role of BMP-2 and OP-1 (BMP-7) in programmed cell death and skeletogenesis during chick limb development Development, January 3, 1997; 124(6): 1109 - 1117. [Abstract] [PDF]

				U. Ripamonti and A. Hari Reddi Tissue Engineering, Morphogenesis, and Regeneration of the Periodontal Tissues By Bone Morphogenetic Proteins Critical Reviews in Oral Biology & Medicine, January 1, 1997; 8(2): 154 - 163. [Abstract] [Full Text] [PDF]

				D. K. Wu and S.-H. Oh Sensory Organ Generation in the Chick Inner Ear J. Neurosci., October 15, 1996; 16(20): 6454 - 6462. [Abstract] [Full Text] [PDF]

				S.-H. Oh, R. Johnson, and D. K. Wu Differential Expression of Bone Morphogenetic Proteins in the Developing Vestibular and Auditory Sensory Organs J. Neurosci., October 15, 1996; 16(20): 6463 - 6475. [Abstract] [Full Text] [PDF]

				A. B. Shafritz, E. M. Shore, F. H. Gannon, M. A. Zasloff, R. Taub, M. Muenke, and F. S. Kaplan Overexpression of an Osteogenic Morphogen in Fibrodysplasia Ossificans Progressiva N. Engl. J. Med., August 22, 1996; 335(8): 555 - 561. [Abstract] [Full Text] [PDF]

				P. Raval, H.H.T. Hsu, D.J. Schneider, M.P. Sarras JR, K. Masuhara, L.F. Bonewald, and H.C. Anderson Expression of Bone Morphogenetic Proteins by Osteoinductive and Non-osteoinductive Human Osteosarcoma Cells Journal of Dental Research, July 1, 1996; 75(7): 1518 - 1523. [Abstract] [PDF]

				B L Hogan Bone morphogenetic proteins: multifunctional regulators of vertebrate development. Genes & Dev., July 1, 1996; 10(13): 1580 - 1594. [PDF]

				G Q Zhao, K Deng, P A Labosky, L Liaw, and B L Hogan The gene encoding bone morphogenetic protein 8B is required for the initiation and maintenance of spermatogenesis in the mouse. Genes & Dev., July 1, 1996; 10(13): 1657 - 1669. [Abstract] [PDF]

				M. Demetriou, C. Binkert, B. Sukhu, H. C. Tenenbaum, and J. W. Dennis Fetuin/alpha 2-HS Glycoprotein Is a Transforming Growth Factor-beta Type II Receptor Mimic and Cytokine Antagonist J. Biol. Chem., May 31, 1996; 271(22): 12755 - 12761. [Abstract] [Full Text] [PDF]

				L Solnica-Krezel, D. Stemple, E Mountcastle-Shah, Z Rangini, S. Neuhauss, J Malicki, A. Schier, D. Stainier, F Zwartkruis, S Abdelilah, et al. Mutations affecting cell fates and cellular rearrangements during gastrulation in zebrafish Development, January 12, 1996; 123(1): 67 - 80. [Abstract] [PDF]

				H Zhang and A Bradley Mice deficient for BMP2 are nonviable and have defects in amnion/chorion and cardiac development Development, January 10, 1996; 122(10): 2977 - 2986. [Abstract] [PDF]

				D. Phippard, S. Weber-Hall, P. Sharpe, M. Naylor, H Jayatalake, R Maas, I Woo, D Roberts-Clark, P. Francis-West, Y. Liu, et al. Regulation of Msx-1, Msx-2, Bmp-2 and Bmp-4 during foetal and postnatal mammary gland development Development, January 9, 1996; 122(9): 2729 - 2737. [Abstract] [PDF]

				E Reissmann, U Ernsberger, P. Francis-West, D Rueger, P. Brickell, and H Rohrer Involvement of bone morphogenetic protein-4 and bone morphogenetic protein-7 in the differentiation of the adrenergic phenotype in developing sympathetic neurons Development, January 7, 1996; 122(7): 2079 - 2088. [Abstract] [PDF]

				S Bellusci, R Henderson, G Winnier, T Oikawa, and B. Hogan Evidence from normal expression and targeted misexpression that bone morphogenetic protein (Bmp-4) plays a role in mouse embryonic lung morphogenesis Development, January 6, 1996; 122(6): 1693 - 1702. [Abstract] [PDF]

				M Kanatsu and S. Nishikawa In vitro analysis of epiblast tissue potency for hematopoietic cell differentiation Development, January 3, 1996; 122(3): 823 - 830. [Abstract] [PDF]

				Z Sheng, D Pennica, W. Wood, and K. Chien Cardiotrophin-1 displays early expression in the murine heart tube and promotes cardiac myocyte survival Development, January 2, 1996; 122(2): 419 - 428. [Abstract] [PDF]

				Y Mishina, A Suzuki, N Ueno, and R R Behringer Bmpr encodes a type I bone morphogenetic protein receptor that is essential for gastrulation during mouse embryogenesis. Genes & Dev., December 15, 1995; 9(24): 3027 - 3037. [Abstract] [PDF]

				J. Q. Feng, D. Chen, A. J. Cooney, M.-J. Tsai, M. A. Harris, S. Y. Tsai, M. Feng, G. R. Mundy, and S. E. Harris The Mouse Bone Morphogenetic Protein-4 Gene J. Biol. Chem., November 24, 1995; 270(47): 28364 - 28373. [Abstract] [Full Text] [PDF]