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Development, Vol 111, Issue 3 657-666, Copyright © 1991 by Company of Biologists
JOURNAL ARTICLES |
RK Blackman, M Sanicola, LA Raftery, T Gillevet and WM Gelbart
Department of Cellular and Developmental Biology, Harvard University, Cambridge, MA 02138-2097.
The decapentaplegic (dpp) gene in Drosophila melanogaster encodes a TGF-beta-like signalling molecule that is expressed in a complex and changing pattern during development. One of dpp's contributions is to proximal-distal outgrowth of the adult appendages, structures derived from the larval imaginal disks. Appendage specific mutations of dpp fall in a 20 kb interval 3' to the known dpp transcripts. Here, we directly test the hypothesis that these mutations define an extended 3' cis-regulatory region. By analysis of germ-line transformants expressing a reporter gene, we show that sequences from this portion of the gene, termed the dppdisk region, are capable of directing expression comparable to that defined by RNA in situ hybridization. We localize two intervals of the dppdisk region that appear to account for much of the dpp spatial pattern in imaginal disks and discuss the positions of these important elements in terms of the genetics of dpp. Finally, we provide evidence to suggest that one of our constructs expresses beta-galactosidase in the early imaginal disk primordia in the embryo, at approximately the time when they are set aside from surrounding larval epidermal tissues. Thus, dpp may be involved directly in the determination of the imaginal disks.
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M Zecca, K Basler, and G Struhl Sequential organizing activities of engrailed, hedgehog and decapentaplegic in the Drosophila wing Development, January 8, 1995; 121(8): 2265 - 2278. [Abstract] [PDF]
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C Ma and K Moses Wingless and patched are negative regulators of the morphogenetic furrow and can affect tissue polarity in the developing Drosophila compound eye Development, January 8, 1995; 121(8): 2279 - 2289. [Abstract] [PDF]
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M Wehrli and A Tomlinson Epithelial planar polarity in the developing Drosophila eye Development, January 8, 1995; 121(8): 2451 - 2459. [Abstract] [PDF]
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A. Jarman, Y Sun, L. Jan, and Y. Jan Role of the proneural gene, atonal, in formation of Drosophila chordotonal organs and photoreceptors Development, January 7, 1995; 121(7): 2019 - 2030. [Abstract] [PDF]
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A. Felsenfeld and J. Kennison Positional signaling by hedgehog in Drosophila imaginal disc development Development, January 1, 1995; 121(1): 1 - 10. [Abstract] [PDF]
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D M Kingsley The TGF-beta superfamily: new members, new receptors, and new genetic tests of function in different organisms. Genes & Dev., January 15, 1994; 8(2): 133 - 146. [PDF]
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G Mardon, N. Solomon, and G. Rubin dachshund encodes a nuclear protein required for normal eye and leg development in Drosophila Development, January 12, 1994; 120(12): 3473 - 3486. [Abstract] [PDF]
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S. Blair Mechanisms of compartment formation: evidence that non-proliferating cells do not play a critical role in defining the D/V lineage restriction in the developing wing of Drosophila Development, January 10, 1993; 119(2): 339 - 351. [Abstract] [PDF]
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