|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 111, Issue 3 749-761, Copyright © 1991 by Company of Biologists
JOURNAL ARTICLES |
U Thomas, SA Speicher and E Knust
Institut fur Entwicklungsphysiologie, Universitat zu Koln, Germany.
We describe the molecular characterization of the Drosophila gene Serrate (Ser), which encodes an integral membrane protein. The extracellular domain contains two cysteine-rich regions, one of which is organized in a tandem array of 14 EGF-like repeats. Antibodies directed against part of the extracellular region confirm the localization of the protein in the membrane. In the wing imaginal discs, the protein is detected in those regions that are affected in the wings of two dominant mutations, SerD and SerBd. Both mutations as well as three out of eight newly induced revertants of SerD could be mapped molecularly to the transcribed region, confirming the identity between the gene Ser and the transcription unit characterized. During embryonic development, RNA and protein exhibit a complex expression pattern, which is, however, not correlated with an appropriate embryonic phenotype. Phenotypic interactions of Ser alleles with the neurogenic genes Notch and Delta coupled with the structural similarity of the proteins encoded by these three genes suggest close interactions at the protein level.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati 
Twitter What's this?
This article has been cited by other articles:
|
|
 |
|
  I. Sorensen, R. H. Adams, and A. Gossler DLL1-mediated Notch activation regulates endothelial identity in mouse fetal arteries Blood, May 28, 2009; 113(22): 5680 - 5688. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. Geffers, K. Serth, G. Chapman, R. Jaekel, K. Schuster-Gossler, R. Cordes, D. B. Sparrow, E. Kremmer, S. L. Dunwoodie, T. Klein, et al. Divergent functions and distinct localization of the Notch ligands DLL1 and DLL3 in vivo J. Cell Biol., July 24, 2007; 178(3): 465 - 476. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. B. Thomas and D. J. van Meyel The glycosyltransferase Fringe promotes Delta-Notch signaling between neurons and glia, and is required for subtype-specific glial gene expression Development, February 1, 2007; 134(3): 591 - 600. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Gallet, L. Ruel, L. Staccini-Lavenant, and P. P. Therond Cholesterol modification is necessary for controlled planar long-range activity of Hedgehog in Drosophila epithelia Development, February 1, 2006; 133(3): 407 - 418. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Tapanes-Castillo and M. K. Baylies Notch signaling patterns Drosophila mesodermal segments by regulating the bHLH transcription factor twist Development, May 15, 2004; 131(10): 2359 - 2372. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. de Celis Ibeas and S. J. Bray Bowl is required downstream of Notch for elaboration of distal limb patterning Development, December 15, 2003; 130(24): 5943 - 5952. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Sasamura, N. Sasaki, F. Miyashita, S. Nakao, H. O. Ishikawa, M. Ito, M. Kitagawa, K. Harigaya, E. Spana, D. Bilder, et al. neurotic, a novel maternal neurogenic gene, encodes an O-fucosyltransferase that is essential for Notch-Delta interactions Development, October 15, 2003; 130(20): 4785 - 4795. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. A. Johansen, D. D. Iwaki, and J. A. Lengyel Localized JAK/STAT signaling is required for oriented cell rearrangement in a tubular epithelium Development, January 1, 2003; 130(1): 135 - 145. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. M. Panin, L. Shao, L. Lei, D. J. Moloney, K. D. Irvine, and R. S. Haltiwanger Notch Ligands Are Substrates for Protein O-Fucosyltransferase-1 and Fringe J. Biol. Chem., August 9, 2002; 277(33): 29945 - 29952. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Towb, A. Bergmann, and S. A. Wasserman The protein kinase Pelle mediates feedback regulation in the Drosophila Toll signaling pathway Development, December 1, 2001; 128(23): 4729 - 4736. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Rauskolb The establishment of segmentation in the Drosophila leg Development, November 15, 2001; 128(22): 4511 - 4521. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Nagaso, T. Murata, N. Day, and K. K. Yokoyama Simultaneous Detection of RNA and Protein by In Situ Hybridization and Immunological Staining J. Histochem. Cytochem., September 1, 2001; 49(9): 1177 - 1182. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. O'Keefe and J. Thomas Drosophila wing development in the absence of dorsal identity Development, January 3, 2001; 128(5): 703 - 710. [Abstract] [PDF]
|
|
|
|
|
|
S. Tsai, J. Fero, and S. Bartelmez Mouse Jagged2 is differentially expressed in hematopoietic progenitors and endothelial cells and promotes the survival and proliferation of hematopoietic progenitors by direct cell-to-cell contact Blood, August 1, 2000; 96(3): 950 - 957. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M Milan and S. Cohen Temporal regulation of apterous activity during development of the Drosophila wing Development, January 7, 2000; 127(14): 3069 - 3078. [Abstract] [PDF]
|
|
|
|
|
|
N Lawrence, T Klein, K Brennan, and A Martinez Arias Structural requirements for notch signalling with delta and serrate during the development and patterning of the wing disc of Drosophila Development, January 7, 2000; 127(14): 3185 - 3195. [Abstract] [PDF]
|
|
|
|
 |
|
 K. Klueg and M. Muskavitch Ligand-receptor interactions and trans-endocytosis of Delta, Serrate and Notch: members of the Notch signalling pathway in Drosophila J. Cell Sci., January 10, 1999; 112(19): 3289 - 3297. [Abstract] [PDF]
|
|
|
|
|
|
T Ikeya and S Hayashi Interplay of Notch and FGF signaling restricts cell fate and MAPK activation in the Drosophila trachea Development, January 10, 1999; 126(20): 4455 - 4463. [Abstract] [PDF]
|
|
|
|
|
|
U Gritzan, V Hatini, and S DiNardo Mutual antagonism between signals secreted by adjacent wingless and engrailed cells leads to specification of complementary regions of the Drosophila parasegment Development, January 9, 1999; 126(18): 4107 - 4115. [Abstract] [PDF]
|
|
|
|
|
|
E. Wiellette and W McGinnis Hox genes differentially regulate Serrate to generate segment-specific structures Development, January 5, 1999; 126(9): 1985 - 1995. [Abstract] [PDF]
|
|
|
|
|
|
R Nagaraj, A. Pickup, R Howes, K Moses, M Freeman, and U Banerjee Role of the EGF receptor pathway in growth and patterning of the Drosophila wing through the regulation of vestigial Development, January 2, 1999; 126(5): 975 - 985. [Abstract] [PDF]
|
|
|
|
 |
|
 M. Milán, F. J. Diaz-Benjumea, and S. M. Cohen Beadex encodes an LMO protein that regulates Apterous LIM-homeodomain activity in Drosophila wing development: a model for LMO oncogene function Genes & Dev., September 15, 1998; 12(18): 2912 - 2920. [Abstract] [Full Text]
|
|
|
|
 |
|
 K. M. Klueg, T. R. Parody, and M. A.T. Muskavitch Complex Proteolytic Processing Acts on Delta, a Transmembrane Ligand for Notch, during Drosophila Development Mol. Biol. Cell, July 1, 1998; 9(7): 1709 - 1723. [Abstract] [Full Text]
|
|
|
|
|
|
C. Zeng, S. Younger-Shepherd, L. Y. Jan, and Y. N. Jan Delta and Serrate are redundant Notch ligands required for asymmetric cell divisions within the Drosophila sensory organ lineage Genes & Dev., April 15, 1998; 12(8): 1086 - 1091. [Abstract] [Full Text]
|
|
|
|
|
|
R. E. Ward IV, R. S. Lamb, and R. G. Fehon A Conserved Functional Domain of Drosophila Coracle Is Required for Localization at the Septate Junction and Has Membrane-organizing Activity J. Cell Biol., March 23, 1998; 140(6): 1463 - 1473. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. de Celis, D. Tyler, J de Celis, and S. Bray Notch signalling mediates segmentation of the Drosophila leg Development, January 12, 1998; 125(23): 4617 - 4626. [Abstract] [PDF]
|
|
|
|
|
|
N. Jones, Y. Kuo, Y. Sun, and S. Beckendorf The Drosophila Pax gene eye gone is required for embryonic salivary duct development Development, January 11, 1998; 125(21): 4163 - 4174. [Abstract] [PDF]
|
|
|
|
|
|
T. Jacobsen, K Brennan, A. Arias, and M. Muskavitch Cis-interactions between Delta and Notch modulate neurogenic signalling in Drosophila Development, January 11, 1998; 125(22): 4531 - 4540. [Abstract] [PDF]
|
|
|
|
|
|
A Majumdar, R Nagaraj, and U Banerjee strawberry notch encodes a conserved nuclear protein that functions downstream of Notch and regulates gene expression along the developing wing margin of Drosophila. Genes & Dev., May 15, 1997; 11(10): 1341 - 1353. [Abstract] [PDF]
|
|
|
|
 |
|
 Z.-Z. Bao and C. L. Cepko The Expression and Function of Notch Pathway Genes in the Developing Rat Eye J. Neurosci., February 15, 1997; 17(4): 1425 - 1434. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S Sotillos, F Roch, and S Campuzano The metalloprotease-disintegrin Kuzbanian participates in Notch activation during growth and patterning of Drosophila imaginal discs Development, January 12, 1997; 124(23): 4769 - 4779. [Abstract] [PDF]
|
|
|
|
|
|
X Sun and S Artavanis-Tsakonas Secreted forms of DELTA and SERRATE define antagonists of Notch signaling in Drosophila Development, January 9, 1997; 124(17): 3439 - 3448. [Abstract] [PDF]
|
|
|
|
|
|
R. Fleming, Y Gu, and N. Hukriede Serrate-mediated activation of Notch is specifically blocked by the product of the gene fringe in the dorsal compartment of the Drosophila wing imaginal disc Development, January 8, 1997; 124(15): 2973 - 2981. [Abstract] [PDF]
|
|
|
|
|
|
L Seugnet, P Simpson, and M Haenlin Transcriptional regulation of Notch and Delta: requirement for neuroblast segregation in Drosophila Development, January 5, 1997; 124(10): 2015 - 2025. [Abstract] [PDF]
|
|
|
|
|
|
T. Mitsiadis, D Henrique, I Thesleff, and U Lendahl Mouse Serrate-1 (Jagged-1): expression in the developing tooth is regulated by epithelial-mesenchymal interactions and fibroblast growth factor-4 Development, January 4, 1997; 124(8): 1473 - 1483. [Abstract] [PDF]
|
|
|
|
|
|
C. Micchelli, E. Rulifson, and S. Blair The function and regulation of cut expression on the wing margin of Drosophila: Notch, Wingless and a dominant negative role for Delta and Serrate Development, January 4, 1997; 124(8): 1485 - 1495. [Abstract] [PDF]
|
|
|
|
 |
|
 S. Goode and N. Perrimon Brainiac and Fringe Are Similar Pioneer Proteins That Impart Specificity to Notch Signaling during Drosophila Development Cold Spring Harb Symp Quant Biol, January 1, 1997; 62(0): 177 - 184. [Abstract] [PDF]
|
|
|
|
|
|
R P Ray and T Schupbach Intercellular signaling and the polarization of body axes during Drosophila oogenesis. Genes & Dev., July 15, 1996; 10(14): 1711 - 1723. [PDF]
|
|
|
|
|
|
X Sun and S Artavanis-Tsakonas The intracellular deletions of Delta and Serrate define dominant negative forms of the Drosophila Notch ligands Development, January 8, 1996; 122(8): 2465 - 2474. [Abstract] [PDF]
|
|
|
|
|
|
Y. Kuo, N Jones, B Zhou, S Panzer, V Larson, and S. Beckendorf Salivary duct determination in Drosophila: roles of the EGF receptor signalling pathway and the transcription factors fork head and trachealess Development, January 6, 1996; 122(6): 1909 - 1917. [Abstract] [PDF]
|
|
|
|
|
|
J. de Celis, A Garcia-Bellido, and S. Bray Activation and function of Notch at the dorsal-ventral boundary of the wing imaginal disc Development, January 1, 1996; 122(1): 359 - 369. [Abstract] [PDF]
|
|
|
|
 |
|
 S Artavanis-Tsakonas, K Matsuno, and M. Fortini Notch signaling Science, April 14, 1995; 268(5208): 225 - 232. [Abstract] [PDF]
|
|
|
|
|
|
F. Diaz-Benjumea and S. Cohen Serrate signals through Notch to establish a Wingless-dependent organizer at the dorsal/ventral compartment boundary of the Drosophila wing Development, January 12, 1995; 121(12): 4215 - 4225. [Abstract] [PDF]
|
|
|
|
|
|
H Nakato, T. Futch, and S. Selleck The division abnormally delayed (dally) gene: a putative integral membrane proteoglycan required for cell division patterning during postembryonic development of the nervous system in Drosophila Development, January 11, 1995; 121(11): 3687 - 3702. [Abstract] [PDF]
|
|
|
|
|
|
K Matsuno, R. Diederich, M. Go, C. Blaumueller, and S Artavanis-Tsakonas Deltex acts as a positive regulator of Notch signaling through interactions with the Notch ankyrin repeats Development, January 8, 1995; 121(8): 2633 - 2644. [Abstract] [PDF]
|
|
|
|
|
|
Y Gu, N. Hukriede, and R. Fleming Serrate expression can functionally replace Delta activity during neuroblast segregation in the Drosophila embryo Development, January 3, 1995; 121(3): 855 - 865. [Abstract] [PDF]
|
|
|
|
|
|
S. Henderson, D Gao, E. Lambie, and J Kimble lag-2 may encode a signaling ligand for the GLP-1 and LIN-12 receptors of C. elegans Development, January 10, 1994; 120(10): 2913 - 2924. [Abstract] [PDF]
|
|
|
|
|
|
S. Speicher, U Thomas, U Hinz, and E Knust The Serrate locus of Drosophila and its role in morphogenesis of the wing imaginal discs: control of cell proliferation Development, January 3, 1994; 120(3): 535 - 544. [Abstract] [PDF]
|
|
|
|
|
|
C. Coyle-Thompson and U Banerjee The strawberry notch gene functions with Notch in common developmental pathways Development, January 10, 1993; 119(2): 377 - 395. [Abstract] [PDF]
|
|
|
|
|
|
E Giniger, L. Jan, and Y. Jan Specifying the path of the intersegmental nerve of the Drosophila embryo: a role for Delta and Notch Development, January 2, 1993; 117(2): 431 - 440. [Abstract] [PDF]
|
|
|
|
|
|
G. Weinmaster, V. J. Roberts, and G. Lemke Notch2: a second mammalian Notch gene Development, December 1, 1992; 116(4): 931 - 941. [Abstract] [PDF]
|
|
|
|
|
|
S Campbell, M Inamdar, V Rodrigues, V Raghavan, M Palazzolo, and A Chovnick The scalloped gene encodes a novel, evolutionarily conserved transcription factor required for sensory organ differentiation in Drosophila. Genes & Dev., March 1, 1992; 6(3): 367 - 379. [Abstract] [PDF]
|
|
