|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 111, Issue 4 1021-1028, Copyright © 1991 by Company of Biologists
JOURNAL ARTICLES |
C Hashimoto, S Gerttula and KV Anderson
Department of Molecular and Cell Biology, University of California, Berkeley 94720.
Formation of the Drosophila embryo's dorsal-ventral pattern requires the maternal product of the Toll gene. DNA sequence and genetic analyses together suggested that the Toll gene product is a transmembrane protein which communicates information from an extracytoplasmic compartment to the cytoplasm. Using antibodies as probes, we show that the Toll protein is a 135 x 10(3) Mr glycoprotein which is tightly associated with embryonic membranes. During the syncytial stage when dorsal-ventral polarity is established, the maternal Toll protein is associated with the plasma membrane around the entire embryo. During later embryonic stages, the Toll protein is expressed zygotically on many cell surfaces, possibly to promote cell adhesion. The plasma membrane localization of the Toll protein in the syncytial embryo suggests that transmembrane signaling from the extracellular perivitelline space to the cytoplasm is required for establishment of the embryonic dorsal-ventral pattern.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati 
Twitter What's this?
This article has been cited by other articles:
|
|
 |
|
  V. I. Korolchuk, M. M. Schutz, C. Gomez-Llorente, J. Rocha, N. R. Lansu, S. M. Collins, Y. P. Wairkar, I. M. Robinson, and C. J. O'Kane Drosophila Vps35 function is necessary for normal endocytic trafficking and actin cytoskeleton organisation J. Cell Sci., December 15, 2007; 120(24): 4367 - 4376. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. DeLotto, Y. DeLotto, R. Steward, and J. Lippincott-Schwartz Nucleocytoplasmic shuttling mediates the dynamic maintenance of nuclear Dorsal levels during Drosophila embryogenesis Development, December 1, 2007; 134(23): 4233 - 4241. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Minakhina and R. Steward Melanotic Mutants in Drosophila: Pathways and Phenotypes Genetics, September 1, 2006; 174(1): 253 - 263. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Frescas, M. Mavrakis, H. Lorenz, R. DeLotto, and J. Lippincott-Schwartz The secretory membrane system in the Drosophila syncytial blastoderm embryo exists as functionally compartmentalized units around individual nuclei J. Cell Biol., April 24, 2006; 173(2): 219 - 230. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Wang, Y. Tao, I. Reim, K. Gajewski, M. Frasch, and R. A. Schulz Expression, Regulation, and Requirement of the Toll Transmembrane Protein during Dorsal Vessel Formation in Drosophila melanogaster Mol. Cell. Biol., May 15, 2005; 25(10): 4200 - 4210. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Bettencourt, T. Tanji, Y. Yagi, and Y. T. Ip Toll and Toll-9 in Drosophila innate immune response Innate Immunity, August 1, 2004; 10(4): 261 - 268. [Abstract] [PDF]
|
|
|
|
|
|
A. J. Chang and D. Morisato Regulation of Easter activity is required for shaping the Dorsal gradient in the Drosophila embryo Development, March 14, 2003; 129(24): 5635 - 5645. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Towb, A. Bergmann, and S. A. Wasserman The protein kinase Pelle mediates feedback regulation in the Drosophila Toll signaling pathway Development, December 1, 2001; 128(23): 4729 - 4736. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Q. Fernandez, J. Grosshans, J. S. Goltz, and D. Stein Separable and redundant regulatory determinants in Cactus mediate its dorsal group dependent degradation Development, August 1, 2001; 128(15): 2963 - 2974. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H Araujo and E Bier sog and dpp exert opposing maternal functions to modify toll signaling and pattern the dorsoventral axis of the Drosophila embryo Development, January 8, 2000; 127(16): 3631 - 3644. [Abstract] [PDF]
|
|
|
|
 |
|
 K. D. Konrad, T. J. Goralski, A. P. Mahowald, and J. L. Marsh The gastrulation defective gene of Drosophila melanogaster is a member of the serine protease superfamily PNAS, June 9, 1998; 95(12): 6819 - 6824. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. M. Chaudhary, C. Ferguson, V. Nguyen, O. Nguyen, H. F. Massa, M. Eby, A. Jasmin, B. J. Trask, L. Hood, and P. S. Nelson Cloning and Characterization of Two Toll/Interleukin-1 Receptor-Like Genes TIL3 and TIL4: Evidence for a Multi-Gene Receptor Family in Humans Blood, June 1, 1998; 91(11): 4020 - 4027. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B Shen and J. Manley Phosphorylation modulates direct interactions between the Toll receptor, Pelle kinase and Tube Development, January 12, 1998; 125(23): 4719 - 4728. [Abstract] [PDF]
|
|
|
|
|
|
E. LeMosy, D Kemler, and C Hashimoto Role of Nudel protease activation in triggering dorsoventral polarization of the Drosophila embryo Development, January 10, 1998; 125(20): 4045 - 4053. [Abstract] [PDF]
|
|
|
|
|
|
J. Schisa and S Strickland Cytoplasmic polyadenylation of Toll mRNA is required for dorsal-ventral patterning in Drosophila embryogenesis Development, January 8, 1998; 125(15): 2995 - 3003. [Abstract] [PDF]
|
|
|
|
|
|
P Towb, R. Galindo, and S. Wasserman Recruitment of Tube and Pelle to signaling sites at the surface of the Drosophila embryo Development, January 7, 1998; 125(13): 2443 - 2450. [Abstract] [PDF]
|
|
|
|
|
|
P Qiu, P. Pan, and S Govind A role for the Drosophila Toll/Cactus pathway in larval hematopoiesis Development, January 5, 1998; 125(10): 1909 - 1920. [Abstract] [PDF]
|
|
|
|
|
|
S Misra, P Hecht, R Maeda, and K. Anderson Positive and negative regulation of Easter, a member of the serine protease family that controls dorsal-ventral patterning in the Drosophila embryo Development, January 4, 1998; 125(7): 1261 - 1267. [Abstract] [PDF]
|
|
|
|
|
|
J. Yang and R. Steward A multimeric complex and the nuclear targeting of the Drosophila Rel protein Dorsal PNAS, December 23, 1997; 94(26): 14524 - 14529. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. M. Huang, J. Rusch, and M. Levine An anteroposterior Dorsal gradient in the Drosophila embryo Genes & Dev., August 1, 1997; 11(15): 1963 - 1973. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Edwards, P Towb, and S. Wasserman An activity-dependent network of interactions links the Rel protein Dorsal with its cytoplasmic regulators Development, January 10, 1997; 124(19): 3855 - 3864. [Abstract] [PDF]
|
|
|
|
|
|
H Kose, D Rose, X Zhu, and A Chiba Homophilic synaptic target recognition mediated by immunoglobulin-like cell adhesion molecule Fasciclin III Development, January 10, 1997; 124(20): 4143 - 4152. [Abstract] [PDF]
|
|
|
|
|
|
T Isshiki, M Takeichi, and A Nose The role of the msh homeobox gene during Drosophila neurogenesis: implication for the dorsoventral specification of the neuroectoderm Development, January 8, 1997; 124(16): 3099 - 3109. [Abstract] [PDF]
|
|
|
|
|
|
D Rose, X Zhu, H Kose, B Hoang, J Cho, and A Chiba Toll, a muscle cell surface molecule, locally inhibits synaptic initiation of the RP3 motoneuron growth cone in Drosophila Development, January 4, 1997; 124(8): 1561 - 1571. [Abstract] [PDF]
|
|
|
|
 |
|
 L.P. Wu and K.V. Anderson Related Signaling Networks in Drosophila That Control Dorsoventral Patterning in the Embryo and the Immune Response Cold Spring Harb Symp Quant Biol, January 1, 1997; 62(0): 97 - 103. [Abstract] [PDF]
|
|
|
|
|
|
T Hsu, C Bagni, J D Sutherland, and F C Kafatos The transcriptional factor CF2 is a mediator of EGF-R-activated dorsoventral patterning in Drosophila oogenesis. Genes & Dev., June 1, 1996; 10(11): 1411 - 1421. [Abstract] [PDF]
|
|
|
|
|
|
M. Lieberfarb, T Chu, C Wreden, W Theurkauf, J. Gergen, and S Strickland Mutations that perturb poly(A)-dependent maternal mRNA activation block the initiation of development Development, January 2, 1996; 122(2): 579 - 588. [Abstract] [PDF]
|
|
|
|
|
|
R. Galindo, D. Edwards, S. Gillespie, and S. Wasserman Interaction of the pelle kinase with the membrane-associated protein tube is required for transduction of the dorsoventral signal in Drosophila embryos Development, January 7, 1995; 121(7): 2209 - 2218. [Abstract] [PDF]
|
|
|
|
|
|
F. S. Neuman-Silberberg and T. Schupbach Dorsoventral axis formation in Drosophila depends on the correct dosage of the gene gurken Development, September 1, 1994; 120(9): 2457 - 2463. [Abstract] [PDF]
|
|
|
|
|
|
A H Brand and N Perrimon Raf acts downstream of the EGF receptor to determine dorsoventral polarity during Drosophila oogenesis. Genes & Dev., March 1, 1994; 8(5): 629 - 639. [Abstract] [PDF]
|
|
|
|
|
|
S. Crittenden, E. Troemel, T. Evans, and J Kimble GLP-1 is localized to the mitotic region of the C. elegans germ line Development, January 10, 1994; 120(10): 2901 - 2911. [Abstract] [PDF]
|
|
|
|
|
|
S Roth and T Schupbach The relationship between ovarian and embryonic dorsoventral patterning in Drosophila Development, January 8, 1994; 120(8): 2245 - 2257. [Abstract] [PDF]
|
|
|
|
|
|
G. Thomas and D. Kiehart Beta heavy-spectrin has a restricted tissue and subcellular distribution during Drosophila embryogenesis Development, January 7, 1994; 120(7): 2039 - 2050. [Abstract] [PDF]
|
|
|
|
|
|
D. Schneider, Y Jin, D Morisato, and K. Anderson A processed form of the Spatzle protein defines dorsal-ventral polarity in the Drosophila embryo Development, January 5, 1994; 120(5): 1243 - 1250. [Abstract] [PDF]
|
|
|
|
|
|
E Eldon, S Kooyer, D D'Evelyn, M Duman, P Lawinger, J Botas, and H Bellen The Drosophila 18 wheeler is required for morphogenesis and has striking similarities to Toll Development, January 4, 1994; 120(4): 885 - 899. [Abstract] [PDF]
|
|
|
|
|
|
R L Kelley Initial organization of the Drosophila dorsoventral axis depends on an RNA-binding protein encoded by the squid gene. Genes & Dev., June 1, 1993; 7(6): 948 - 960. [Abstract] [PDF]
|
|
|
|
|
|
S Roth Mechanisms of dorsal-ventral axis determination in Drosophila embryos revealed by cytoplasmic transplantations Development, January 4, 1993; 117(4): 1385 - 1396. [Abstract] [PDF]
|
|
|
|
|
|
S. Govind, L. Brennan, and R. Steward Homeostatic balance between dorsal and cactus proteins in the Drosophila embryo Development, January 1, 1993; 117(1): 135 - 148. [Abstract] [PDF]
|
|
|
|
|
|
J L Norris and J L Manley Selective nuclear transport of the Drosophila morphogen dorsal can be established by a signaling pathway involving the transmembrane protein Toll and protein kinase A. Genes & Dev., September 1, 1992; 6(9): 1654 - 1667. [Abstract] [PDF]
|
|
|
|
|
|
C Klambt, L Glazer, and B Z Shilo breathless, a Drosophila FGF receptor homolog, is essential for migration of tracheal and specific midline glial cells. Genes & Dev., September 1, 1992; 6(9): 1668 - 1678. [Abstract] [PDF]
|
|
|
|
|
|
K.V. Anderson, D.S. Schneider, D. Morisato, Y. Jin, and E.L. Ferguson Extracellular Morphogens in Drosophila Embryonic Dorsal-Ventral Patterning Cold Spring Harb Symp Quant Biol, January 1, 1992; 57(0): 409 - 417. [Abstract] [PDF]
|
|
|
|
|
|
E. K. LeMosy, Y.-Q. Tan, and C. Hashimoto Activation of a protease cascade involved in patterning the Drosophila embryo PNAS, April 24, 2001; 98(9): 5055 - 5060. [Abstract] [Full Text] [PDF]
|
|
