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Development, Vol 111, Issue 4 1045-1055, Copyright © 1991 by Company of Biologists
JOURNAL ARTICLES |
JL Christian, JA McMahon, AP McMahon and RT Moon
Department of Pharmacology, University of Washington School of Medicine, Seattle 98195.
In amphibian embryos, formation of the basic body plan depends on positional differences in the mesoderm. Although peptide growth factors involved in mesoderm induction have tentatively been identified, additional signals are required to generate pattern in this tissue. We have isolated a Xenopus cDNA for a Wnt-1 related gene, designated Xwnt-8, which is activated in response to mesoderm-inducing growth factors. Xwnt-8 transcripts are transiently expressed, being most abundant during gastrulation at which time expression is confined primarily to ventral mesodermal cells. Embryos dorsoanteriorized by exposure to lithium exhibit greatly reduced levels of Xwnt-8 mRNA, supporting a correlation between Xwnt-8 expression and a ventral mesodermal cell fate. Surprisingly, ectopic expression of Xwnt-8 in embryos causes a dorsoanterior-enhanced phenotype. These findings suggest that Xwnt-8 may be a secondary signalling agent which is produced in response to mesoderm-inducing factors and is involved in the early steps of mesodermal patterning.
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M. Fan and S. Sokol A role for Siamois in Spemann organizer formation Development, January 7, 1997; 124(13): 2581 - 2589. [Abstract] [PDF]
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C Wylie, M Kofron, C Payne, R Anderson, M Hosobuchi, E Joseph, and J Heasman Maternal beta-catenin establishes a 'dorsal signal' in early Xenopus embryos Development, January 10, 1996; 122(10): 2987 - 2996. [Abstract] [PDF]
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M Moos, S Wang, and M Krinks Anti-dorsalizing morphogenetic protein is a novel TGF-beta homolog expressed in the Spemann organizer Development, January 12, 1995; 121(12): 4293 - 4301. [Abstract] [PDF]
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