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Development, Vol 111, Issue 4 1173-1178, Copyright © 1991 by Company of Biologists

JOURNAL ARTICLES

Cyclin B mRNA depletion only transiently inhibits the Xenopus embryonic cell cycle

DL Weeks, JA Walder and JM Dagle
Department of Biochemistry, University of Iowa, Iowa City 52242.

The control of the cell cycle is dependent on the ability to synthesize and degrade proteins called cyclins. When antisense oligonucleotides are used to deplete Xenopus embryos of mRNA encoding cyclin B protein, embryonic cleavage is inhibited. Surprisingly, after missing several rounds of cleavage, the cell cycle and cell division resumes. These studies indicate that the early embryonic cell cycle can proceed with undetectable levels of cyclin B encoding mRNA. In contrast, other events of normal development, including the activation of embryonic transcription and gastrulation, are inhibited.


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© The Company of Biologists Ltd 1991