|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 112, Issue 1 231-240, Copyright © 1991 by Company of Biologists
JOURNAL ARTICLES |
EJ Lambie and J Kimble
Department of Biochemistry, College of Agriculture and Life Sciences, University of Wisconsin-Madison 53706.
Two homologous genes, lin-12 and glp-1, encode transmembrane proteins required for regulatory cell interactions during C. elegans development. Based on their single mutant phenotypes, each gene has been thought to govern a distinct set of cell fates. We show here that lin-12 and glp-1 are functionally redundant during embryogenesis: Unlike either single mutant, the lin-12 glp-1 double mutant dies soon after hatching. Numerous cellular defects can be observed in these Lag (for lin-12 and glp-1) double mutants. Furthermore, we have identified two genes, lag-1 and lag-2, that appear to be required for both lin-12 and glp-1-mediated cell interactions. Strong loss-of-function lag mutants are phenotypically indistinguishable from the lin-12 glp-1 double; weak lag mutants have phenotypes typical of lin-12 and glp-1 single mutants. We speculate that the lin-12 and glp-1 proteins are biochemically interchangeable and that their divergent roles in development may rely largely on differences in gene expression.
This article has been cited by other articles:
|
|
 |
|
  M. W. Kankel, G. D. Hurlbut, G. Upadhyay, V. Yajnik, B. Yedvobnick, and S. Artavanis-Tsakonas Investigating the Genetic Circuitry of Mastermind in Drosophila, a Notch Signal Effector Genetics, December 1, 2007; 177(4): 2493 - 2505. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Liu and E. M. Maine The Bro1-Domain Protein, EGO-2, Promotes Notch Signaling in Caenorhabditis elegans Genetics, August 1, 2007; 176(4): 2265 - 2277. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. J. Hwang, A. D. Meruelo, and P. W. Sternberg C. elegans EVI1 proto-oncogene, EGL-43, is necessary for Notch-mediated cell fate specification and regulates cell invasion Development, February 15, 2007; 134(4): 669 - 679. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Katic and I. Greenwald EMB-4: A Predicted ATPase That Facilitates lin-12 Activity in Caenorhabditis elegans Genetics, December 1, 2006; 174(4): 1907 - 1915. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Katic, L. G. Vallier, and I. Greenwald New Positive Regulators of lin-12 Activity in Caenorhabditis elegans Include the BRE-5/Brainiac Glycosphingolipid Biosynthesis Enzyme Genetics, December 1, 2005; 171(4): 1605 - 1615. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. A. Berset, E. F. Hoier, and A. Hajnal The C. elegans homolog of the mammalian tumor suppressor Dep-1/Scc1 inhibits EGFR signaling to regulate binary cell fate decisions Genes & Dev., June 1, 2005; 19(11): 1328 - 1340. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Tian, D. Hansen, T. Schedl, and J. B. Skeath Epsin potentiates Notch pathway activity in Drosophila and C. elegans Development, December 1, 2004; 131(23): 5807 - 5815. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Yochem, L. R. Bell, and R. K. Herman The Identities of sym-2, sym-3 and sym-4, Three Genes That Are Synthetically Lethal With mec-8 in Caenorhabditis elegans Genetics, November 1, 2004; 168(3): 1293 - 1306. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. M. Maine, D. Hansen, D. Springer, and V. E. Vought Caenorhabditis elegans atx-2 Promotes Germline Proliferation and the Oocyte Fate Genetics, October 1, 2004; 168(2): 817 - 830. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. MacKenzie, P. Duriez, B. Larrivee, L. Chang, I. Pollet, F. Wong, C. Yip, and A. Karsan Notch4-induced inhibition of endothelial sprouting requires the ankyrin repeats and involves signaling through RBP-J{kappa} Blood, September 15, 2004; 104(6): 1760 - 1768. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Good, R. Ciosk, J. Nance, A. Neves, R. J. Hill, and J. R. Priess The T-box transcription factors TBX-37 and TBX-38 link GLP-1/Notch signaling to mesoderm induction in C. elegans embryos Development, May 1, 2004; 131(9): 1967 - 1978. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. J. Killian and E. J. A. Hubbard C. elegans pro-1 activity is required for soma/germline interactions that influence proliferation and differentiation in the germ line Development, March 15, 2004; 131(6): 1267 - 1278. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. C. Lai Notch signaling: control of cell communication and cell fate Development, March 1, 2004; 131(5): 965 - 973. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Hansen, L. Wilson-Berry, T. Dang, and T. Schedl Control of the proliferation versus meiotic development decision in the C. elegans germline through regulation of GLD-1 protein accumulation Development, January 1, 2004; 131(1): 93 - 104. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Karp and I. Greenwald Post-transcriptional regulation of the E/Daughterless ortholog HLH-2, negative feedback, and birth order bias during the AC/VU decision in C. elegans Genes & Dev., December 15, 2003; 17(24): 3100 - 3111. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. H. Thomas, C. J. Ceol, H. T. Schwartz, and H. R. Horvitz New Genes That Interact With lin-35 Rb to Negatively Regulate the let-60 ras Pathway in Caenorhabditis elegans Genetics, May 1, 2003; 164(1): 135 - 151. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. C. Oates and R. K. Ho Hairy/E(spl)-related (Her) genes are central components of the segmentation oscillator and display redundancy with the Delta/Notch signaling pathway in the formation of anterior segmental boundaries in the zebrafish Development, March 8, 2003; 129(12): 2929 - 2946. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. S.-R. Pepper, D. J. Killian, and E. J. A. Hubbard Genetic Analysis of Caenorhabditis elegans glp-1 Mutants Suggests Receptor Interaction or Competition Genetics, January 1, 2003; 163(1): 115 - 132. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Rudel and J. Kimble Conservation of glp-1 Regulation and Function in Nematodes Genetics, February 1, 2001; 157(2): 639 - 654. [Abstract] [Full Text]
|
|
|
|
 |
|
 T. G. Doyle, C. Wen, and I. Greenwald SEL-8, a nuclear protein required for LIN-12 and GLP-1 signaling in Caenorhabditis elegans PNAS, July 5, 2000; 97(14): 7877 - 7881. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. T. Krebs, Y. Xue, C. R. Norton, J. R. Shutter, M. Maguire, J. P. Sundberg, D. Gallahan, V. Closson, J. Kitajewski, R. Callahan, et al. Notch signaling is essential for vascular morphogenesis in mice Genes & Dev., June 1, 2000; 14(11): 1343 - 1352. [Abstract] [Full Text]
|
|
|
|
|
|
A. K. Corsi, S. A. Kostas, A. Fire, and M. Krause Caenorhabditis elegans twist plays an essential role in non-striated muscle development Development, May 15, 2000; 127(10): 2041 - 2051. [Abstract] [PDF]
|
|
|
|
|
|
L Molin, A Mounsey, S Aslam, P Bauer, J Young, M James, A Sharma-Oates, and I. Hope Evolutionary conservation of redundancy between a diverged pair of forkhead transcription factor homologues Development, January 11, 2000; 127(22): 4825 - 4835. [Abstract] [PDF]
|
|
|
|
|
|
G. Hermann, B Leung, and J. Priess Left-right asymmetry in C. elegans intestine organogenesis involves a LIN-12/Notch signaling pathway Development, January 8, 2000; 127(16): 3429 - 3440. [Abstract] [PDF]
|
|
|
|
|
|
C Goutte, W Hepler, K. Mickey, and J. Priess aph-2 encodes a novel extracellular protein required for GLP-1-mediated signaling Development, January 6, 2000; 127(11): 2481 - 2492. [Abstract] [PDF]
|
|
|
|
|
|
H. Fares and I. Greenwald SEL-5, A Serine/Threonine Kinase That Facilitates lin-12 Activity in Caenorhabditis elegans Genetics, December 1, 1999; 153(4): 1641 - 1654. [Abstract] [Full Text]
|
|
|
|
|
|
H. M. Chamberlin, K. B. Brown, P. W. Sternberg, and J. H. Thomas Characterization of Seven Genes Affecting Caenorhabditis elegans Hindgut Development Genetics, October 1, 1999; 153(2): 731 - 742. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. G. Davies, C. A. Spike, J. E. Shaw, and R. K. Herman Functional Overlap Between the mec-8 Gene and Five sym Genes in Caenorhabditis elegans Genetics, September 1, 1999; 153(1): 117 - 134. [Abstract] [Full Text]
|
|
|
|
 |
|
 C. Wen and I. Greenwald p24 Proteins and Quality Control of LIN-12 and GLP-1 Trafficking in Caenorhabditis elegans J. Cell Biol., June 14, 1999; 145(6): 1165 - 1175. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Westlund, D. Parry, R. Clover, M. Basson, and C. D. Johnson Reverse genetic analysis of Caenorhabditis elegans presenilins reveals redundant but unequal roles for sel-12 and hop-1 in Notch-pathway signaling PNAS, March 2, 1999; 96(5): 2497 - 2502. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Greenwald LIN-12/Notch signaling: lessons from worms and flies Genes & Dev., June 15, 1998; 12(12): 1751 - 1762. [Full Text]
|
|
|
|
|
|
P Ligoxygakis, S. Yu, C Delidakis, and N. Baker A subset of notch functions during Drosophila eye development require Su(H) and the E(spl) gene complex Development, January 8, 1998; 125(15): 2893 - 2900. [Abstract] [PDF]
|
|
|
|
|
|
D Levitan and I Greenwald LIN-12 protein expression and localization during vulval development in C. elegans Development, January 8, 1998; 125(16): 3101 - 3109. [Abstract] [PDF]
|
|
|
|
|
|
L. Kadyk and J Kimble Genetic regulation of entry into meiosis in Caenorhabditis elegans Development, January 5, 1998; 125(10): 1803 - 1813. [Abstract] [PDF]
|
|
|
|
|
|
J. Zhu, R. J. Hill, P. J. Heid, M. Fukuyama, A. Sugimoto, J. R. Priess, and J. H. Rothman end-1 encodes an apparent GATA factor that specifies the endoderm precursor in Caenorhabditis elegans embryos Genes & Dev., November 1, 1997; 11(21): 2883 - 2896. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Li and I. Greenwald HOP-1, a Caenorhabditis elegans presenilin, appears to be functionally redundant with SEL-12 presenilin and to facilitate LIN-12 and GLP-1 signaling PNAS, October 28, 1997; 94(22): 12204 - 12209. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. C. Aster, E. S. Robertson, R. P. Hasserjian, J. R. Turner, E. Kieff, and J. Sklar Oncogenic Forms of NOTCH1 Lacking Either the Primary Binding Site for RBP-Jkappa or Nuclear Localization Sequences Retain the Ability to Associate with RBP-Jkappa and Activate Transcription J. Biol. Chem., April 25, 1997; 272(17): 11336 - 11343. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Huppert, T. Jacobsen, and M. Muskavitch Feedback regulation is central to Delta-Notch signalling required for Drosophila wing vein morphogenesis Development, January 9, 1997; 124(17): 3283 - 3291. [Abstract] [PDF]
|
|
|
|
|
|
D. Sherwood and D. McClay Identification and localization of a sea urchin Notch homologue: insights into vegetal plate regionalization and Notch receptor regulation Development, January 9, 1997; 124(17): 3363 - 3374. [Abstract] [PDF]
|
|
|
|
|
|
M Krause, M Park, J. Zhang, J Yuan, B Harfe, S. Xu, I Greenwald, M Cole, B Paterson, and A Fire A C. elegans E/Daughterless bHLH protein marks neuronal but not striated muscle development Development, January 6, 1997; 124(11): 2179 - 2189. [Abstract] [PDF]
|
|
|
|
|
|
B Grant and I Greenwald Structure, function, and expression of SEL-1, a negative regulator of LIN-12 and GLP-1 in C. elegans Development, January 2, 1997; 124(3): 637 - 644. [Abstract] [PDF]
|
|
|
|
|
|
L. Berry, B Westlund, and T Schedl Germ-line tumor formation caused by activation of glp-1, a Caenorhabditis elegans member of the Notch family of receptors Development, January 2, 1997; 124(4): 925 - 936. [Abstract] [PDF]
|
|
|
|
|
|
M. E. Gruidl, P. A. Smith, K. A. Kuznicki, J. S. McCrone, J. Kirchner, D. L. Roussell, S. Strome, and K. L. Bennett Multiple potential germ-line helicases are components of the germ-line-specific P granules of Caenorhabditis elegans PNAS, November 26, 1996; 93(24): 13837 - 13842. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Moskowitz and J. Rothman lin-12 and glp-1 are required zygotically for early embryonic cellular interactions and are regulated by maternal GLP-1 signaling in Caenorhabditis elegans Development, January 12, 1996; 122(12): 4105 - 4117. [Abstract] [PDF]
|
|
|
|
|
|
C Guenther and G Garriga Asymmetric distribution of the C. elegans HAM-1 protein in neuroblasts enables daughter cells to adopt distinct fates Development, January 11, 1996; 122(11): 3509 - 3518. [Abstract] [PDF]
|
|
|
|
|
|
C. Shelton and B Bowerman Time-dependent responses to glp-1-mediated inductions in early C. elegans embryos Development, January 7, 1996; 122(7): 2043 - 2050. [Abstract] [PDF]
|
|
|
|
|
|
K. Mickey, C. Mello, M. Montgomery, A Fire, and J. Priess An inductive interaction in 4-cell stage C. elegans embryos involves APX-1 expression in the signalling cell Development, January 6, 1996; 122(6): 1791 - 1798. [Abstract] [PDF]
|
|
|
|
|
|
S Christensen, V Kodoyianni, M Bosenberg, L Friedman, and J Kimble lag-1, a gene required for lin-12 and glp-1 signaling in Caenorhabditis elegans, is homologous to human CBF1 and Drosophila Su(H) Development, January 5, 1996; 122(5): 1373 - 1383. [Abstract] [PDF]
|
|
|
|
 |
|
 S Artavanis-Tsakonas, K Matsuno, and M. Fortini Notch signaling Science, April 14, 1995; 268(5208): 225 - 232. [Abstract] [PDF]
|
|
|
|
|
|
K Fitzgerald and I Greenwald Interchangeability of Caenorhabditis elegans DSL proteins and intrinsic signalling activity of their extracellular domains in vivo Development, January 12, 1995; 121(12): 4275 - 4282. [Abstract] [PDF]
|
|
|
|
|
|
H Hutter and R Schnabel Establishment of left-right asymmetry in the Caenorhabditis elegans embryo: a multistep process involving a series of inductive events Development, January 10, 1995; 121(10): 3417 - 3424. [Abstract] [PDF]
|
|
|
|
|
|
D. Church, K. Guan, and E. Lambie Three genes of the MAP kinase cascade, mek-2, mpk-1/sur-1 and let-60 ras, are required for meiotic cell cycle progression in Caenorhabditis elegans Development, January 8, 1995; 121(8): 2525 - 2535. [Abstract] [PDF]
|
|
|
|
|
|
F Schweisguth Suppressor of Hairless is required for signal reception during lateral inhibition in the Drosophila pupal notum Development, January 6, 1995; 121(6): 1875 - 1884. [Abstract] [PDF]
|
|
|
|
|
|
A. Newman, J. White, and P. Sternberg The Caenorhabditis elegans lin-12 gene mediates induction of ventral uterine specialization by the anchor cell Development, January 2, 1995; 121(2): 263 - 271. [Abstract] [PDF]
|
|
|
|
|
|
P J Swiatek, C E Lindsell, F F del Amo, G Weinmaster, and T Gridley Notch1 is essential for postimplantation development in mice. Genes & Dev., March 15, 1994; 8(6): 707 - 719. [Abstract] [PDF]
|
|
|
|
|
|
I. Moskowitz, S. Gendreau, and J. Rothman Combinatorial specification of blastomere identity by glp-1-dependent cellular interactions in the nematode Caenorhabditis elegans Development, January 11, 1994; 120(11): 3325 - 3338. [Abstract] [PDF]
|
|
|
|
|
|
S. Crittenden, E. Troemel, T. Evans, and J Kimble GLP-1 is localized to the mitotic region of the C. elegans germ line Development, January 10, 1994; 120(10): 2901 - 2911. [Abstract] [PDF]
|
|
|
|
|
|
S. Henderson, D Gao, E. Lambie, and J Kimble lag-2 may encode a signaling ligand for the GLP-1 and LIN-12 receptors of C. elegans Development, January 10, 1994; 120(10): 2913 - 2924. [Abstract] [PDF]
|
|
|
|
|
|
S. Mango, C. Thorpe, P. Martin, S. Chamberlain, and B Bowerman Two maternal genes, apx-1 and pie-1, are required to distinguish the fates of equivalent blastomeres in the early Caenorhabditis elegans embryo Development, January 8, 1994; 120(8): 2305 - 2315. [Abstract] [PDF]
|
|
|
|
|
|
H Hutter and R Schnabel glp-1 and inductions establishing embryonic axes in C. elegans Development, January 7, 1994; 120(7): 2051 - 2064. [Abstract] [PDF]
|
|
|
|
|
|
J Austin and C Kenyon Cell contact regulates neuroblast formation in the Caenorhabditis elegans lateral epidermis Development, January 2, 1994; 120(2): 313 - 323. [Abstract] [PDF]
|
|
|
|
|
|
K. Fitzgerald, H. A. Wilkinson, and I. Greenwald glp-1 can substitute for lin-12 in specifying cell fate decisions in Caenorhabditis elegans Development, December 1, 1993; 119(4): 1019 - 1027. [Abstract] [PDF]
|
|
|
|
|
|
G. Weinmaster, V. J. Roberts, and G. Lemke Notch2: a second mammalian Notch gene Development, December 1, 1992; 116(4): 931 - 941. [Abstract] [PDF]
|
|
|
|
|
|
B. Bowerman, F. E. Tax, J. H. Thomas, and J. R. Priess Cell interactions involved in development of the bilaterally symmetrical intestinal valve cells during embryogenesis in Caenorhabditis elegans Development, December 1, 1992; 116(4): 1113 - 1122. [Abstract] [PDF]
|
|
|
|
|
|
C. Goutte, M. Tsunozaki, V. A. Hale, and J. R. Priess APH-1 is a multipass membrane protein essential for the Notch signaling pathway in Caenorhabditis elegans embryos PNAS, January 22, 2002; 99(2): 775 - 779. |
