|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 112, Issue 4 945-958, Copyright © 1991 by Company of Biologists
JOURNAL ARTICLES |
A Ruiz i Altaba and TM Jessell
Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032.
Neural cell markers have been used to examine the effect of retinoic acid (RA) on the development of the central nervous system (CNS) of Xenopus embryos. RA treatment of neurula stage embryos resulted in a concentration-dependent perturbation of anterior CNS development leading to a reduction in the size of the forebrain, midbrain and hindbrain. In addition the overt segmental organization of the hindbrain was abolished by high concentrations of RA. The regional expression of two cell-specific markers, the homeobox protein Xhox3 and the neurotransmitter serotonin was also examined in embryos exposed to RA. Treatment with RA caused a concentration-dependent change in the pattern of expression of Xhox3 and serotonin and resulted in the ectopic appearance of immunoreactive neurons in anterior regions of the CNS, including the forebrain. Collectively, our results extend previous studies by showing that RA treatment of embryos at the neurula stage inhibits the development of anterior regions of the CNS while promoting the differentiation of more posterior cell types. The relevance of these findings to the possible role of endogenous retinoids in the determination of neural cell fate and axial patterning is discussed.
This article has been cited by other articles:
|
|
 |
|
  G. S. Daftary and H. S. Taylor Endocrine Regulation of HOX Genes Endocr. Rev., June 1, 2006; 27(4): 331 - 355. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Nguyen, A. L. Chokas, B. Stecca, and A. R. i Altaba Cooperative requirement of the Gli proteins in neurogenesis Development, July 15, 2005; 132(14): 3267 - 3279. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Aamar and D. Frank Xenopus Meis3 protein forms a hindbrain-inducing center by activating FGF/MAP kinase and PCP pathways Development, January 1, 2004; 131(1): 153 - 163. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Halilagic, M. H. Zile, and M. Studer A novel role for retinoids in patterning the avian forebrain during presomite stages Development, May 15, 2003; 130(10): 2039 - 2050. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Dibner, S. Elias, and D. Frank XMeis3 protein activity is required for proper hindbrain patterning in Xenopus laevis embryos Development, September 15, 2001; 128(18): 3415 - 3426. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O Kazanskaya, A Glinka, and C Niehrs The role of Xenopus dickkopf1 in prechordal plate specification and neural patterning Development, January 11, 2000; 127(22): 4981 - 4992. [Abstract] [PDF]
|
|
|
|
|
|
A. Foley, I Skromne, and C. Stern Reconciling different models of forebrain induction and patterning: a dual role for the hypoblast Development, January 9, 2000; 127(17): 3839 - 3854. [Abstract] [PDF]
|
|
|
|
 |
|
 C. J. Forehand, E. B. Ezerman, J. P. Goldblatt, D. L. Skidmore, and J. C. Glover Segment-specific pattern of sympathetic preganglionic projections in the chicken embryo spinal cord is altered by retinoids PNAS, September 1, 1998; 95(18): 10878 - 10883. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. B. Goodman Three independent lines of evidence suggest retinoids as causal to schizophrenia PNAS, June 23, 1998; 95(13): 7240 - 7244. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J van der Wees, J. Schilthuis, C. Koster, H Diesveld-Schipper, G. Folkers, P. van der Saag, M. Dawson, K Shudo, B van der Burg, and A. Durston Inhibition of retinoic acid receptor-mediated signalling alters positional identity in the developing hindbrain Development, January 2, 1998; 125(3): 545 - 556. [Abstract] [PDF]
|
|
|
|
|
|
M. Taira, J.-P. Saint-Jeannet, and I. B. Dawid Role of the Xlim-1 and Xbra genes in anteroposterior patterning of neural tissue by the head and trunk organizer PNAS, February 4, 1997; 94(3): 895 - 900. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J Lee, K. Platt, P Censullo, and A Ruiz i Altaba Gli1 is a target of Sonic hedgehog that induces ventral neural tube development Development, January 7, 1997; 124(13): 2537 - 2552. [Abstract] [PDF]
|
|
|
|
|
|
A Grapin-Botton, M. Bonnin, and N. Le Douarin Hox gene induction in the neural tube depends on three parameters: competence, signal supply and paralogue group Development, January 2, 1997; 124(4): 849 - 859. [Abstract] [PDF]
|
|
|
|
|
|
C. Sharpe and K Goldstone Retinoid receptors promote primary neurogenesis in Xenopus Development, January 1, 1997; 124(2): 515 - 523. [Abstract] [PDF]
|
|
|
|
|
|
N Papalopulu and C Kintner A posteriorising factor, retinoic acid, reveals that anteroposterior patterning controls the timing of neuronal differentiation in Xenopus neuroectoderm Development, January 11, 1996; 122(11): 3409 - 3418. [Abstract] [PDF]
|
|
|
|
|
|
M Kengaku and H Okamoto bFGF as a possible morphogen for the anteroposterior axis of the central nervous system in Xenopus Development, January 9, 1995; 121(9): 3121 - 3130. [Abstract] [PDF]
|
|
|
|
|
|
T Yamada Caudalization by the amphibian organizer: brachyury, convergent extension and retinoic acid Development, January 11, 1994; 120(11): 3051 - 3062. [Abstract] [PDF]
|
|
|
|
|
|
M. Kelley, J. Turner, and T. Reh Retinoic acid promotes differentiation of photoreceptors in vitro Development, January 8, 1994; 120(8): 2091 - 2102. [Abstract] [PDF]
|
|
|
|
|
|
J. Green, J. Smith, and J. Gerhart Slow emergence of a multithreshold response to activin requires cell-contact-dependent sharpening but not prepattern Development, January 8, 1994; 120(8): 2271 - 2278. [Abstract] [PDF]
|
|
|
|
|
|
M Taira, H Otani, M Jamrich, and I. Dawid Expression of the LIM class homeobox gene Xlim-1 in pronephros and CNS cell lineages of Xenopus embryos is affected by retinoic acid and exogastrulation Development, January 6, 1994; 120(6): 1525 - 1536. [Abstract] [PDF]
|
|
|
|
|
|
E Noll and R. Miller Regulation of oligodendrocyte differentiation: a role for retinoic acid in the spinal cord Development, January 3, 1994; 120(3): 649 - 660. [Abstract] [PDF]
|
|
|
|
|
|
M. W. Kelley, X. M. Xu, M. A. Wagner, M. E. Warchol, and J. T. Corwin The developing organ of Corti contains retinoic acid and forms supernumerary hair cells in response to exogenous retinoic acid in culture Development, December 1, 1993; 119(4): 1041 - 1053. [Abstract] [PDF]
|
|
|
|
|
|
T. Schuh, B. Hall, J. Kraft, M. Privalsky, and D Kimelman v-erbA and citral reduce the teratogenic effects of all-trans retinoic acid and retinol, respectively, in Xenopus embryogenesis Development, January 11, 1993; 119(3): 785 - 798. [Abstract] [PDF]
|
|
|
|
 |
|
 M Taira, M Jamrich, P J Good, and I B Dawid The LIM domain-containing homeo box gene Xlim-1 is expressed specifically in the organizer region of Xenopus gastrula embryos. Genes & Dev., March 1, 1992; 6(3): 356 - 366. [Abstract] [PDF]
|
|
|
|
|
|
M Wagner, B Han, and T. Jessell Regional differences in retinoid release from embryonic neural tissue detected by an in vitro reporter assay Development, January 9, 1992; 116(1): 55 - 66. [Abstract] [PDF]
|
|
|
|
|
|
A Ruiz i Altaba Planar and vertical signals in the induction and patterning of the Xenopus nervous system Development, January 9, 1992; 116(1): 67 - 80. [Abstract] [PDF]
|
|
|
|
|
|
A Ruiz i Altaba and T. Jessell Pintallavis, a gene expressed in the organizer and midline cells of frog embryos: involvement in the development of the neural axis Development, January 9, 1992; 116(1): 81 - 93. [Abstract] [PDF]
|
|
|
|
|
|
C. Chuong, S. Ting, R. Widelitz, and Y. Lee Mechanism of skin morphogenesis. II. Retinoic acid modulates axis orientation and phenotypes of skin appendages Development, January 7, 1992; 115(3): 839 - 852. [Abstract] [PDF]
|
|
