|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 113, Issue 2 515-526, Copyright © 1991 by Company of Biologists
JOURNAL ARTICLES |
SE Baird, DH Fitch, IA Kassem and SW Emmons
Department of Molecular Genetics, Albert Einstein College of Medicine, Bronx, NY 10461.
The developmental process that determines the arrangement of ray sensilla in the Caenorhabditis elegans male tail has been studied. It is shown that the adult arrangement of rays is determined by the placement of ray cells at specific sites in the epidermis of the last larval (L4) stage. Placement of ray cells at specific epidermal sites results from the generation of neurons and support cells in the epidermis near to their final positions, and the subsequent refinement of these positions by an active mechanism involving specific cellular associations. Positions of ray cells and adjacent epidermal cells have been studied during ray development by means of indirect immunofluorescence staining with an antibody to a cell junctional antigen. Mutations are described in six genes that alter the adult arrangement of the rays, frequently resulting in fusion of rays. Changes in the adult pattern of rays in mutants appear to result from prior changes in the epidermal positions of ray cells, and for two mutants it is suggested that this may be due to the inappropriate clustering of processes from neurons and support cells of adjacent rays. Development of the wild-type arrangement of rays appears to require the specification of molecular differences between the rays that affect the specificity of their cellular associations.
This article has been cited by other articles:
|
|
 |
|
  A. D. Chisholm Semaphorin signaling in morphogenesis: found in translation Genes & Dev., April 15, 2008; 22(8): 955 - 959. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Nukazuka, H. Fujisawa, T. Inada, Y. Oda, and S. Takagi Semaphorin controls epidermal morphogenesis by stimulating mRNA translation via eIF2{alpha} in Caenorhabditis elegans Genes & Dev., April 15, 2008; 22(8): 1025 - 1036. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Nakao, M. L. Hudson, M. Suzuki, Z. Peckler, R. Kurokawa, Z. Liu, K. Gengyo-Ando, A. Nukazuka, T. Fujii, F. Suto, et al. The Plexin PLX-2 and the Ephrin EFN-4 Have Distinct Roles in MAB-20/Semaphorin 2A Signaling in Caenorhabditis elegans Morphogenesis Genetics, July 1, 2007; 176(3): 1591 - 1607. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Gattegno, A. Mittal, C. Valansi, K. C.Q. Nguyen, D. H. Hall, L. V. Chernomordik, and B. Podbilewicz Genetic Control of Fusion Pore Expansion in the Epidermis of Caenorhabditis elegans Mol. Biol. Cell, April 1, 2007; 18(4): 1153 - 1166. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Jia and S. W. Emmons Genes That Control Ray Sensory Neuron Axon Development in the Caenorhabditis elegans Male Genetics, July 1, 2006; 173(3): 1241 - 1258. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Dalpe, L. W. Zhang, H. Zheng, and J. G. Culotti Conversion of cell movement responses to Semaphorin-1 and Plexin-1 from attraction to repulsion by lowered levels of specific RAC GTPases in C. elegans Development, May 1, 2004; 131(9): 2073 - 2088. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. P. Gupta, M. Wang, and P. W. Sternberg The C. elegans LIM homeobox gene lin-11 specifies multiple cell fates during vulval development Development, June 15, 2003; 130(12): 2589 - 2601. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Yamada, Y. Mizutani-Koseki, T. Hasegawa, N. Osumi, H. Koseki, and N. Takahashi Cell-autonomous involvement of Mab21l1 is essential for lens placode development Development, May 1, 2003; 130(9): 1759 - 1770. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. C. P. Eschenlauer and A. P. Page The Caenorhabditis elegans ERp60 Homolog Protein Disulfide Isomerase-3 Has Disulfide Isomerase and Transglutaminase-like Cross-linking Activity and Is Involved in the Maintenance of Body Morphology J. Biol. Chem., January 31, 2003; 278(6): 4227 - 4237. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Kuno, C. Baba, A. Asaka, C. Matsushima, K. Matsushima, and R. Hosono The Caenorhabditis elegans ADAMTS Family Gene adt-1 Is Necessary for Morphogenesis of the Male Copulatory Organs J. Biol. Chem., March 29, 2002; 277(14): 12228 - 12236. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. D. Chin-Sang, S. L. Moseley, M. Ding, R. J. Harrington, S. E. George, and A. D. Chisholm The divergent C. elegans ephrin EFN-4 functions inembryonic morphogenesis in a pathway independent of the VAB-1 Eph receptor Development, January 12, 2002; 129(23): 5499 - 5510. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Fujii, F. Nakao, Y. Shibata, G. Shioi, E. Kodama, H. Fujisawa, and S. Takagi Caenorhabditis elegans PlexinA, PLX-1, interacts with transmembrane semaphorins and regulates epidermal morphogenesis Development, January 5, 2002; 129(9): 2053 - 2063. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. E. Ginzburg, P. J. Roy, and J. G. Culotti Semaphorin 1a and semaphorin 1b are required for correct epidermal cell positioning and adhesion during morphogenesis in C. elegans Development, January 5, 2002; 129(9): 2065 - 2078. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. I. Rugarli, E. Di Schiavi, M. A. Hilliard, S. Arbucci, C. Ghezzi, A. Facciolli, G. Coppola, A. Ballabio, and P. Bazzicalupo The Kallmann syndrome gene homolog in C. elegans is involved in epidermal morphogenesis and neurite branching Development, January 3, 2002; 129(5): 1283 - 1294. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H Zhang and S. Emmons The novel C. elegans gene sop-3 modulates Wnt signaling to regulate Hox gene expression Development, January 3, 2001; 128(5): 767 - 777. [Abstract] [PDF]
|
|
|
|
|
|
P. Roy, H Zheng, C. Warren, and J. Culotti mab-20 encodes Semaphorin-2a and is required to prevent ectopic cell contacts during epidermal morphogenesis in Caenorhabditis elegans Development, January 2, 2000; 127(4): 755 - 767. [Abstract] [PDF]
|
|
|
|
|
|
H. Fares and I. Greenwald SEL-5, A Serine/Threonine Kinase That Facilitates lin-12 Activity in Caenorhabditis elegans Genetics, December 1, 1999; 153(4): 1641 - 1654. [Abstract] [Full Text]
|
|
|
|
|
|
R Lints and S. Emmons Patterning of dopaminergic neurotransmitter identity among Caenorhabditis elegans ray sensory neurons by a TGFbeta family signaling pathway and a Hox gene Development, January 12, 1999; 126(24): 5819 - 5831. [Abstract] [PDF]
|
|
|
|
|
|
K Morita, K. Chow, and N Ueno Regulation of body length and male tail ray pattern formation of Caenorhabditis elegans by a member of TGF-beta family Development, January 3, 1999; 126(6): 1337 - 1347. [Abstract] [PDF]
|
|
|
|
|
|
R Sharma-Kishore, J. White, E Southgate, and B Podbilewicz Formation of the vulva in Caenorhabditis elegans: a paradigm for organogenesis Development, January 2, 1999; 126(4): 691 - 699. [Abstract] [PDF]
|
|
|
|
|
|
S Krishna, L. Maduzia, and R. Padgett Specificity of TGFbeta signaling is conferred by distinct type I receptors and their associated SMAD proteins in Caenorhabditis elegans Development, January 1, 1999; 126(2): 251 - 260. [Abstract] [PDF]
|
|
|
|
|
|
S. Salser and C Kenyon A C. elegans Hox gene switches on, off, on and off again to regulate proliferation, differentiation and morphogenesis Development, January 5, 1996; 122(5): 1651 - 1661. [Abstract] [PDF]
|
|
|
|
|
|
K. Chow, D. Hall, and S. Emmons The mab-21 gene of Caenorhabditis elegans encodes a novel protein required for choice of alternate cell fates Development, January 11, 1995; 121(11): 3615 - 3626. [Abstract] [PDF]
|
|
|
|
|
|
K. L. Chow and S. W. Emmons HOM-C/Hox genes and four interacting loci determine the morphogenetic properties of single cells in the nematode male tail Development, September 1, 1994; 120(9): 2579 - 2592. [Abstract] [PDF]
|
|
