The origin of reactive oxygen species in mouse embryos cultured in vitro

QUICK SEARCH:

[advanced]

	Author:		Keyword(s):

Home Help Feedback Subscriptions Archive Search Table of Contents

This Article

	Full Text (PDF)
	Alert me when this article is cited
	Alert me if a correction is posted

Services

	Email this article to a friend
	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new issues of the journal
	Download to citation manager


Citing Articles

	Citing Articles via HighWire
	Citing Articles via Google Scholar

Google Scholar

	Articles by Nasr-Esfahani, M. M.
	Articles by Johnson, M. H.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by Nasr-Esfahani, M. M.
	Articles by Johnson, M. H.


Social Bookmarking

	What's this?

JOURNAL ARTICLES

The origin of reactive oxygen species in mouse embryos cultured in vitro

MM Nasr-Esfahani and MH Johnson
Department of Obstetrics and Gynaecology, St Thomas's Hospital, London, UK.

The increase in production of reactive oxygen species such as H2O2 at the G2/M phase of the second cell cycle may be related to the in vitro block to development of mouse 2-cell embryos. The occurrence of the H2O2 rise is independent of the activation of the embryonic genome and of passage through the S, G2 and M phases of the first cell cycle and G1 and M phases of the second cell cycle, but does require the activation of the unfertilized oocyte. The H2O2 is produced via dismutation of superoxide by the enzyme superoxide dismutase. Production of superoxide via mitochondrial, NADPH-oxidase and xanthine/xanthine oxidase systems has been investigated. The evidence suggests that superoxide, and thereby H2O2, is produced by the xanthine/xanthine oxidase system, but an involvement of the other superoxide generating systems has not been excluded. The relation between H2O2 and development in vitro is discussed.
Add to CiteULike CiteULike Add to Complore Complore Add to Connotea Connotea Add to Del.icio.us Del.icio.us Add to Digg Digg Add to Reddit Reddit Add to Technorati Technorati Twitter What's this?

This article has been cited by other articles:

P. Y. Chin, A. M. Macpherson, J. G. Thompson, M. Lane, and S. A. Robertson
Stress response genes are suppressed in mouse preimplantation embryos by granulocyte-macrophage colony-stimulating factor (GM-CSF)
Hum. Reprod., December 1, 2009; 24(12): 2997 - 3009.
[Abstract] [Full Text] [PDF]

X.L. Jin, V. Chandrakanthan, H.D. Morgan, and C. O'Neill
Preimplantation Embryo Development in the Mouse Requires the Latency of TRP53 Expression, Which Is Induced by a Ligand-Activated PI3 Kinase/AKT/MDM2-Mediated Signaling Pathway (Reprinted with Correction)
Biol Reprod, July 1, 2009; 81(1): 233 - 242.
[Abstract] [Full Text] [PDF]

X.L. Jin, V. Chandrakanthan, H.D. Morgan, and C. O'Neill
Preimplantation Embryo Development in the Mouse Requires the Latency of TRP53 Expression, Which Is Induced by a Ligand-Activated PI3 Kinase/AKT/MDM2-Mediated Signaling Pathway
Biol Reprod, February 1, 2009; 80(2): 286 - 294.
[Abstract] [Full Text] [PDF]

C. O'Neill
The potential roles for embryotrophic ligands in preimplantation embryo development
Hum. Reprod. Update, May 1, 2008; 14(3): 275 - 288.
[Abstract] [Full Text] [PDF]

N. Sakamoto, M. Ozawa, K. Yokotani-Tomita, A. Morimoto, T. Matsuzuka, D. Ijiri, M. Hirabayashi, A. Ushitani, and Y. Kanai
DL-{alpha}-Tocopherol acetate mitigates maternal hyperthermia-induced pre-implantation embryonic death accompanied by a reduction of physiological oxidative stress in mice
Reproduction, April 1, 2008; 135(4): 489 - 496.
[Abstract] [Full Text] [PDF]

A. Li, V. Chandrakanthan, O. Chami, and C. O'Neill
Culture of Zygotes Increases p53 Expression in B6 Mouse Embryos, which Reduces Embryo Viability
Biol Reprod, March 1, 2007; 76(3): 362 - 367.
[Abstract] [Full Text] [PDF]

C. LaRosa and S. M. Downs
Stress Stimulates AMP-Activated Protein Kinase and Meiotic Resumption in Mouse Oocytes
Biol Reprod, March 1, 2006; 74(3): 585 - 592.
[Abstract] [Full Text] [PDF]

M. Ozawa, T. Matsuzuka, M. Hirabayashi, and Y. Kanai
Redox Status of the Oviduct and Cdc2 Activity in 2-Cell Stage Embryos in Heat-Stressed Mice
Biol Reprod, July 1, 2004; 71(1): 291 - 296.
[Abstract] [Full Text] [PDF]

A.S. Lequarre, J. Marchandise, B. Moreau, A. Massip, and I. Donnay
Cell Cycle Duration at the Time of Maternal Zygotic Transition for In Vitro Produced Bovine Embryos: Effect of Oxygen Tension and Transcription Inhibition
Biol Reprod, November 1, 2003; 69(5): 1707 - 1713.
[Abstract] [Full Text] [PDF]

Y. Hu, I. Betzendahl, R. Cortvrindt, J. Smitz, and U. Eichenlaub-Ritter
Effects of low O2 and ageing on spindles and chromosomes in mouse oocytes from pre-antral follicle culture
Hum. Reprod., April 1, 2001; 16(4): 737 - 748.
[Abstract] [Full Text] [PDF]

S. El Mouatassim, P. Guerin, and Y. Menezo
Expression of genes encoding antioxidant enzymes in human and mouse oocytes during the final stages of maturation
Mol. Hum. Reprod., August 1, 1999; 5(8): 720 - 725.
[Abstract] [Full Text] [PDF]

M. Vernet, C. Cavard, A. Zider, P. Fergelot, G. Grimber, and P. Briand
In vitro manipulation of early mouse embryos induces HIV1-LTRlacZ transgene expression
Development, December 1, 1993; 119(4): 1293 - 1300.
[Abstract] [PDF]

				X.L. Jin, V. Chandrakanthan, H.D. Morgan, and C. O'Neill Preimplantation Embryo Development in the Mouse Requires the Latency of TRP53 Expression, Which Is Induced by a Ligand-Activated PI3 Kinase/AKT/MDM2-Mediated Signaling Pathway (Reprinted with Correction) Biol Reprod, July 1, 2009; 81(1): 233 - 242. [Abstract] [Full Text] [PDF]

				C. O'Neill The potential roles for embryotrophic ligands in preimplantation embryo development Hum. Reprod. Update, May 1, 2008; 14(3): 275 - 288. [Abstract] [Full Text] [PDF]

				N. Sakamoto, M. Ozawa, K. Yokotani-Tomita, A. Morimoto, T. Matsuzuka, D. Ijiri, M. Hirabayashi, A. Ushitani, and Y. Kanai DL-{alpha}-Tocopherol acetate mitigates maternal hyperthermia-induced pre-implantation embryonic death accompanied by a reduction of physiological oxidative stress in mice Reproduction, April 1, 2008; 135(4): 489 - 496. [Abstract] [Full Text] [PDF]

				A. Li, V. Chandrakanthan, O. Chami, and C. O'Neill Culture of Zygotes Increases p53 Expression in B6 Mouse Embryos, which Reduces Embryo Viability Biol Reprod, March 1, 2007; 76(3): 362 - 367. [Abstract] [Full Text] [PDF]

				C. LaRosa and S. M. Downs Stress Stimulates AMP-Activated Protein Kinase and Meiotic Resumption in Mouse Oocytes Biol Reprod, March 1, 2006; 74(3): 585 - 592. [Abstract] [Full Text] [PDF]

				M. Ozawa, T. Matsuzuka, M. Hirabayashi, and Y. Kanai Redox Status of the Oviduct and Cdc2 Activity in 2-Cell Stage Embryos in Heat-Stressed Mice Biol Reprod, July 1, 2004; 71(1): 291 - 296. [Abstract] [Full Text] [PDF]

				A.S. Lequarre, J. Marchandise, B. Moreau, A. Massip, and I. Donnay Cell Cycle Duration at the Time of Maternal Zygotic Transition for In Vitro Produced Bovine Embryos: Effect of Oxygen Tension and Transcription Inhibition Biol Reprod, November 1, 2003; 69(5): 1707 - 1713. [Abstract] [Full Text] [PDF]

				Y. Hu, I. Betzendahl, R. Cortvrindt, J. Smitz, and U. Eichenlaub-Ritter Effects of low O2 and ageing on spindles and chromosomes in mouse oocytes from pre-antral follicle culture Hum. Reprod., April 1, 2001; 16(4): 737 - 748. [Abstract] [Full Text] [PDF]

				S. El Mouatassim, P. Guerin, and Y. Menezo Expression of genes encoding antioxidant enzymes in human and mouse oocytes during the final stages of maturation Mol. Hum. Reprod., August 1, 1999; 5(8): 720 - 725. [Abstract] [Full Text] [PDF]

				M. Vernet, C. Cavard, A. Zider, P. Fergelot, G. Grimber, and P. Briand In vitro manipulation of early mouse embryos induces HIV1-LTRlacZ transgene expression Development, December 1, 1993; 119(4): 1293 - 1300. [Abstract] [PDF]