|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 113, Issue 3 723-734, Copyright © 1991 by Company of Biologists
JOURNAL ARTICLES |
C Mendelsohn, E Ruberte, M LeMeur, G Morriss-Kay and P Chambon
Laboratoire de Genetique Moleculaire des Eucaryotes du CNRS, Institut de Chimie Biologique, Faculte de Medecine, Strasbourg, France.
Retinoic acid (RA) is a signalling molecule important for pattern formation during development. There are three known types of nuclear receptors for RA in mammals, RAR-alpha, RAR-beta and RAR-gamma, which transduce the RA signal by inducing or repressing the transcription of target genes. Here we describe the developmental expression pattern of the mouse RAR-beta 2 promoter. Independent lines of transgenic animals expressing RAR-beta 2 promoter sequences fused to the E. coli beta-galactosidase gene were examined throughout the course of embryogenesis and found to exhibit reproducible and specific patterns of beta-galactosidase expression in a majority of sites that have been shown previously to contain mRAR-beta transcripts. In the limbs, mRAR-beta 2 promoter activity and mRAR-beta transcripts were both excluded from precartilagenous condensations; interestingly, mRAR-beta 2 promoter activity was observed in the apical ectodermal ridge (AER) where mRAR-beta transcripts could not be detected, while no mRAR-beta 2 promoter activity or mRAR-beta transcripts were associated with the limb region that contains the zone of polarizing activity (ZPA). Analysis of the lacZ expression pattern in embryos from mothers treated with teratogenic doses of RA, indicated that mRAR-beta 2 promoter is selectively induced in a manner suggesting that overexpression of the mRAR-beta 2 isoform is involved in RA-generated malformations. The normal and induced expression pattern of the mRAR-beta 2 promoter suggests several possible roles for mRAR-beta 2 in development of the limbs, as an inhibitor of cartilage formation, in programmed cell death and in the formation of loose connective tissue.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati 
Twitter What's this?
This article has been cited by other articles:
|
|
 |
|
  I. Strate, T. H. Min, D. Iliev, and E. M. Pera Retinol dehydrogenase 10 is a feedback regulator of retinoic acid signalling during axis formation and patterning of the central nervous system Development, February 1, 2009; 136(3): 461 - 472. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y.-K. Kim, L. Wassef, L. Hamberger, R. Piantedosi, K. Palczewski, W. S. Blaner, and L. Quadro Retinyl Ester Formation by Lecithin:Retinol Acyltransferase Is a Key Regulator of Retinoid Homeostasis in Mouse Embryogenesis J. Biol. Chem., February 29, 2008; 283(9): 5611 - 5621. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. S. Daftary and H. S. Taylor Endocrine Regulation of HOX Genes Endocr. Rev., June 1, 2006; 27(4): 331 - 355. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Quadro, L. Hamberger, M. E. Gottesman, F. Wang, V. Colantuoni, W. S. Blaner, and C. L. Mendelsohn Pathways of Vitamin A Delivery to the Embryo: Insights from a New Tunable Model of Embryonic Vitamin A Deficiency Endocrinology, October 1, 2005; 146(10): 4479 - 4490. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 O. Strauss The Retinal Pigment Epithelium in Visual Function Physiol Rev, July 1, 2005; 85(3): 845 - 881. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Kobayashi, K.-M. Kwan, T. J. Carroll, A. P. McMahon, C. L. Mendelsohn, and R. R. Behringer Distinct and sequential tissue-specific activities of the LIM-class homeobox gene Lim1 for tubular morphogenesis during kidney development Development, June 15, 2005; 132(12): 2809 - 2823. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Serpente, S. Tumpel, N. B. Ghyselinck, K. Niederreither, L. M. Wiedemann, P. Dolle, P. Chambon, R. Krumlauf, and A. P. Gould Direct crossregulation between retinoic acid receptor {beta} and Hox genes during hindbrain segmentation Development, February 1, 2005; 132(3): 503 - 513. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Taimi, C. Helvig, J. Wisniewski, H. Ramshaw, J. White, M.'a. Amad, B. Korczak, and M. Petkovich A Novel Human Cytochrome P450, CYP26C1, Involved in Metabolism of 9-cis and All-trans Isomers of Retinoic Acid J. Biol. Chem., January 2, 2004; 279(1): 77 - 85. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Matt, N. B. Ghyselinck, O. Wendling, P. Chambon, and M. Mark Retinoic acid-induced developmental defects are mediated by RAR{beta}/RXR heterodimers in the pharyngeal endoderm Development, May 15, 2003; 130(10): 2083 - 2093. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. M. Hoffman, A. D. Weston, and T. M. Underhill Molecular Mechanisms Regulating Chondroblast Differentiation J. Bone Joint Surg. Am., April 28, 2003; 85(90002): 124 - 132. [Abstract] [Full Text]
|
|
|
|
|
|
E. Remboutsika, K. Yamamoto, M. Harbers, and M. Schmutz The Bromodomain Mediates Transcriptional Intermediary Factor 1alpha -Nucleosome Interactions J. Biol. Chem., December 20, 2002; 277(52): 50318 - 50325. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. D. Weston, R. A.S. Chandraratna, J. Torchia, and T. M. Underhill Requirement for RAR-mediated gene repression in skeletal progenitor differentiation J. Cell Biol., July 8, 2002; 158(1): 39 - 51. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Dong and D. J. Tweardy Interactions of STAT5b-RARalpha , a novel acute promyelocytic leukemia fusion protein, with retinoic acid receptor and STAT3 signaling pathways Blood, April 15, 2002; 99(8): 2637 - 2646. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Begemann, T. F. Schilling, G.-J. Rauch, R. Geisler, and P. W. Ingham The zebrafish neckless mutation reveals a requirement for raldh2 in mesodermal signals that pattern the hindbrain Development, August 15, 2001; 128(16): 3081 - 3094. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Dupe and A. Lumsden Hindbrain patterning involves graded responses to retinoic acid signalling Development, June 15, 2001; 128(12): 2199 - 2208. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Abu-Abed, P. Dollé, D. Metzger, B. Beckett, P. Chambon, and M. Petkovich The retinoic acid-metabolizing enzyme, CYP26A1, is essential for normal hindbrain patterning, vertebral identity, and development of posterior structures Genes & Dev., January 15, 2001; 15(2): 226 - 240. [Abstract] [Full Text]
|
|
|
|
 |
|
 M. Kobayashi, R. T. Yu, K. Yasuda, and K. Umesono Cell-Type-Specific Regulation of the Retinoic Acid Receptor Mediated by the Orphan Nuclear Receptor TLX Mol. Cell. Biol., December 1, 2000; 20(23): 8731 - 8739. [Abstract] [Full Text]
|
|
|
|
|
|
R. L. Redner, J. D. Chen, E. A. Rush, H. Li, and S. L. Pollock The t(5;17) acute promyelocytic leukemia fusion protein NPM-RAR interacts with co-repressor and co-activator proteins and exhibits both positive and negative transcriptional properties Blood, April 15, 2000; 95(8): 2683 - 2690. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L.-N. Wei, X. Hu, and C. Chinpaisal Constitutive Activation of Retinoic Acid Receptor beta 2 Promoter by Orphan Nuclear Receptor TR2 J. Biol. Chem., April 14, 2000; 275(16): 11907 - 11914. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. D. Weston, V. Rosen, R. A.S. Chandraratna, and T. M. Underhill Regulation of Skeletal Progenitor Differentiation by the Bmp and Retinoid Signaling Pathways J. Cell Biol., February 21, 2000; 148(4): 679 - 690. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N Mercader, E Leonardo, M. Piedra, C Martinez-A, M. Ros, and M Torres Opposing RA and FGF signals control proximodistal vertebrate limb development through regulation of Meis genes Development, January 9, 2000; 127(18): 3961 - 3970. [Abstract] [PDF]
|
|
|
|
|
|
O Wendling, C Dennefeld, P Chambon, and M Mark Retinoid signaling is essential for patterning the endoderm of the third and fourth pharyngeal arches Development, January 4, 2000; 127(8): 1553 - 1562. [Abstract] [PDF]
|
|
|
|
|
|
A. Moon, A. Boulet, and M. Capecchi Normal limb development in conditional mutants of Fgf4 Development, January 3, 2000; 127(5): 989 - 996. [Abstract] [PDF]
|
|
|
|
 |
|
 A. Mata de Urquiza, L. Solomin, and T. Perlmann Feedback-inducible nuclear-receptor-driven reporter gene expression in transgenic mice PNAS, November 9, 1999; 96(23): 13270 - 13275. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C Chazaud, P Chambon, and P Dolle Retinoic acid is required in the mouse embryo for left-right asymmetry determination and heart morphogenesis Development, January 6, 1999; 126(12): 2589 - 2596. [Abstract] [PDF]
|
|
|
|
 |
|
 F. S. Buckner, A. J. Wilson, and W. C. Van Voorhis Detection of Live Trypanosoma cruzi in Tissues of Infected Mice by Using Histochemical Stain for beta -Galactosidase Infect. Immun., January 1, 1999; 67(1): 403 - 409. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. E. Folkers, B. van der Burg, and P. T. van der Saag Promoter Architecture, Cofactors, and Orphan Receptors Contribute to Cell-specific Activation of the Retinoic Acid Receptor beta 2 Promoter J. Biol. Chem., November 27, 1998; 273(48): 32200 - 32212. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Ferrari, M. Pfahl, and G. Levi Retinoic Acid Receptor gamma 1 (RARgamma 1) Levels Control RARbeta 2 Expression in SK-N-BE2(c) Neuroblastoma Cells and Regulate a Differentiation-Apoptosis Switch Mol. Cell. Biol., November 1, 1998; 18(11): 6482 - 6492. [Abstract] [Full Text]
|
|
|
|
|
|
N. Moghal and B. G. Neel Integration of Growth Factor, Extracellular Matrix, and Retinoid Signals during Bronchial Epithelial Cell Differentiation Mol. Cell. Biol., November 1, 1998; 18(11): 6666 - 6678. [Abstract] [Full Text]
|
|
|
|
|
|
B Mascrez, M Mark, A Dierich, N. Ghyselinck, P Kastner, and P Chambon The RXRalpha ligand-dependent activation function 2 (AF-2) is important for mouse development Development, January 12, 1998; 125(23): 4691 - 4707. [Abstract] [PDF]
|
|
|
|
|
|
T. Manshouri, Y. Yang, H. Lin, S. A. Stass, A. B. Glassman, M. J. Keating, and M. Albitar Downregulation of RARalpha in Mice by Antisense Transgene Leads to a Compensatory Increase in RARbeta and RARgamma and Development of Lymphoma Blood, April 1, 1997; 89(7): 2507 - 2515. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. E. Cash, C. B. Bock, K. Schughart, E. Linney, and T. M. Underhill Retinoic Acid Receptor {alpha} Function in Vertebrate Limb Skeletogenesis: a Modulator of Chondrogenesis J. Cell Biol., January 27, 1997; 136(2): 445 - 457. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A Morrison, M. Moroni, L Ariza-McNaughton, R Krumlauf, and F Mavilio In vitro and transgenic analysis of a human HOXD4 retinoid-responsive enhancer Development, January 6, 1996; 122(6): 1895 - 1907. [Abstract] [PDF]
|
|
|
|
|
|
J. Helms, C. Kim, G Eichele, and C Thaller Retinoic acid signaling is required during early chick limb development Development, January 5, 1996; 122(5): 1385 - 1394. [Abstract] [PDF]
|
|
|
|
|
|
H. Sucov, J. Izpisua-Belmonte, Y Ganan, and R. Evans Mouse embryos lacking RXR alpha are resistant to retinoic-acid-induced limb defects Development, January 12, 1995; 121(12): 3997 - 4003. [Abstract] [PDF]
|
|
|
|
 |
|
 C. Fisher, M. Blumenberg, and M. Tomic-Canic Retinoid Receptors and Keratinocytes Critical Reviews in Oral Biology & Medicine, January 1, 1995; 6(4): 284 - 301. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Carroll, S. Tsirka, W. Richards, M. Frohman, and S Strickland The mouse tissue plasminogen activator gene 5' flanking region directs appropriate expression in development and a seizure-enhanced response in the CNS Development, January 11, 1994; 120(11): 3173 - 3183. [Abstract] [PDF]
|
|
|
|
|
|
D Lohnes, M Mark, C Mendelsohn, P Dolle, A Dierich, P Gorry, A Gansmuller, and P Chambon Function of the retinoic acid receptors (RARs) during development (I). Craniofacial and skeletal abnormalities in RAR double mutants Development, January 10, 1994; 120(10): 2723 - 2748. [Abstract] [PDF]
|
|
|
|
|
|
E Noll and R. Miller Regulation of oligodendrocyte differentiation: a role for retinoic acid in the spinal cord Development, January 3, 1994; 120(3): 649 - 660. [Abstract] [PDF]
|
|
|
|
|
|
M. W. Kelley, X. M. Xu, M. A. Wagner, M. E. Warchol, and J. T. Corwin The developing organ of Corti contains retinoic acid and forms supernumerary hair cells in response to exogenous retinoic acid in culture Development, December 1, 1993; 119(4): 1041 - 1053. [Abstract] [PDF]
|
|
|
|
|
|
E Ruberte, V Friederich, P Chambon, and G Morriss-Kay Retinoic acid receptors and cellular retinoid binding proteins. III. Their differential transcript distribution during mouse nervous system development Development, January 5, 1993; 118(1): 267 - 282. [Abstract] [PDF]
|
|
|
|
|
|
A. Gustafson, L Dencker, and U Eriksson Non-overlapping expression of CRBP I and CRABP I during pattern formation of limbs and craniofacial structures in the early mouse embryo Development, January 2, 1993; 117(2): 451 - 460. [Abstract] [PDF]
|
|
|
|
|
|
A. Zimmer and A. Zimmer Induction of a RAR beta 2-lacZ transgene by retinoic acid reflects the neuromeric organization of the central nervous system Development, December 1, 1992; 116(4): 977 - 983. [Abstract] [PDF]
|
|
|
|
|
|
M Wagner, B Han, and T. Jessell Regional differences in retinoid release from embryonic neural tissue detected by an in vitro reporter assay Development, January 9, 1992; 116(1): 55 - 66. [Abstract] [PDF]
|
|
|
|
|
|
J. M. Richman The Role of Retinoids in Normal and Abnormal Embryonic Craniofacial Morphogenesis Critical Reviews in Oral Biology & Medicine, January 1, 1992; 4(1): 93 - 109. [Abstract] [Full Text] [PDF]
|
|
