Development, Vol 113, Issue 4 1093-1104, Copyright © 1991 by Company of Biologists

JOURNAL ARTICLES

The transcription factor TTF-1 is expressed at the onset of thyroid and lung morphogenesis and in restricted regions of the foetal brain

D Lazzaro, M Price, M de Felice and R Di Lauro
European Molecular Biology Laboratory (EMBL), Heidelberg, FRG.

TTF-1, a homeodomain-containing transcription factor, which is required for the specific expression of the thyroglobulin and thyroperoxidase gene promoters in differentiated thyroid cell lines, is expressed at the very beginning of rat thyroid differentiation. TTF-1 mRNA is detected in the endodermal cells of the thyroid rudiment in the rat embryo and precedes the expression of the two known target genes by 5 days. No delay is observed between the appearance of TTF-1 mRNA and protein, which shows a clear nuclear localization. In the adult thyroid, TTF-1 is present only in the endoderm-derived follicular cells. Two additional domains of expression of TTF-1 have been observed, the lung and restricted areas of the brain. In the lung, TTF-1 mRNA and protein are also present at the earliest stages of differentiation and are later confined to the bronchial epithelium. In the brain, TTF-1 appears to be restricted to structures of diencephalic origin, including the developing neurohypophysis. The early detection of TTF-1 in the endodermal cells of the thyroid and lung anlage and in restricted neuroblast populations indicates that TTF-1 may have a role in cell determination in these three systems and that additional mechanisms may be involved in the activation of thyroid-specific gene expression.
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				A. Naltner, S. Wert, J. A. Whitsett, and C. Yan Temporal/spatial expression of nuclear receptor coactivators in the mouse lung Am J Physiol Lung Cell Mol Physiol, December 1, 2000; 279(6): L1066 - L1074. [Abstract] [Full Text] [PDF]

				T. Yano, R. J. Mason, T. Pan, R. R. Deterding, L. D. Nielsen, and J. M. Shannon KGF regulates pulmonary epithelial proliferation and surfactant protein gene expression in adult rat lung Am J Physiol Lung Cell Mol Physiol, December 1, 2000; 279(6): L1146 - L1158. [Abstract] [Full Text] [PDF]

				L. Pellizzari, A. D'Elia, A. Rustighi, G. Manfioletti, G. Tell, and G. Damante Expression and function of the homeodomain-containing protein Hex in thyroid cells Nucleic Acids Res., July 1, 2000; 28(13): 2503 - 2511. [Abstract] [Full Text] [PDF]

				A. De la Vieja, O. Dohan, O. Levy, and N. Carrasco Molecular Analysis of the Sodium/Iodide Symporter: Impact on Thyroid and Extrathyroid Pathophysiology Physiol Rev, July 1, 2000; 80(3): 1083 - 1105. [Abstract] [Full Text] [PDF]

				A. Losada, J. A. Tovar, H. M. Xia, J. A. Diez-Pardo, and P. Santisteban Down-Regulation of Thyroid Transcription Factor-1 Gene Expression in Fetal Lung Hypoplasia Is Restored by Glucocorticoids Endocrinology, June 1, 2000; 141(6): 2166 - 2173. [Abstract] [Full Text] [PDF]

				S. W. Glasser, M. S. Burhans, S. K. Eszterhas, M. D. Bruno, and T. R. Korfhagen Human SP-C gene sequences that confer lung epithelium-specific expression in transgenic mice Am J Physiol Lung Cell Mol Physiol, May 1, 2000; 278(5): L933 - L945. [Abstract] [Full Text] [PDF]

				C. Missero, M. T. Pirro, and R. Di Lauro Multiple Ras Downstream Pathways Mediate Functional Repression of the Homeobox Gene Product TTF-1 Mol. Cell. Biol., April 15, 2000; 20(8): 2783 - 2793. [Abstract] [Full Text]

				M. Tanaka, N. Yamasaki, and S. Izumo Phenotypic Characterization of the Murine Nkx2.6 Homeobox Gene by Gene Targeting Mol. Cell. Biol., April 15, 2000; 20(8): 2874 - 2879. [Abstract] [Full Text]

				T. N. Cassel, L. Nordlund-Möller, O. Andersson, J.-A. Gustafsson, and M. Nord C/EBPalpha and C/EBPdelta Activate the Clara Cell Secretory Protein Gene through Interaction with Two Adjacent C/EBP-Binding Sites Am. J. Respir. Cell Mol. Biol., April 1, 2000; 22(4): 469 - 480. [Abstract] [Full Text]

				L Gunhaga, T. Jessell, and T Edlund Sonic hedgehog signaling at gastrula stages specifies ventral telencephalic cells in the chick embryo Development, January 8, 2000; 127(15): 3283 - 3293. [Abstract] [PDF]

				A. Naltner, M. Ghaffari, J. A. Whitsett, and C. Yan Retinoic Acid Stimulation of the Human Surfactant Protein B Promoter Is Thyroid Transcription Factor 1 Site-dependent J. Biol. Chem., January 7, 2000; 275(1): 56 - 62. [Abstract] [Full Text] [PDF]

				C Vesque, S Ellis, A Lee, M Szabo, P Thomas, R Beddington, and M Placzek Development of chick axial mesoderm: specification of prechordal mesoderm by anterior endoderm-derived TGFbeta family signalling Development, January 7, 2000; 127(13): 2795 - 2809. [Abstract] [PDF]

				J. Martinez Barbera, M Clements, P Thomas, T Rodriguez, D Meloy, D Kioussis, and R. Beddington The homeobox gene Hex is required in definitive endodermal tissues for normal forebrain, liver and thyroid formation Development, January 6, 2000; 127(11): 2433 - 2445. [Abstract] [PDF]

				R. S. Brown, V. Shalhoub, S. Coulter, S. Alex, I. Joris, W. De Vito, J. Lian, and G. S. Stein Developmental Regulation of Thyrotropin Receptor Gene Expression in the Fetal and Neonatal Rat Thyroid: Relation to Thyroid Morphology and to Thyroid-Specific Gene Expression Endocrinology, January 1, 2000; 141(1): 340 - 345. [Abstract] [Full Text] [PDF]

				M. Hallonet, T. Hollemann, T. Pieler, and P. Gruss Vax1, a novel homeobox-containing gene, directs development of the basal forebrain and visual system Genes & Dev., December 1, 1999; 13(23): 3106 - 3114. [Abstract] [Full Text]

				L. Ortiz, P. Aza-Blanc, M. Zannini, A. C. B. Cato, and P. Santisteban The Interaction between the Forkhead Thyroid Transcription Factor TTF-2 and the Constitutive Factor CTF/NF-1 Is Required for Efficient Hormonal Regulation of the Thyroperoxidase Gene Transcription J. Biol. Chem., May 21, 1999; 274(21): 15213 - 15221. [Abstract] [Full Text] [PDF]

				M. Ohno, M. Zannini, O. Levy, N. Carrasco, and R. di Lauro The Paired-Domain Transcription Factor Pax8 Binds to the Upstream Enhancer of the Rat Sodium/Iodide Symporter Gene and Participates in Both Thyroid-Specific and Cyclic-AMP-Dependent Transcription Mol. Cell. Biol., March 1, 1999; 19(3): 2051 - 2060. [Abstract] [Full Text] [PDF]

				J. R. Shaw-White, M. D. Bruno, and J. A. Whitsett GATA-6 Activates Transcription of Thyroid Transcription Factor-1 J. Biol. Chem., January 29, 1999; 274(5): 2658 - 2664. [Abstract] [Full Text] [PDF]

				J. Zoltewicz, N. Plummer, M. Lin, and A. Peterson oto is a homeotic locus with a role in anteroposterior development that is partially redundant with Lim1 Development, January 11, 1999; 126(22): 5085 - 5095. [Abstract] [PDF]

				F Ristoratore, A Spagnuolo, F Aniello, M Branno, F Fabbrini, and R Di Lauro Expression and functional analysis of Cititf1, an ascidian NK-2 class gene, suggest its role in endoderm development Development, January 11, 1999; 126(22): 5149 - 5159. [Abstract] [PDF]