|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 113, Issue 4 1159-1170, Copyright © 1991 by Company of Biologists
JOURNAL ARTICLES |
N Holder and J Hill
Developmental Biology Research Division of Biomedical Sciences, Kings College, London, UK.
Considerable evidence now suggests that retinoic acid (RA) is an important modulator of patterning events in early neuronal development in vertebrates. In this paper, we describe the effects of exogenously applied RA on early neural development in the zebrafish embryo. Neural anatomy is assessed by immunocytochemical and histochemical analysis of the developing embryo in whole mounts at 24 h post-fertilization. RA was applied for one hour at concentrations ranging from 10(-9) to 10(-6) M to embryos at 50% epiboly, the midgastrula stage, and at 10(-7) M to embryos at early and late gastrula stages. The neuroanatomical analysis shows that 10(-7) M RA causes a defined lesion to the developing central nervous system which corresponds to a loss of a region of the brain in the caudal midbrain-rostral hindbrain area, the precursor of the cerebellum and associated neural structures. The region that fails to develop corresponds to the cranial expression domain of the engrailed protein as assessed by the monoclonal antibody 4D9 (Patel et al. 1989: Expression of engrailed proteins in arthropods, annelids and chordates. Cell 58, 955-968). Structures caudal to rhombomere 4 are unaffected by 10(-7) M RA, as are the cranial midbrain and forebrain: 10(-7) M RA also affects the development of cranial ganglia, principally the Vth, anterior lateral line and VIIIth ganglia, suggesting that RA affects normal development of the cranial neural crest. Effects of RA at stages immediately prior to and after gastrulation show some similar and some distinct features. Results are discussed in terms of the possible role of RA as an endogenous moderator of normal head development.
This article has been cited by other articles:
|
|
 |
|
  Y. Murakami, M. Pasqualetti, Y. Takio, S. Hirano, F. M. Rijli, and S. Kuratani Segmental development of reticulospinal and branchiomotor neurons in lamprey: insights into the evolution of the vertebrate hindbrain Development, March 1, 2004; 131(5): 983 - 995. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Holzschuh, A. Barrallo-Gimeno, A.-K. Ettl, K. Durr, E. W. Knapik, and W. Driever Noradrenergic neurons in the zebrafish hindbrain are induced by retinoic acid and require tfap2a for expression of the neurotransmitter phenotype Development, December 1, 2003; 130(23): 5741 - 5754. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Scholpp, C. Lohs, and M. Brand Engrailed and Fgf8 act synergistically to maintain the boundary between diencephalon and mesencephalon Development, October 15, 2003; 130(20): 4881 - 4893. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Grandel, K. Lun, G.-J. Rauch, M. Rhinn, T. Piotrowski, C. Houart, P. Sordino, A. M. Kuchler, S. Schulte-Merker, R. Geisler, et al. Retinoic acid signalling in the zebrafish embryo is necessary during pre-segmentation stages to pattern the anterior-posterior axis of the CNS and to induce a pectoral fin bud Development, March 8, 2003; 129(12): 2851 - 2865. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. E. Erter, T. P. Wilm, N. Basler, C. V. E. Wright, and L. Solnica-Krezel Wnt8 is required in lateral mesendodermal precursors for neural posteriorization in vivo Development, September 15, 2001; 128(18): 3571 - 3583. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. C. Oates, S. J. Pratt, B. Vail, Y.-l. Yan, R. K. Ho, S. L. Johnson, J. H. Postlethwait, and L. I. Zon The zebrafish klf gene family Blood, September 15, 2001; 98(6): 1792 - 1801. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Maden, E. Gale, and M. Zile The Role of Vitamin A in the Development of the Central Nervous System J. Nutr., February 1, 1998; 128(2): 471 - 471. [Abstract] [Full Text]
|
|
|
|
|
|
D Huang, S. Chen, A. Langston, and L. Gudas A conserved retinoic acid responsive element in the murine Hoxb-1 gene is required for expression in the developing gut Development, January 8, 1998; 125(16): 3235 - 3246. [Abstract] [PDF]
|
|
|
|
|
|
J van der Wees, J. Schilthuis, C. Koster, H Diesveld-Schipper, G. Folkers, P. van der Saag, M. Dawson, K Shudo, B van der Burg, and A. Durston Inhibition of retinoic acid receptor-mediated signalling alters positional identity in the developing hindbrain Development, January 2, 1998; 125(3): 545 - 556. [Abstract] [PDF]
|
|
|
|
 |
|
 A. W. Langston, J. R. Thompson, and L. J. Gudas Retinoic Acid-responsive Enhancers Located 3' of the Hox A and Hox B Homeobox Gene Clusters. FUNCTIONAL ANALYSIS J. Biol. Chem., January 24, 1997; 272(4): 2167 - 2175. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Lu, G Eichele, and C Thaller Ligand-bound RXR can mediate retinoid signal transduction during embryogenesis Development, January 1, 1997; 124(1): 195 - 203. [Abstract] [PDF]
|
|
|
|
|
|
C. Sharpe and K Goldstone Retinoid receptors promote primary neurogenesis in Xenopus Development, January 1, 1997; 124(2): 515 - 523. [Abstract] [PDF]
|
|
|
|
|
|
L. Holland and N. Holland Expression of AmphiHox-1 and AmphiPax-1 in amphioxus embryos treated with retinoic acid: insights into evolution and patterning of the chordate nerve cord and pharynx Development, January 6, 1996; 122(6): 1829 - 1838. [Abstract] [PDF]
|
|
|
|
|
|
D Alexandre, J. Clarke, E Oxtoby, Y. Yan, T Jowett, and N Holder Ectopic expression of Hoxa-1 in the zebrafish alters the fate of the mandibular arch neural crest and phenocopies a retinoic acid-induced phenotype Development, January 3, 1996; 122(3): 735 - 746. [Abstract] [PDF]
|
|
|
|
|
|
E Gale, V Prince, A Lumsden, J Clarke, N Holder, and M Maden Late effects of retinoic acid on neural crest and aspects of rhombomere Development, January 3, 1996; 122(3): 783 - 793. [Abstract] [PDF]
|
|
|
|
|
|
Y. Lee, N Osumi-Yamashita, Y Ninomiya, C. Moon, U Eriksson, and K Eto Retinoic acid stage-dependently alters the migration pattern and identity of hindbrain neural crest cells Development, January 3, 1995; 121(3): 825 - 837. [Abstract] [PDF]
|
|
|
|
|
|
T. Schuh, B. Hall, J. Kraft, M. Privalsky, and D Kimelman v-erbA and citral reduce the teratogenic effects of all-trans retinoic acid and retinol, respectively, in Xenopus embryogenesis Development, January 11, 1993; 119(3): 785 - 798. [Abstract] [PDF]
|
|
|
|
|
|
A. Zimmer and A. Zimmer Induction of a RAR beta 2-lacZ transgene by retinoic acid reflects the neuromeric organization of the central nervous system Development, December 1, 1992; 116(4): 977 - 983. [Abstract] [PDF]
|
|
|
|
|
|
M Wagner, B Han, and T. Jessell Regional differences in retinoid release from embryonic neural tissue detected by an in vitro reporter assay Development, January 9, 1992; 116(1): 55 - 66. [Abstract] [PDF]
|
|
