|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 113, Issue 4 1171-1179, Copyright © 1991 by Company of Biologists
JOURNAL ARTICLES |
CC Zhang, J Muller, M Hoch, H Jackle and M Bienz
Zoological Institute, University of Zurich, Switzerland.
Boundaries of Ultrabithorax expression are mediated by long-range repression acting through the PBX or ABX control region. We show here that either of these control regions confers an early band of beta-galactosidase expression which is restricted along the anteroposterior axis of the blastoderm embryo. This band is succeeded by a stripe pattern with very similar anteroposterior limits. Dissection of the PBX control region demonstrates that the two patterns are conferred by distinct cis-regulatory sequences contained within separate PBX subfragments. We find several binding sites for hunchback protein within both PBX subfragments. Zygotic hunchback function is required to prevent ectopic PBX expression. Moreover, the PBX pattern is completely suppressed in embryos containing uniformly distributed maternal hunchback protein. Our results strongly suggest that hunchback protein directly binds to the PBX control region and acts as a repressor to specify the boundary positions of the PBX pattern.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati 
Twitter What's this?
This article has been cited by other articles:
|
|
 |
|
  R. K. Maeda and F. Karch The ABC of the BX-C: the bithorax complex explained. Development, April 1, 2006; 133(8): 1413 - 1422. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Busturia, A. Lloyd, F. Bejarano, M. Zavortink, H. Xin, and S. Sakonju The MCP silencer of the Drosophila Abd-B gene requires both Pleiohomeotic and GAGA factor for the maintenance of repression Development, June 1, 2001; 128(11): 2163 - 2173. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D Beuchle, G Struhl, and J Muller Polycomb group proteins and heritable silencing of Drosophila Hox genes Development, January 3, 2001; 128(6): 993 - 1004. [Abstract] [PDF]
|
|
|
|
|
|
C Fritsch, J. Brown, J. Kassis, and J Muller The DNA-binding polycomb group protein pleiohomeotic mediates silencing of a Drosophila homeotic gene Development, January 9, 1999; 126(17): 3905 - 3913. [Abstract] [PDF]
|
|
|
|
|
|
J Castelli-Gair The lines gene of Drosophila is required for specific functions of the Abdominal-B HOX protein Development, January 4, 1998; 125(7): 1269 - 1274. [Abstract] [PDF]
|
|
|
|
|
|
A Busturia, C. Wightman, and S Sakonju A silencer is required for maintenance of transcriptional repression throughout Drosophila development Development, January 11, 1997; 124(21): 4343 - 4350. [Abstract] [PDF]
|
|
|
|
|
|
M. Arnone and E. Davidson The hardwiring of development: organization and function of genomic regulatory systems Development, January 5, 1997; 124(10): 1851 - 1864. [Abstract] [PDF]
|
|
|
|
|
|
J. Laney and M. Biggin Redundant control of Ultrabithorax by zeste involves functional levels of zeste protein binding at the Ultrabithorax promoter Development, July 1, 1996; 122(7): 2303 - 2311. [Abstract] [PDF]
|
|
|
|
 |
|
 S Gray and M Levine Short-range transcriptional repressors mediate both quenching and direct repression within complex loci in Drosophila. Genes & Dev., March 15, 1996; 10(6): 700 - 710. [Abstract] [PDF]
|
|
|
|
|
|
I. Sulston and K. Anderson Embryonic patterning mutants of Tribolium castaneum Development, January 3, 1996; 122(3): 805 - 814. [Abstract] [PDF]
|
|
|
|
|
|
J Muller, S Gaunt, and P. Lawrence Function of the Polycomb protein is conserved in mice and flies Development, January 9, 1995; 121(9): 2847 - 2852. [Abstract] [PDF]
|
|
|
|
|
|
J Castelli-Gair and M Akam How the Hox gene Ultrabithorax specifies two different segments: the significance of spatial and temporal regulation within metameres Development, January 9, 1995; 121(9): 2973 - 2982. [Abstract] [PDF]
|
|
|
|
|
|
F Casares and E Sanchez-Herrero Regulation of the infraabdominal regions of the bithorax complex of Drosophila by gap genes Development, January 6, 1995; 121(6): 1855 - 1866. [Abstract] [PDF]
|
|
|
|
 |
|
 M. Shimell, J Simon, W Bender, and M. O'Connor Enhancer point mutation results in a homeotic transformation in Drosophila Science, May 13, 1994; 264(5161): 968 - 971. [Abstract] [PDF]
|
|
|
|
|
|
E. Davidson Later embryogenesis: regulatory circuitry in morphogenetic fields Development, January 7, 1993; 118(3): 665 - 690. [Abstract] [PDF]
|
|
|
|
|
|
J D Laney and M D Biggin zeste, a nonessential gene, potently activates Ultrabithorax transcription in the Drosophila embryo. Genes & Dev., August 1, 1992; 6(8): 1531 - 1541. [Abstract] [PDF]
|
|
