Development, Vol 113, Issue 4 1193-1206, Copyright © 1991 by Company of Biologists

JOURNAL ARTICLES

Expression of the zebrafish paired box gene pax[zf-b] during early neurogenesis

S Krauss, T Johansen, V Korzh and A Fjose
Department of Microbiology, University of Tromso, Norway.

The paired box-containing (pax) gene family encodes a group of putative transcription factors differentially expressed during embryonic development. In this study, we describe the cloning and expression of a zebrafish gene pax[zf-b], which most probably is a direct homologue to the mouse Pax2 gene. The putative protein encoded by pax[zf-b] contains a paired box, an octapeptide, but no homeobox. However, a region of homology to the N-terminal half of paired-type homeoboxes is detected C-terminal to the pax[zf-b] paired domain. In zebrafish embryos, pax[zf-b] transcripts are first seen during the formation of the neural keel. At 9-10 h of development, two laterally located transverse stripes of cells expressing the gene appear in the rostral 1/3 of the embryo. The two areas subsequently move towards the midline and form the posterior portion of the midbrain. In the following stages of development, at 10-12 h, transcripts are detected in the otic placode, the Wolffian duct including the nephritic primodium and in the optic stalk. At a later time point, beginning at 14-15 h, single cells along the spinal cord, presumably interneurons, start to express the gene. The characteristic expression pattern of pax[zf-b] in the neural tube suggests an involvement of this gene in the regionalization of the midbrain as well as in the specification of neuronal cell fates at early embryonic stages.
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				M. Goulding, A Lumsden, and P Gruss Signals from the notochord and floor plate regulate the region-specific expression of two Pax genes in the developing spinal cord Development, January 3, 1993; 117(3): 1001 - 1016. [Abstract] [PDF]

				K Schneitz, P Spielmann, and M Noll Molecular genetics of aristaless, a prd-type homeo box gene involved in the morphogenesis of proximal and distal pattern elements in a subset of appendages in Drosophila. Genes & Dev., January 1, 1993; 7(1): 114 - 129. [Abstract] [PDF]

				B Adams, P Dorfler, A Aguzzi, Z Kozmik, P Urbanek, I Maurer-Fogy, and M Busslinger Pax-5 encodes the transcription factor BSAP and is expressed in B lymphocytes, the developing CNS, and adult testis. Genes & Dev., September 1, 1992; 6(9): 1589 - 1607. [Abstract] [PDF]

				S Krauss, V Korzh, A Fjose, and T Johansen Expression of four zebrafish wnt-related genes during embryogenesis Development, January 9, 1992; 116(1): 249 - 259. [Abstract] [PDF]