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Development, Vol 114, Issue 1 233-243, Copyright © 1992 by Company of Biologists
JOURNAL ARTICLES |
KG Peters, S Werner, G Chen and LT Williams
Howard Hughes Medical Institute, Department of Medicine, University of California, San Francisco 94147.
Fibroblast growth factors (FGFs) can influence the growth and differentiation of cultured cells derived from neuroectoderm, ectoderm or mesenchyme. The FGFs interact with a family of at least four closely related receptor tyrosine kinases that are products of individual genes. To investigate the role of FGFs in the growth and differentiation of embryonic tissues and to determine whether the individual FGF receptor genes might have specific functions, we compared the localization of mRNA for two FGF receptor genes, FGFR1 (the flg gene product) and FGFR2 (the bek gene product), during limb formation and organogenesis in mouse embryos (E9.5-E16.5). Although the two genes were coexpressed in some tissues, the differential expression of FGFR1 and FGFR2 in most embryonic tissues was striking. FGFR1 was expressed diffusely in mesenchyme of limb buds, somites and organ rudiments. In contrast, FGFR2 was expressed predominantly in the epithelial cells of embryonic skin and of developing organs. The differential expression of FGFR1 and FGFR2 in mesenchyme and epithelium respectively, suggests the receptor genes are independently regulated and that they mediate different functions of FGFs during development.
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P Kury, N Schaeren-Wiemers, and D Monard Protease nexin-1 is expressed at the mouse met-/mesencephalic junction and FGF signaling regulates its promoter activity in primary met-/mesencephalic cells Development, January 3, 1997; 124(6): 1251 - 1262. [Abstract] [PDF]
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 I. Thesleff and J. Jernvall The Enamel Knot: A Putative Signaling Center Regulating Tooth Development Cold Spring Harb Symp Quant Biol, January 1, 1997; 62(0): 257 - 267. [Abstract] [PDF]
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 P. Henrich-Noack, J.H.M. Prehn, J. Krieglstein, and K. G Peters TGF-ß1 Protects Hippocampal Neurons Against Degeneration Caused by Transient Global Ischemia: Dose-Response Relationship and Potential Neuroprotective Mechanisms Stroke, September 1, 1996; 27(9): 1609 - 1615. [Abstract] [Full Text]
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S. Santos-Ocampo, J. S. Colvin, A. Chellaiah, and D. M. Ornitz Expression and Biological Activity of Mouse Fibroblast Growth Factor-9 J. Biol. Chem., January 19, 1996; 271(3): 1726 - 1731. [Abstract] [Full Text] [PDF]
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A Vogel, C Rodriguez, and J. Izpisua-Belmonte Involvement of FGF-8 in initiation, outgrowth and patterning of the vertebrate limb Development, January 6, 1996; 122(6): 1737 - 1750. [Abstract] [PDF]
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Z Sheng, D Pennica, W. Wood, and K. Chien Cardiotrophin-1 displays early expression in the murine heart tube and promotes cardiac myocyte survival Development, January 2, 1996; 122(2): 419 - 428. [Abstract] [PDF]
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N Itoh, T Mima, and T Mikawa Loss of fibroblast growth factor receptors is necessary for terminal differentiation of embryonic limb muscle Development, January 1, 1996; 122(1): 291 - 300. [Abstract] [PDF]
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K. B.S. Pasumarthi, E. Kardami, and P. A. Cattini High and Low Molecular Weight Fibroblast Growth Factor-2 Increase Proliferation of Neonatal Rat Cardiac Myocytes but Have Differential Effects on Binucleation and Nuclear Morphology : Evidence for Both Paracrine and Intracrine Actions of Fibroblast GrowthFactor-2 Circ. Res., January 1, 1996; 78(1): 126 - 136. [Abstract] [Full Text]
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K. M. Patrie, A. J. Kudla, B. B. Olwin, and I.-M. Chiu Conservation of Ligand Specificity between the Mammalian and Amphibian Fibroblast Growth Factor Receptors J. Biol. Chem., December 1, 1995; 270(48): 29018 - 29024. [Abstract] [Full Text] [PDF]
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C. MacArthur, A Lawshe, J Xu, S Santos-Ocampo, M Heikinheimo, A. Chellaiah, and D. Ornitz FGF-8 isoforms activate receptor splice forms that are expressed in mesenchymal regions of mouse development Development, January 11, 1995; 121(11): 3603 - 3613. [Abstract] [PDF]
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A Patapoutian, J. Yoon, J. Miner, S Wang, K Stark, and B Wold Disruption of the mouse MRF4 gene identifies multiple waves of myogenesis in the myotome Development, January 10, 1995; 121(10): 3347 - 3358. [Abstract] [PDF]
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P Souza, M Kuliszewski, J Wang, I Tseu, A. Tanswell, and M Post PDGF-AA and its receptor influence early lung branching via an epithelial-mesenchymal interaction Development, January 8, 1995; 121(8): 2559 - 2567. [Abstract] [PDF]
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H Nogawa and T Ito Branching morphogenesis of embryonic mouse lung epithelium in mesenchyme-free culture Development, January 4, 1995; 121(4): 1015 - 1022. [Abstract] [PDF]
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P. Crossley and G. Martin The mouse Fgf8 gene encodes a family of polypeptides and is expressed in regions that direct outgrowth and patterning in the developing embryo Development, January 2, 1995; 121(2): 439 - 451. [Abstract] [PDF]
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S Werner, H Smola, X Liao, M. Longaker, T Krieg, P. Hofschneider, and L. Williams The function of KGF in morphogenesis of epithelium and reepithelialization of wounds Science, November 4, 1994; 266(5186): 819 - 822. [Abstract] [PDF]
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W. Filsell, J. C. Little, A. J. Stones, S. P. Granger, and S. A. Bayley Transfection of rat dermal papilla cells with a gene encoding a temperature-sensitive polyomavirus large T antigen generates cell lines retaining a differentiated phenotype J. Cell Sci., July 1, 1994; 107(7): 1761 - 1772. [Abstract] [PDF]
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D. Shi, V Fromentoux, C Launay, M Umbhauer, and J. Boucaut Isolation and developmental expression of the amphibian homolog of the fibroblast growth factor receptor 3 J. Cell Sci., January 3, 1994; 107(3): 417 - 425. [Abstract] [PDF]
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C Marcelle, A Eichmann, O Halevy, C Breant, and N. Le Douarin Distinct developmental expression of a new avian fibroblast growth factor receptor Development, January 3, 1994; 120(3): 683 - 694. [Abstract] [PDF]
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Y. Kinoshita, C. Kinoshita, J. G. Heuer, and M. Bothwell Basic fibroblast growth factor promotes adhesive interactions of neuroepithelial cells from chick neural tube with extracellular matrix proteins in culture Development, November 1, 1993; 119(3): 943 - 956. [Abstract] [PDF]
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H. Schnurch and W. Risau Expression of tie-2, a member of a novel family of receptor tyrosine kinases, in the endothelial cell lineage Development, November 1, 1993; 119(3): 957 - 968. [Abstract] [PDF]
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M. Poulin, K. Patrie, M. Botelho, R. Tassava, and I. Chiu Heterogeneity in the expression of fibroblast growth factor receptors during limb regeneration in newts (Notophthalmus viridescens) Development, January 10, 1993; 119(2): 353 - 361. [Abstract] [PDF]
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A Vogel and C Tickle FGF-4 maintains polarizing activity of posterior limb bud cells in vivo and in vitro Development, January 9, 1993; 119(1): 199 - 206. [Abstract] [PDF]
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L Niswander and G. Martin FGF-4 regulates expression of Evx-1 in the developing mouse limb Development, January 9, 1993; 119(1): 287 - 294. [Abstract] [PDF]
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