|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 114, Issue 1 59-66, Copyright © 1992 by Company of Biologists
JOURNAL ARTICLES |
TL Wood, RD Streck and JE Pintar
Department of Anatomy and Cell Biology, Columbia University College of Physicians and Surgeons, New York, NY 10032.
The insulin-like growth factors (IGFs) stimulate mitogenesis in a variety of cell types both in vitro and in vivo. These effects are mediated by both IGF receptors and a family of IGF binding proteins (IGFBPs), which are found complexed with the IGFs in serum and tissue fluids. Here we compare the sites of expression during early rat embryogenesis of the genes encoding the RGD-containing IGF binding protein IGFBP-2 and IGF-II. At all ages from early post-implantation through mid-gestation, the expression of IGFBP-2 was highly complementary to IGF-II. IGFBP-2 mRNA was detected throughout the epiblast of the egg cylinder as early as e7, when IGF-II expression was restricted to trophectoderm and other extraembryonic cells. As gastrulation proceeded, IGFBP-2 expression ceased as IGF-II expression began in the newly formed embryonic and extra-embryonic mesoderm, but was retained in other epiblast derivatives including the surface ectoderm and neuroectoderm, throughout its rostral-caudal extent. By e10-e11, IGFBP-2 expression in neuroectoderm was restricted to the rostral brain of the primary neural tube and was found in the new population of neuroepithelium formed in the tail bud during secondary neurulation. IGFBP-2 expression remained high in the ventricular layer of the rostral brain into mid-gestation ages but decreased or disappeared as cells entered the mantle layer and began to express the neurofilament-related gene alpha-internexin. IGFBP-2 mRNA was abundant in surface ectoderm, particularly that of the branchial arches, and all ectodermal placodes.(ABSTRACT TRUNCATED AT 250 WORDS)
This article has been cited by other articles:
|
|
 |
|
  Y. Ning, A. G. P. Schuller, C. A. Conover, and J. E. Pintar Insulin-Like Growth Factor (IGF) Binding Protein-4 Is Both a Positive and Negative Regulator of IGF Activity in Vivo Mol. Endocrinol., May 1, 2008; 22(5): 1213 - 1225. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. C. Russo, P. D. Gluckman, E. L. Feldman, and G. A. Werther The Insulin-Like Growth Factor System and Its Pleiotropic Functions in Brain Endocr. Rev., December 1, 2005; 26(7): 916 - 943. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Wang, H. Wang, W. Shen, H. Huang, L. Hu, L. Ramdas, Y.-H. Zhou, W. S-L. Liao, G. N. Fuller, and W. Zhang Insulin-like Growth Factor Binding Protein 2 Enhances Glioblastoma Invasion by Activating Invasion-enhancing Genes Cancer Res., August 1, 2003; 63(15): 4315 - 4321. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. L. Wood, L. E. Rogler, M. E. Czick, A. G.P. Schuller, and J. E. Pintar Selective Alterations in Organ Sizes in Mice with a Targeted Disruption of the Insulin-Like Growth Factor Binding Protein-2 Gene Mol. Endocrinol., September 1, 2000; 14(9): 1472 - 1482. [Abstract] [Full Text]
|
|
|
|
 |
|
 M. van Kleffens, C. A. H. Groffen, N. F. J. Dits, D. J. Lindenbergh-Kortleve, A. G. P. Schuller, S. L. Bradshaw, J. E. Pintar, E. C. Zwarthoff, S. L. S. Drop, and J. W. van Neck Generation of Antisera to Mouse Insulin-Like Growth Factor Binding Proteins (IGFBP)-1 to -6: Comparison of IGFBP Protein and Messenger Ribonucleic Acid Localization in the Mouse Embryo Endocrinology, December 1, 1999; 140(12): 5944 - 5952. [Abstract] [Full Text]
|
|
|
|
|
|
G. N. Fuller, C. H. Rhee, K. R. Hess, L. S. Caskey, R. Wang, J. M. Bruner, W. K. A. Yung, and W. Zhang Reactivation of Insulin-like Growth Factor Binding Protein 2 Expression in Glioblastoma Multiforme: A Revelation by Parallel Gene Expression Profiling Cancer Res., September 1, 1999; 59(17): 4228 - 4232. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. W. Hay Jr, C. S. Catz, G. D. Grave, and S. J. Yaffe Workshop Summary: Fetal Growth: Its Regulation and Disorders Pediatrics, April 1, 1997; 99(4): 585 - 591. [Full Text] [PDF]
|
|
|
|
|
|
T. S. Reynolds, K. R. Stevenson, and D. C. Wathes Pregnancy-Specific Alterations in the Expression of the Insulin-Like Growth Factor System during Early Placental Development in the Ewe Endocrinology, March 1, 1997; 138(3): 886 - 897. [Abstract] [Full Text] [PDF]
|
|
