|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 114, Issue 2 493-505, Copyright © 1992 by Company of Biologists
JOURNAL ARTICLES |
J Simon, A Chiang and W Bender
Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115.
Mutations in genes of the Polycomb (Pc) group cause abnormal segmental development due to ectopic expression of the homeotic products of the Antennapedia and bithorax complexes. Here the requirements for Pc group genes in controlling the abdA and AbdB products of the bithorax complex are described. Embryos containing mutations in the genes Polycomb (Pc), extra sex combs (esc), Enhancer of zeste [E(z)], polyhomeotic (ph), Sex comb on midleg (Scm), Polycomb-like (Pcl), Sex comb extra (Sce), Additional sex combs (Asx), Posterior sex combs (Psc) and pleiohomeotic (pho) were examined. In every case, both abdA and AbdB are expressed outside of their normal domains along the anterior-posterior (A-P) axis, consistent with these Pc group products acting in a single pathway or molecular complex. The earliest detectable ectopic expression is highest in the parasegments immediately adjacent to the normal expression boundary. Surprisingly, in the most severe Pc group mutants, the earliest ectopic AbdB is distributed in a pair-rule pattern. At all stages, ectopic abdA in the epidermis is highest along the anterior edges of the parasegments, in a pattern that mimics the normal abdA cell-specific pattern. These examples of highly patterned mis-expression show that Pc group mutations do not cause indiscriminate activation of homeotic products. We suggest that the ectopic expression patterns result from factors that normally activate abdA and AbdB only in certain parasegments, but that in Pc group mutants these factors gain access to regulatory DNA in all parasegments.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati 
Twitter What's this?
This article has been cited by other articles:
|
|
 |
|
  D. A. R. Sinclair, M. Syrzycka, M. S. Macauley, T. Rastgardani, I. Komljenovic, D. J. Vocadlo, H. W. Brock, and B. M. Honda Drosophila O-GlcNAc transferase (OGT) is encoded by the Polycomb group (PcG) gene, super sex combs (sxc) PNAS, August 11, 2009; 106(32): 13427 - 13432. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Soshnikova and D. Duboule Epigenetic Temporal Control of Mouse Hox Genes in Vivo Science, June 5, 2009; 324(5932): 1320 - 1323. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 O. Karakuzu, D. P. Wang, and S. Cameron MIG-32 and SPAT-3A are PRC1 homologs that control neuronal migration in Caenorhabditis elegans Development, March 15, 2009; 136(6): 943 - 953. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Joshi, E. A. Carrington, L. Wang, C. S. Ketel, E. L. Miller, R. S. Jones, and J. A. Simon Dominant Alleles Identify SET Domain Residues Required for Histone Methyltransferase of Polycomb Repressive Complex 2 J. Biol. Chem., October 10, 2008; 283(41): 27757 - 27766. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. G. de Ayala Alonso, L. Gutierrez, C. Fritsch, B. Papp, D. Beuchle, and J. Muller A Genetic Screen Identifies Novel Polycomb Group Genes in Drosophila Genetics, August 1, 2007; 176(4): 2099 - 2108. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Z. Parrish, K. Emoto, L. Y. Jan, and Y. N. Jan Polycomb genes interact with the tumor suppressor genes hippo and warts in the maintenance of Drosophila sensory neuron dendrites Genes & Dev., April 15, 2007; 21(8): 956 - 972. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Ringrose and R. Paro Polycomb/Trithorax response elements and epigenetic memory of cell identity Development, January 15, 2007; 134(2): 223 - 232. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Wang, N. Jahren, M. L. Vargas, E. F. Andersen, J. Benes, J. Zhang, E. L. Miller, R. S. Jones, and J. A. Simon Alternative ESC and ESC-Like Subunits of a Polycomb Group Histone Methyltransferase Complex Are Differentially Deployed during Drosophila Development. Mol. Cell. Biol., April 1, 2006; 26(7): 2637 - 2647. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Wang, C.-H. J. Lee, S. Lin, and T. Lee Steroid hormone-dependent transformation of polyhomeotic mutant neurons in the Drosophila brain Development, April 1, 2006; 133(7): 1231 - 1240. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Kindler Postnatal stem cell survival: does the niche, a rare harbor where to resist the ebb tide of differentiation, also provide lineage-specific instructions? J. Leukoc. Biol., October 1, 2005; 78(4): 836 - 844. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. F. G. King, R. B. Emmons, N. J. Francis, B. Wild, J. Muller, R. E. Kingston, and C.-t. Wu Analysis of a Polycomb Group Protein Defines Regions That Link Repressive Activity on Nucleosomal Templates to In Vivo Function Mol. Cell. Biol., August 1, 2005; 25(15): 6578 - 6591. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Caretti, M. Di Padova, B. Micales, G. E. Lyons, and V. Sartorelli The Polycomb Ezh2 methyltransferase regulates muscle gene expression and skeletal muscle differentiation Genes & Dev., November 1, 2004; 18(21): 2627 - 2638. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Kirmizis and P. J. Farnham Genomic Approaches That Aid in the Identification of Transcription Factor Target Genes Experimental Biology and Medicine, September 1, 2004; 229(8): 705 - 721. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. J. Peterson, D. R. Mallin, N. J. Francis, C. S. Ketel, J. Stamm, R. K. Voeller, R. E. Kingston, and J. A. Simon Requirement for Sex Comb on Midleg Protein Interactions in Drosophila Polycomb Group Repression Genetics, July 1, 2004; 167(3): 1225 - 1239. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Narbonne, F. Besse, J. Brissard-Zahraoui, A.-M. Pret, and D. Busson polyhomeotic is required for somatic cell proliferation and differentiation during ovarian follicle formation in Drosophila Development, March 15, 2004; 131(6): 1389 - 1400. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Tie, J. Prasad-Sinha, A. Birve, A. Rasmuson-Lestander, and P. J. Harte A 1-Megadalton ESC/E(Z) Complex from Drosophila That Contains Polycomblike and RPD3 Mol. Cell. Biol., May 1, 2003; 23(9): 3352 - 3362. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Boivin, C. Gally, S. Netter, D. Anxolabehere, and S. Ronsseray Telomeric Associated Sequences of Drosophila Recruit Polycomb-Group Proteins in Vivo and Can Induce Pairing-Sensitive Repression Genetics, May 1, 2003; 164(1): 195 - 208. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Faucheux, J.-Y. Roignant, S. Netter, J. Charollais, C. Antoniewski, and L. Theodore batman Interacts with Polycomb and trithorax Group Genes and Encodes a BTB/POZ Protein That Is Included in a Complex Containing GAGA Factor Mol. Cell. Biol., February 15, 2003; 23(4): 1181 - 1195. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. F. G. King, N. J. Francis, and R. E. Kingston Native and Recombinant Polycomb Group Complexes Establish a Selective Block to Template Accessibility To Repress Transcription In Vitro Mol. Cell. Biol., November 15, 2002; 22(22): 7919 - 7928. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. M. Moshkin, J. A. Armstrong, R. K. Maeda, J. W. Tamkun, P. Verrijzer, J. A. Kennison, and F. Karch Histone chaperone ASF1 cooperates with the Brahma chromatin-remodelling machinery Genes & Dev., October 15, 2002; 16(20): 2621 - 2626. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. G. A. B. Sewalt, M. Lachner, M. Vargas, K. M. Hamer, J. L. den Blaauwen, T. Hendrix, M. Melcher, D. Schweizer, T. Jenuwein, and A. P. Otte Selective Interactions between Vertebrate Polycomb Homologs and the SUV39H1 Histone Lysine Methyltransferase Suggest that Histone H3-K9 Methylation Contributes to Chromosomal Targeting of Polycomb Group Proteins Mol. Cell. Biol., August 1, 2002; 22(15): 5539 - 5553. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Calgaro, M. Boube, D. L. Cribbs, and H.-M. Bourbon The Drosophila Gene taranis Encodes a Novel Trithorax Group Member Potentially Linked to the Cell Cycle Regulatory Apparatus Genetics, February 1, 2002; 160(2): 547 - 560. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. O'Connell, L. Wang, S. Robert, C. A. Jones, R. Saint, and R. S. Jones Polycomblike PHD Fingers Mediate Conserved Interaction with Enhancer of Zeste Protein J. Biol. Chem., November 9, 2001; 276(46): 43065 - 43073. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Poux, R. Melfi, and V. Pirrotta Establishment of Polycomb silencing requires a transient interaction between PC and ESC Genes & Dev., October 1, 2001; 15(19): 2509 - 2514. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Birve, A. K. Sengupta, D. Beuchle, J. Larsson, J. A. Kennison, A. Rasmuson-Lestander, and J. Muller Su(z)12, a novel Drosophila Polycomb group gene that is conserved in vertebrates and plants Development, September 1, 2001; 128(17): 3371 - 3379. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. W. Hodgson, B. Argiropoulos, and H. W. Brock Site-Specific Recognition of a 70-Base-Pair Element Containing d(GA)n Repeats Mediates bithoraxoid Polycomb Group Response Element-Dependent Silencing Mol. Cell. Biol., July 15, 2001; 21(14): 4528 - 4543. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D Beuchle, G Struhl, and J Muller Polycomb group proteins and heritable silencing of Drosophila Hox genes Development, January 3, 2001; 128(6): 993 - 1004. [Abstract] [PDF]
|
|
|
|
|
|
S Poux, D McCabe, and V Pirrotta Recruitment of components of Polycomb Group chromatin complexes in Drosophila Development, January 1, 2001; 128(1): 75 - 85. [Abstract] [PDF]
|
|
|
|
|
|
F Tie, T Furuyama, J Prasad-Sinha, E Jane, and P. Harte The Drosophila Polycomb Group proteins ESC and E(Z) are present in a complex containing the histone-binding protein p55 and the histone deacetylase RPD3 Development, January 1, 2001; 128(2): 275 - 286. [Abstract] [PDF]
|
|
|
|
|
|
J. J. Gildea, R. Lopez, and A. Shearn A Screen for New Trithorax Group Genes Identified little imaginal discs, the Drosophila melanogaster Homologue of Human Retinoblastoma Binding Protein 2 Genetics, October 1, 2000; 156(2): 645 - 663. [Abstract] [Full Text]
|
|
|
|
|
|
J. Ng, C. M. Hart, K. Morgan, and J. A. Simon A Drosophila ESC-E(Z) Protein Complex Is Distinct from Other Polycomb Group Complexes and Contains Covalently Modified ESC Mol. Cell. Biol., May 1, 2000; 20(9): 3069 - 3078. [Abstract] [Full Text]
|
|
|
|
|
|
M del Mar Lorente, C Marcos-Gutierrez, C Perez, J Schoorlemmer, A Ramirez, T Magin, and M Vidal Loss- and gain-of-function mutations show a polycomb group function for Ring1A in mice Development, January 12, 2000; 127(23): 5093 - 5100. [Abstract] [PDF]
|
|
|
|
|
|
M. Muller, K. Hagstrom, H. Gyurkovics, V. Pirrotta, and P. Schedl The Mcp Element From the Drosophila melanogaster Bithorax Complex Mediates Long-Distance Regulatory Interactions Genetics, November 1, 1999; 153(3): 1333 - 1356. [Abstract] [Full Text]
|
|
|
|
|
|
J. Strouboulis, S. Damjanovski, D. Vermaak, F. Meric, and A. P. Wolffe Transcriptional Repression by XPc1, a New Polycomb Homolog in Xenopus laevis Embryos, Is Independent of Histone Deacetylase Mol. Cell. Biol., June 1, 1999; 19(6): 3958 - 3968. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Bornemann, E. Miller, and J. Simon Expression and Properties of Wild-Type and Mutant Forms of the Drosophila Sex Comb on Midleg (SCM) Repressor Protein Genetics, October 1, 1998; 150(2): 675 - 686. [Abstract] [Full Text]
|
|
|
|
|
|
T. Belenkaya, A. Soldatov, E. Nabirochkina, I. Birjukova, S. Georgieva, and P. Georgiev P-Element Insertion at the polyhomeotic Gene Leads to Formation of a Novel Chimeric Protein That Negatively Regulates yellow Gene Expression in P-Element-Induced Alleles of Drosophila melanogaster Genetics, October 1, 1998; 150(2): 687 - 697. [Abstract] [Full Text]
|
|
|
|
|
|
W. G. M. Damen, M. Hausdorf, E.-A. Seyfarth, and D. Tautz A conserved mode of head segmentation in arthropods revealed by the expression pattern of Hox genes in a spider PNAS, September 1, 1998; 95(18): 10665 - 10670. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. Saget, F. Forquignon, P. Santamaria, and N. B. Randsholt Needs and Targets for the multi sex combs Gene Product in Drosophila melanogaster Genetics, August 1, 1998; 149(4): 1823 - 1838. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Kyba and H. W. Brock The Drosophila Polycomb Group Protein Psc Contacts ph and Pc through Specific Conserved Domains Mol. Cell. Biol., May 1, 1998; 18(5): 2712 - 2720. [Abstract] [Full Text]
|
|
|
|
|
|
C. A. Jones, J. Ng, A. J. Peterson, K. Morgan, J. Simon, and R. S. Jones The Drosophila esc and E(z) Proteins Are Direct Partners in Polycomb Group-Mediated Repression Mol. Cell. Biol., May 1, 1998; 18(5): 2825 - 2834. [Abstract] [Full Text]
|
|
|
|
 |
|
 P. Buchenau, J. Hodgson, H. Strutt, and D. J. Arndt-Jovin The Distribution of Polycomb-Group Proteins During Cell Division and Development in Drosophila Embryos: Impact on Models for Silencing J. Cell Biol., April 20, 1998; 141(2): 469 - 481. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Lessard, S. Baban, and G. Sauvageau Stage-Specific Expression of Polycomb Group Genes in Human Bone Marrow Cells Blood, February 15, 1998; 91(4): 1216 - 1224. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K Stankunas, J Berger, C Ruse, D. Sinclair, F Randazzo, and H. Brock The enhancer of polycomb gene of Drosophila encodes a chromatin protein conserved in yeast and mammals Development, January 10, 1998; 125(20): 4055 - 4066. [Abstract] [PDF]
|
|
|
|
|
|
F Tie, T Furuyama, and P. Harte The Drosophila Polycomb Group proteins ESC and E(Z) bind directly to each other and co-localize at multiple chromosomal sites Development, January 9, 1998; 125(17): 3483 - 3496. [Abstract] [PDF]
|
|
|
|
|
|
S Bel, N Core, M Djabali, K Kieboom, N Van der Lugt, M. Alkema, and M Van Lohuizen Genetic interactions and dosage effects of Polycomb group genes in mice Development, January 9, 1998; 125(18): 3543 - 3551. [Abstract] [PDF]
|
|
|
|
|
|
D. Sinclair, T. Milne, J. Hodgson, J Shellard, C. Salinas, M Kyba, F Randazzo, and H. Brock The Additional sex combs gene of Drosophila encodes a chromatin protein that binds to shared and unique Polycomb group sites on polytene chromosomes Development, January 4, 1998; 125(7): 1207 - 1216. [Abstract] [PDF]
|
|
|
|
|
|
Enhancer of Polycomb Is a Suppressor of Position-Effect Variegation in Drosophila melanogaster Genetics, January 1, 1998; 148(1): 211 - 220.
|
|
|
|
|
|
A Busturia, C. Wightman, and S Sakonju A silencer is required for maintenance of transcriptional repression throughout Drosophila development Development, January 11, 1997; 124(21): 4343 - 4350. [Abstract] [PDF]
|
|
|
|
|
|
Y Yamamoto, F Girard, B Bello, M Affolter, and W. Gehring The cramped gene of Drosophila is a member of the Polycomb-group, and interacts with mus209, the gene encoding Proliferating Cell Nuclear Antigen Development, January 9, 1997; 124(17): 3385 - 3394. [Abstract] [PDF]
|
|
|
|
|
|
D LaJeunesse and A Shearn E(z): a polycomb group gene or a trithorax group gene? Development, July 1, 1996; 122(7): 2189 - 2197. [Abstract] [PDF]
|
|
|
|
|
|
E. Carrington and R. Jones The Drosophila Enhancer of zeste gene encodes a chromosomal protein: examination of wild-type and mutant protein distribution Development, January 12, 1996; 122(12): 4073 - 4083. [Abstract] [PDF]
|
|
|
|
|
|
T Akasaka, M Kanno, R Balling, M. Mieza, M Taniguchi, and H Koseki A role for mel-18, a Polycomb group-related vertebrate gene, during theanteroposterior specification of the axial skeleton Development, January 5, 1996; 122(5): 1513 - 1522. [Abstract] [PDF]
|
|
|
|
|
|
D Bornemann, E Miller, and J Simon The Drosophila Polycomb group gene Sex comb on midleg (Scm) encodes a zinc finger protein with similarity to polyhomeotic protein Development, January 5, 1996; 122(5): 1621 - 1630. [Abstract] [PDF]
|
|
|
|
|
|
S. Tiong, D Nash, and W Bender Dorsal wing, a locus that affects dorsoventral wing patterning in Drosophila Development, January 6, 1995; 121(6): 1649 - 1656. [Abstract] [PDF]
|
|
|
|
|
|
N Serrano, H. Brock, C Demeret, J. Dura, N. Randsholt, T. Kornberg, and F Maschat polyhomeotic appears to be a target of engrailed regulation in Drosophila Development, January 6, 1995; 121(6): 1691 - 1703. [Abstract] [PDF]
|
|
|
|
|
|
M Boyle and S DiNardo Specification, migration and assembly of the somatic cells of the Drosophila gonad Development, January 6, 1995; 121(6): 1815 - 1825. [Abstract] [PDF]
|
|
|
|
|
|
A. Prokop and G. M. Technau Early tagma-specific commitment of Drosophila CNS progenitor NB1-1 Development, September 1, 1994; 120(9): 2567 - 2578. [Abstract] [PDF]
|
|
|
|
|
|
M O Fauvarque and J M Dura polyhomeotic regulatory sequences induce developmental regulator-dependent variegation and targeted P-element insertions in Drosophila. Genes & Dev., August 1, 1993; 7(8): 1508 - 1520. [Abstract] [PDF]
|
|
|
|
|
|
E. Martin and P. Adler The Polycomb group gene Posterior Sex Combs encodes a chromosomal protein Development, January 2, 1993; 117(2): 641 - 655. [Abstract] [PDF]
|
|
|
|
 |
|
 J. Vazquez, G. Farkas, M. Gaszner, A. Udvardy, M. Muller, K. Hagstrom, H. Gyurkovics, L. Sipos, J. Gausz, M. Galloni, et al. Genetic and Molecular Analysis of Chromatin Domains Cold Spring Harb Symp Quant Biol, January 1, 1993; 58(0): 45 - 54. [Abstract] [PDF]
|
|
|
|
|
|
J. J. Brookman, A. T. Toosy, L. S. Shashidhara, and R. A. White The 412 retrotransposon and the development of gonadal mesoderm in Drosophila Development, December 1, 1992; 116(4): 1185 - 1192. [Abstract] [PDF]
|
|
|
|
|
|
S Messmer, A Franke, and R Paro Analysis of the functional role of the Polycomb chromo domain in Drosophila melanogaster. Genes & Dev., July 1, 1992; 6(7): 1241 - 1254. [Abstract] [PDF]
|
|
|
|
|
|
D Moazed and P. O'Farrell Maintenance of the engrailed expression pattern by Polycomb group genes in Drosophila Development, January 11, 1992; 116(3): 805 - 810. [Abstract] [PDF]
|
|
