|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 114, Issue 3 721-727, Copyright © 1992 by Company of Biologists
JOURNAL ARTICLES |
N di Clemente, S Ghaffari, RB Pepinsky, C Pieau, N Josso, RL Cate and B Vigier
Unite de Recherches sur l'Endocrinologie du Developpement, INSERM Ecole Normale Superieure Departement de Biologie, Montrouge, France.
Anti-Mullerian hormone (AMH), also known as Mullerian-inhibiting substance or factor, has previously been shown to sex-reverse the steroidogenic pattern of fetal mammalian ovaries through repression of aromatase biosynthesis. Study of the ontogeny of the response of cyclic AMP-stimulated aromatase activity of rat fetal ovaries to AMH has allowed us to develop a quantitative bioassay for the hormone. Linear responses as a function of the logarithm of AMH concentration were observed over ranges of 0.2-7.5 micrograms/ml for the bovine protein and 0.15-2 micrograms/ml for the human protein, with a maximal decrease in aromatase activity of 90% for both proteins. Under the same in vitro conditions, AMH treatment did not affect cyclic AMP-stimulated fetal rat testicular aromatase activity. Partially purified chick AMH also decreased rat ovarian aromatase activity, allowing us to use this test to study AMH ontogeny in chick gonads. Analysis of the species specificity of AMH repression of ovarian aromatase activity indicated that turtle and rat fetal ovaries responded to AMH of other vertebrate classes, whereas aromatase activity of chick embryo ovaries could be repressed only by the homospecific hormone.
This article has been cited by other articles:
|
|
 |
|
  D. Monniaux, N. d. Clemente, J.-L. Touze, C. Belville, C. Rico, M. Bontoux, J.-Y. Picard, and S. Fabre Intrafollicular Steroids and Anti-Mullerian Hormone During Normal and Cystic Ovarian Follicular Development in the Cow Biol Reprod, August 1, 2008; 79(2): 387 - 396. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Yding Andersen, M. Rosendahl, and A. G. Byskov Concentration of Anti-Mullerian Hormone and Inhibin-B in Relation to Steroids and Age in Follicular Fluid from Small Antral Human Follicles J. Clin. Endocrinol. Metab., June 1, 2008; 93(6): 2344 - 2349. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. S. Hossain, A. Larsson, N. Scherbak, P.-E. Olsson, and L. Orban Zebrafish Androgen Receptor: Isolation, Molecular, and Biochemical Characterization Biol Reprod, February 1, 2008; 78(2): 361 - 369. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Morinaga, D. Saito, S. Nakamura, T. Sasaki, S. Asakawa, N. Shimizu, H. Mitani, M. Furutani-Seiki, M. Tanaka, and H. Kondoh The hotei mutation of medaka in the anti-Mullerian hormone receptor causes the dysregulation of germ cell and sexual development PNAS, June 5, 2007; 104(23): 9691 - 9696. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. S. Wachs, M. S. Coffler, P. J. Malcom, and R. J. Chang Serum Anti-Mullerian Hormone Concentrations Are Not Altered by Acute Administration of Follicle Stimulating Hormone in Polycystic Ovary Syndrome and Normal Women J. Clin. Endocrinol. Metab., May 1, 2007; 92(5): 1871 - 1874. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Shirak, E. Seroussi, A. Cnaani, A. E. Howe, R. Domokhovsky, N. Zilberman, T. D. Kocher, G. Hulata, and M. Ron Amh and Dmrta2 Genes Map to Tilapia (Oreochromis spp.) Linkage Group 23 Within Quantitative Trait Locus Regions for Sex Determination Genetics, November 1, 2006; 174(3): 1573 - 1581. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Y. Andersen and A. G. Byskov Estradiol and Regulation of Anti-Mullerian Hormone, Inhibin-A, and Inhibin-B Secretion: Analysis of Small Antral and Preovulatory Human Follicles' Fluid J. Clin. Endocrinol. Metab., October 1, 2006; 91(10): 4064 - 4069. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Bielinska, S. Kiiveri, H. Parviainen, S. Mannisto, M. Heikinheimo, and D. B. Wilson Gonadectomy-induced Adrenocortical Neoplasia in the Domestic Ferret (Mustela putorius furo) and Laboratory Mouse. Vet. Pathol., February 1, 2006; 43(2): 97 - 117. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Eldar-Geva, E. J. Margalioth, M. Gal, A. Ben-Chetrit, N. Algur, E. Zylber-Haran, B. Brooks, M. Huerta, and I. M. Spitz Serum anti-Mullerian hormone levels during controlled ovarian hyperstimulation in women with polycystic ovaries with and without hyperandrogenism Hum. Reprod., July 1, 2005; 20(7): 1814 - 1819. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Jonard and D. Dewailly The follicular excess in polycystic ovaries, due to intra-ovarian hyperandrogenism, may be the main culprit for the follicular arrest Hum. Reprod. Update, March 1, 2004; 10(2): 107 - 117. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Salva, M. P. Hardy, X.-f. Wu, C. M. Sottas, D. T. MacLaughlin, P. K. Donahoe, and M. M. Lee Mullerian-Inhibiting Substance Inhibits Rat Leydig Cell Regeneration after Ethylene Dimethanesulphonate Ablation Biol Reprod, March 1, 2004; 70(3): 600 - 607. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Fanchin, L. M. Schonauer, C. Righini, N. Frydman, R. Frydman, and J. Taieb Serum anti-Mullerian hormone dynamics during controlled ovarian hyperstimulation Hum. Reprod., February 1, 2003; 18(2): 328 - 332. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R.A. Cushman, C.M. Wahl, and J.E. Fortune Bovine ovarian cortical pieces grafted to chick embryonic membranes: A model for studies on the activation of primordial follicles Hum. Reprod., January 1, 2002; 17(1): 48 - 54. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. A. McGee, R. Smith, N. Spears, M. W. Nachtigal, H. Ingraham, and A. J.W. Hsueh Mullerian Inhibitory Substance Induces Growth of Rat Preantral Ovarian Follicles Biol Reprod, January 1, 2001; 64(1): 293 - 298. [Abstract] [Full Text]
|
|
|
|
|
|
T. Rhen, E. Willingham, J. T. Sakata, and D. Crews Incubation Temperature Influences Sex-Steroid Levels in Juvenile Red-Eared Slider Turtles, Trachemys scripta, a Species with Temperature-Dependent Sex Determination Biol Reprod, November 1, 1999; 61(5): 1275 - 1280. [Abstract] [Full Text]
|
|
|
|
 |
|
 T. Rhen and D. Crews Embryonic Temperature and Gonadal Sex Organize Male-Typical Sexual and Aggressive Behavior in a Lizard with Temperature-Dependent Sex Determination Endocrinology, October 1, 1999; 140(10): 4501 - 4508. [Abstract] [Full Text]
|
|
|
|
|
|
V. Rouiller-Fabre, S. Carmona, R. A. Merhi, R. Cate, R. Habert, and B. Vigier Effect of Anti-Mullerian Hormone on Sertoli and Leydig Cell Functions in Fetal and Immature Rats Endocrinology, March 1, 1998; 139(3): 1213 - 1220. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. M. HAQQ and P. K. DONAHOE Regulation of Sexual Dimorphism in Mammals Physiol Rev, January 1, 1998; 78(1): 1 - 33. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D.èl. C. Eusèbe, N. di Clemente, R. Rey, C. Pieau, B. Vigier, N. Josso, and J.-Y. Picard Cloning and Expression of the Chick Anti-Müllerian Hormone Gene J. Biol. Chem., March 1, 1996; 271(9): 4798 - 4804. [Abstract] [Full Text] [PDF]
|
|
