Development, Vol 115, Issue 1 11-20, Copyright © 1992 by Company of Biologists

JOURNAL ARTICLES

c-ros: the vertebrate homolog of the sevenless tyrosine kinase receptor is tightly regulated during organogenesis in mouse embryonic development

L Tessarollo, L Nagarajan and LF Parada
Molecular Embryology Section, NCI-Frederick Cancer Research and Development Center, MD 21702-1201.

The c-ros proto-oncogene is the vertebrate homologue of the Drosophila sevenless tyrosine kinase receptor. Examination of c-ros mRNA transcripts in the mouse embryo reveals a stringent pattern of expression. Only kidney, intestine and lung exhibit ros-specific RNA using sensitive techniques such as RNAase protection and in situ hybridization. The temporal and spatial arrangement of c-ros transcripts is coincident with the phenotypic induction and proliferation of epithelium during organogenesis of the kidney and intestine. The data provide evidence for a role of c-ros in the obligate cell-cell interactions that characterize the morphogenic induction and proliferation of epithelial cells in the kidney, intestine and lung. The c-ros tyrosine kinase receptor may provide a signal transduction pathway for epithelial-mesenchymal interactions.
CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				A. Charest, E. W. Wilker, M. E. McLaughlin, K. Lane, R. Gowda, S. Coven, K. McMahon, S. Kovach, Y. Feng, M. B. Yaffe, et al. ROS Fusion Tyrosine Kinase Activates a SH2 Domain-Containing Phosphatase-2/Phosphatidylinositol 3-Kinase/Mammalian Target of Rapamycin Signaling Axis to Form Glioblastoma in Mice. Cancer Res., August 1, 2006; 66(15): 7473 - 7481. [Abstract] [Full Text] [PDF]

				K.-H. Shin, M. K. Kang, R. H. Kim, R. Christensen, and N.-H. Park Heterogeneous Nuclear Ribonucleoprotein G Shows Tumor Suppressive Effect against Oral Squamous Cell Carcinoma Cells. Clin. Cancer Res., May 15, 2006; 12(10): 3222 - 3228. [Abstract] [Full Text] [PDF]

				K. M. Schmidt-Ott, J. Yang, X. Chen, H. Wang, N. Paragas, K. Mori, J.-Y. Li, B. Lu, F. Costantini, M. Schiffer, et al. Novel Regulators of Kidney Development from the Tips of the Ureteric Bud J. Am. Soc. Nephrol., July 1, 2005; 16(7): 1993 - 2002. [Abstract] [Full Text] [PDF]

				T. G. Cooper, A. Wagenfeld, G. A. Cornwall, N. Hsia, S. T. Chu, M.-C. Orgebin-Crist, J. Drevet, P. Vernet, C. Avram, E. Nieschlag, et al. Gene and Protein Expression in the Epididymis of Infertile c-ros Receptor Tyrosine Kinase-Deficient Mice Biol Reprod, November 1, 2003; 69(5): 1750 - 1762. [Abstract] [Full Text] [PDF]

				S. Uttamsingh, C. S. Zong, and L.-H. Wang Matrix-independent Activation of Phosphatidylinositol 3-Kinase, Stat3, and Cyclin A-associated Cdk2 Is Essential for Anchorage-independent Growth of v-Ros-transformed Chicken Embryo Fibroblasts J. Biol. Chem., May 23, 2003; 278(21): 18798 - 18810. [Abstract] [Full Text] [PDF]

				A. Wagenfeld, C.-H. Yeung, W. Lehnert, E. Nieschlag, and T. G. Cooper Lack of Glutamate Transporter EAAC1 in the Epididymis of Infertile c-ros Receptor Tyrosine-Kinase Deficient Mice J Androl, November 1, 2002; 23(6): 772 - 782. [Abstract] [Full Text] [PDF]

				C. E. Fisher, L. Michael, M. W. Barnett, and J. A. Davies Erk MAP kinase regulates branching morphogenesis in the developing mouse kidney Development, November 1, 2001; 128(21): 4329 - 4338. [Abstract] [Full Text] [PDF]

				C.-H. Yeung, A. Wagenfeld, E. Nieschlag, and T. G. Cooper The Cause of Infertility of Male c-ros Tyrosine Kinase Receptor Knockout Mice Biol Reprod, August 1, 2000; 63(2): 612 - 618. [Abstract] [Full Text]

				L. A. Mamounas, C. A. Altar, M. E. Blue, D. R. Kaplan, L. Tessarollo, and W. E. Lyons BDNF Promotes the Regenerative Sprouting, But Not Survival, of Injured Serotonergic Axons in the Adult Rat Brain J. Neurosci., January 15, 2000; 20(2): 771 - 782. [Abstract] [Full Text] [PDF]

				C Hartmann and C. Tabin Dual roles of Wnt signaling during chondrogenesis in the chicken limb Development, January 7, 2000; 127(14): 3141 - 3159. [Abstract] [PDF]

				C.-H. Yeung, E. Sonnenberg-Riethmacher, and T. G. Cooper Infertile Spermatozoa of c-ros Tyrosine Kinase Receptor Knockout Mice Show Flagellar Angulation and Maturational Defects in Cell Volume Regulatory Mechanisms Biol Reprod, October 1, 1999; 61(4): 1062 - 1069. [Abstract] [Full Text]

				Z. Bao, B. G. Bruneau, J. G. Seidman, C. E. Seidman, and C. L. Cepko Regulation of Chamber-Specific Gene Expression in the Developing Heart by Irx4 Science, February 19, 1999; 283(5405): 1161 - 1164. [Abstract] [Full Text]

				M. E. Palko, V. Coppola, and L. Tessarollo Evidence for a Role of Truncated trkC Receptor Isoforms in Mouse Development J. Neurosci., January 15, 1999; 19(2): 775 - 782. [Abstract] [Full Text] [PDF]

				M.-J. Tang, D. Worley, M. Sanicola, and G. R. Dressler The RET-Glial Cell-derived Neurotrophic Factor (GDNF) Pathway Stimulates Migration and Chemoattraction of Epithelial Cells J. Cell Biol., September 7, 1998; 142(5): 1337 - 1345. [Abstract] [Full Text] [PDF]

				E Sonnenberg-Riethmacher, B Walter, D Riethmacher, S Godecke, and C Birchmeier The c-ros tyrosine kinase receptor controls regionalization and differentiation of epithelial cells in the epididymis. Genes & Dev., May 15, 1996; 10(10): 1184 - 1193. [Abstract] [PDF]

				C. Nelson, B. Morgan, A. Burke, E Laufer, E DiMambro, L. Murtaugh, E Gonzales, L Tessarollo, L. Parada, and C Tabin Analysis of Hox gene expression in the chick limb bud Development, January 5, 1996; 122(5): 1449 - 1466. [Abstract] [PDF]

				V Marigo, M. Scott, R. Johnson, L. Goodrich, and C. Tabin, Conservation in hedgehog signaling: induction of a chicken patched homolog by Sonic hedgehog in the developing limb Development, January 4, 1996; 122(4): 1225 - 1233. [Abstract] [PDF]

				J.G. Pichel, L. Shen, H.Z. Sheng, A.-C. Granholm, J. Drago, A. Grinberg, E.J. Lee, S.P. Huang, M. Saarma, B.J. Hoffer, et al. GDNF Is Required for Kidney Development and Enteric Innervation Cold Spring Harb Symp Quant Biol, January 1, 1996; 61(0): 445 - 457. [Abstract] [PDF]

				J Davies, M Lyon, J Gallagher, and D Garrod Sulphated proteoglycan is required for collecting duct growth and branching but not nephron formation during kidney development Development, January 5, 1995; 121(5): 1507 - 1517. [Abstract] [PDF]

				L Tessarollo, P Tsoulfas, D Martin-Zanca, D. Gilbert, N. Jenkins, N. Copeland, and L. Parada trkC, a receptor for neurotrophin-3, is widely expressed in the developing nervous system and in non-neuronal tissues Development, January 6, 1993; 118(2): 463 - 475. [Abstract] [PDF]

				B R Stanton, A S Perkins, L Tessarollo, D A Sassoon, and L F Parada Loss of N-myc function results in embryonic lethality and failure of the epithelial component of the embryo to develop. Genes & Dev., December 1, 1992; 6(12a): 2235 - 2247. [Abstract] [PDF]

				L.F. Parada, P. Tsoulfas, L. Tessarollo, J. Blair, S.W. Reid, and D. Soppet The Trk Family of Tyrosine Kinases: Receptors for NGF-related Neurotrophins Cold Spring Harb Symp Quant Biol, January 1, 1992; 57(0): 43 - 51. [Abstract] [PDF]