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Development, Vol 115, Issue 1 313-318, Copyright © 1992 by Company of Biologists

JOURNAL ARTICLES

Synthesis and phosphorylation of uvomorulin during mouse early development

M Sefton, MH Johnson and L Clayton
Department of Anatomy, University of Cambridge, UK.

The cell adhesion molecule, uvomorulin, is synthesised in both the 135 x 10(3) M(r) precursor and 120 x 10(3) M(r) mature forms on maternal mRNA templates in unfertilized and newly fertilized mouse oocytes. Synthesis on maternal message ceases during the 2-cell stage to resume later on mRNA encoded presumptively by the embryonic genome. Uvomorulin is detectable by immunoblotting at all stages upto the blastocyst stage, but shows variations in its total amount and processing with embryonic stage. Whilst only trace levels of phosphorylated uvomorulin are detectable in early and late 4-cell embryos, uvomorulin in 8-cell embryos is phosphorylated.


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© The Company of Biologists Ltd 1992