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Development, Vol 115, Issue 3 737-744, Copyright © 1992 by Company of Biologists
JOURNAL ARTICLES |
FF Del Amo, DE Smith, PJ Swiatek, M Gendron-Maguire, RJ Greenspan, AP McMahon and T Gridley
Department of Cell and Developmental Biology, Roche Research Center, Nutley, NJ 07110.
The Notch gene of Drosophila encodes a large transmembrane protein involved in cell-cell interactions and cell fate decisions in the Drosophila embryo. To determine if a gene homologous to Drosophila Notch plays a role in early mouse development, we screened a mouse embryo cDNA library with probes from the Xenopus Notch homolog, Xotch. A partial cDNA clone encoding the mouse Notch homolog, which we have termed Motch, was used to analyze expression of the Motch gene. Motch transcripts were detected in a wide variety of adult tissues, which included derivatives of all three germ layers. Differentiation of P19 embryonal carcinoma cells into neuronal cell types resulted in increased expression of Motch RNA. In the postimplantation mouse embryo Motch transcripts were first detected in mesoderm at 7.5 days post coitum (dpc). By 8.5 dpc, transcript levels were highest in presomitic mesoderm, mesenchyme and endothelial cells, while much lower levels were detected in neuroepithelium. In contrast, at 9.5 dpc, neuroepithelium was a major site of Motch expression. Transcripts were also abundant in cell types derived from neural crest. These data suggest that the Motch gene plays multiple roles in patterning and differentiation of the early postimplantation mouse embryo.
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R. Conlon, A. Reaume, and J Rossant Notch1 is required for the coordinate segmentation of somites Development, January 5, 1995; 121(5): 1533 - 1545. [Abstract] [PDF]
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A. Newman, J. White, and P. Sternberg The Caenorhabditis elegans lin-12 gene mediates induction of ventral uterine specialization by the anchor cell Development, January 2, 1995; 121(2): 263 - 271. [Abstract] [PDF]
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R. Kopan, J. S. Nye, and H. Weintraub The intracellular domain of mouse Notch: a constitutively activated repressor of myogenesis directed at the basic helix-loop-helix region of MyoD Development, September 1, 1994; 120(9): 2385 - 2396. [Abstract] [PDF]
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J. S. Nye, R. Kopan, and R. Axel An activated Notch suppresses neurogenesis and myogenesis but not gliogenesis in mammalian cells Development, September 1, 1994; 120(9): 2421 - 2430. [Abstract] [PDF]
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P J Swiatek, C E Lindsell, F F del Amo, G Weinmaster, and T Gridley Notch1 is essential for postimplantation development in mice. Genes & Dev., March 15, 1994; 8(6): 707 - 719. [Abstract] [PDF]
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B Jennings, A Preiss, C Delidakis, and S Bray The Notch signalling pathway is required for Enhancer of split bHLH protein expression during neurogenesis in the Drosophila embryo Development, January 12, 1994; 120(12): 3537 - 3548. [Abstract] [PDF]
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R. Diederich, K Matsuno, H Hing, and S Artavanis-Tsakonas Cytosolic interaction between deltex and Notch ankyrin repeats implicates deltex in the Notch signaling pathway Development, January 3, 1994; 120(3): 473 - 481. [Abstract] [PDF]
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K. Fitzgerald, H. A. Wilkinson, and I. Greenwald glp-1 can substitute for lin-12 in specifying cell fate decisions in Caenorhabditis elegans Development, December 1, 1993; 119(4): 1019 - 1027. [Abstract] [PDF]
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P J Swiatek and T Gridley Perinatal lethality and defects in hindbrain development in mice homozygous for a targeted mutation of the zinc finger gene Krox20. Genes & Dev., November 1, 1993; 7(11): 2071 - 2084. [Abstract] [PDF]
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T Lieber, S Kidd, E Alcamo, V Corbin, and M W Young Antineurogenic phenotypes induced by truncated Notch proteins indicate a role in signal transduction and may point to a novel function for Notch in nuclei. Genes & Dev., October 1, 1993; 7(10): 1949 - 1965. [Abstract] [PDF]
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L Shum, Y Sakakura, P Bringas, W Luo, M. Snead, M Mayo, C Crohin, S Millar, Z Werb, S Buckley, et al. EGF abrogation-induced fusilli-form dysmorphogenesis of Meckel's cartilage during embryonic mouse mandibular morphogenesis in vitro Development, January 7, 1993; 118(3): 903 - 917. [Abstract] [PDF]
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D. E. Smith, F. Franco del Amo, and T. Gridley Isolation of Sna, a mouse gene homologous to the Drosophila genes snail and escargot: its expression pattern suggests multiple roles during postimplantation development Development, December 1, 1992; 116(4): 1033 - 1039. [Abstract] [PDF]
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J. Galceran, S.-C. Hsu, and R. Grosschedl Rescue of a Wnt mutation by an activated form of LEF-1: Regulation of maintenance but not initiation of Brachyury expression PNAS, July 17, 2001; 98(15): 8668 - 8673. [Abstract] [Full Text] [PDF]
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T. Mizutani, Y. Taniguchi, T. Aoki, N. Hashimoto, and T. Honjo Conservation of the biochemical mechanisms of signal transduction among mammalian Notch family members PNAS, July 31, 2001; 98(16): 9026 - 9031. [Abstract] [Full Text] [PDF]
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