|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 115, Issue 3 737-744, Copyright © 1992 by Company of Biologists
JOURNAL ARTICLES |
FF Del Amo, DE Smith, PJ Swiatek, M Gendron-Maguire, RJ Greenspan, AP McMahon and T Gridley
Department of Cell and Developmental Biology, Roche Research Center, Nutley, NJ 07110.
The Notch gene of Drosophila encodes a large transmembrane protein involved in cell-cell interactions and cell fate decisions in the Drosophila embryo. To determine if a gene homologous to Drosophila Notch plays a role in early mouse development, we screened a mouse embryo cDNA library with probes from the Xenopus Notch homolog, Xotch. A partial cDNA clone encoding the mouse Notch homolog, which we have termed Motch, was used to analyze expression of the Motch gene. Motch transcripts were detected in a wide variety of adult tissues, which included derivatives of all three germ layers. Differentiation of P19 embryonal carcinoma cells into neuronal cell types resulted in increased expression of Motch RNA. In the postimplantation mouse embryo Motch transcripts were first detected in mesoderm at 7.5 days post coitum (dpc). By 8.5 dpc, transcript levels were highest in presomitic mesoderm, mesenchyme and endothelial cells, while much lower levels were detected in neuroepithelium. In contrast, at 9.5 dpc, neuroepithelium was a major site of Motch expression. Transcripts were also abundant in cell types derived from neural crest. These data suggest that the Motch gene plays multiple roles in patterning and differentiation of the early postimplantation mouse embryo.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati 
Twitter What's this?
This article has been cited by other articles:
|
|
 |
|
  M. R. Swift and B. M. Weinstein Arterial-Venous Specification During Development Circ. Res., March 13, 2009; 104(5): 576 - 588. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. A. Venkatesh, K.-S. Park, A. Harrington, L. Miceli-Libby, J. K. Yoon, and L. Liaw Cardiovascular and Hematopoietic Defects Associated With Notch1 Activation in Embryonic Tie2-Expressing Populations Circ. Res., August 15, 2008; 103(4): 423 - 431. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Bolos, J. Grego-Bessa, and J. L. de la Pompa Notch Signaling in Development and Cancer Endocr. Rev., May 1, 2007; 28(3): 339 - 363. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. K. Williams, J.-L. Li, M. Murga, A. L. Harris, and G. Tosato Up-regulation of the Notch ligand Delta-like 4 inhibits VEGF-induced endothelial cell function Blood, February 1, 2006; 107(3): 931 - 939. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. P. Limbourg, K. Takeshita, F. Radtke, R. T. Bronson, M. T. Chin, and J. K. Liao Essential Role of Endothelial Notch1 in Angiogenesis Circulation, April 12, 2005; 111(14): 1826 - 1832. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. L. Hahn, J. Johnson, B. J. Beres, S. Howard, and J. Wilson-Rawls Lunatic fringe null female mice are infertile due to defects in meiotic maturation Development, February 15, 2005; 132(4): 817 - 828. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. K. Hadland, S. S. Huppert, J. Kanungo, Y. Xue, R. Jiang, T. Gridley, R. A. Conlon, A. M. Cheng, R. Kopan, and G. D. Longmore A requirement for Notch1 distinguishes 2 phases of definitive hematopoiesis during development Blood, November 15, 2004; 104(10): 3097 - 3105. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. T. Tetzlaff, W. Yu, M. Li, P. Zhang, M. Finegold, K. Mahon, J. W. Harper, R. J. Schwartz, and S. J. Elledge Inaugural Article, From The Cover: Defective cardiovascular development and elevated cyclin E and Notch proteins in mice lacking the Fbw7 F-box protein PNAS, March 9, 2004; 101(10): 3338 - 3345. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. A. Timmerman, J. Grego-Bessa, A. Raya, E. Bertran, J. M. Perez-Pomares, J. Diez, S. Aranda, S. Palomo, F. McCormick, J. C. Izpisua-Belmonte, et al. Notch promotes epithelial-mesenchymal transition during cardiac development and oncogenic transformation Genes & Dev., January 1, 2004; 18(1): 99 - 115. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Schroeder, S. T. Fraser, M. Ogawa, S. Nishikawa, C. Oka, G. W. Bornkamm, S.-I. Nishikawa, T. Honjo, and U. Just Recombination signal sequence-binding protein Jkappa alters mesodermal cell fate decisions by suppressing cardiomyogenesis PNAS, April 1, 2003; 100(7): 4018 - 4023. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Iso, Y. Hamamori, and L. Kedes Notch Signaling in Vascular Development Arterioscler. Thromb. Vasc. Biol., April 1, 2003; 23(4): 543 - 553. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Lutolf, F. Radtke, M. Aguet, U. Suter, and V. Taylor Notch1 is required for neuronal and glial differentiation in the cerebellum Development, March 3, 2003; 129(2): 373 - 385. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Kunisato, S. Chiba, E. Nakagami-Yamaguchi, K. Kumano, T. Saito, S. Masuda, T. Yamaguchi, M. Osawa, R. Kageyama, H. Nakauchi, et al. HES-1 preserves purified hematopoietic stem cells ex vivo and accumulates side population cells in vivo Blood, March 1, 2003; 101(5): 1777 - 1783. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Varnum-Finney, C. Brashem-Stein, and I. D. Bernstein Combined effects of Notch signaling and cytokines induce a multiple log increase in precursors with lymphoid and myeloid reconstituting ability Blood, March 1, 2003; 101(5): 1784 - 1789. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. K. H. Przemeck, U. Heinzmann, J. Beckers, and M. Hrabe de Angelis Node and midline defects are associated with left-right development in Delta1 mutant embryos Development, January 1, 2003; 130(1): 3 - 13. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. E. Berechid, M. Kitzmann, D. R. Foltz, A. H. Roach, D. Seiffert, L. A. Thompson, R. E. Olson, A. Bernstein, D. B. Donoviel, and J. S. Nye Identification and Characterization of Presenilin-independent Notch Signaling J. Biol. Chem., March 1, 2002; 277(10): 8154 - 8165. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B.M. WEINSTEIN and N.D. LAWSON Arteries, Veins, Notch, and VEGF Cold Spring Harb Symp Quant Biol, January 1, 2002; 67(0): 155 - 162. [Abstract] [PDF]
|
|
|
|
|
|
N. D. Lawson, N. Scheer, V. N. Pham, C.-H. Kim, A. B. Chitnis, J. A. Campos-Ortega, and B. M. Weinstein Notch signaling is required for arterial-venous differentiation during embryonic vascular development Development, October 1, 2001; 128(19): 3675 - 3683. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Mizutani, Y. Taniguchi, T. Aoki, N. Hashimoto, and T. Honjo Conservation of the biochemical mechanisms of signal transduction among mammalian Notch family members PNAS, July 13, 2001; (2001) 161269998. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Galceran, S.-C. Hsu, and R. Grosschedl Rescue of a Wnt mutation by an activated form of LEF-1: Regulation of maintenance but not initiation of Brachyury expression PNAS, July 5, 2001; (2001) 151258098. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Gridley Notch signaling during vascular development PNAS, May 8, 2001; 98(10): 5377 - 5378. [Full Text] [PDF]
|
|
|
|
 |
|
 S. Jeffries and A. J. Capobianco Neoplastic Transformation by Notch Requires Nuclear Localization Mol. Cell. Biol., June 1, 2000; 20(11): 3928 - 3941. [Abstract] [Full Text]
|
|
|
|
|
|
L. T. Krebs, Y. Xue, C. R. Norton, J. R. Shutter, M. Maguire, J. P. Sundberg, D. Gallahan, V. Closson, J. Kitajewski, R. Callahan, et al. Notch signaling is essential for vascular morphogenesis in mice Genes & Dev., June 1, 2000; 14(11): 1343 - 1352. [Abstract] [Full Text]
|
|
|
|
|
|
M. Rones, K. McLaughlin, M Raffin, and M Mercola Serrate and Notch specify cell fates in the heart field by suppressing cardiomyogenesis Development, January 9, 2000; 127(17): 3865 - 3876. [Abstract] [PDF]
|
|
|
|
|
|
T Ito, N Udaka, T Yazawa, K Okudela, H Hayashi, T Sudo, F Guillemot, R Kageyama, and H Kitamura Basic helix-loop-helix transcription factors regulate the neuroendocrine differentiation of fetal mouse pulmonary epithelium Development, January 9, 2000; 127(18): 3913 - 3921. [Abstract] [PDF]
|
|
|
|
|
|
M Handler, X Yang, and J Shen Presenilin-1 regulates neuronal differentiation during neurogenesis Development, January 6, 2000; 127(12): 2593 - 2606. [Abstract] [PDF]
|
|
|
|
|
|
J. Wilson-Rawls, J. D. Molkentin, B. L. Black, and E. N. Olson Activated Notch Inhibits Myogenic Activity of the MADS-Box Transcription Factor Myocyte Enhancer Factor 2C Mol. Cell. Biol., April 1, 1999; 19(4): 2853 - 2862. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y Hamada, Y Kadokawa, M Okabe, M Ikawa, J. Coleman, and Y Tsujimoto Mutation in ankyrin repeats of the mouse Notch2 gene induces early embryonic lethality Development, January 8, 1999; 126(15): 3415 - 3424. [Abstract] [PDF]
|
|
|
|
|
|
C Takke and J. Campos-Ortega her1, a zebrafish pair-rule like gene, acts downstream of notch signalling to control somite development Development, January 7, 1999; 126(13): 3005 - 3014. [Abstract] [PDF]
|
|
|
|
|
|
H. K. Kim and G. Siu The Notch Pathway Intermediate HES-1 Silences CD4 Gene Expression Mol. Cell. Biol., December 1, 1998; 18(12): 7166 - 7175. [Abstract] [Full Text]
|
|
|
|
|
|
W. Shawlot, J. M. Deng, and R. R. Behringer Expression of the mouse cerberus-related gene, Cerr1, suggests a role in anterior neural induction and somitogenesis PNAS, May 26, 1998; 95(11): 6198 - 6203. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Bigas, D. I. K. Martin, and L. A. Milner Notch1 and Notch2 Inhibit Myeloid Differentiation in Response to Different Cytokines Mol. Cell. Biol., April 1, 1998; 18(4): 2324 - 2333. [Abstract] [Full Text]
|
|
|
|
|
|
K. Goh, J. Yang, and R. Hynes Mesodermal defects and cranial neural crest apoptosis in alpha5 integrin-null embryos Development, January 11, 1997; 124(21): 4309 - 4319. [Abstract] [PDF]
|
|
|
|
|
|
S. Dunwoodie, D Henrique, S. Harrison, and R. Beddington Mouse Dll3: a novel divergent Delta gene which may complement the function of other Delta homologues during early pattern formation in the mouse embryo Development, January 8, 1997; 124(16): 3065 - 3076. [Abstract] [PDF]
|
|
|
|
|
|
S. Johnston, C Rauskolb, R Wilson, B Prabhakaran, K. Irvine, and T. Vogt A family of mammalian Fringe genes implicated in boundary determination and the Notch pathway Development, January 6, 1997; 124(11): 2245 - 2254. [Abstract] [PDF]
|
|
|
|
|
|
J. de la Pompa, A Wakeham, K. Correia, E Samper, S Brown, R. Aguilera, T Nakano, T Honjo, T. Mak, J Rossant, et al. Conservation of the Notch signalling pathway in mammalian neurogenesis Development, January 3, 1997; 124(6): 1139 - 1148. [Abstract] [PDF]
|
|
|
|
|
|
W. Jen, D Wettstein, D Turner, A Chitnis, and C Kintner The Notch ligand, X-Delta-2, mediates segmentation of the paraxial mesoderm in Xenopus embryos Development, January 3, 1997; 124(6): 1169 - 1178. [Abstract] [PDF]
|
|
|
|
|
|
L. A. Milner, A. Bigas, R. Kopan, C. Brashem-Stein, I. D. Bernstein, and D. I. K. Martin Inhibition of granulocytic differentiation by mNotch1 PNAS, November 12, 1996; 93(23): 13014 - 13019. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L Girard, Z Hanna, N Beaulieu, C D Hoemann, C Simard, C A Kozak, and P Jolicoeur Frequent provirus insertional mutagenesis of Notch1 in thymomas of MMTVD/myc transgenic mice suggests a collaboration of c-myc and Notch1 for oncogenesis. Genes & Dev., August 1, 1996; 10(15): 1930 - 1944. [Abstract] [PDF]
|
|
|
|
|
|
Y. Jiang, M Brand, C. Heisenberg, D Beuchle, M Furutani-Seiki, R. Kelsh, R. Warga, M Granato, P Haffter, M Hammerschmidt, et al. Mutations affecting neurogenesis and brain morphology in the zebrafish, Danio rerio Development, January 12, 1996; 123(1): 205 - 216. [Abstract] [PDF]
|
|
|
|
|
|
D. Raible and J. Eisen Regulative interactions in zebrafish neural crest Development, January 2, 1996; 122(2): 501 - 507. [Abstract] [PDF]
|
|
|
|
 |
|
 S Artavanis-Tsakonas, K Matsuno, and M. Fortini Notch signaling Science, April 14, 1995; 268(5208): 225 - 232. [Abstract] [PDF]
|
|
|
|
|
|
C. Austin, D. Feldman, J. Ida, and C. Cepko Vertebrate retinal ganglion cells are selected from competent progenitors by the action of Notch Development, January 11, 1995; 121(11): 3637 - 3650. [Abstract] [PDF]
|
|
|
|
|
|
B Bettenhausen, M Hrabe de Angelis, D Simon, J. Guenet, and A Gossler Transient and restricted expression during mouse embryogenesis of Dll1, a murine gene closely related to Drosophila Delta Development, January 8, 1995; 121(8): 2407 - 2418. [Abstract] [PDF]
|
|
|
|
|
|
R. Conlon, A. Reaume, and J Rossant Notch1 is required for the coordinate segmentation of somites Development, January 5, 1995; 121(5): 1533 - 1545. [Abstract] [PDF]
|
|
|
|
|
|
A. Newman, J. White, and P. Sternberg The Caenorhabditis elegans lin-12 gene mediates induction of ventral uterine specialization by the anchor cell Development, January 2, 1995; 121(2): 263 - 271. [Abstract] [PDF]
|
|
|
|
|
|
R. Kopan, J. S. Nye, and H. Weintraub The intracellular domain of mouse Notch: a constitutively activated repressor of myogenesis directed at the basic helix-loop-helix region of MyoD Development, September 1, 1994; 120(9): 2385 - 2396. [Abstract] [PDF]
|
|
|
|
|
|
J. S. Nye, R. Kopan, and R. Axel An activated Notch suppresses neurogenesis and myogenesis but not gliogenesis in mammalian cells Development, September 1, 1994; 120(9): 2421 - 2430. [Abstract] [PDF]
|
|
|
|
|
|
P J Swiatek, C E Lindsell, F F del Amo, G Weinmaster, and T Gridley Notch1 is essential for postimplantation development in mice. Genes & Dev., March 15, 1994; 8(6): 707 - 719. [Abstract] [PDF]
|
|
|
|
|
|
B Jennings, A Preiss, C Delidakis, and S Bray The Notch signalling pathway is required for Enhancer of split bHLH protein expression during neurogenesis in the Drosophila embryo Development, January 12, 1994; 120(12): 3537 - 3548. [Abstract] [PDF]
|
|
|
|
|
|
R. Diederich, K Matsuno, H Hing, and S Artavanis-Tsakonas Cytosolic interaction between deltex and Notch ankyrin repeats implicates deltex in the Notch signaling pathway Development, January 3, 1994; 120(3): 473 - 481. [Abstract] [PDF]
|
|
|
|
|
|
J. Aster, W. Pear, R. Hasserjian, H. Erba, F. Davi, B. Luo, M. Scott, D. Baltimore, and J. Sklar Functional Analysis of the TAN-1 Gene, a Human Homolog of Drosophila Notch Cold Spring Harb Symp Quant Biol, January 1, 1994; 59(0): 125 - 136. [Abstract] [PDF]
|
|
|
|
|
|
K. Fitzgerald, H. A. Wilkinson, and I. Greenwald glp-1 can substitute for lin-12 in specifying cell fate decisions in Caenorhabditis elegans Development, December 1, 1993; 119(4): 1019 - 1027. [Abstract] [PDF]
|
|
|
|
|
|
P J Swiatek and T Gridley Perinatal lethality and defects in hindbrain development in mice homozygous for a targeted mutation of the zinc finger gene Krox20. Genes & Dev., November 1, 1993; 7(11): 2071 - 2084. [Abstract] [PDF]
|
|
|
|
|
|
T Lieber, S Kidd, E Alcamo, V Corbin, and M W Young Antineurogenic phenotypes induced by truncated Notch proteins indicate a role in signal transduction and may point to a novel function for Notch in nuclei. Genes & Dev., October 1, 1993; 7(10): 1949 - 1965. [Abstract] [PDF]
|
|
|
|
|
|
L Shum, Y Sakakura, P Bringas, W Luo, M. Snead, M Mayo, C Crohin, S Millar, Z Werb, S Buckley, et al. EGF abrogation-induced fusilli-form dysmorphogenesis of Meckel's cartilage during embryonic mouse mandibular morphogenesis in vitro Development, January 7, 1993; 118(3): 903 - 917. [Abstract] [PDF]
|
|
|
|
|
|
D. E. Smith, F. Franco del Amo, and T. Gridley Isolation of Sna, a mouse gene homologous to the Drosophila genes snail and escargot: its expression pattern suggests multiple roles during postimplantation development Development, December 1, 1992; 116(4): 1033 - 1039. [Abstract] [PDF]
|
|
|
|
|
|
J. Galceran, S.-C. Hsu, and R. Grosschedl Rescue of a Wnt mutation by an activated form of LEF-1: Regulation of maintenance but not initiation of Brachyury expression PNAS, July 17, 2001; 98(15): 8668 - 8673. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Mizutani, Y. Taniguchi, T. Aoki, N. Hashimoto, and T. Honjo Conservation of the biochemical mechanisms of signal transduction among mammalian Notch family members PNAS, July 31, 2001; 98(16): 9026 - 9031. [Abstract] [Full Text] [PDF]
|
|
