|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 115, Issue 4 913-922, Copyright © 1992 by Company of Biologists
JOURNAL ARTICLES |
T Xu, LA Caron, RG Fehon and S Artavanis-Tsakonas
Howard Hughes Medical Institute, Yale University, Department of Cell Biology, New Haven, CT 06536-0812.
The Notch gene in Drosophila encodes a transmembrane protein with homology to EGF that, in a variety of tissues, appears to mediate cell interactions necessary for cell fate choices. Here we demonstrate that oogenesis and spermatogenesis depend on Notch. We examine the phenotypes of the temperature-sensitive Notch allele, Nts1, and, using a monoclonal antibody, determine the cellular and subcellular distribution of Notch protein during oogenesis. We show that Nts1 is associated with a missense mutation in the extracellular, EGF homologous region of Notch and that at non-permissive temperatures oogenesis is blocked and the subcellular distribution of the protein is altered. In wild-type ovaries, Notch protein is found on the apical surface of somatically derived follicle cells, while in the germline-derived cells the protein is not polarized. These findings are discussed in view of the hypothesis that Notch acts as a multifunctional receptor to mediate developmentally important cell interactions.
This article has been cited by other articles:
|
|
 |
|
  A.-C. Tien, A. Rajan, K. L. Schulze, H. D. Ryoo, M. Acar, H. Steller, and H. J. Bellen Ero1L, a thiol oxidase, is required for Notch signaling through cysteine bridge formation of the Lin12-Notch repeats in Drosophila melanogaster J. Cell Biol., September 22, 2008; 182(6): 1113 - 1125. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Furriols, G. Ventura, and J. Casanova Two distinct but convergent groups of cells trigger Torso receptor tyrosine kinase activation by independently expressing torso-like PNAS, July 10, 2007; 104(28): 11660 - 11665. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X. Song, G. B. Call, D. Kirilly, and T. Xie Notch signaling controls germline stem cell niche formation in the Drosophila ovary Development, March 15, 2007; 134(6): 1071 - 1080. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. M. O'Reilly, A. C. Ballew, B. Miyazawa, H. Stocker, E. Hafen, and M. A. Simon Csk differentially regulates Src64 during distinct morphological events in Drosophila germ cells Development, July 15, 2006; 133(14): 2627 - 2638. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Gilboa and R. Lehmann How different is Venus from Mars? The genetics of germ-line stem cells in Drosophila females and males Development, October 15, 2004; 131(20): 4895 - 4905. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Sakamoto, S. Yamaguchi, R. Ando, A. Miyawaki, Y. Kabasawa, M. Takagi, C. L. Li, B. Perbal, and K.-i. Katsube The Nephroblastoma Overexpressed Gene (NOV/ccn3) Protein Associates with Notch1 Extracellular Domain and Inhibits Myoblast Differentiation via Notch Signaling Pathway J. Biol. Chem., August 9, 2002; 277(33): 29399 - 29405. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W.-M. Deng, C. Althauser, and H. Ruohola-Baker Notch-Delta signaling induces a transition from mitotic cell cycle to endocycle in Drosophila follicle cells Development, December 1, 2001; 128(23): 4737 - 4746. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Vollrath, K. J. Fitzgerald, and P. Leder A Murine Homologue of the Drosophila brainiac Gene Shows Homology to Glycosyltransferases and Is Required for Preimplantation Development of the Mouse Mol. Cell. Biol., August 15, 2001; 21(16): 5688 - 5697. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Grammont and K. D. Irvine fringe and Notch specify polar cell fate during Drosophila oogenesis Development, June 15, 2001; 128(12): 2243 - 2253. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. L.-S. a. D. St. Johnston Delta signaling from the germ line controls the proliferation and differentiation of the somatic follicle cells during Drosophila oogenesis Genes & Dev., June 1, 2001; 15(11): 1393 - 1405. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D Zhao, D Clyde, and M Bownes Expression of fringe is down regulated by Gurken/Epidermal Growth Factor Receptor signalling and is required for the morphogenesis of ovarian follicle cells J. Cell Sci., January 11, 2000; 113(21): 3781 - 3794. [Abstract] [PDF]
|
|
|
|
|
|
D. C. Zarnescu and G. H. Thomas Apical Spectrin Is Essential for Epithelial Morphogenesis but Not Apicobasal Polarity in Drosophila J. Cell Biol., September 6, 1999; 146(5): 1075 - 1086. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. M. Jackson and C. A. Berg Soma-to-Germline Interactions During Drosophila Oogenesis Are Influenced by Dose-Sensitive Interactions Between cut and the Genes cappuccino, ovarian tumor and agnostic Genetics, September 1, 1999; 153(1): 289 - 303. [Abstract] [Full Text]
|
|
|
|
|
|
C. S. Wesley Notch and Wingless Regulate Expression of Cuticle Patterning Genes Mol. Cell. Biol., August 1, 1999; 19(8): 5743 - 5758. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Tworoger, M. K. Larkin, Z. Bryant, and H. Ruohola-Baker Mosaic Analysis in the Drosophila Ovary Reveals a Common Hedgehog-Inducible Precursor Stage for Stalk and Polar Cells Genetics, February 1, 1999; 151(2): 739 - 748. [Abstract] [Full Text]
|
|
|
|
|
|
W Deng, K Leaper, and M Bownes A targeted gene silencing technique shows that Drosophila myosin VI is required for egg chamber and imaginal disc morphogenesis J. Cell Sci., January 11, 1999; 112(21): 3677 - 3690. [Abstract] [PDF]
|
|
|
|
|
|
T Ikeya and S Hayashi Interplay of Notch and FGF signaling restricts cell fate and MAPK activation in the Drosophila trachea Development, January 10, 1999; 126(20): 4455 - 4463. [Abstract] [PDF]
|
|
|
|
|
|
C Takke and J. Campos-Ortega her1, a zebrafish pair-rule like gene, acts downstream of notch signalling to control somite development Development, January 7, 1999; 126(13): 3005 - 3014. [Abstract] [PDF]
|
|
|
|
|
|
F. King and H Lin Somatic signaling mediated by fs(1)Yb is essential for germline stem cell maintenance during Drosophila oogenesis Development, January 5, 1999; 126(9): 1833 - 1844. [Abstract] [PDF]
|
|
|
|
|
|
D. N. Cox, A. Chao, J. Baker, L. Chang, D. Qiao, and H. Lin A novel class of evolutionarily conserved genes defined by piwi are essential for stem cell self-renewal Genes & Dev., December 1, 1998; 12(23): 3715 - 3727. [Abstract] [Full Text]
|
|
|
|
|
|
A Gonzalez-Reyes and D St Johnston Patterning of the follicle cell epithelium along the anterior-posterior axis during Drosophila oogenesis Development, January 8, 1998; 125(15): 2837 - 2846. [Abstract] [PDF]
|
|
|
|
|
|
A Majumdar, R Nagaraj, and U Banerjee strawberry notch encodes a conserved nuclear protein that functions downstream of Notch and regulates gene expression along the developing wing margin of Drosophila. Genes & Dev., May 15, 1997; 11(10): 1341 - 1353. [Abstract] [PDF]
|
|
|
|
|
|
M Grammont, B Dastugue, and J. Couderc The Drosophila toucan (toc) gene is required in germline cells for the somatic cell patterning during oogenesis Development, January 12, 1997; 124(24): 4917 - 4926. [Abstract] [PDF]
|
|
|
|
|
|
S Frankel, E. Sigel, C Craig, S. Elgin, M. Mooseker, and S Artavanis-Tsakonas An actin-related protein in Drosophila colocalizes with heterochromatin protein 1 in pericentric heterochromatin J. Cell Sci., January 9, 1997; 110(17): 1999 - 2012. [Abstract] [PDF]
|
|
|
|
|
|
D. Sherwood and D. McClay Identification and localization of a sea urchin Notch homologue: insights into vegetal plate regionalization and Notch receptor regulation Development, January 9, 1997; 124(17): 3363 - 3374. [Abstract] [PDF]
|
|
|
|
|
|
S. Jackson and K Blochlinger cut interacts with Notch and protein kinase A to regulate egg chamber formation and to maintain germline cyst integrity during Drosophila oogenesis Development, January 9, 1997; 124(18): 3663 - 3672. [Abstract] [PDF]
|
|
|
|
|
|
R. Fleming, Y Gu, and N. Hukriede Serrate-mediated activation of Notch is specifically blocked by the product of the gene fringe in the dorsal compartment of the Drosophila wing imaginal disc Development, January 8, 1997; 124(15): 2973 - 2981. [Abstract] [PDF]
|
|
|
|
|
|
J. Lee, E Brandin, D Branton, and L. Goldstein alpha-Spectrin is required for ovarian follicle monolayer integrity in Drosophila melanogaster Development, January 1, 1997; 124(2): 353 - 362. [Abstract] [PDF]
|
|
|
|
|
|
S Goode, M Melnick, T. Chou, and N Perrimon The neurogenic genes egghead and brainiac define a novel signaling pathway essential for epithelial morphogenesis during Drosophila oogenesis Development, January 12, 1996; 122(12): 3863 - 3879. [Abstract] [PDF]
|
|
|
|
|
|
M. Larkin, K Holder, C Yost, E Giniger, and H Ruohola-Baker Expression of constitutively active Notch arrests follicle cells at a precursor stage during Drosophila oogenesis and disrupts the anterior-posterior axis of the oocyte Development, January 11, 1996; 122(11): 3639 - 3650. [Abstract] [PDF]
|
|
|
|
|
|
M Gho, M Lecourtois, G Geraud, J. Posakony, and F Schweisguth Subcellular localization of Suppressor of Hairless in Drosophila sense organ cells during Notch signalling Development, January 6, 1996; 122(6): 1673 - 1682. [Abstract] [PDF]
|
|
|
|
|
|
A. Forbes, H Lin, P. Ingham, and A. Spradling hedgehog is required for the proliferation and specification of ovarian somatic cells prior to egg chamber formation in Drosophila Development, January 4, 1996; 122(4): 1125 - 1135. [Abstract] [PDF]
|
|
|
|
 |
|
 S Artavanis-Tsakonas, K Matsuno, and M. Fortini Notch signaling Science, April 14, 1995; 268(5208): 225 - 232. [Abstract] [PDF]
|
|
|
|
|
|
R. Dirkx Jr., A. Thomas, L. Li, Åk. Lernmark, R. S. Sherwin, P. De Camilli, and M. Solimena Targeting of the 67-kDa Isoform of Glutamic Acid Decarboxylase to Intracellular Organelles Is Mediated by Its Interaction with the NH(2)-terminal Region of the 65-kDa Isoform of Glutamic Acid Decarboxylase J. Biol. Chem., February 3, 1995; 270(5): 2241 - 2246. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y Gu, N. Hukriede, and R. Fleming Serrate expression can functionally replace Delta activity during neuroblast segregation in the Drosophila embryo Development, January 3, 1995; 121(3): 855 - 865. [Abstract] [PDF]
|
|
|
|
|
|
B Jennings, A Preiss, C Delidakis, and S Bray The Notch signalling pathway is required for Enhancer of split bHLH protein expression during neurogenesis in the Drosophila embryo Development, January 12, 1994; 120(12): 3537 - 3548. [Abstract] [PDF]
|
|
|
|
|
|
I. Moskowitz, S. Gendreau, and J. Rothman Combinatorial specification of blastomere identity by glp-1-dependent cellular interactions in the nematode Caenorhabditis elegans Development, January 11, 1994; 120(11): 3325 - 3338. [Abstract] [PDF]
|
|
|
|
|
|
R. Diederich, K Matsuno, H Hing, and S Artavanis-Tsakonas Cytosolic interaction between deltex and Notch ankyrin repeats implicates deltex in the Notch signaling pathway Development, January 3, 1994; 120(3): 473 - 481. [Abstract] [PDF]
|
|
|
|
|
|
C. Cummings and C Cronmiller The daughterless gene functions together with Notch and Delta in the control of ovarian follicle development in Drosophila Development, January 2, 1994; 120(2): 381 - 394. [Abstract] [PDF]
|
|
|
|
|
|
T. Menne and C Klambt The formation of commissures in the Drosophila CNS depends on the midline cells and on the Notch gene Development, January 1, 1994; 120(1): 123 - 133. [Abstract] [PDF]
|
|
|
|
|
|
T Lieber, S Kidd, E Alcamo, V Corbin, and M W Young Antineurogenic phenotypes induced by truncated Notch proteins indicate a role in signal transduction and may point to a novel function for Notch in nuclei. Genes & Dev., October 1, 1993; 7(10): 1949 - 1965. [Abstract] [PDF]
|
|
|
|
|
|
C. Coyle-Thompson and U Banerjee The strawberry notch gene functions with Notch in common developmental pathways Development, January 10, 1993; 119(2): 377 - 395. [Abstract] [PDF]
|
|
|
|
|
|
P Heitzler and P Simpson Altered epidermal growth factor-like sequences provide evidence for a role of Notch as a receptor in cell fate decisions Development, January 3, 1993; 117(3): 1113 - 1123. [Abstract] [PDF]
|
|
|
|
|
|
S. K. Park, S. A. Sedore, C. Cronmiller, and J. Hirsh Type II cAMP-dependent Protein Kinase-deficient Drosophila Are Viable but Show Developmental, Circadian, and Drug Response Phenotypes J. Biol. Chem., June 30, 2000; 275(27): 20588 - 20596. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. E. Kiernan, N. Ahituv, H. Fuchs, R. Balling, K. B. Avraham, K. P. Steel, and M. Hrabe de Angelis The Notch ligand Jagged1 is required for inner ear sensory development PNAS, March 27, 2001; 98(7): 3873 - 3878. [Abstract] [Full Text] [PDF]
|
|
