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Development, Vol 116, Issue 1 239-247, Copyright © 1992 by Company of Biologists

JOURNAL ARTICLES

Drosophila PS2 integrin mediates RGD-dependent cell-matrix interactions

TA Bunch and DL Brower
Department of Molecular and Cellular Biology, University of Arizona, Tucson 85721.

Integrins are a family of transmembrane glycoproteins that mediate cell-matrix and cell-cell interactions. We have transfected cultured Drosophila cells with genes that express the Drosophila PS2 integrin. We demonstrate that this integrin is expressed on the surface of the cells and can mediate cell spreading on an undefined component of fetal calf serum or on the purified vertebrate matrix molecules vitronectin and fibronectin. Additionally, PS2 integrin can cause cell spreading on RGD peptide. The spreading on matrix components or RGD peptide can be inhibited by soluble RGD peptide and is dependent on divalent cations.
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© The Company of Biologists Ltd 1992