|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 116, Issue 1 31-40, Copyright © 1992 by Company of Biologists
JOURNAL ARTICLES |
Y Rao, R Bodmer, LY Jan and YN Jan
Howard Hughes Medical Institute, University of California, San Francisco 94143-0724.
big brain (bib) is one of the six known zygotic neurogenic genes involved in the decision of an ectodermal cell to take on the neurogenic or the epidermogenic cell fate. Previous studies suggest that bib functions in a pathway separate from the one involving Notch and other known neurogenic genes. For a better understanding of the bib function, it is essential first to characterize the mutant phenotype in detail. Our mutant analyses show that loss of bib function approximately doubles the number of neuronal precursors and their progeny cells in the embryonic peripheral nervous system. Mosaic studies reveal a hypertrophy of sensory bristles in bib mutant patches in adult flies. Our observations are compatible with a function of bib in specifying neuronal precursors of both the embryonic and adult sensory nervous system. This is in contrast to the function of Notch, which continues to be required at multiple stages of neural development subsequent to this initial determination event.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati 
Twitter What's this?
This article has been cited by other articles:
|
|
 |
|
  T. Weil, J. Korb, and M. Rehli Comparison of Queen-Specific Gene Expression in Related Lower Termite Species Mol. Biol. Evol., August 1, 2009; 26(8): 1841 - 1850. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. J. Yool Aquaporins: Multiple Roles in the Central Nervous System Neuroscientist, October 1, 2007; 13(5): 470 - 485. [Abstract] [PDF]
|
|
|
|
 |
|
 G. M. Yanochko and A. J. Yool Regulated Cationic Channel Function in Xenopus Oocytes Expressing Drosophila Big Brain J. Neurosci., April 1, 2002; 22(7): 2530 - 2540. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Abdelilah-Seyfried, Y.-M. Chan, C. Zeng, N. J. Justice, S. Younger-Shepherd, L. E. Sharp, S. Barbel, S. A. Meadows, L. Y. Jan, and Y. N. Jan A Gain-of-Function Screen for Genes That Affect the Development of the Drosophila Adult External Sensory Organ Genetics, June 1, 2000; 155(2): 733 - 752. [Abstract] [Full Text]
|
|
|
|
|
|
Q. Zhang, Q. Zheng, and X. Lu A Genetic Screen for Modifiers of Drosophila Src42A Identifies Mutations in Egfr, rolled and a Novel Signaling Gene Genetics, February 1, 1999; 151(2): 697 - 711. [Abstract] [Full Text]
|
|
|
|
 |
|
 D Doherty, L. Jan, and Y. Jan The Drosophila neurogenic gene big brain, which encodes a membrane-associated protein, acts cell autonomously and can act synergistically with Notch and Delta Development, January 10, 1997; 124(19): 3881 - 3893. [Abstract] [PDF]
|
|
|
|
|
|
L Seugnet, P Simpson, and M Haenlin Transcriptional regulation of Notch and Delta: requirement for neuroblast segregation in Drosophila Development, January 5, 1997; 124(10): 2015 - 2025. [Abstract] [PDF]
|
|
