|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 116, Issue 3 653-661, Copyright © 1992 by Company of Biologists
JOURNAL ARTICLES |
PW Holland, LZ Holland, NA Williams and ND Holland
Department of Zoology, University of Oxford, UK.
The embryology of amphioxus has much in common with vertebrate embryology, reflecting a close phylogenetic relationship between the two groups. Amphioxus embryology is simpler in several key respects, however, including a lack of pronounced craniofacial morphogenesis. To gain an insight into the molecular changes that accompanied the evolution of vertebrate embryology, and into the relationship between the amphioxus and vertebrate body plans, we have undertaken the first molecular level investigation of amphioxus embryonic development. We report the cloning, complete DNA sequence determination, sequence analysis and expression analysis of an amphioxus homeobox gene, AmphiHox3, evolutionarily homologous to the third-most 3' paralogous group of mammalian Hox genes. Sequence comparison to a mammalian homologue, mouse Hox-2.7 (HoxB3), reveals several stretches of amino acid conservation within the deduced protein sequences. Whole mount in situ hybridization reveals localized expression of AmphiHox3 in the posterior mesoderm (but not in the somites), and region-specific expression in the dorsal nerve cord, of amphioxus neurulae, later embryos and larvae. The anterior limit to expression in the nerve cord is at the level of the four/five somite boundary at the neurula stage, and stabilises to just anterior to the first nerve cord pigment spot to form. Comparison to the anterior expression boundary of mouse Hox-2.7 (HoxB3) and related genes suggests that the vertebrate brain is homologous to an extensive region of the amphioxus nerve cord that contains the cerebral vesicle (a region at the extreme rostral tip) and extends posterior to somite four.(ABSTRACT TRUNCATED AT 250 WORDS)
This article has been cited by other articles:
|
|
 |
|
  L. Z. Holland, N. D. Holland, and E. Gilland Amphioxus and the evolution of head segmentation Integr. Comp. Biol., June 21, 2008; (2008) icn060v1. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. Wang, J. Zhong, B. Su, Y. Zhou, and Y.-Q. Wang Comparison of Pax1/9 Locus Reveals 500-Myr-Old Syntenic Block and Evolutionary Conserved Noncoding Regions Mol. Biol. Evol., March 1, 2007; 24(3): 784 - 791. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Kafri, M. Levy, and Y. Pilpel The regulatory utilization of genetic redundancy through responsive backup circuits PNAS, August 1, 2006; 103(31): 11653 - 11658. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Murakami, M. Pasqualetti, Y. Takio, S. Hirano, F. M. Rijli, and S. Kuratani Segmental development of reticulospinal and branchiomotor neurons in lamprey: insights into the evolution of the vertebrate hindbrain Development, March 1, 2004; 131(5): 983 - 995. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K Yasui, S Zhang, M Uemura, and H Saiga Left-right asymmetric expression of BbPtx, a Ptx-related gene, in a lancelet species and the developmental left-sidedness in deuterostomes Development, January 1, 2000; 127(1): 187 - 195. [Abstract] [PDF]
|
|
|
|
|
|
A Locascio, F Aniello, A Amoroso, M Manzanares, R Krumlauf, and M Branno Patterning the ascidian nervous system: structure, expression and transgenic analysis of the CiHox3 gene Development, January 11, 1999; 126(21): 4737 - 4748. [Abstract] [PDF]
|
|
|
|
|
|
Z Kozmik, N. Holland, A Kalousova, J Paces, M Schubert, and L. Holland Characterization of an amphioxus paired box gene, AmphiPax2/5/8: developmental expression patterns in optic support cells, nephridium, thyroid-like structures and pharyngeal gill slits, but not in the midbrain-hindbrain boundary region Development, January 3, 1999; 126(6): 1295 - 1304. [Abstract] [PDF]
|
|
|
|
|
|
M. J. Telford and R. H. Thomas Expression of homeobox genes shows chelicerate arthropods retain their deutocerebral segment PNAS, September 1, 1998; 95(18): 10671 - 10675. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S Glardon, L. Holland, W. Gehring, and N. Holland Isolation and developmental expression of the amphioxus Pax-6 gene (AmphiPax-6): insights into eye and photoreceptor evolution Development, January 7, 1998; 125(14): 2701 - 2710. [Abstract] [PDF]
|
|
|
|
|
|
H Wada, H Saiga, N Satoh, and P. Holland Tripartite organization of the ancestral chordate brain and the antiquity of placodes: insights from ascidian Pax-2/5/8, Hox and Otx genes Development, January 3, 1998; 125(6): 1113 - 1122. [Abstract] [PDF]
|
|
|
|
|
|
L. Holland, M Kene, N. Williams, and N. Holland Sequence and embryonic expression of the amphioxus engrailed gene (AmphiEn): the metameric pattern of transcription resembles that of its segment-polarity homolog in Drosophila Development, January 5, 1997; 124(9): 1723 - 1732. [Abstract] [PDF]
|
|
|
|
|
|
N. Holland, G Panganiban, E. Henyey, and L. Holland Sequence and developmental expression of AmphiDll, an amphioxus Distal-less gene transcribed in the ectoderm, epidermis and nervous system: insights into evolution of craniate forebrain and neural crest Development, January 9, 1996; 122(9): 2911 - 2920. [Abstract] [PDF]
|
|
|
|
|
|
L. Holland and N. Holland Expression of AmphiHox-1 and AmphiPax-1 in amphioxus embryos treated with retinoic acid: insights into evolution and patterning of the chordate nerve cord and pharynx Development, January 6, 1996; 122(6): 1829 - 1838. [Abstract] [PDF]
|
|
|
|
|
|
P. Holland, B Koschorz, L. Holland, and B. Herrmann Conservation of Brachyury (T) genes in amphioxus and vertebrates: developmental and evolutionary implications Development, January 12, 1995; 121(12): 4283 - 4291. [Abstract] [PDF]
|
|
|
|
|
|
Y Katsuyama, S Wada, S Yasugi, and H Saiga Expression of the labial group Hox gene HrHox-1 and its alteration induced by retinoic acid in development of the ascidian Halocynthia roretzi Development, January 10, 1995; 121(10): 3197 - 3205. [Abstract] [PDF]
|
|
|
|
 |
|
 D E Rancourt, T Tsuzuki, and M R Capecchi Genetic interaction between hoxb-5 and hoxb-6 is revealed by nonallelic noncomplementation. Genes & Dev., January 1, 1995; 9(1): 108 - 122. [Abstract] [PDF]
|
|
