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Development, Vol 116, Issue 3 711-719, Copyright © 1992 by Company of Biologists
JOURNAL ARTICLES |
J Noordermeer, P Johnston, F Rijsewijk, R Nusse and PA Lawrence
Howard Hughes Medical Institute, Stanford University, California 94305-5428.
The segment polarity gene wingless has an essential function in cell-to-cell communication during various stages of Drosophila development. The wingless gene encodes a secreted protein that affects gene expression in surrounding cells but does not spread far from the cells where it is made. In larvae, wingless is necessary to generate naked cuticle in a restricted part of each segment. To test whether the local accumulation of wingless is essential for its function, we made transgenic flies that express wingless under the control of a hsp70 promoter (HS-wg flies). Uniform wingless expression results in a complete naked cuticle, uniform armadillo accumulation and broadening of the engrailed domain. The expression patterns of patched, cubitus interruptus Dominant and Ultrabithorax follow the change in engrailed. The phenotype of heatshocked HS-wg embryos resembles the segment polarity mutant naked, suggesting that embryos that overexpress wingless or lack the naked gene enter similar developmental pathways. The ubiquitous effects of ectopic wingless expression may indicate that most cells in the embryo can receive and interpret the wingless signal. For the development of the wild-type pattern, it is required that wingless is expressed in a subset of these cells.
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M J Benedyk, J R Mullen, and S DiNardo odd-paired: a zinc finger pair-rule protein required for the timely activation of engrailed and wingless in Drosophila embryos. Genes & Dev., January 1, 1994; 8(1): 105 - 117. [Abstract] [PDF]
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J Klingensmith, R Nusse, and N Perrimon The Drosophila segment polarity gene dishevelled encodes a novel protein required for response to the wingless signal. Genes & Dev., January 1, 1994; 8(1): 118 - 130. [Abstract] [PDF]
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P. A. Lawrence and J. Sampedro Drosophila segmentation: after the first three hours Development, December 1, 1993; 119(4): 971 - 976. [PDF]
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N T Parkin, J Kitajewski, and H E Varmus Activity of Wnt-1 as a transmembrane protein. Genes & Dev., November 1, 1993; 7(11): 2181 - 2193. [Abstract] [PDF]
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A Bejsovec and E Wieschaus Segment polarity gene interactions modulate epidermal patterning in Drosophila embryos Development, January 10, 1993; 119(2): 501 - 517. [Abstract] [PDF]
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E. Davidson Later embryogenesis: regulatory circuitry in morphogenetic fields Development, January 7, 1993; 118(3): 665 - 690. [Abstract] [PDF]
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W Zeng, D. Andrew, L. Mathies, M. Horner, and M. Scott Ectopic expression and function of the Antp and Scr homeotic genes: the N terminus of the homeodomain is critical to functional specificity Development, January 6, 1993; 118(2): 339 - 352. [Abstract] [PDF]
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R. Phillips and J. Whittle wingless expression mediates determination of peripheral nervous system elements in late stages of Drosophila wing disc development Development, January 6, 1993; 118(2): 427 - 438. [Abstract] [PDF]
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J Sampedro, P Johnston, and P. Lawrence A role for wingless in the segmental gradient of Drosophila? Development, January 2, 1993; 117(2): 677 - 687. [Abstract] [PDF]
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