|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 116, Issue 3 745-754, Copyright © 1992 by Company of Biologists
JOURNAL ARTICLES |
H. Skaer and A. Martinez Arias
Cell division in the Malpighian tubules of Drosophila melanogaster depends on the presence of a specialised cell at the tip of each tubule (Skaer, H. le B (1989) Nature 342, 566-569). Here we show that cell division also depends on the normal expression of the segment polarity gene, wingless. The pattern of wingless RNA and protein in developing tubules is consistent with a requirement for wingless for cell division. Analysis of the temporal requirement for wingless using a temperature- sensitive allele confirms that the normal expression of wingless is necessary during cell proliferation in the Malpighian tubules. Over-expression of the gene, induced in a stock containing the wg gene under the control of a heat-shock promoter, results in supernumerary cells in the tubules. We discuss the role of wingless in the cell interactions that govern cell division in the Malpighian tubules.
This article has been cited by other articles:
|
|
 |
|
  E. Hatton-Ellis, C. Ainsworth, Y. Sushama, S. Wan, K. VijayRaghavan, and H. Skaer From the Cover: Genetic regulation of patterned tubular branching in Drosophila PNAS, January 2, 2007; 104(1): 169 - 174. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Keller Mechanisms of elongation in embryogenesis Development, June 15, 2006; 133(12): 2291 - 2302. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. K. Allan, J. Du, S. A. Davies, and J. A. T. Dow Genome-wide survey of V-ATPase genes in Drosophila reveals a conserved renal phenotype for lethal alleles Physiol Genomics, July 14, 2005; 22(2): 128 - 138. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Sudarsan, S. Pasalodos-Sanchez, S. Wan, A. Gampel, and H. Skaer A genetic hierarchy establishes mitogenic signalling and mitotic competence in the renal tubules of Drosophila Development, March 4, 2003; 129(4): 935 - 944. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B San Martin and M Bate Hindgut visceral mesoderm requires an ectodermal template for normal development in Drosophila Development, January 1, 2001; 128(2): 233 - 242. [Abstract] [PDF]
|
|
|
|
|
|
L Jones, H Richardson, and R Saint Tissue-specific regulation of cyclin E transcription during Drosophila melanogaster embryogenesis Development, January 11, 2000; 127(21): 4619 - 4630. [Abstract] [PDF]
|
|
|
|
|
|
S. Lee, S Tole, E Grove, and A. McMahon A local Wnt-3a signal is required for development of the mammalian hippocampus Development, January 2, 2000; 127(3): 457 - 467. [Abstract] [PDF]
|
|
|
|
 |
|
 X. Liu, I. Kiss, and J. A. Lengyel Identification of Genes Controlling Malpighian Tubule and Other Epithelial Morphogenesis in Drosophila melanogaster Genetics, February 1, 1999; 151(2): 685 - 695. [Abstract] [Full Text]
|
|
|
|
 |
|
 S Dennis, M Aikawa, W Szeto, P. d'Amore, and J Papkoff A secreted frizzled related protein, FrzA, selectively associates with Wnt-1 protein and regulates wnt-1 signaling J. Cell Sci., January 11, 1999; 112(21): 3815 - 3820. [Abstract] [PDF]
|
|
|
|
|
|
L. Wu and J. Lengyel Role of caudal in hindgut specification and gastrulation suggests homology between Drosophila amnioproctodeal invagination and vertebrate blastopore Development, January 7, 1998; 125(13): 2433 - 2442. [Abstract] [PDF]
|
|
|
|
|
|
U Hacker, X Lin, and N Perrimon The Drosophila sugarless gene modulates Wingless signaling and encodes an enzyme involved in polysaccharide biosynthesis Development, January 9, 1997; 124(18): 3565 - 3573. [Abstract] [PDF]
|
|
|
|
|
|
J. Singer, R Harbecke, T Kusch, R Reuter, and J. Lengyel Drosophila brachyenteron regulates gene activity and morphogenesis in the gut Development, January 12, 1996; 122(12): 3707 - 3718. [Abstract] [PDF]
|
|
|
|
|
|
S. Monkley, S. Delaney, D. Pennisi, J. Christiansen, and B. Wainwright Targeted disruption of the Wnt2 gene results in placentation defects Development, January 11, 1996; 122(11): 3343 - 3353. [Abstract] [PDF]
|
|
|
|
|
|
A Kispert, S Vainio, L Shen, D. Rowitch, and A. McMahon Proteoglycans are required for maintenance of Wnt-11 expression in the ureter tips Development, January 11, 1996; 122(11): 3627 - 3637. [Abstract] [PDF]
|
|
|
|
|
|
C. Neumann and S. Cohen Distinct mitogenic and cell fate specification functions of wingless in different regions of the wing Development, January 6, 1996; 122(6): 1781 - 1789. [Abstract] [PDF]
|
|
|
|
|
|
X Yu, S Hoppler, S Eresh, and M Bienz decapentaplegic, a target gene of the wingless signalling pathway in the Drosophila midgut Development, January 3, 1996; 122(3): 849 - 858. [Abstract] [PDF]
|
|
|
|
|
|
M. Pankratz and M Hoch Control of epithelial morphogenesis by cell signaling and integrin molecules in the Drosophila foregut Development, January 6, 1995; 121(6): 1885 - 1898. [Abstract] [PDF]
|
|
|
|
|
|
L Maves and G Schubiger Wingless induces transdetermination in developing Drosophila imaginal discs Development, January 5, 1995; 121(5): 1263 - 1272. [Abstract] [PDF]
|
|
|
|
|
|
Y Graba, K Gieseler, D Aragnol, P Laurenti, M. Mariol, H Berenger, T Sagnier, and J Pradel DWnt-4, a novel Drosophila Wnt gene acts downstream of homeotic complex genes in the visceral mesoderm Development, January 1, 1995; 121(1): 209 - 218. [Abstract] [PDF]
|
|
|
|
|
|
P. Cubas, J. Modolell, and M. Ruiz-Gomez The helix-loop-helix extramacrochaetae protein is required for proper specification of many cell types in the Drosophila embryo Development, September 1, 1994; 120(9): 2555 - 2566. [Abstract] [PDF]
|
|
|
|
|
|
M Hoch, K Broadie, H Jackle, and H Skaer Sequential fates in a single cell are established by the neurogenic cascade in the Malpighian tubules of Drosophila Development, January 12, 1994; 120(12): 3439 - 3450. [Abstract] [PDF]
|
|
|
|
|
|
Y Echelard, G Vassileva, and A. McMahon Cis-acting regulatory sequences governing Wnt-1 expression in the developing mouse CNS Development, January 8, 1994; 120(8): 2213 - 2224. [Abstract] [PDF]
|
|
|
|
|
|
M. Dickinson, R Krumlauf, and A. McMahon Evidence for a mitogenic effect of Wnt-1 in the developing mammalian central nervous system Development, January 6, 1994; 120(6): 1453 - 1471. [Abstract] [PDF]
|
|
|
|
|
|
R. Duronio and P. O'Farrell Developmental control of a G1-S transcriptional program in Drosophila Development, January 6, 1994; 120(6): 1503 - 1515. [Abstract] [PDF]
|
|
|
|
|
|
M. Ku and D. A. Melton Xwnt-11: a maternally expressed Xenopus wnt gene Development, December 1, 1993; 119(4): 1161 - 1173. [Abstract] [PDF]
|
|
|
|
 |
|
 Q Chu-LaGraff and C. Doe Neuroblast specification and formation regulated by wingless in the Drosophila CNS Science, September 17, 1993; 261(5128): 1594 - 1597. [Abstract] [PDF]
|
|
|
|
|
|
B. Parr, M. Shea, G Vassileva, and A. McMahon Mouse Wnt genes exhibit discrete domains of expression in the early embryonic CNS and limb buds Development, January 9, 1993; 119(1): 247 - 261. [Abstract] [PDF]
|
|
