Development, Vol 116, Issue 4 1021-1032, Copyright © 1992 by Company of Biologists

JOURNAL ARTICLES

The protein product of the zebrafish homologue of the mouse T gene is expressed in nuclei of the germ ring and the notochord of the early embryo

S Schulte-Merker, RK Ho, BG Herrmann and C Nusslein-Volhard
Abteilung Genetik, Max-Planck-Institut fur Entwicklungsbiologie, Tubingen, Germany.

Embryos mutant for the T gene, in mice, make insufficient mesoderm and fail to develop a notochord. We report the cloning and sequencing of the T gene in the zebrafish (Brachydanio rerio) and show the nuclear localization of the protein product. Both RNA and protein are found in cells of the germ ring, including enveloping layer cells, prior to and during gastrulation of zebrafish embryos. Nuclei of the yolk syncytial layer do not express Zf-T. High levels of expression are maintained throughout early development in the notochord, while in paraxial mesoderm cells the gene is turned off during gastrulation. Exposure of animal cap cells to activinA induces Zf-T expression, as does transplantation into the germ ring.
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				Y H Edwards, W Putt, K M Lekoape, D Stott, M Fox, D A Hopkinson, and J Sowden The human homolog T of the mouse T(Brachyury) gene; gene structure, cDNA sequence, and assignment to chromosome 6q27. Genome Res., March 1, 1996; 6(3): 226 - 233. [Abstract] [PDF]

				L Solnica-Krezel, D. Stemple, E Mountcastle-Shah, Z Rangini, S. Neuhauss, J Malicki, A. Schier, D. Stainier, F Zwartkruis, S Abdelilah, et al. Mutations affecting cell fates and cellular rearrangements during gastrulation in zebrafish Development, January 12, 1996; 123(1): 67 - 80. [Abstract] [PDF]

				M. Mullins, M Hammerschmidt, D. Kane, J Odenthal, M Brand, F. van Eeden, M Furutani-Seiki, M Granato, P Haffter, C. Heisenberg, et al. Genes establishing dorsoventral pattern formation in the zebrafish embryo: the ventral specifying genes Development, January 12, 1996; 123(1): 81 - 93. [Abstract] [PDF]

				M Hammerschmidt, F Pelegri, M. Mullins, D. Kane, F. van Eeden, M Granato, M Brand, M Furutani-Seiki, P Haffter, C. Heisenberg, et al. dino and mercedes, two genes regulating dorsal development in the zebrafish embryo Development, January 12, 1996; 123(1): 95 - 102. [Abstract] [PDF]

				J Odenthal, P Haffter, E Vogelsang, M Brand, F. van Eeden, M Furutani-Seiki, M Granato, M Hammerschmidt, C. Heisenberg, Y. Jiang, et al. Mutations affecting the formation of the notochord in the zebrafish, Danio rerio Development, January 12, 1996; 123(1): 103 - 115. [Abstract] [PDF]

				D. Stemple, L Solnica-Krezel, F Zwartkruis, S. Neuhauss, A. Schier, J Malicki, D. Stainier, S Abdelilah, Z Rangini, E Mountcastle-Shah, et al. Mutations affecting development of the notochord in zebrafish Development, January 12, 1996; 123(1): 117 - 128. [Abstract] [PDF]

				M Brand, C. Heisenberg, R. Warga, F Pelegri, R. Karlstrom, D Beuchle, A Picker, Y. Jiang, M Furutani-Seiki, F. van Eeden, et al. Mutations affecting development of the midline and general body shape during zebrafish embryogenesis Development, January 12, 1996; 123(1): 129 - 142. [Abstract] [PDF]