Mox-1 and Mox-2 define a novel homeobox gene subfamily and are differentially expressed during early mesodermal patterning in mouse embryos

QUICK SEARCH:

[advanced]

	Author:		Keyword(s):

Home Help Feedback Subscriptions Archive Search Table of Contents

This Article

	Full Text (PDF)
	References
	Alert me when this article is cited
	Alert me if a correction is posted

Services

	Email this article to a friend
	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new issues of the journal
	Download to citation manager


Citing Articles

	Citing Articles via HighWire
	Citing Articles via Google Scholar

Google Scholar

	Articles by Candia, A. F.
	Articles by Wright, C. V.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by Candia, A. F.
	Articles by Wright, C. V.

JOURNAL ARTICLES

Mox-1 and Mox-2 define a novel homeobox gene subfamily and are differentially expressed during early mesodermal patterning in mouse embryos

AF Candia, J Hu, J Crosby, PA Lalley, D Noden, JH Nadeau and CV Wright
Department of Cell Biology, Vanderbilt University Medical School, Nashville TN 37232-2175.

We have isolated two mouse genes, Mox-1 and Mox-2 that, by sequence, genomic structure and expression pattern, define a novel homeobox gene family probably involved in mesodermal regionalization and somitic differentiation. Mox-1 is genetically linked to the keratin and Hox-2 genes of chromosome 11, while Mox-2 maps to chromosome 12. At primitive streak stages (approximately 7.0 days post coitum), Mox-1 is expressed in mesoderm lying posterior of the future primordial head and heart. It is not expressed in neural tissue, ectoderm, or endoderm. Mox-1 expression may therefore define an extensive 'posterior' domain of embryonic mesoderm before, or at the earliest stages of, patterning of the mesoderm and neuroectoderm by the Hox cluster genes. Between 7.5 and 9.5 days post coitum, Mox-1 is expressed in presomitic mesoderm, epithelial and differentiating somites (dermatome, myotome and sclerotome) and in lateral plate mesoderm. In the body of midgestation embryos, Mox-1 signal is restricted to loose undifferentiated mesenchyme. Mox-1 signal is also prominent over the mesenchyme of the heart cushions and truncus arteriosus, which arises from epithelial-mesenchymal transformation and over a limited number of craniofacial foci of neural crest-derived mesenchyme that are associated with muscle attachment sites. The expression profile of Mox-2 is similar to, but different from, that of Mox-1. For example, Mox-2 is apparently not expressed before somites form, is then expressed over the entire epithelial somite, but during somitic differentiation, Mox-2 signal rapidly becomes restricted to sclerotomal derivatives. The expression patterns of these genes suggest regulatory roles for Mox-1 and Mox-2 in the initial anterior-posterior regionalization of vertebrate embryonic mesoderm and, in addition, in somite specification and differentiation.

This article has been cited by other articles:

M. J. Garcia-Garcia, M. Shibata, and K. V. Anderson
Chato, a KRAB zinc-finger protein, regulates convergent extension in the mouse embryo
Development, September 15, 2008; 135(18): 3053 - 3062.
[Abstract] [Full Text] [PDF]

A. Sawada, H. Kiyonari, K. Ukita, N. Nishioka, Y. Imuta, and H. Sasaki
Redundant Roles of Tead1 and Tead2 in Notochord Development and the Regulation of Cell Proliferation and Survival
Mol. Cell. Biol., May 15, 2008; 28(10): 3177 - 3189.
[Abstract] [Full Text] [PDF]

P. Wasteson, B. R. Johansson, T. Jukkola, S. Breuer, L. M. Akyurek, J. Partanen, and P. Lindahl
Developmental origin of smooth muscle cells in the descending aorta in mice
Development, May 15, 2008; 135(10): 1823 - 1832.
[Abstract] [Full Text] [PDF]

E. T. Shifley, K. M. VanHorn, A. Perez-Balaguer, J. D. Franklin, M. Weinstein, and S. E. Cole
Oscillatory lunatic fringe activity is crucial for segmentation of the anterior but not posterior skeleton
Development, March 1, 2008; 135(5): 899 - 908.
[Abstract] [Full Text] [PDF]

D. D'Andrea, G. L. Liguori, J. A. Le Good, E. Lonardo, O. Andersson, D. B. Constam, M. G. Persico, and G. Minchiotti
Cripto promotes A-P axis specification independently of its stimulatory effect on Nodal autoinduction
J. Cell Biol., February 6, 2008; 180(3): 597 - 605.
[Abstract] [Full Text] [PDF]

P. Gadue, T. L. Huber, P. J. Paddison, and G. M. Keller
Wnt and TGF-beta signaling are required for the induction of an in vitro model of primitive streak formation using embryonic stem cells
PNAS, November 7, 2006; 103(45): 16806 - 16811.
[Abstract] [Full Text] [PDF]

J. D. Kulman, J. E. Harris, N. Nakazawa, M. Ogasawara, M. Satake, and E. W. Davie
Vitamin K-dependent proteins in Ciona intestinalis, a basal chordate lacking a blood coagulation cascade
PNAS, October 24, 2006; 103(43): 15794 - 15799.
[Abstract] [Full Text] [PDF]

S. Miura, S. Davis, J. Klingensmith, and Y. Mishina
BMP signaling in the epiblast is required for proper recruitment of the prospective paraxial mesoderm and development of the somites
Development, October 1, 2006; 133(19): 3767 - 3775.
[Abstract] [Full Text] [PDF]

S. Glaser, J. Schaft, S. Lubitz, K. Vintersten, F. van der Hoeven, K. R. Tufteland, R. Aasland, K. Anastassiadis, S.-L. Ang, and A. F. Stewart
Multiple epigenetic maintenance factors implicated by the loss of Mll2 in mouse development
Development, April 15, 2006; 133(8): 1423 - 1432.
[Abstract] [Full Text] [PDF]

S. Willey, A. Ayuso-Sacido, H. Zhang, S. T. Fraser, K. E. Sahr, M. J. Adlam, M. Kyba, G. Q. Daley, G. Keller, and M. H. Baron
Acceleration of mesoderm development and expansion of hematopoietic progenitors in differentiating ES cells by the mouse Mix-like homeodomain transcription factor
Blood, April 15, 2006; 107(8): 3122 - 3130.
[Abstract] [Full Text] [PDF]

W. Satoh, T. Gotoh, Y. Tsunematsu, S. Aizawa, and A. Shimono
Sfrp1 and Sfrp2 regulate anteroposterior axis elongation and somite segmentation during mouse embryogenesis
Development, March 15, 2006; 133(6): 989 - 999.
[Abstract] [Full Text] [PDF]

P. J. Gianakopoulos and I. S. Skerjanc
Hedgehog Signaling Induces Cardiomyogenesis in P19 Cells
J. Biol. Chem., June 3, 2005; 280(22): 21022 - 21028.
[Abstract] [Full Text] [PDF]

T. Ikuta, N. Yoshida, N. Satoh, and H. Saiga
Ciona intestinalis Hox gene cluster: Its dispersed structure and residual colinear expression in development
PNAS, October 19, 2004; 101(42): 15118 - 15123.
[Abstract] [Full Text] [PDF]

H. Petropoulos, P. J. Gianakopoulos, A. G. Ridgeway, and I. S. Skerjanc
Disruption of Meox or Gli Activity Ablates Skeletal Myogenesis in P19 Cells
J. Biol. Chem., June 4, 2004; 279(23): 23874 - 23881.
[Abstract] [Full Text] [PDF]

K. Chawengsaksophak, W. de Graaff, J. Rossant, J. Deschamps, and F. Beck
Cdx2 is essential for axial elongation in mouse development
PNAS, May 18, 2004; 101(20): 7641 - 7645.
[Abstract] [Full Text] [PDF]

M. Bussen, M. Petry, K. Schuster-Gossler, M. Leitges, A. Gossler, and A. Kispert
The T-box transcription factor Tbx18 maintains the separation of anterior and posterior somite compartments
Genes & Dev., May 15, 2004; 18(10): 1209 - 1221.
[Abstract] [Full Text] [PDF]

I. Rodrigo, P. Bovolenta, B. S. Mankoo, and K. Imai
Meox Homeodomain Proteins Are Required for Bapx1 Expression in the Sclerotome and Activate Its Transcription by Direct Binding to Its Promoter
Mol. Cell. Biol., April 1, 2004; 24(7): 2757 - 2766.
[Abstract] [Full Text] [PDF]

S. C. Linn, R. B. West, J. R. Pollack, S. Zhu, T. Hernandez-Boussard, T. O. Nielsen, B. P. Rubin, R. Patel, J. R. Goldblum, D. Siegmund, et al.
Gene Expression Patterns and Gene Copy Number Changes in Dermatofibrosarcoma Protuberans
Am. J. Pathol., December 1, 2003; 163(6): 2383 - 2395.
[Abstract] [Full Text]

B. S. Mankoo, S. Skuntz, I. Harrigan, E. Grigorieva, A. Candia, C. V. E. Wright, H. Arnheiter, and V. Pachnis
The concerted action of Meox homeobox genes is required upstream of genetic pathways essential for the formation, patterning and differentiation of somites
Development, October 1, 2003; 130(19): 4655 - 4664.
[Abstract] [Full Text] [PDF]

F. Bladt, E. Aippersbach, S. Gelkop, G. A. Strasser, P. Nash, A. Tafuri, F. B. Gertler, and T. Pawson
The Murine Nck SH2/SH3 Adaptors Are Important for the Development of Mesoderm-Derived Embryonic Structures and for Regulating the Cellular Actin Network
Mol. Cell. Biol., July 1, 2003; 23(13): 4586 - 4597.
[Abstract] [Full Text] [PDF]

P. F. Giampietro, R. D. Blank, C. L. Raggio, S. Merchant, F. S. Jacobsen, T. Faciszewski, S. K. Shukla, A. R. Greenlee, C. Reynolds, and D. B. Schowalter
Congenital and Idiopathic Scoliosis: Clinical and Genetic Aspects
Clin. Med. Res., April 1, 2003; 1(2): 125 - 136.
[Abstract] [Full Text] [PDF]

M. Kanai-Azuma, Y. Kanai, J. M. Gad, Y. Tajima, C. Taya, M. Kurohmaru, Y. Sanai, H. Yonekawa, K. Yazaki, P. P. L. Tam, et al.
Depletion of definitive gut endoderm in Sox17-null mutant mice
Development, March 7, 2003; 129(10): 2367 - 2379.
[Abstract] [Full Text] [PDF]

I. Rodrigo, R. E. Hill, R. Balling, A. Munsterberg, and K. Imai
Pax1 and Pax9 activate Bapx1 to induce chondrogenic differentiation in the sclerotome
Development, February 1, 2003; 130(3): 473 - 482.
[Abstract] [Full Text] [PDF]

H. Petropoulos and I. S. Skerjanc
beta -Catenin Is Essential and Sufficient for Skeletal Myogenesis in P19 Cells
J. Biol. Chem., May 3, 2002; 277(18): 15393 - 15399.
[Abstract] [Full Text] [PDF]

M. Jamali, P. J. Rogerson, S. Wilton, and I. S. Skerjanc
Nkx2-5 Activity Is Essential for Cardiomyogenesis
J. Biol. Chem., November 2, 2001; 276(45): 42252 - 42258.
[Abstract] [Full Text] [PDF]

T. Kume, H. Jiang, J. M. Topczewska, and B. L.M. Hogan
The murine winged helix transcription factors, Foxc1 and Foxc2, are both required for cardiovascular development and somitogenesis
Genes & Dev., September 15, 2001; 15(18): 2470 - 2482.
[Abstract] [Full Text] [PDF]

Y Xue, X Wang, Z Li, N Gotoh, D Chapman, and E. Skolnik
Mesodermal patterning defect in mice lacking the Ste20 NCK interacting kinase (NIK)
Development, January 5, 2001; 128(9): 1559 - 1572.
[Abstract] [PDF]

D. H. Gorski and K. Walsh
The Role of Homeobox Genes in Vascular Remodeling and Angiogenesis
Circ. Res., November 10, 2000; 87(10): 865 - 872.
[Abstract] [Full Text] [PDF]

D. C. Goldman, G. R. Martin, and P. P. Tam
Fate and function of the ventral ectodermal ridge during mouse tail development
Development, May 15, 2000; 127(10): 2113 - 2123.
[Abstract] [PDF]

S Kitajima, A Takagi, T Inoue, and Y Saga
MesP1 and MesP2 are essential for the development of cardiac mesoderm
Development, January 8, 2000; 127(15): 3215 - 3226.
[Abstract] [PDF]

A. S. Boyer, W. T. Finch, and R. B. Runyan
Trichloroethylene Inhibits Development of Embryonic Heart Valve Precursors in Vitro
Toxicol. Sci., January 1, 2000; 53(1): 109 - 117.
[Abstract] [Full Text] [PDF]

S. Kawamoto, T. Ohnishi, H. Kita, O. Chisaka, and K. Okubo
Expression Profiling by iAFLP: A PCR-Based Method for Genome-Wide Gene Expression Profiling
Genome Res., December 1, 1999; 9(12): 1305 - 1312.
[Abstract] [Full Text]

U Borello, M Coletta, S Tajbakhsh, L Leyns, E. De Robertis, M Buckingham, and G Cossu
Transplacental delivery of the Wnt antagonist Frzb1 inhibits development of caudal paraxial mesoderm and skeletal myogenesis in mouse embryos
Development, January 10, 1999; 126(19): 4247 - 4255.
[Abstract] [PDF]

Y Saga, S Miyagawa-Tomita, A Takagi, S Kitajima, J. Miyazaki, and T Inoue
MesP1 is expressed in the heart precursor cells and required for the formation of a single heart tube
Development, January 8, 1999; 126(15): 3437 - 3447.
[Abstract] [PDF]

A. Kasarskis, K. Manova, and K. V. Anderson
A phenotype-based screen for embryonic lethal mutations in the mouse
PNAS, June 23, 1998; 95(13): 7485 - 7490.
[Abstract] [Full Text] [PDF]

M Rhinn, A Dierich, W Shawlot, R. Behringer, M Le Meur, and S. Ang
Sequential roles for Otx2 in visceral endoderm and neuroectoderm for forebrain and midbrain induction and specification
Development, January 3, 1998; 125(5): 845 - 856.
[Abstract] [PDF]

X Xu, M Weinstein, C Li, M Naski, R. Cohen, D. Ornitz, P Leder, and C Deng
Fibroblast growth factor receptor 2 (FGFR2)-mediated reciprocal regulation loop between FGF8 and FGF10 is essential for limb induction
Development, January 2, 1998; 125(4): 753 - 765.
[Abstract] [PDF]

C. Sirard, J. L. de la Pompa, A. Elia, A. Itie, C. Mirtsos, A. Cheung, S. Hahn, A. Wakeham, L. Schwartz, S. E. Kern, et al.
The tumor suppressor gene Smad4/Dpc4 is required for gastrulation and later for anterior development of the mouse�embryo
Genes & Dev., January 1, 1998; 12(1): 107 - 119.
[Abstract] [Full Text]

Y Saga, N Hata, H Koseki, and M M Taketo
Mesp2: a novel mouse gene expressed in the presegmented mesoderm and essential for segmentation initiation.
Genes & Dev., July 15, 1997; 11(14): 1827 - 1839.
[Abstract] [PDF]

J D Molkentin, Q Lin, S A Duncan, and E N Olson
Requirement of the transcription factor GATA4 for heart tube formation and ventral morphogenesis.
Genes & Dev., April 15, 1997; 11(8): 1061 - 1072.
[Abstract] [PDF]

G E Winnier, L Hargett, and B L Hogan
The winged helix transcription factor MFH1 is required for proliferation and patterning of paraxial mesoderm in the mouse embryo.
Genes & Dev., April 1, 1997; 11(7): 926 - 940.
[Abstract] [PDF]

K. Goh, J. Yang, and R. Hynes
Mesodermal defects and cranial neural crest apoptosis in alpha5 integrin-null embryos
Development, January 11, 1997; 124(21): 4309 - 4319.
[Abstract] [PDF]

L. Sanford, I Ormsby, A. Gittenberger-de Groot, H Sariola, R Friedman, G. Boivin, E. Cardell, and T Doetschman
TGFbeta2 knockout mice have multiple developmental defects that are non-overlapping with other TGFbeta knockout phenotypes
Development, January 7, 1997; 124(13): 2659 - 2670.
[Abstract] [PDF]

P Soriano
The PDGF alpha receptor is required for neural crest cell development and for normal patterning of the somites
Development, January 7, 1997; 124(14): 2691 - 2700.
[Abstract] [PDF]

B. Ciruna, L Schwartz, K Harpal, T. Yamaguchi, and J Rossant
Chimeric analysis of fibroblast growth factor receptor-1 (Fgfr1) function: a role for FGFR1 in morphogenetic movement through the primitive streak
Development, January 7, 1997; 124(14): 2829 - 2841.
[Abstract] [PDF]

S Filosa, J. Rivera-Perez, A. Gomez, A Gansmuller, H Sasaki, R. Behringer, and S. Ang
Goosecoid and HNF-3beta genetically interact to regulate neural tube patterning during mouse embryogenesis
Development, January 7, 1997; 124(14): 2843 - 2854.
[Abstract] [PDF]

S. Johnston, C Rauskolb, R Wilson, B Prabhakaran, K. Irvine, and T. Vogt
A family of mammalian Fringe genes implicated in boundary determination and the Notch pathway
Development, January 6, 1997; 124(11): 2245 - 2254.
[Abstract] [PDF]

T L Greco, S Takada, M M Newhouse, J A McMahon, A P McMahon, and S A Camper
Analysis of the vestigial tail mutation demonstrates that Wnt-3a gene dosage regulates mouse axial development.
Genes & Dev., February 1, 1996; 10(3): 313 - 324.
[Abstract] [PDF]

D Onichtchouk, V Gawantka, R Dosch, H Delius, K Hirschfeld, C Blumenstock, and C Niehrs
The Xvent-2 homeobox gene is part of the BMP-4 signalling pathway controlling [correction of controling] dorsoventral patterning of Xenopus mesoderm
Development, January 10, 1996; 122(10): 3045 - 3053.
[Abstract] [PDF]

L Larue, C Antos, S Butz, O Huber, V Delmas, M Dominis, and R Kemler
A role for cadherins in tissue formation
Development, January 10, 1996; 122(10): 3185 - 3194.
[Abstract] [PDF]

R Sporle, T Gunther, M Struwe, and K Schughart
Severe defects in the formation of epaxial musculature in open brain (opb) mutant mouse embryos
Development, January 1, 1996; 122(1): 79 - 86.
[Abstract] [PDF]

S. Ang, O Jin, M Rhinn, N Daigle, L Stevenson, and J Rossant
A targeted mouse Otx2 mutation leads to severe defects in gastrulation and formation of axial mesoderm and to deletion of rostral brain
Development, January 1, 1996; 122(1): 243 - 252.
[Abstract] [PDF]

C Oka, T Nakano, A Wakeham, J. de la Pompa, C Mori, T Sakai, S Okazaki, M Kawaichi, K Shiota, T. Mak, et al.
Disruption of the mouse RBP-J kappa gene results in early embryonic death
Development, January 10, 1995; 121(10): 3291 - 3301.
[Abstract] [PDF]

R. Conlon, A. Reaume, and J Rossant
Notch1 is required for the coordinate segmentation of somites
Development, January 5, 1995; 121(5): 1533 - 1545.
[Abstract] [PDF]

T P Yamaguchi, K Harpal, M Henkemeyer, and J Rossant
fgfr-1 is required for embryonic growth and mesodermal patterning during mouse gastrulation.
Genes & Dev., December 15, 1994; 8(24): 3032 - 3044.
[Abstract] [PDF]

W S Chen, K Manova, D C Weinstein, S A Duncan, A S Plump, V R Prezioso, R F Bachvarova, and J E Darnell
Disruption of the HNF-4 gene, expressed in visceral endoderm, leads to cell death in embryonic ectoderm and impaired gastrulation of mouse embryos.
Genes & Dev., October 15, 1994; 8(20): 2466 - 2477.
[Abstract] [PDF]

C. Byrne, M. Tainsky, and E. Fuchs
Programming gene expression in developing epidermis
Development, September 1, 1994; 120(9): 2369 - 2383.
[Abstract] [PDF]

P. A. Trainor, S. S. Tan, and P. P. Tam
Cranial paraxial mesoderm: regionalisation of cell fate and impact on craniofacial development in mouse embryos
Development, September 1, 1994; 120(9): 2397 - 2408.
[Abstract] [PDF]

S Takada, K L Stark, M J Shea, G Vassileva, J A McMahon, and A P McMahon
Wnt-3a regulates somite and tailbud formation in the mouse embryo.
Genes & Dev., January 15, 1994; 8(2): 174 - 189.
[Abstract] [PDF]

C Chiang, N. Patel, K. Young, and P. Beachy
The novel homeodomain gene buttonless specifies differentiation and axonal guidance functions of Drosophila dorsal median cells
Development, January 12, 1994; 120(12): 3581 - 3593.
[Abstract] [PDF]

F. Conlon, K. Lyons, N Takaesu, K. Barth, A Kispert, B Herrmann, and E. Robertson
A primary requirement for nodal in the formation and maintenance of the primitive streak in the mouse
Development, January 7, 1994; 120(7): 1919 - 1928.
[Abstract] [PDF]

S. Pruitt
Primitive streak mesoderm-like cell lines expressing Pax-3 and Hox gene autoinducing activities
Development, January 1, 1994; 120(1): 37 - 47.
[Abstract] [PDF]

H Sasaki and B. Hogan
Differential expression of multiple fork head related genes during gastrulation and axial pattern formation in the mouse embryo

				A. Sawada, H. Kiyonari, K. Ukita, N. Nishioka, Y. Imuta, and H. Sasaki Redundant Roles of Tead1 and Tead2 in Notochord Development and the Regulation of Cell Proliferation and Survival Mol. Cell. Biol., May 15, 2008; 28(10): 3177 - 3189. [Abstract] [Full Text] [PDF]

				P. Wasteson, B. R. Johansson, T. Jukkola, S. Breuer, L. M. Akyurek, J. Partanen, and P. Lindahl Developmental origin of smooth muscle cells in the descending aorta in mice Development, May 15, 2008; 135(10): 1823 - 1832. [Abstract] [Full Text] [PDF]

				E. T. Shifley, K. M. VanHorn, A. Perez-Balaguer, J. D. Franklin, M. Weinstein, and S. E. Cole Oscillatory lunatic fringe activity is crucial for segmentation of the anterior but not posterior skeleton Development, March 1, 2008; 135(5): 899 - 908. [Abstract] [Full Text] [PDF]

				D. D'Andrea, G. L. Liguori, J. A. Le Good, E. Lonardo, O. Andersson, D. B. Constam, M. G. Persico, and G. Minchiotti Cripto promotes A-P axis specification independently of its stimulatory effect on Nodal autoinduction J. Cell Biol., February 6, 2008; 180(3): 597 - 605. [Abstract] [Full Text] [PDF]

				P. Gadue, T. L. Huber, P. J. Paddison, and G. M. Keller Wnt and TGF-beta signaling are required for the induction of an in vitro model of primitive streak formation using embryonic stem cells PNAS, November 7, 2006; 103(45): 16806 - 16811. [Abstract] [Full Text] [PDF]

				J. D. Kulman, J. E. Harris, N. Nakazawa, M. Ogasawara, M. Satake, and E. W. Davie Vitamin K-dependent proteins in Ciona intestinalis, a basal chordate lacking a blood coagulation cascade PNAS, October 24, 2006; 103(43): 15794 - 15799. [Abstract] [Full Text] [PDF]

				S. Miura, S. Davis, J. Klingensmith, and Y. Mishina BMP signaling in the epiblast is required for proper recruitment of the prospective paraxial mesoderm and development of the somites Development, October 1, 2006; 133(19): 3767 - 3775. [Abstract] [Full Text] [PDF]

				S. Glaser, J. Schaft, S. Lubitz, K. Vintersten, F. van der Hoeven, K. R. Tufteland, R. Aasland, K. Anastassiadis, S.-L. Ang, and A. F. Stewart Multiple epigenetic maintenance factors implicated by the loss of Mll2 in mouse development Development, April 15, 2006; 133(8): 1423 - 1432. [Abstract] [Full Text] [PDF]

				S. Willey, A. Ayuso-Sacido, H. Zhang, S. T. Fraser, K. E. Sahr, M. J. Adlam, M. Kyba, G. Q. Daley, G. Keller, and M. H. Baron Acceleration of mesoderm development and expansion of hematopoietic progenitors in differentiating ES cells by the mouse Mix-like homeodomain transcription factor Blood, April 15, 2006; 107(8): 3122 - 3130. [Abstract] [Full Text] [PDF]

				W. Satoh, T. Gotoh, Y. Tsunematsu, S. Aizawa, and A. Shimono Sfrp1 and Sfrp2 regulate anteroposterior axis elongation and somite segmentation during mouse embryogenesis Development, March 15, 2006; 133(6): 989 - 999. [Abstract] [Full Text] [PDF]

				P. J. Gianakopoulos and I. S. Skerjanc Hedgehog Signaling Induces Cardiomyogenesis in P19 Cells J. Biol. Chem., June 3, 2005; 280(22): 21022 - 21028. [Abstract] [Full Text] [PDF]

				T. Ikuta, N. Yoshida, N. Satoh, and H. Saiga Ciona intestinalis Hox gene cluster: Its dispersed structure and residual colinear expression in development PNAS, October 19, 2004; 101(42): 15118 - 15123. [Abstract] [Full Text] [PDF]

				H. Petropoulos, P. J. Gianakopoulos, A. G. Ridgeway, and I. S. Skerjanc Disruption of Meox or Gli Activity Ablates Skeletal Myogenesis in P19 Cells J. Biol. Chem., June 4, 2004; 279(23): 23874 - 23881. [Abstract] [Full Text] [PDF]

				K. Chawengsaksophak, W. de Graaff, J. Rossant, J. Deschamps, and F. Beck Cdx2 is essential for axial elongation in mouse development PNAS, May 18, 2004; 101(20): 7641 - 7645. [Abstract] [Full Text] [PDF]

				M. Bussen, M. Petry, K. Schuster-Gossler, M. Leitges, A. Gossler, and A. Kispert The T-box transcription factor Tbx18 maintains the separation of anterior and posterior somite compartments Genes & Dev., May 15, 2004; 18(10): 1209 - 1221. [Abstract] [Full Text] [PDF]

				I. Rodrigo, P. Bovolenta, B. S. Mankoo, and K. Imai Meox Homeodomain Proteins Are Required for Bapx1 Expression in the Sclerotome and Activate Its Transcription by Direct Binding to Its Promoter Mol. Cell. Biol., April 1, 2004; 24(7): 2757 - 2766. [Abstract] [Full Text] [PDF]

				S. C. Linn, R. B. West, J. R. Pollack, S. Zhu, T. Hernandez-Boussard, T. O. Nielsen, B. P. Rubin, R. Patel, J. R. Goldblum, D. Siegmund, et al. Gene Expression Patterns and Gene Copy Number Changes in Dermatofibrosarcoma Protuberans Am. J. Pathol., December 1, 2003; 163(6): 2383 - 2395. [Abstract] [Full Text]

				B. S. Mankoo, S. Skuntz, I. Harrigan, E. Grigorieva, A. Candia, C. V. E. Wright, H. Arnheiter, and V. Pachnis The concerted action of Meox homeobox genes is required upstream of genetic pathways essential for the formation, patterning and differentiation of somites Development, October 1, 2003; 130(19): 4655 - 4664. [Abstract] [Full Text] [PDF]

				F. Bladt, E. Aippersbach, S. Gelkop, G. A. Strasser, P. Nash, A. Tafuri, F. B. Gertler, and T. Pawson The Murine Nck SH2/SH3 Adaptors Are Important for the Development of Mesoderm-Derived Embryonic Structures and for Regulating the Cellular Actin Network Mol. Cell. Biol., July 1, 2003; 23(13): 4586 - 4597. [Abstract] [Full Text] [PDF]

				P. F. Giampietro, R. D. Blank, C. L. Raggio, S. Merchant, F. S. Jacobsen, T. Faciszewski, S. K. Shukla, A. R. Greenlee, C. Reynolds, and D. B. Schowalter Congenital and Idiopathic Scoliosis: Clinical and Genetic Aspects Clin. Med. Res., April 1, 2003; 1(2): 125 - 136. [Abstract] [Full Text] [PDF]

				M. Kanai-Azuma, Y. Kanai, J. M. Gad, Y. Tajima, C. Taya, M. Kurohmaru, Y. Sanai, H. Yonekawa, K. Yazaki, P. P. L. Tam, et al. Depletion of definitive gut endoderm in Sox17-null mutant mice Development, March 7, 2003; 129(10): 2367 - 2379. [Abstract] [Full Text] [PDF]

				I. Rodrigo, R. E. Hill, R. Balling, A. Munsterberg, and K. Imai Pax1 and Pax9 activate Bapx1 to induce chondrogenic differentiation in the sclerotome Development, February 1, 2003; 130(3): 473 - 482. [Abstract] [Full Text] [PDF]

				H. Petropoulos and I. S. Skerjanc beta -Catenin Is Essential and Sufficient for Skeletal Myogenesis in P19 Cells J. Biol. Chem., May 3, 2002; 277(18): 15393 - 15399. [Abstract] [Full Text] [PDF]

				M. Jamali, P. J. Rogerson, S. Wilton, and I. S. Skerjanc Nkx2-5 Activity Is Essential for Cardiomyogenesis J. Biol. Chem., November 2, 2001; 276(45): 42252 - 42258. [Abstract] [Full Text] [PDF]

				T. Kume, H. Jiang, J. M. Topczewska, and B. L.M. Hogan The murine winged helix transcription factors, Foxc1 and Foxc2, are both required for cardiovascular development and somitogenesis Genes & Dev., September 15, 2001; 15(18): 2470 - 2482. [Abstract] [Full Text] [PDF]

				Y Xue, X Wang, Z Li, N Gotoh, D Chapman, and E. Skolnik Mesodermal patterning defect in mice lacking the Ste20 NCK interacting kinase (NIK) Development, January 5, 2001; 128(9): 1559 - 1572. [Abstract] [PDF]

				D. H. Gorski and K. Walsh The Role of Homeobox Genes in Vascular Remodeling and Angiogenesis Circ. Res., November 10, 2000; 87(10): 865 - 872. [Abstract] [Full Text] [PDF]

				D. C. Goldman, G. R. Martin, and P. P. Tam Fate and function of the ventral ectodermal ridge during mouse tail development Development, May 15, 2000; 127(10): 2113 - 2123. [Abstract] [PDF]

				S Kitajima, A Takagi, T Inoue, and Y Saga MesP1 and MesP2 are essential for the development of cardiac mesoderm Development, January 8, 2000; 127(15): 3215 - 3226. [Abstract] [PDF]

				A. S. Boyer, W. T. Finch, and R. B. Runyan Trichloroethylene Inhibits Development of Embryonic Heart Valve Precursors in Vitro Toxicol. Sci., January 1, 2000; 53(1): 109 - 117. [Abstract] [Full Text] [PDF]