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Development, Vol 116, Issue 4 1203-1220, Copyright © 1992 by Company of Biologists
JOURNAL ARTICLES |
AY Hartenstein, A Rugendorff, U Tepass and V Hartenstein
Department of Biology, University of California, Los Angeles 90024.
The complex embryonic phenotype of the six neurogenic mutations Notch, mastermind, big brain, Delta, Enhancer of split and neuralized was analyzed by using different antibodies and PlacZ markers, which allowed us to label most of the known embryonic tissues. Our results demonstrate that all of the neurogenic mutants show abnormalities in many different organs derived from all three germ layers. Defects caused by the neurogenic mutations in ectodermally derived tissues fell into two categories. First, all cell types that delaminate from the ectoderm (neuroblasts, sensory neurons, peripheral glia cells and oenocytes) are increased in number. Secondly, ectodermal tissues that in the wild type form epithelial structures lose their epithelial phenotype and dissociate (optic lobe, stomatogastric nervous system) or show significant differentiative abnormalities (trachea, Malpighian tubules and salivary gland). Abnormalities in tissues derived from the mesoderm were observed in all six neurogenic mutations. Most importantly, somatic myoblasts do not fuse and/or form an aberrant muscle pattern. Cardioblasts (which form the embryonic heart) are increased in number and show differentiative abnormalities; other mesodermal cell types (fat body, pericardial cells) are significantly decreased. The development of the endoderm (midgut rudiments) is disrupted in most of the neurogenic mutations (Notch, Delta, Enhancer of split and neuralized) during at least two stages. Defects occur as early as during gastrulation when the invaginating midgut rudiments prematurely lose their epithelial characteristics. Later, the transition of the midgut rudiments to form the midgut epithelium does not occur. In addition, the number of adult midgut precursor cells that segregate from the midgut rudiments is strongly increased. We propose that, at least in the ectodermally and endodermally derived tissues, neurogenic gene function is primarily involved in interactions among cells that need to acquire or to maintain an epithelial phenotype.
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H Miyamoto, I Nihonmatsu, S Kondo, R Ueda, S Togashi, K Hirata, Y Ikegami, and D Yamamoto canoe encodes a novel protein containing a GLGF/DHR motif and functions with Notch and scabrous in common developmental pathways in Drosophila. Genes & Dev., March 1, 1995; 9(5): 612 - 625. [Abstract] [PDF]
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E. Rulifson and S. Blair Notch regulates wingless expression and is not required for reception of the paracrine wingless signal during wing margin neurogenesis in Drosophila Development, January 9, 1995; 121(9): 2813 - 2824. [Abstract] [PDF]
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B Bettenhausen, M Hrabe de Angelis, D Simon, J. Guenet, and A Gossler Transient and restricted expression during mouse embryogenesis of Dll1, a murine gene closely related to Drosophila Delta Development, January 8, 1995; 121(8): 2407 - 2418. [Abstract] [PDF]
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F Schweisguth Suppressor of Hairless is required for signal reception during lateral inhibition in the Drosophila pupal notum Development, January 6, 1995; 121(6): 1875 - 1884. [Abstract] [PDF]
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M. Pankratz and M Hoch Control of epithelial morphogenesis by cell signaling and integrin molecules in the Drosophila foregut Development, January 6, 1995; 121(6): 1885 - 1898. [Abstract] [PDF]
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R Baker and G Schubiger Ectoderm induces muscle-specific gene expression in Drosophila embryos Development, January 5, 1995; 121(5): 1387 - 1398. [Abstract] [PDF]
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R. Conlon, A. Reaume, and J Rossant Notch1 is required for the coordinate segmentation of somites Development, January 5, 1995; 121(5): 1533 - 1545. [Abstract] [PDF]
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U Tepass and V Hartenstein Neurogenic and proneural genes control cell fate specification in the Drosophila endoderm Development, January 2, 1995; 121(2): 393 - 405. [Abstract] [PDF]
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A Giangrande Proneural genes influence gliogenesis in Drosophila Development, January 2, 1995; 121(2): 429 - 438. [Abstract] [PDF]
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D. K. Hoshizaki, T. Blackburn, C. Price, M. Ghosh, K. Miles, M. Ragucci, and R. Sweis Embryonic fat-cell lineage in Drosophila melanogaster Development, September 1, 1994; 120(9): 2489 - 2499. [Abstract] [PDF]
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P. Cubas, J. Modolell, and M. Ruiz-Gomez The helix-loop-helix extramacrochaetae protein is required for proper specification of many cell types in the Drosophila embryo Development, September 1, 1994; 120(9): 2555 - 2566. [Abstract] [PDF]
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P J Swiatek, C E Lindsell, F F del Amo, G Weinmaster, and T Gridley Notch1 is essential for postimplantation development in mice. Genes & Dev., March 15, 1994; 8(6): 707 - 719. [Abstract] [PDF]
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M Hoch, K Broadie, H Jackle, and H Skaer Sequential fates in a single cell are established by the neurogenic cascade in the Malpighian tubules of Drosophila Development, January 12, 1994; 120(12): 3439 - 3450. [Abstract] [PDF]
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B Jennings, A Preiss, C Delidakis, and S Bray The Notch signalling pathway is required for Enhancer of split bHLH protein expression during neurogenesis in the Drosophila embryo Development, January 12, 1994; 120(12): 3537 - 3548. [Abstract] [PDF]
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C Chiang, N. Patel, K. Young, and P. Beachy The novel homeodomain gene buttonless specifies differentiation and axonal guidance functions of Drosophila dorsal median cells Development, January 12, 1994; 120(12): 3581 - 3593. [Abstract] [PDF]
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I. Moskowitz, S. Gendreau, and J. Rothman Combinatorial specification of blastomere identity by glp-1-dependent cellular interactions in the nematode Caenorhabditis elegans Development, January 11, 1994; 120(11): 3325 - 3338. [Abstract] [PDF]
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F Schweisguth and J. Posakony Antagonistic activities of Suppressor of Hairless and Hairless control alternative cell fates in the Drosophila adult epidermis Development, January 6, 1994; 120(6): 1433 - 1441. [Abstract] [PDF]
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R Reuter The gene serpent has homeotic properties and specifies endoderm versus ectoderm within the Drosophila gut Development, January 5, 1994; 120(5): 1123 - 1135. [Abstract] [PDF]
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B. Williams and C. Ordahl Pax-3 expression in segmental mesoderm marks early stages in myogenic cell specification Development, January 4, 1994; 120(4): 785 - 796. [Abstract] [PDF]
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T. Menne and C Klambt The formation of commissures in the Drosophila CNS depends on the midline cells and on the Notch gene Development, January 1, 1994; 120(1): 123 - 133. [Abstract] [PDF]
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