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Development, Vol 116, Issue 4 855-863, Copyright © 1992 by Company of Biologists
JOURNAL ARTICLES |
CQ Doe
Department of Cell and Structural Biology, University of Illinois, Urbana 61801.
The first step in generating cellular diversity in the Drosophila central nervous system is the formation of a segmentally reiterated array of neural precursor cells, called neuroblasts. Subsequently, each neuroblast goes through an invariant cell lineage to generate neurons and/or glia. Using molecular lineage markers, I show that (1) each neuroblast forms at a stereotyped time and position; (2) the neuroblast pattern is indistinguishable between thoracic and abdominal segments; (3) the development of individual neuroblasts can be followed throughout early neurogenesis; (4) gene expression in a neuroblast can be reproducibly modulated during its cell lineage; (5) identified ganglion mother cells form at stereotyped times and positions; and (6) the cell lineage of four well-characterized neurons can be traced back to two identified neuroblasts. These results set the stage for investigating neuroblast specification and the mechanisms controlling neuroblast cell lineages.
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E. Spana and C. Doe The prospero transcription factor is asymmetrically localized to the cell cortex during neuroblast mitosis in Drosophila Development, January 10, 1995; 121(10): 3187 - 3195. [Abstract] [PDF]
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A. Prokop and G. M. Technau Early tagma-specific commitment of Drosophila CNS progenitor NB1-1 Development, September 1, 1994; 120(9): 2567 - 2578. [Abstract] [PDF]
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B Jennings, A Preiss, C Delidakis, and S Bray The Notch signalling pathway is required for Enhancer of split bHLH protein expression during neurogenesis in the Drosophila embryo Development, January 12, 1994; 120(12): 3537 - 3548. [Abstract] [PDF]
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T Bossing and G. Technau The fate of the CNS midline progenitors in Drosophila as revealed by a new method for single cell labelling Development, January 7, 1994; 120(7): 1895 - 1906. [Abstract] [PDF]
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J. Skeath, G. Panganiban, and S. Carroll The ventral nervous system defective gene controls proneural gene expression at two distinct steps during neuroblast formation in Drosophila Development, January 6, 1994; 120(6): 1517 - 1524. [Abstract] [PDF]
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Y Zhang, A Ungar, C Fresquez, and R Holmgren Ectopic expression of either the Drosophila gooseberry-distal or proximal gene causes alterations of cell fate in the epidermis and central nervous system Development, January 5, 1994; 120(5): 1151 - 1161. [Abstract] [PDF]
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T. Menne and C Klambt The formation of commissures in the Drosophila CNS depends on the midline cells and on the Notch gene Development, January 1, 1994; 120(1): 123 - 133. [Abstract] [PDF]
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X. Cui and C. Q. Doe ming is expressed in neuroblast sublineages and regulates gene expression in the Drosophila central nervous system Development, December 1, 1992; 116(4): 943 - 952. [Abstract] [PDF]
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