Development, Vol 116, Issue 4 931-941, Copyright © 1992 by Company of Biologists

JOURNAL ARTICLES

Notch2: a second mammalian Notch gene

G Weinmaster, VJ Roberts and G Lemke
Molecular Neurobiology Laboratory, Salk Institute, San Diego, CA 92186.

Notch is a cell surface receptor that mediates a wide variety of cellular interactions that specify cell fate during Drosophila development. Recently, homologs of Drosophila Notch have been isolated from Xenopus, human and rat, and the expression patterns of these vertebrate proteins suggest that they may be functionally analogous to their Drosophila counterpart. We have now identified a second rat gene that exhibits substantial nucleic and amino acid sequence identity to Drosophila Notch. This gene, designated Notch2, encodes a protein that contains all the structural motifs characteristic of a Notch protein. Thus, mammals differ from Drosophila in having more than one Notch gene. Northern and in situ hybridisation analyses in the developing and adult rat identify distinct spatial and temporal patterns of expression for Notch1 and Notch2, indicating that these genes are not redundant. These results suggest that the great diversity of cell-fate decisions regulated by Notch in Drosophila may be further expanded in vertebrates by the activation of distinct Notch proteins.
CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				A. N. Riesenberg, Z. Liu, R. Kopan, and N. L. Brown Rbpj Cell Autonomous Regulation of Retinal Ganglion Cell and Cone Photoreceptor Fates in the Mouse Retina J. Neurosci., October 14, 2009; 29(41): 12865 - 12877. [Abstract] [Full Text] [PDF]

				A. Theodosiou, S. Arhondakis, M. Baumann, and S. Kossida Evolutionary Scenarios of Notch Proteins Mol. Biol. Evol., July 1, 2009; 26(7): 1631 - 1640. [Abstract] [Full Text] [PDF]

				V. Bolos, J. Grego-Bessa, and J. L. de la Pompa Notch Signaling in Development and Cancer Endocr. Rev., May 1, 2007; 28(3): 339 - 363. [Abstract] [Full Text] [PDF]

				I. Rubio-Aliaga, D. Soewarto, S. Wagner, M. Klaften, H. Fuchs, S. Kalaydjiev, D. H. Busch, M. Klempt, B. Rathkolb, E. Wolf, et al. A Genetic Screen for Modifiers of the Delta1-Dependent Notch Signaling Function in the Mouse Genetics, March 1, 2007; 175(3): 1451 - 1463. [Abstract] [Full Text] [PDF]

				J. B. Rutenberg, A. Fischer, H. Jia, M. Gessler, T. P. Zhong, and M. Mercola Developmental patterning of the cardiac atrioventricular canal by Notch and Hairy-related transcription factors Development, November 1, 2006; 133(21): 4381 - 4390. [Abstract] [Full Text] [PDF]

				C. K. Williams, J.-L. Li, M. Murga, A. L. Harris, and G. Tosato Up-regulation of the Notch ligand Delta-like 4 inhibits VEGF-induced endothelial cell function Blood, February 1, 2006; 107(3): 931 - 939. [Abstract] [Full Text] [PDF]

				S. L. DeHart, M. J. Heikens, and S. Tsai Jagged2 promotes the development of natural killer cells and the establishment of functional natural killer cell lines Blood, May 1, 2005; 105(9): 3521 - 3527. [Abstract] [Full Text] [PDF]

				J. Wu, F. Iwata, J. A. Grass, C. S. Osborne, L. Elnitski, P. Fraser, O. Ohneda, M. Yamamoto, and E. H. Bresnick Molecular Determinants of NOTCH4 Transcription in Vascular Endothelium Mol. Cell. Biol., February 15, 2005; 25(4): 1458 - 1474. [Abstract] [Full Text] [PDF]

				K. L. Hahn, J. Johnson, B. J. Beres, S. Howard, and J. Wilson-Rawls Lunatic fringe null female mice are infertile due to defects in meiotic maturation Development, February 15, 2005; 132(4): 817 - 828. [Abstract] [Full Text] [PDF]

				M. Schubert, J.-K. Yu, N. D. Holland, H. Escriva, V. Laudet, and L. Z. Holland Retinoic acid signaling acts via Hox1 to establish the posterior limit of the pharynx in the chordate amphioxus Development, January 1, 2005; 132(1): 61 - 73. [Abstract] [Full Text] [PDF]

				F. MacKenzie, P. Duriez, B. Larrivee, L. Chang, I. Pollet, F. Wong, C. Yip, and A. Karsan Notch4-induced inhibition of endothelial sprouting requires the ankyrin repeats and involves signaling through RBP-J{kappa} Blood, September 15, 2004; 104(6): 1760 - 1768. [Abstract] [Full Text] [PDF]

				M. F. Stidworthy, S. Genoud, W.-W. Li, D. P. Leone, N. Mantei, U. Suter, and R. J. M. Franklin Notch1 and Jagged1 are expressed after CNS demyelination, but are not a major rate-determining factor during remyelination Brain, September 1, 2004; 127(9): 1928 - 1941. [Abstract] [Full Text] [PDF]

				M. Bussen, M. Petry, K. Schuster-Gossler, M. Leitges, A. Gossler, and A. Kispert The T-box transcription factor Tbx18 maintains the separation of anterior and posterior somite compartments Genes & Dev., May 15, 2004; 18(10): 1209 - 1221. [Abstract] [Full Text] [PDF]

				G. R. Sander and B. C. Powell Expression of Notch Receptors and Ligands in the Adult Gut J. Histochem. Cytochem., April 1, 2004; 52(4): 509 - 516. [Abstract] [Full Text] [PDF]

				C. H. Jensen, E. I. Jauho, E. Santoni-Rugiu, U. Holmskov, B. Teisner, N. Tygstrup, and H. C. Bisgaard Transit-Amplifying Ductular (Oval) Cells and Their Hepatocytic Progeny Are Characterized by a Novel and Distinctive Expression of Delta-Like Protein/Preadipocyte Factor 1/Fetal Antigen 1 Am. J. Pathol., April 1, 2004; 164(4): 1347 - 1359. [Abstract] [Full Text] [PDF]

				M. T. Tetzlaff, W. Yu, M. Li, P. Zhang, M. Finegold, K. Mahon, J. W. Harper, R. J. Schwartz, and S. J. Elledge Inaugural Article, From The Cover: Defective cardiovascular development and elevated cyclin E and Notch proteins in mice lacking the Fbw7 F-box protein PNAS, March 9, 2004; 101(10): 3338 - 3345. [Abstract] [Full Text] [PDF]

				H.-T. Cheng, J. H. Miner, M. Lin, M. G. Tansey, K. Roth, and R. Kopan {gamma}-Secretase activity is dispensable for mesenchyme-to-epithelium transition but required for podocyte and proximal tubule formation in developing mouse kidney Development, October 15, 2003; 130(20): 5031 - 5042. [Abstract] [Full Text] [PDF]

				P. Wang, F. A. Pereira, D. Beasley, and H. Zheng Presenilins are required for the formation of comma- and S-shaped bodies during nephrogenesis Development, October 15, 2003; 130(20): 5019 - 5029. [Abstract] [Full Text] [PDF]

				L. Espinosa, J. Ingles-Esteve, C. Aguilera, and A. Bigas Phosphorylation by Glycogen Synthase Kinase-3{beta} Down-regulates Notch Activity, a Link for Notch and Wnt Pathways J. Biol. Chem., August 22, 2003; 278(34): 32227 - 32235. [Abstract] [Full Text] [PDF]

				G. R. Sander, S. J.H. Brookes, and B. C. Powell Expression of Notch1 and Jagged2 in the Enteric Nervous System J. Histochem. Cytochem., July 1, 2003; 51(7): 969 - 972. [Abstract] [Full Text] [PDF]

				L. M. Johansen, C. D. Deppmann, K. D. Erickson, W. F. Coffin III, T. M. Thornton, S. E. Humphrey, J. M. Martin, and E. J. Taparowsky EBNA2 and Activated Notch Induce Expression of BATF J. Virol., May 15, 2003; 77(10): 6029 - 6040. [Abstract] [Full Text] [PDF]

				K. Serth, K. Schuster-Gossler, R. Cordes, and A. Gossler Transcriptional oscillation of Lunatic fringe is essential for somitogenesis Genes & Dev., April 1, 2003; 17(7): 912 - 925. [Abstract] [Full Text] [PDF]

				T. Iso, Y. Hamamori, and L. Kedes Notch Signaling in Vascular Development Arterioscler Thromb Vasc Biol, April 1, 2003; 23(4): 543 - 553. [Abstract] [Full Text] [PDF]

				T. Yamada, H. Yamazaki, T. Yamane, M. Yoshino, H. Okuyama, M. Tsuneto, T. Kurino, S.-I. Hayashi, and S. Sakano Regulation of osteoclast development by Notch signaling directed to osteoclast precursors and through stromal cells Blood, March 15, 2003; 101(6): 2227 - 2234. [Abstract] [Full Text] [PDF]

				F. Clotman, V. J. Lannoy, M. Reber, S. Cereghini, D. Cassiman, P. Jacquemin, T. Roskams, G. G. Rousseau, and F. P. Lemaigre The onecut transcription factor HNF6 is required for normal development of the biliary tract Development, March 6, 2003; 129(8): 1819 - 1828. [Abstract] [Full Text] [PDF]

				A. Kunisato, S. Chiba, E. Nakagami-Yamaguchi, K. Kumano, T. Saito, S. Masuda, T. Yamaguchi, M. Osawa, R. Kageyama, H. Nakauchi, et al. HES-1 preserves purified hematopoietic stem cells ex vivo and accumulates side population cells in vivo Blood, March 1, 2003; 101(5): 1777 - 1783. [Abstract] [Full Text] [PDF]

				B. Varnum-Finney, C. Brashem-Stein, and I. D. Bernstein Combined effects of Notch signaling and cytokines induce a multiple log increase in precursors with lymphoid and myeloid reconstituting ability Blood, March 1, 2003; 101(5): 1784 - 1789. [Abstract] [Full Text] [PDF]

				K. Fujimori, Y. Fujitani, K. Kadoyama, H. Kumanogoh, K. Ishikawa, and Y. Urade Regulation of Lipocalin-type Prostaglandin D Synthase Gene Expression by Hes-1 through E-box and Interleukin-1beta via Two NF-kappa B Elements in Rat Leptomeningeal Cells J. Biol. Chem., February 14, 2003; 278(8): 6018 - 6026. [Abstract] [Full Text] [PDF]

				M. Dorsch, G. Zheng, D. Yowe, P. Rao, Y. Wang, Q. Shen, C. Murphy, X. Xiong, Q. Shi, J.-C. Gutierrez-Ramos, et al. Ectopic expression of Delta4 impairs hematopoietic development and leads to lymphoproliferative disease Blood, August 28, 2002; 100(6): 2046 - 2055. [Abstract] [Full Text] [PDF]

				V. Sriuranpong, M. W. Borges, C. L. Strock, E. K. Nakakura, D. N. Watkins, C. M. Blaumueller, B. D. Nelkin, and D. W. Ball Notch Signaling Induces Rapid Degradation of Achaete-Scute Homolog 1 Mol. Cell. Biol., May 1, 2002; 22(9): 3129 - 3139. [Abstract] [Full Text] [PDF]

				S. Stier, T. Cheng, D. Dombkowski, N. Carlesso, and D. T. Scadden Notch1 activation increases hematopoietic stem cell self-renewal in vivo and favors lymphoid over myeloid lineage outcome Blood, April 1, 2002; 99(7): 2369 - 2378. [Abstract] [Full Text] [PDF]

				S. L. Dunwoodie, M. Clements, D. B. Sparrow, X. Sa, R. A. Conlon, and R. S. P. Beddington Axial skeletal defects caused by mutation in the spondylocostal dysplasia/pudgy gene Dll3 are associated with disruption of the segmentation clock within the presomitic mesoderm Development, January 4, 2002; 129(7): 1795 - 1806. [Abstract] [Full Text] [PDF]

				K. Kumano, S. Chiba, K. Shimizu, T. Yamagata, N. Hosoya, T. Saito, T. Takahashi, Y. Hamada, and H. Hirai Notch1 inhibits differentiation of hematopoietic cells by sustaining GATA-2 expression Blood, December 1, 2001; 98(12): 3283 - 3289. [Abstract] [Full Text] [PDF]

				K. Ohishi, B. Varnum-Finney, R. E. Serda, C. Anasetti, and I. D. Bernstein The Notch ligand, Delta-1, inhibits the differentiation of monocytes into macrophages but permits their differentiation into dendritic cells Blood, September 1, 2001; 98(5): 1402 - 1407. [Abstract] [Full Text] [PDF]

				T. Mizutani, Y. Taniguchi, T. Aoki, N. Hashimoto, and T. Honjo Conservation of the biochemical mechanisms of signal transduction among mammalian Notch family members PNAS, July 13, 2001; (2001) 161269998. [Abstract] [Full Text] [PDF]

				A. V. Gordadze, R. Peng, J. Tan, G. Liu, R. Sutton, B. Kempkes, G. W. Bornkamm, and P. D. Ling Notch1IC Partially Replaces EBNA2 Function in B Cells Immortalized by Epstein-Barr Virus J. Virol., July 1, 2001; 75(13): 5899 - 5912. [Abstract] [Full Text] [PDF]

				J. Wang, L. Shelly, L. Miele, R. Boykins, M. A. Norcross, and E. Guan Human Notch-1 Inhibits NF-{{kappa}}B Activity in the Nucleus Through a Direct Interaction Involving a Novel Domain J. Immunol., July 1, 2001; 167(1): 289 - 295. [Abstract] [Full Text] [PDF]

				K. W. Makar, D. Ulgiati, J. Hagman, and V. M. Holers A site in the complement receptor 2 (CR2/CD21) silencer is necessary for lineage specific transcriptional regulation Int. Immunol., May 1, 2001; 13(5): 657 - 664. [Abstract] [Full Text] [PDF]

				H. Höfelmayr, L. J. Strobl, G. Marschall, G. W. Bornkamm, and U. Zimber-Strobl Activated Notch1 Can Transiently Substitute for EBNA2 in the Maintenance of Proliferation of LMP1-Expressing Immortalized B Cells J. Virol., March 1, 2001; 75(5): 2033 - 2040. [Abstract] [Full Text]

				T. Morimura, S. Miyatani, D. Kitamura, and R. Goitsuka Notch Signaling Suppresses IgH Gene Expression in Chicken B Cells: Implication in Spatially Restricted Expression of Serrate2/Notch1 in the Bursa of Fabricius J. Immunol., March 1, 2001; 166(5): 3277 - 3283. [Abstract] [Full Text] [PDF]

				K. Koizumi, M Nakajima, S Yuasa, Y Saga, T Sakai, T Kuriyama, T Shirasawa, and H Koseki The role of presenilin 1 during somite segmentation Development, January 4, 2001; 128(8): 1391 - 1402. [Abstract] [PDF]

				B McCright, X Gao, L Shen, J Lozier, Y Lan, M Maguire, D Herzlinger, G Weinmaster, R Jiang, and T Gridley Defects in development of the kidney, heart and eye vasculature in mice homozygous for a hypomorphic Notch2 mutation Development, January 2, 2001; 128(4): 491 - 502. [Abstract] [PDF]

				K. Shimizu, S. Chiba, N. Hosoya, K. Kumano, T. Saito, M. Kurokawa, Y. Kanda, Y. Hamada, and H. Hirai Binding of Delta1, Jagged1, and Jagged2 to Notch2 Rapidly Induces Cleavage, Nuclear Translocation, and Hyperphosphorylation of Notch2 Mol. Cell. Biol., September 15, 2000; 20(18): 6913 - 6922. [Abstract] [Full Text]

				S. Tsai, J. Fero, and S. Bartelmez Mouse Jagged2 is differentially expressed in hematopoietic progenitors and endothelial cells and promotes the survival and proliferation of hematopoietic progenitors by direct cell-to-cell contact Blood, August 1, 2000; 96(3): 950 - 957. [Abstract] [Full Text] [PDF]

				S. Jeffries and A. J. Capobianco Neoplastic Transformation by Notch Requires Nuclear Localization Mol. Cell. Biol., June 1, 2000; 20(11): 3928 - 3941. [Abstract] [Full Text]

				J. R. Shutter, S. Scully, W. Fan, W. G. Richards, J. Kitajewski, G. A. Deblandre, C. R. Kintner, and K. L. Stark Dll4, a novel Notch ligand expressed in arterial endothelium Genes & Dev., June 1, 2000; 14(11): 1313 - 1318. [Abstract] [Full Text]

				K. Ohishi, B. Varnum-Finney, D. Flowers, C. Anasetti, D. Myerson, and I. D. Bernstein Monocytes express high amounts of Notch and undergo cytokine specific apoptosis following interaction with the Notch ligand, Delta-1 Blood, May 1, 2000; 95(9): 2847 - 2854. [Abstract] [Full Text] [PDF]

				F. Radtke, I. Ferrero, A. Wilson, R. Lees, M. Aguet, and H. R. MacDonald Notch1 Deficiency Dissociates the Intrathymic Development of Dendritic Cells and T Cells J. Exp. Med., April 3, 2000; 191(7): 1085 - 1094. [Abstract] [Full Text] [PDF]

				W. Han, Q. Ye, and M. A. S. Moore A soluble form of human Delta-like-1 inhibits differentiation of hematopoietic progenitor cells Blood, March 1, 2000; 95(5): 1616 - 1625. [Abstract] [Full Text] [PDF]

				L. J. Strobl, H. Höfelmayr, G. Marschall, M. Brielmeier, G. W. Bornkamm, and U. Zimber-Strobl Activated Notch1 Modulates Gene Expression in B Cells Similarly to Epstein-Barr Viral Nuclear Antigen 2 J. Virol., February 15, 2000; 74(4): 1727 - 1735. [Abstract] [Full Text]

				G. F. Hoyne, I. Le Roux, M. Corsin-Jimenez, K. Tan, J. Dunne, L. M. G. Forsyth, M. J. Dallman, M. J. Owen, D. Ish-Horowicz, and J. R. Lamb Serrate1-induced Notch signalling regulates the decision between immunity and tolerance made by peripheral CD4+ T cells Int. Immunol., February 1, 2000; 12(2): 177 - 185. [Abstract] [Full Text] [PDF]

				M. Rones, K. McLaughlin, M Raffin, and M Mercola Serrate and Notch specify cell fates in the heart field by suppressing cardiomyogenesis Development, January 9, 2000; 127(17): 3865 - 3876. [Abstract] [PDF]

				T Ito, N Udaka, T Yazawa, K Okudela, H Hayashi, T Sudo, F Guillemot, R Kageyama, and H Kitamura Basic helix-loop-helix transcription factors regulate the neuroendocrine differentiation of fetal mouse pulmonary epithelium Development, January 9, 2000; 127(18): 3913 - 3921. [Abstract] [PDF]

				A Zine, T. Van De Water, and F de Ribaupierre Notch signaling regulates the pattern of auditory hair cell differentiation in mammals Development, January 8, 2000; 127(15): 3373 - 3383. [Abstract] [PDF]

				M. Lin, C Leimeister, M Gessler, and R Kopan Activation of the Notch pathway in the hair cortex leads to aberrant differentiation of the adjacent hair-shaft layers Development, January 6, 2000; 127(11): 2421 - 2432. [Abstract] [PDF]

				K. Shimizu, S. Chiba, K. Kumano, N. Hosoya, T. Takahashi, Y. Kanda, Y. Hamada, Y. Yazaki, and H. Hirai Mouse Jagged1 Physically Interacts with Notch2 and Other Notch Receptors. ASSESSMENT BY QUANTITATIVE METHODS J. Biol. Chem., November 12, 1999; 274(46): 32961 - 32969. [Abstract] [Full Text] [PDF]

				M. P. Felli, M. Maroder, T. A. Mitsiadis, A. F. Campese, D. Bellavia, A. Vacca, R. S. Mann, L. Frati, U. Lendahl, A. Gulino, et al. Expression pattern of Notch1, 2 and 3 and Jagged1 and 2 in lymphoid and stromal thymus components: distinct ligand–receptor interactions in intrathymic T cell development Int. Immunol., July 1, 1999; 11(7): 1017 - 1025. [Abstract] [Full Text] [PDF]

				J. Wilson-Rawls, J. D. Molkentin, B. L. Black, and E. N. Olson Activated Notch Inhibits Myogenic Activity of the MADS-Box Transcription Factor Myocyte Enhancer Factor 2C Mol. Cell. Biol., April 1, 1999; 19(4): 2853 - 2862. [Abstract] [Full Text] [PDF]

				N. Carlesso, J. C. Aster, J. Sklar, and D. T. Scadden Notch1-Induced Delay of Human Hematopoietic Progenitor Cell Differentiation Is Associated With Altered Cell Cycle Kinetics Blood, February 1, 1999; 93(3): 838 - 848. [Abstract] [Full Text] [PDF]

				Y Hamada, Y Kadokawa, M Okabe, M Ikawa, J. Coleman, and Y Tsujimoto Mutation in ankyrin repeats of the mouse Notch2 gene induces early embryonic lethality Development, January 8, 1999; 126(15): 3415 - 3424. [Abstract] [PDF]

				W. PEAR, Z. TANG, S. DEROCCO, D. ALLMAN, R. HARDY, J. PUI, L. XU, F. KARNELL, J. ASTER, and T. KADESCH Consequences of Notch-mediated Inhibition of the Transcription Factor E47 Cold Spring Harb Symp Quant Biol, January 1, 1999; 64(0): 33 - 38. [Abstract] [PDF]

				H. K. Kim and G. Siu The Notch Pathway Intermediate HES-1 Silences CD4 Gene Expression Mol. Cell. Biol., December 1, 1998; 18(12): 7166 - 7175. [Abstract] [Full Text]

				S. Jarriault, O. Le Bail, E. Hirsinger, O. Pourquié, F. Logeat, C. F. Strong, C. Brou, N. G. Seidah, and A. Israël Delta-1 Activation of Notch-1 Signaling Results in HES-1 Transactivation Mol. Cell. Biol., December 1, 1998; 18(12): 7423 - 7431. [Abstract] [Full Text]

				S. V. Ivanov, I. Kuzmin, M.-H. Wei, S. Pack, L. Geil, B. E. Johnson, E. J. Stanbridge, and M. I. Lerman Down-regulation of transmembrane carbonic anhydrases in renal cell carcinoma cell lines by wild-type von Hippel-Lindau transgenes PNAS, October 13, 1998; 95(21): 12596 - 12601. [Abstract] [Full Text] [PDF]

				P. Jones, G. May, L. Healy, J. Brown, G. Hoyne, S. Delassus, and T. Enver Stromal Expression of Jagged 1 Promotes Colony Formation by Fetal Hematopoietic Progenitor Cells Blood, September 1, 1998; 92(5): 1505 - 1511. [Abstract] [Full Text] [PDF]

				S. K. Halder, H. Takemori, O. Hatano, Y. Nonaka, A. Wada, and M. Okamoto Cloning of a Membrane-Spanning Protein with Epidermal Growth Factor-Like Repeat Motifs from Adrenal Glomerulosa Cells Endocrinology, July 1, 1998; 139(7): 3316 - 3328. [Abstract] [Full Text] [PDF]

				B. Varnum-Finney, L. E. Purton, M. Yu, C. Brashem-Stein, D. Flowers, S. Staats, K. A. Moore, I. Le Roux, R. Mann, G. Gray, et al. The Notch Ligand, Jagged-1, Influences the Development of Primitive Hematopoietic Precursor Cells Blood, June 1, 1998; 91(11): 4084 - 4091. [Abstract] [Full Text] [PDF]

				A. Bigas, D. I. K. Martin, and L. A. Milner Notch1 and Notch2 Inhibit Myeloid Differentiation in Response to Different Cytokines Mol. Cell. Biol., April 1, 1998; 18(4): 2324 - 2333. [Abstract] [Full Text]

				Z.-Z. Bao and C. L. Cepko The Expression and Function of Notch Pathway Genes in the Developing Rat Eye J. Neurosci., February 15, 1997; 17(4): 1425 - 1434. [Abstract] [Full Text] [PDF]

				W Zhong, M. Jiang, G Weinmaster, L. Jan, and Y. Jan Differential expression of mammalian Numb, Numblike and Notch1 suggests distinct roles during mouse cortical neurogenesis Development, January 5, 1997; 124(10): 1887 - 1897. [Abstract] [PDF]

				T. Mitsiadis, D Henrique, I Thesleff, and U Lendahl Mouse Serrate-1 (Jagged-1): expression in the developing tooth is regulated by epithelial-mesenchymal interactions and fibroblast growth factor-4 Development, January 4, 1997; 124(8): 1473 - 1483. [Abstract] [PDF]

				J. de la Pompa, A Wakeham, K. Correia, E Samper, S Brown, R. Aguilera, T Nakano, T Honjo, T. Mak, J Rossant, et al. Conservation of the Notch signalling pathway in mammalian neurogenesis Development, January 3, 1997; 124(6): 1139 - 1148. [Abstract] [PDF]

				M. K. Lee, H. H. Slunt, L. J. Martin, G. Thinakaran, G. Kim, S. E. Gandy, M. Seeger, E. Koo, D. L. Price, and S. S. Sisodia Expression of Presenilin 1 and 2 (PS1 and PS2) in Human and Murine Tissues J. Neurosci., December 1, 1996; 16(23): 7513 - 7525. [Abstract] [Full Text] [PDF]

				L. A. Milner, A. Bigas, R. Kopan, C. Brashem-Stein, I. D. Bernstein, and D. I. K. Martin Inhibition of granulocytic differentiation by mNotch1 PNAS, November 12, 1996; 93(23): 13014 - 13019. [Abstract] [Full Text] [PDF]

				L Girard, Z Hanna, N Beaulieu, C D Hoemann, C Simard, C A Kozak, and P Jolicoeur Frequent provirus insertional mutagenesis of Notch1 in thymomas of MMTVD/myc transgenic mice suggests a collaboration of c-myc and Notch1 for oncogenesis. Genes & Dev., August 1, 1996; 10(15): 1930 - 1944. [Abstract] [PDF]

				H Uyttendaele, G Marazzi, G Wu, Q Yan, D Sassoon, and J Kitajewski Notch4/int-3, a mammary proto-oncogene, is an endothelial cell-specific mammalian Notch gene Development, July 1, 1996; 122(7): 2251 - 2259. [Abstract] [PDF]

				C Shawber, D Nofziger, J. Hsieh, C Lindsell, O Bogler, D Hayward, and G Weinmaster Notch signaling inhibits muscle cell differentiation through a CBF1-independent pathway Development, January 12, 1996; 122(12): 3765 - 3773. [Abstract] [PDF]

				D. Raible and J. Eisen Regulative interactions in zebrafish neural crest Development, January 2, 1996; 122(2): 501 - 507. [Abstract] [PDF]

				S Artavanis-Tsakonas, K Matsuno, and M. Fortini Notch signaling Science, April 14, 1995; 268(5208): 225 - 232. [Abstract] [PDF]

				C. Austin, D. Feldman, J. Ida, and C. Cepko Vertebrate retinal ganglion cells are selected from competent progenitors by the action of Notch Development, January 11, 1995; 121(11): 3637 - 3650. [Abstract] [PDF]

				C Oka, T Nakano, A Wakeham, J. de la Pompa, C Mori, T Sakai, S Okazaki, M Kawaichi, K Shiota, T. Mak, et al. Disruption of the mouse RBP-J kappa gene results in early embryonic death Development, January 10, 1995; 121(10): 3291 - 3301. [Abstract] [PDF]

				B Bettenhausen, M Hrabe de Angelis, D Simon, J. Guenet, and A Gossler Transient and restricted expression during mouse embryogenesis of Dll1, a murine gene closely related to Drosophila Delta Development, January 8, 1995; 121(8): 2407 - 2418. [Abstract] [PDF]

				R. Conlon, A. Reaume, and J Rossant Notch1 is required for the coordinate segmentation of somites Development, January 5, 1995; 121(5): 1533 - 1545. [Abstract] [PDF]

				A. Newman, J. White, and P. Sternberg The Caenorhabditis elegans lin-12 gene mediates induction of ventral uterine specialization by the anchor cell Development, January 2, 1995; 121(2): 263 - 271. [Abstract] [PDF]

				R. Kopan, J. S. Nye, and H. Weintraub The intracellular domain of mouse Notch: a constitutively activated repressor of myogenesis directed at the basic helix-loop-helix region of MyoD Development, September 1, 1994; 120(9): 2385 - 2396. [Abstract] [PDF]

				J. S. Nye, R. Kopan, and R. Axel An activated Notch suppresses neurogenesis and myogenesis but not gliogenesis in mammalian cells Development, September 1, 1994; 120(9): 2421 - 2430. [Abstract] [PDF]

				P J Swiatek, C E Lindsell, F F del Amo, G Weinmaster, and T Gridley Notch1 is essential for postimplantation development in mice. Genes & Dev., March 15, 1994; 8(6): 707 - 719. [Abstract] [PDF]

				R. Diederich, K Matsuno, H Hing, and S Artavanis-Tsakonas Cytosolic interaction between deltex and Notch ankyrin repeats implicates deltex in the Notch signaling pathway Development, January 3, 1994; 120(3): 473 - 481. [Abstract] [PDF]

				J. Aster, W. Pear, R. Hasserjian, H. Erba, F. Davi, B. Luo, M. Scott, D. Baltimore, and J. Sklar Functional Analysis of the TAN-1 Gene, a Human Homolog of Drosophila Notch Cold Spring Harb Symp Quant Biol, January 1, 1994; 59(0): 125 - 136. [Abstract] [PDF]

				K. Fitzgerald, H. A. Wilkinson, and I. Greenwald glp-1 can substitute for lin-12 in specifying cell fate decisions in Caenorhabditis elegans Development, December 1, 1993; 119(4): 1019 - 1027. [Abstract] [PDF]

				T Lieber, S Kidd, E Alcamo, V Corbin, and M W Young Antineurogenic phenotypes induced by truncated Notch proteins indicate a role in signal transduction and may point to a novel function for Notch in nuclei. Genes & Dev., October 1, 1993; 7(10): 1949 - 1965. [Abstract] [PDF]

				K. Shimizu, S. Chiba, T. Saito, K. Kumano, T. Takahashi, and H. Hirai Manic Fringe and Lunatic Fringe Modify Different Sites of the Notch2 Extracellular Region, Resulting in Different Signaling Modulation J. Biol. Chem., July 6, 2001; 276(28): 25753 - 25758. [Abstract] [Full Text] [PDF]

				J. Ingles-Esteve, L. Espinosa, L. A. Milner, C. Caelles, and A. Bigas Phosphorylation of Ser2078 Modulates the Notch2 Function in 32D Cell Differentiation J. Biol. Chem., November 21, 2001; 276(48): 44873 - 44880. [Abstract] [Full Text] [PDF]

				T. Mizutani, Y. Taniguchi, T. Aoki, N. Hashimoto, and T. Honjo Conservation of the biochemical mechanisms of signal transduction among mammalian Notch family members PNAS, July 31, 2001; 98(16): 9026 - 9031. [Abstract] [Full Text] [PDF]