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Development, Vol 117, Issue 1 283-291, Copyright © 1993 by Company of Biologists
JOURNAL ARTICLES |
PW Ingham and A Hidalgo
ICRF Developmental Biology Unit, Department of Zoology, Oxford, UK.
The segment polarity gene wingless (wg) is expressed in a complex pattern during embryogenesis suggesting that it plays multiple roles in the development of the embryo. The best characterized of these is its role in cell pattening in each parasegment, a process that requires the activity of other segment polarity genes including patched (ptc) and hedgehog (hh). Here we present further evidence that ptc and hh encode components of a signal transduction pathway that regulate the expression of wg transcription following its activation by pair-rule genes. We also show that most other aspects of wg expression are independent of this regulatory network.
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