|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 117, Issue 2 807-822, Copyright © 1993 by Company of Biologists
JOURNAL ARTICLES |
KA Wharton, RP Ray and WM Gelbart
Department of Cellular and Developmental Biology, Harvard University, Cambridge, Massachusetts 02138.
decapentaplegic (dpp) is a zygotically expressed gene encoding a TGF-beta-related ligand that is necessary for dorsal-ventral patterning in the Drosophila embryo. We show here that dpp is an integral part of a gradient that specifies many different cell fates via intercellular signalling. There is a graded requirement for dpp activity in the early embryo: high levels of dpp activity specify the amnioserosa, while progressively lower levels specify dorsal and lateral ectoderm. This potential for dpp to specify cell fate is highly dosage sensitive. In the wild-type embryo, increasing the gene dosage of dpp can shift cell fates along the dorsal-ventral axis. Furthermore, in mutant embryos, in which only a subset of the dorsal-ventral pattern elements are represented, increasing the gene dosage of dpp can specifically transform those pattern elements into more dorsal ones. We present evidence that the zygotic dpp gradient and the maternal dorsal gradient specify distinct, non-overlapping domains of the dorsal-ventral pattern.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati 
Twitter What's this?
This article has been cited by other articles:
|
|
 |
|
  V. Twombly, E. Bangi, V. Le, B. Malnic, M. A. Singer, and K. A. Wharton Functional Analysis of saxophone, the Drosophila Gene Encoding the BMP Type I Receptor Ortholog of Human ALK1/ACVRL1 and ACVR1/ALK2 Genetics, October 1, 2009; 183(2): 563 - 579. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. O. Miles, E. Jaffray, S. G. Campbell, S. Takeda, L. J. Bayston, S. P. Basu, M. Li, L. A. Raftery, M. P. Ashe, R. T. Hay, et al. Medea SUMOylation restricts the signaling range of the Dpp morphogen in the Drosophila embryo Genes & Dev., September 15, 2008; 22(18): 2578 - 2590. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. S. Pinto, S. R. Wilmington, E. E. L. Hornick, L. L. Wallrath, and P. K. Geyer Tissue-Specific Defects Are Caused by Loss of the Drosophila MAN1 LEM Domain Protein Genetics, September 1, 2008; 180(1): 133 - 145. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Wang, Z. Li, and Y. Cai The JAK/STAT pathway positively regulates DPP signaling in the Drosophila germline stem cell niche J. Cell Biol., February 25, 2008; 180(4): 721 - 728. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M.-c. Lin, J. Park, N. Kirov, and C. Rushlow Threshold response of C15 to the Dpp gradient in Drosophila is established by the cumulative effect of Smad and Zen activators and negative cues Development, December 15, 2006; 133(24): 4805 - 4813. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Ikeya, M. Kawada, H. Kiyonari, N. Sasai, K. Nakao, Y. Furuta, and Y. Sasai Essential pro-Bmp roles of crossveinless 2 in mouse organogenesis Development, November 15, 2006; 133(22): 4463 - 4473. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. v. d. Zee, O. Stockhammer, C. v. Levetzow, R. N. d. Fonseca, and S. Roth Sog/Chordin is required for ventral-to-dorsal Dpp/BMP transport and head formation in a short germ insect PNAS, October 31, 2006; 103(44): 16307 - 16312. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. M. Umulis, M. Serpe, M. B. O'Connor, and H. G. Othmer Robust, bistable patterning of the dorsal surface of the Drosophila embryo PNAS, August 1, 2006; 103(31): 11613 - 11618. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Li, W. X. Li, and W. M. Gelbart A Genetic Screen for Maternal-Effect Suppressors of decapentaplegic Identifies the eukaryotic translation initiation factor 4A in Drosophila Genetics, December 1, 2005; 171(4): 1629 - 1641. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Xu, N. Kirov, and C. Rushlow Peak levels of BMP in the Drosophila embryo control target genes by a feed-forward mechanism Development, April 1, 2005; 132(7): 1637 - 1647. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Garrigue-Antar, V. Francois, and K. E. Kadler Deletion of Epidermal Growth Factor-like Domains Converts Mammalian Tolloid into a Chordinase and Effective Procollagen C-proteinase J. Biol. Chem., November 26, 2004; 279(48): 49835 - 49841. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Yu, K.-H. Kang, P. Heine, U. Pyati, S. Srinivasan, B. Biehs, D. Kimelman, and E. Bier Cysteine Repeat Domains and Adjacent Sequences Determine Distinct Bone Morphogenetic Protein Modulatory Activities of the Drosophila Sog Protein Genetics, March 1, 2004; 166(3): 1323 - 1336. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. J. Sutherland, M. Li, X.-q. Liu, R. Stefancsik, and L. A. Raftery Stepwise formation of a SMAD activity gradient during dorsal-ventral patterning of the Drosophila embryo Development, December 1, 2003; 130(23): 5705 - 5716. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Xiao, J.-h. Shim, M. Kluppel, S. S.-M. Zhang, C. Dong, R. A. Flavell, X.-Y. Fu, J. L. Wrana, B. L.M. Hogan, and S. Ghosh Ecsit is required for Bmp signaling and mesoderm formation during mouse embryogenesis Genes & Dev., December 1, 2003; 17(23): 2933 - 2949. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. Shimmi and M. B. O'Connor Physical properties of Tld, Sog, Tsg and Dpp protein interactions are predicted to help create a sharp boundary in Bmp signals during dorsoventral patterning of the Drosophila embryo Development, October 1, 2003; 130(19): 4673 - 4682. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Li and W. X. Li Drosophila Gain-of-Function Mutant RTK Torso Triggers Ectopic Dpp and STAT Signaling Genetics, May 1, 2003; 164(1): 247 - 258. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. P. Ray and K. A. Wharton Context-dependent relationships between the BMPs gbb and dpp during development of the Drosophila wing imaginal disk Development, October 15, 2001; 128(20): 3913 - 3925. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Decotto and E. L. Ferguson A positive role for Short gastrulation in modulating BMP signaling during dorsoventral patterning in the Drosophila embryo Development, October 1, 2001; 128(19): 3831 - 3841. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Rushlow, P. F. Colosimo, M.-c. Lin, M. Xu, and N. Kirov Transcriptional regulation of the Drosophila gene zen by competing Smad and Brinker inputs Genes & Dev., February 1, 2001; 15(3): 340 - 351. [Abstract] [Full Text]
|
|
|
|
|
|
M. A. Su, R. G. Wisotzkey, and S. J. Newfeld A Screen for Modifiers of decapentaplegic Mutant Phenotypes Identifies lilliputian, the Only Member of the Fragile-X/Burkitt's Lymphoma Family of Transcription Factors in Drosophila melanogaster Genetics, February 1, 2001; 157(2): 717 - 725. [Abstract] [Full Text]
|
|
|
|
|
|
J Torres-Vazquez, S Park, R Warrior, and K Arora The transcription factor Schnurri plays a dual role in mediating Dpp signaling during embryogenesis Development, January 5, 2001; 128(9): 1657 - 1670. [Abstract] [PDF]
|
|
|
|
|
|
R Dorfman and B. Shilo Biphasic activation of the BMP pathway patterns the Drosophila embryonic dorsal region Development, January 3, 2001; 128(6): 965 - 972. [Abstract] [PDF]
|
|
|
|
|
|
K. Yu, S. Srinivasan, O. Shimmi, B. Biehs, K. E. Rashka, D. Kimelman, M. B. O'Connor, and E. Bier Processing of the Drosophila Sog protein creates a novel BMP inhibitory activity Development, May 15, 2000; 127(10): 2143 - 2154. [Abstract] [PDF]
|
|
|
|
|
|
H. Ashe, M Mannervik, and M Levine Dpp signaling thresholds in the dorsal ectoderm of the Drosophila embryo Development, January 8, 2000; 127(15): 3305 - 3312. [Abstract] [PDF]
|
|
|
|
|
|
H Araujo and E Bier sog and dpp exert opposing maternal functions to modify toll signaling and pattern the dorsoventral axis of the Drosophila embryo Development, January 8, 2000; 127(16): 3631 - 3644. [Abstract] [PDF]
|
|
|
|
|
|
J Curtiss and M Mlodzik Morphogenetic furrow initiation and progression during eye development in Drosophila: the roles of decapentaplegic, hedgehog and eyes absent Development, January 3, 2000; 127(6): 1325 - 1336. [Abstract] [PDF]
|
|
|
|
|
|
A Jazwinska, C Rushlow, and S Roth The role of brinker in mediating the graded response to Dpp in early Drosophila embryos Development, January 8, 1999; 126(15): 3323 - 3334. [Abstract] [PDF]
|
|
|
|
|
|
R Chen, G Halder, Z Zhang, and G Mardon Signaling by the TGF-beta homolog decapentaplegic functions reiteratively within the network of genes controlling retinal cell fate determination in Drosophila Development, January 2, 1999; 126(5): 935 - 943. [Abstract] [PDF]
|
|
|
|
|
|
S. J. Newfeld and N. T. Takaesu Local Transposition of a hobo Element Within the decapentaplegic Locus of Drosophila Genetics, January 1, 1999; 151(1): 177 - 187. [Abstract] [Full Text]
|
|
|
|
|
|
R. E. Nicholls and W. M. Gelbart Identification of Chromosomal Regions Involved in decapentaplegic Function in Drosophila Genetics, May 1, 1998; 149(1): 203 - 215. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Martín-Blanco, A. Gampel, J. Ring, K. Virdee, N. Kirov, A. M. Tolkovsky, and A. Martinez-Arias puckered encodes a phosphatase that mediates a feedback loop regulating JNK activity during dorsal closure in Drosophila Genes & Dev., February 15, 1998; 12(4): 557 - 570. [Abstract] [Full Text]
|
|
|
|
|
|
K. Simin, E. A. Bates, M. A. Horner, and A. Letsou Genetic Analysis of Punt, a Type II Dpp Receptor That Functions Throughout the Drosophila melanogaster Life Cycle Genetics, February 1, 1998; 148(2): 801 - 814. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Haerry, O Khalsa, M. O'Connor, and K. Wharton Synergistic signaling by two BMP ligands through the SAX and TKV receptors controls wing growth and patterning in Drosophila Development, January 10, 1998; 125(20): 3977 - 3987. [Abstract] [PDF]
|
|
|
|
|
|
O Khalsa, J. Yoon, S Torres-Schumann, and K. Wharton TGF-beta/BMP superfamily members, Gbb-60A and Dpp, cooperate to provide pattern information and establish cell identity in the Drosophila wing Development, January 7, 1998; 125(14): 2723 - 2734. [Abstract] [PDF]
|
|
|
|
|
|
Y Chen, M. Riese, M. Killinger, and F. Hoffmann A genetic screen for modifiers of Drosophila decapentaplegic signaling identifies mutations in punt, Mothers against dpp and the BMP-7 homologue, 60A Development, January 5, 1998; 125(9): 1759 - 1768. [Abstract] [PDF]
|
|
|
|
|
|
J. Hudson, S. Podos, K Keith, S. Simpson, and E. Ferguson The Drosophila Medea gene is required downstream of dpp and encodes a functional homolog of human Smad4 Development, January 4, 1998; 125(8): 1407 - 1420. [Abstract] [PDF]
|
|
|
|
|
|
R. Wisotzkey, A Mehra, D. Sutherland, L. Dobens, X Liu, C Dohrmann, L Attisano, and L. Raftery Medea is a Drosophila Smad4 homolog that is differentially required to potentiate DPP responses Development, January 4, 1998; 125(8): 1433 - 1445. [Abstract] [PDF]
|
|
|
|
|
|
D Onichtchouk, A Glinka, and C Niehrs Requirement for Xvent-1 and Xvent-2 gene function in dorsoventral patterning of Xenopus mesoderm Development, January 4, 1998; 125(8): 1447 - 1456. [Abstract] [PDF]
|
|
|
|
|
|
T Miya, K Morita, A Suzuki, N Ueno, and N Satoh Functional analysis of an ascidian homologue of vertebrate Bmp-2/Bmp-4 suggests its role in the inhibition of neural fate specification Development, January 12, 1997; 124(24): 5149 - 5159. [Abstract] [PDF]
|
|
|
|
|
|
J Heasman Patterning the Xenopus blastula Development, January 11, 1997; 124(21): 4179 - 4191. [Abstract] [PDF]
|
|
|
|
|
|
Y Kishimoto, K. Lee, L Zon, M Hammerschmidt, and S Schulte-Merker The molecular nature of zebrafish swirl: BMP2 function is essential during early dorsoventral patterning Development, January 11, 1997; 124(22): 4457 - 4466. [Abstract] [PDF]
|
|
|
|
|
|
S. Jackson, H Nakato, M Sugiura, A Jannuzi, R Oakes, V Kaluza, C Golden, and S. Selleck dally, a Drosophila glypican, controls cellular responses to the TGF-beta-related morphogen, Dpp Development, January 10, 1997; 124(20): 4113 - 4120. [Abstract] [PDF]
|
|
|
|
|
|
T. Haerry, T. Heslip, J. Marsh, and M. O'Connor Defects in glucuronate biosynthesis disrupt Wingless signaling in Drosophila Development, January 8, 1997; 124(16): 3055 - 3064. [Abstract] [PDF]
|
|
|
|
|
|
S. Newfeld, A Mehra, M. Singer, J. Wrana, L Attisano, and W. Gelbart Mothers against dpp participates in a DDP/TGF-beta responsive serine-threonine kinase signal transduction cascade Development, January 8, 1997; 124(16): 3167 - 3176. [Abstract] [PDF]
|
|
|
|
|
|
P. Wilson, G Lagna, A Suzuki, and A Hemmati-Brivanlou Concentration-dependent patterning of the Xenopus ectoderm by BMP4 and its signal transducer Smad1 Development, January 8, 1997; 124(16): 3177 - 3184. [Abstract] [PDF]
|
|
|
|
|
|
R Dosch, V Gawantka, H Delius, C Blumenstock, and C Niehrs Bmp-4 acts as a morphogen in dorsoventral mesoderm patterning in Xenopus Development, January 6, 1997; 124(12): 2325 - 2334. [Abstract] [PDF]
|
|
|
|
|
|
M Boyle, N Bonini, and S DiNardo Expression and function of clift in the development of somatic gonadal precursors within the Drosophila mesoderm Development, January 3, 1997; 124(5): 971 - 982. [Abstract] [PDF]
|
|
|
|
|
|
J. de Celis Expression and function of decapentaplegic and thick veins during the differentiation of the veins in the Drosophila wing Development, January 3, 1997; 124(5): 1007 - 1018. [Abstract] [PDF]
|
|
|
|
|
|
M. Singer, A Penton, V Twombly, F. Hoffmann, and W. Gelbart Signaling through both type I DPP receptors is required for anterior-posterior patterning of the entire Drosophila wing Development, January 1, 1997; 124(1): 79 - 89. [Abstract] [PDF]
|
|
|
|
|
|
M Freeman Cell determination strategies in the Drosophila eye Development, January 1, 1997; 124(2): 261 - 270. [Abstract] [PDF]
|
|
|
|
|
|
F Chanut and U Heberlein Role of decapentaplegic in initiation and progression of the morphogenetic furrow in the developing Drosophila retina Development, January 1, 1997; 124(2): 559 - 567. [Abstract] [PDF]
|
|
|
|
|
|
S Gisselbrecht, J B Skeath, C Q Doe, and A M Michelson heartless encodes a fibroblast growth factor receptor (DFR1/DFGF-R2) involved in the directional migration of early mesodermal cells in the Drosophila embryo. Genes & Dev., December 1, 1996; 10(23): 3003 - 3017. [Abstract] [PDF]
|
|
|
|
|
|
B Biehs, V Francois, and E Bier The Drosophila short gastrulation gene prevents Dpp from autoactivating and suppressing neurogenesis in the neuroectoderm. Genes & Dev., November 15, 1996; 10(22): 2922 - 2934. [Abstract] [PDF]
|
|
|
|
|
|
M Hammerschmidt, G N Serbedzija, and A P McMahon Genetic analysis of dorsoventral pattern formation in the zebrafish: requirement of a BMP-like ventralizing activity and its dorsal repressor. Genes & Dev., October 1, 1996; 10(19): 2452 - 2461. [Abstract] [PDF]
|
|
|
|
|
|
V. Wiersdorff, T. Lecuit, S. M. Cohen, and M. Mlodzik Mad acts downstream of Dpp receptors, revealing a differential requirement for dpp signaling in initiation and propagation of morphogenesis in the Drosophila eye Development, July 1, 1996; 122(7): 2153 - 2162. [Abstract] [PDF]
|
|
|
|
|
|
R Burke and K Basler Dpp receptors are autonomously required for cell proliferation in the entire developing Drosophila wing Development, July 1, 1996; 122(7): 2261 - 2269. [Abstract] [PDF]
|
|
|
|
|
|
B L Hogan Bone morphogenetic proteins: multifunctional regulators of vertebrate development. Genes & Dev., July 1, 1996; 10(13): 1580 - 1594. [PDF]
|
|
|
|
|
|
C Merli, D E Bergstrom, J A Cygan, and R K Blackman Promoter specificity mediates the independent regulation of neighboring genes. Genes & Dev., May 15, 1996; 10(10): 1260 - 1270. [Abstract] [PDF]
|
|
|
|
|
|
M. Mullins, M Hammerschmidt, D. Kane, J Odenthal, M Brand, F. van Eeden, M Furutani-Seiki, M Granato, P Haffter, C. Heisenberg, et al. Genes establishing dorsoventral pattern formation in the zebrafish embryo: the ventral specifying genes Development, January 12, 1996; 123(1): 81 - 93. [Abstract] [PDF]
|
|
|
|
|
|
K Yu, M. Sturtevant, B Biehs, V Francois, R. Padgett, R. Blackman, and E Bier The Drosophila decapentaplegic and short gastrulation genes function antagonistically during adult wing vein development Development, January 12, 1996; 122(12): 4033 - 4044. [Abstract] [PDF]
|
|
|
|
|
|
S. Newfeld, E. Chartoff, J. Graff, D. Melton, and W. Gelbart Mothers against dpp encodes a conserved cytoplasmic protein required in DPP/TGF-beta responsive cells Development, January 7, 1996; 122(7): 2099 - 2108. [Abstract] [PDF]
|
|
|
|
|
|
P Bokor and S DiNardo The roles of hedgehog, wingless and lines in patterning the dorsal epidermis in Drosophila Development, January 4, 1996; 122(4): 1083 - 1092. [Abstract] [PDF]
|
|
|
|
|
|
J Schmidt, V Francois, E Bier, and D Kimelman Drosophila short gastrulation induces an ectopic axis in Xenopus: evidence for conserved mechanisms of dorsal-ventral patterning Development, January 12, 1995; 121(12): 4319 - 4328. [Abstract] [PDF]
|
|
|
|
|
|
M Zecca, K Basler, and G Struhl Sequential organizing activities of engrailed, hedgehog and decapentaplegic in the Drosophila wing Development, January 8, 1995; 121(8): 2265 - 2278. [Abstract] [PDF]
|
|
|
|
|
|
K Arora, M S Levine, and M B O'Connor The screw gene encodes a ubiquitously expressed member of the TGF-beta family required for specification of dorsal cell fates in the Drosophila embryo. Genes & Dev., November 1, 1994; 8(21): 2588 - 2601. [Abstract] [PDF]
|
|
|
|
|
|
V Francois, M Solloway, J W O'Neill, J Emery, and E Bier Dorsal-ventral patterning of the Drosophila embryo depends on a putative negative growth factor encoded by the short gastrulation gene. Genes & Dev., November 1, 1994; 8(21): 2602 - 2616. [Abstract] [PDF]
|
|
|
|
|
|
E D Mason, K D Konrad, C D Webb, and J L Marsh Dorsal midline fate in Drosophila embryos requires twisted gastrulation, a gene encoding a secreted protein related to human connective tissue growth factor. Genes & Dev., July 1, 1994; 8(13): 1489 - 1501. [Abstract] [PDF]
|
|
|
|
 |
|
 T Xie, A. Finelli, and R. Padgett The Drosophila saxophone gene: a serine-threonine kinase receptor of the TGF-beta superfamily Science, March 25, 1994; 263(5154): 1756 - 1759. [Abstract] [PDF]
|
|
|
|
|
|
D M Kingsley The TGF-beta superfamily: new members, new receptors, and new genetic tests of function in different organisms. Genes & Dev., January 15, 1994; 8(2): 133 - 146. [PDF]
|
|
|
|
|
|
M Affolter, D Nellen, U Nussbaumer, and K Basler Multiple requirements for the receptor serine/threonine kinase thick veins reveal novel functions of TGF beta homologs during Drosophila embryogenesis Development, January 11, 1994; 120(11): 3105 - 3117. [Abstract] [PDF]
|
|
|
|
|
|
A. Finelli, C. Bossie, T Xie, and R. Padgett Mutational analysis of the Drosophila tolloid gene, a human BMP-1 homolog Development, January 4, 1994; 120(4): 861 - 870. [Abstract] [PDF]
|
|
|
|
|
|
E Raz and B Z Shilo Establishment of ventral cell fates in the Drosophila embryonic ectoderm requires DER, the EGF receptor homolog. Genes & Dev., October 1, 1993; 7(10): 1937 - 1948. [Abstract] [PDF]
|
|
|
|
|
|
H. Kirkpatrick, K. Johnson, and A. Laughon Repression of Dpp Targets by Binding of Brinker to Mad Sites J. Biol. Chem., May 18, 2001; 276(21): 18216 - 18222. [Abstract] [Full Text] [PDF]
|
|
